Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis

Microbes and Infection

Volumn 8, Issue 6, 2006, Pages 1560-1568

  Nyakeriga, Alice M ^a   Perlmann, Hedvig ^a   Hagstedt, Margareta ^a   Berzins, Klavs ^a   Troye Blomberg, Marita ^a   Zhivotovsky, Boris ^b   Perlmann, Peter ^a   Grandien, Alf ^c  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; Cell death; Plasmodium falciparum

Indexed keywords

ANTIMALARIAL AGENT; ATOVAQUONE; CHLOROQUINE; DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE DONOR;

APOPTOSIS; ARTICLE; ASEXUAL REPRODUCTION; CELL DEATH; CONTROLLED STUDY; DNA DEGRADATION; DRUG ACTIVITY; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NICK END LABELING; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

PLASMODIUM FALCIPARUM;

EID: 33745175566     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2006.01.016     Document Type: Article

References (30)

1. Malaria Fact Sheet No. 94 (1996), World Health Organisation, Geneva, Switzerland
2. Antimalarial Drug Combination Therapy. Report of a WHO Technical Consultation, 4-5 April 2001 (2001), World Health Organization, Geneva, Switzerland
3. Cowman A.F., and Karcz S. Drug resistance and the P-glycoprotein homologues of Plasmodium falciparum. Semin. Cell Biol. 4 (1993) 29-35
4. Picot S., Burnod J., Bracchi V., Chumpitazi B.F., and Ambroise-Thomas P. Apoptosis related to chloroquine sensitivity of the human malaria parasite Plasmodium falciparum. Trans. R. Soc. Trop. Med. Hyg. 91 (1997) 590-591
5. Srivastava I.K., Rottenberg H., and Vaidya A.B. Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J. Biol. Chem. 272 (1997) 3961-3966
6. Vaidya A.B., and Mather M.W. Atovaquone resistance in malaria parasites. Drug Resist. Updat. 3 (2000) 283-287
7. James E.R., and Green D.R. Infection and the origins of apoptosis. Cell Death Differ. 9 (2002) 355-357
8. Koonin E.V., and Aravind L. Origin and evolution of eukaryotic apoptosis: the bacterial connection. Cell Death Differ. 9 (2002) 394-404
9. Debrabant A., Lee N., Bertholet S., Duncan R., and Nakhasi H.L. Programmed cell death in trypanosomatids and other unicellular organisms. Int. J. Parasitol. 33 (2003) 257-267
10. Deponte M., and Becker K. Plasmodium falciparum - do killers commit suicide?. Trends Parasitol. 20 (2004) 165-169
11. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673-675
12. A. Nyakeriga, In vitro reinvasion and growth inhibition assay by flow cytometric measurement of parasitemia using propidium iodide (PI) staining in: I. Ljungstrom, H. Perlmann, M. Schichtherle, A. Scherf, M. Wahlgren (Eds.), Methods in Malaria Research. MR4/ATCC, Manassas, VA, 2004, pp. 85-86.
13. Snounou G., Viriyakosol S., Zhu X.P., Jarra W., Pinheiro L., do Rosario V.E., Thaithong S., and Brown K.N. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol. Biochem. Parasitol. 61 (1993) 315-320
14. Djerbi M., Darreh-Shori T., Zhivotovsky B., and Grandien A. Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different flip isoforms. Scand. J. Immunol. 54 (2001) 180-189
15. Zhivotovsky B., Wade D., Gahm A., Orrenius S., and Nicotera P. Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation. FEBS Lett. 351 (1994) 150-154
16. Famin O., Krugliak M., and Ginsburg H. Kinetics of inhibition of glutathione-mediated degradation of ferriprotoporphyrin IX by antimalarial drugs. Biochem. Pharmacol. 58 (1999) 59-68
17. Cheesman S., McAleese S., Goman M., Johnson D., Horrocks P., Ridley R.G., and Kilbey B.J. The gene encoding topoisomerase II from Plasmodium falciparum. Nucleic Acids Res. 22 (1994) 2547-2551
18. Chen G.L., Yang L., Rowe T.C., Halligan B.D., Tewey K.M., and Liu L.F. Non-intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem. 259 (1984) 13560-13566
19. Jacobberger J.W., Horan P.K., and Hare J.D. Cell cycle analysis of asexual stages of erythrocytic malaria parasites. Cell Prolif. 25 (1992) 431-445
20. Green D.R., and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305 (2004) 626-629
21. Balmer P., Phillips H.M., Maestre A.E., McMonagle F.A., and Phillips R.S. The effect of nitric oxide on the growth of Plasmodium falciparum, P. chabaudi and P. berghei in vitro. Parasite Immunol. 22 (2000) 97-106
22. Peng B.W., Lin J., Lin J.Y., Jiang M.S., and Zhang T. Exogenous nitric oxide induces apoptosis in Toxoplasma gondii tachyzoites via a calcium signal transduction pathway. Parasitology 126 (2003) 541-550
23. Williamson D.H., Preiser P.R., Moore P.W., McCready S., Strath M., and Wilson R.J. The plastid DNA of the malaria parasite Plasmodium falciparum is replicated by two mechanisms. Mol. Microbiol. 45 (2002) 533-542
24. Kwiatkowski D. Febrile temperatures can synchronize the growth of Plasmodium falciparum in vitro. J. Exp. Med. 169 (1989) 357-361
25. Jensen J.B., Boland M.T., and Akood M. Induction of crisis forms in cultured Plasmodium falciparum with human immune serum from Sudan. Science 216 (1982) 1230-1233
26. Taylor-Robinson A.W. Are nitric oxide, malaria crisis form factor and malaria paroxysm factor, one and the same?. Int. J. Parasitol. 26 (1996) 333-334
27. Lee S., and Inselburg J. In vitro sensitivity of Plasmodium falciparum to drugs that bind DNA or inhibit its synthesis. J. Parasitol. 79 (1993) 780-782
28. Onishi Y., Azuma Y., Sato Y., Mizuno Y., Tadakuma T., and Kizaki H. Topoisomerase inhibitors induce apoptosis in thymocytes. Biochim. Biophys. Acta 1175 (1993) 147-154
29. Lanzer M., Wertheimer S.P., de Bruin D., and Ravetch J.V. Chromatin structure determines the sites of chromosome breakages in Plasmodium falciparum. Nucleic Acids Res. 22 (1994) 3099-3103
30. Al-Olayan E.M., Williams G.T., and Hurd H. Apoptosis in the malaria protozoan, Plasmodium berghei: a possible mechanism for limiting intensity of infection in the mosquito. Int. J. Parasitol. 32 (2002) 1133-1143