Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 29, Issue 1, 2007, Pages 33-38

  Mu, D ^a,b   Chen, W ^b   Yu, B ^b   Zhang, C ^b   Zhang, Y ^b   Qi, Haowen ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 4; Dihydroartemisinin; Intracellular calcium concentration; SPC A 1 cell; Survivin

Indexed keywords

CALCIUM; CASPASE 4; DIHYDROARTEMISININ; DNA NUCLEOTIDYLEXOTRANSFERASE; SURVIVIN;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LASER MICROSCOPY; LUNG CANCER; NICK END LABELING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARTEMISIA ANNUA; ARTEMISININS; CALCIUM; CALCIUM SIGNALING; CASPASES, INITIATOR; CELL LINE, TUMOR; DOWN-REGULATION; DRUGS, CHINESE HERBAL; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; LUNG NEOPLASMS; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; RNA, MESSENGER; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 33947385343     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2007.29.1.1063493     Document Type: Article

References (26)

1. Gerl, R., Vaux, D.L. Apoptosis in the development and treatment of cancer. Carcinogenesis 2005, 26(2): 263-70.
2. Singh, N.P., Lai, H.C. Artemisinin induces apoptosis in human cancer cells. Anticancer Res 2004, 24(4): 2277-80.
3. Yamachika, E., Habte, T., Oda, D. Artemisinin: An alternative treatment for oral squamous cell carcinoma. Anticancer Res 2004, 24(4): 2153-60.
4. Singh, N.P., Lai, H. Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells. Life Sci 2001, 70(1): 49-56.
5. Zaffaroni, N., Pennati, M., Daidone, M.G. Survivin as a target for new anticancer interventions. J Cell Mol Med 2005, 9(2): 360-72.
6. Trump, B.F., Berezesky, I.K. Calcium-mediated cell injury and cell death. FASEB J 1995, 9(2): 219-28.
7. Hitomi, J., Katayama, T., Eguchi, Y. et al. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol 2004, 165(3): 347-56.
8. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65(1/2): 55-63.
9. Chen, H.H., Zhou, H.J., Fang, X. Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro. Pharmacol Res 2003, 48(3): 231-6.
10. Meshnick, S.R., Yang, Y.Z., Lima, V. et al. Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu). Antimicrob Agents Chemother 1993, 37(5): 1108-14.
11. Moore, J.C., Lai, H., Li, J.R. et al. Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat. Cancer Lett 1995, 98(1): 83-7.
12. Efferth, T., Benakis, A., Romero, M.R. et al. Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med 2004, 37(7): 998-1009.
13. Lai, H., Singh, N.P. Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin. Cancer Lett 1995, 91(1): 41-6.
14. Beekman, A.C., Woerdenbag, H.J., Van Uden, W. et al. Stability of artemisinin in aqueous environments: Impact on its cytotoxic action to Ehrlich ascites tumour cells. J Pharm Pharmacol 1997, 49(12): 1254-8.
15. Eckstein-Ludwig, U., Webb, R.J., Van Goethem, I.D. et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature 2003, 424(6951): 957-61.
16. 2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. J Biol Chem 2002, 277(16): 13812-20.
17. Obeng, E.A., Boise, L.H. Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis. J Biol Chem 2005, 280(33): 29578-87.
18. Lee, W., Kim, D.H., Boo, J.H. et al. ER stress-induced caspase-12 activation is inhibited by PKC in neuronal cells. Apoptosis 2005, 10(2): 407-15.
19. Li, F. Survivin study: What is the next wave? J Cell Physiol 2003, 197(1): 8-29.
20. Olie, R.A., Simoes-Wust, A.P., Baumann, B. et al. A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res 2000, 60(11): 2805-9.
21. O'Connor, D.S., Grossman, D., Plescia, J. et al. Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A 2000, 97(24): 13103-7.
22. Grossman, D., McNiff, J.M., Li, F. et al. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line. Lab Invest 1999, 79(9): 1121-6.
23. Ambrosini, G., Adida, C., Sirugo, G. et al. Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting. J Biol Chem 1998, 273(18): 11177-82.
24. Li, F., Ambrosini, G., Chu, E.Y. et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998, 396(6711): 580-4.
25. Li, F., Altieri, D.C. The cancer antiapoptosis mouse survivin gene: Characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression. Cancer Res 1999, 59(13): 3143-51.
26. Li, Y., Shan, F., Wu, J.M. et al. Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle. Bioorg Med Chem Lett 2001, 11(1): 5-8.