Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model

Experimental Neurology

Volumn 161, Issue 2, 2000, Pages 503-516

  Rosenblad, Carl ^a   Kirik, Deniz ^a   Björklund, Anders ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

6 OHDA; BTCP binding; Dopaminergic; GDNF; Globus pallidus; Nigrostriatal axons; Retrograde degeneration; Sprouting; Substantia nigra

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; OXIDOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; FEMALE; NERVE CELL LESION; NERVE FIBER GROWTH; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

EID: 0034097605     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7296     Document Type: Article

References (36)

1. Barami K., Iversen K., Furneaux H., Goldman S. A. Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain. J. Neurobiol. 28:1995;82-101.
2. Beck K. D., Valverde J., Alexi T., Poulsen K., Moffat B., Vandlen R. A., Rosenthal A., Hefti F. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult rat. Nature. 373:1995;339-341.
3. Bowenkamp K. E., Hoffman A. F., Gerhardt G. A., Henry M. A., Biddle P. T., Hoffer B. J., Granholm A.-C. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J. Comp. Neurol. 355:1995;479-489.
4. Brown V. J., Dunnett S. B. Comparison of adrenal and foetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions. Exp. Brain Res. 78:1989;214-218.
5. Cerruti C., Drian M.-J., Kamenka J.-M., Privat A. Localization of dopamine carriers by BTCP, a dopamine uptake inhibitor, on nigral cells cultured in vitro. Brain Res. 555:1991;51-57.
6. Crews L. L., Wigston D. J. The dependence of motorneurons on their target muscle during postnatal development of the mouse. J. Neurosci. 10:1990;1643-1653.
7. Dunnett S. B., Whishaw I. Q., Rogers D. C., Jones G. H. Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions. Brain Res. 415:1987;63-78.
8. Gash D. M., Zhang Z., Ovadia A., Cass W. A., Yi A., Simmerman L., Russel D., Martin D., Lapchac P. A., Collins F., Hoffer B. J., Gerhardt G. A. Functional recovery in parkinsonian monkeys treated with GDNF. Nature. 380:1996;352-355.
9. Gerfen C. R., Baimbridge K. G., Thibault J. The neostriatal mosaic. III. Biochemical and developmental dissociation of patch-matrix mesostriatal systems. J. Neurosci. 7:1987;3935-3944.
10. Guyenet P. G., Crane J. K. Non-dopaminergic nigrostriatal pathway. Brain Res. 213:1981;291-305.
11. Hoffer B. J., Hoffman A., Bowencamp K., Huettl P., Hudson J., Martin D., Lin L.-F. H., Gerhardt G. Glial cell line-derived neurotrophic factor reverses toxin induced injury to midbrain dopaminergic neurons in vivo. Neurosci. Lett. 182:1994;107-111.
12. Horger B., Nishimura M., Armanini M., Wang L.-C., Poulsen K., Rosenblad C., Kirik D., Moffat B., Simmons L., Johnson E., Milbrandt J., Rosenthal A., Bjorklund Anders, Vandlen R., Hynes M., Phillips H. Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. J. Neurosci. 18:1998;4929-4937.
13. 3H]BTCP: A high-affinity antagonist for the DA uptake complex. BioTech. Update. 7:1992;132-135.
14. Kearns C. M., Gash D. M. GDNF protects nigral dopaminergic neurons against 6-hydroxydopamine in vivo. Brain Res. 672:1995;104-111.
15. Kirik D., Rosenblad C., Björklund A. Characterization of behavioural and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp. Neurol. 152:1998;259-277.
16. Kirik, D, C. Rosenblad, and, A. Björklund, 1998, Functional recovery in the partial lesion model of Parkinson's disease after delayed infusion of GDNF. IBAGS Abstract 1.50.
17. Lapchak P. A., Miller P. J., Collins F., Jiao S. Glial cell line-derived neurotrophic factor attenuates behavioural dificits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: Comparison of intraventricular and intranigral delivery. Neuroscience. 78:1997;61-72.
18. Lavoie B., Parent A. Dopaminergic neurons expressing calbindin in normal and parkinsonian monkeys. NeuroReport. 2:1991;601-604.
19. Lin L.-F. H., Doherty D. H., Lile J. D., Bektesh S., Collins F. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 260:1993;1130-1132.
20. Lu X., Hagg T. Glial cell line-derived neurotrophic factor prevents death, but not reductions in tyrosine hydroxylase, of injured nigrostriatal neurons in adult rats. J. Comp. Neurol. 388:1997;484-494.
21. Meyer M., Sautter J., Seiler R., Zimmer J., Widmer H. R. GDNF increases the density of cells containing calbindin but not of cells containing calretinin in cultured fetal nigral tissue. Forum Eur. Neurosci. Abstr. 52:1998;17.
22. Olsson M., Nikkhah G., Bentlage C., Bjorklund A. Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J. Neurosci. 15:1995;3863-3875.
23. Opacka-Juffrey L., Ashworth S., Hume S. P., Martin D., Brooks D. J., Blunt S. B. GDNF protects against 6-OHDA nigrostriatal lesion: In vivo study with microdialysis and PET. NeuroReport. 7:1995;348-352.
24. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1997;Academic Press, San Diego.
25. Rosenblad C., Kirik D., Devaux B., Moffat B., Phillips H. S., Björklund A. Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle. Eur. J. Neurosci. 11:1999;1554-1566.
26. Rosenblad C., Martinez-Serrano A., Björklund A. Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigraostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscience. 82:1998;129-137.
27. Sauer H., Oertel W. H. Progressive degeneration of nigrostriatal dopamine neurons following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat. Neuroscience. 59:1994;401-415.
28. Sauer H., Rosenblad C., Björklund A. Glial cell line-derived neurotrophic factor but not transforming growth factor-β prevents degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc. Natl. Acad. Sci. USA. 92:1995;8935-8939.
29. Schallert T., Norton D., Jones T. A. A clinically relevant unilateral rat model of parkinsonian akinesia. J. Neur. Transp. Plast. 3:1992;332-333.
30. Shults C. W., Kimber T., Martin D. Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine. NeuroReport. 7:1996;627-631.
31. Sullivan A. M., Opacka-Juffrey J., Blunt S. B. Long-term protection of the rat nigrostriatal dopaminergic system by glial cell line-derived neurotrophic factor against 6-hydroxydopamine in vivo. Eur. J. Neurosci. 10:1998;57-63.
32. Tomac A., Lindqvist E., Lin L.-F. H., Ögren S. O., Young D., Hoffer B. J., Olson L. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature. 373:1995;335-339.
33. Ungerstedt U., Arbuthnott G. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res. 24:1970;485-493.
34. West M. J., Slomianka L., Gundersen H. J. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231:1991;482-497.
35. Winkler C., Sauer H., Lee C. S., Björklund A. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 16:1996;7206-7215.
36. Yamada T., McGeer P. L., Baimbridge K. G., McGeer E. G. Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K. Brain Res. 526:1990;303-307.