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Volumn 886, Issue 1-2, 2000, Pages 82-98

Towards a neuroprotective gene therapy for Parkinson's disease: Use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

Author keywords

Adeno associated virus; Adenovirus; Gene transfer; Glial cell line derived neurotrophic factor; Lentivirus; Neuroprotection; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DEXAMPHETAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; OXIDOPAMINE;

EID: 0034672304     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02915-2     Document Type: Article
Times cited : (299)

References (71)
  • 32
    • 0032143368 scopus 로고    scopus 로고
    • Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    • (1998) Exp. Neurol. , vol.152 , pp. 259-277
    • Kirik, D.1    Rosenblad, C.2    Bjorklund, A.3
  • 33
    • 0006825141 scopus 로고    scopus 로고
    • D. Kirik, C. Rosenblad, A. Bjorklund, Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on site of administration of the trophic factor, Eur. J. Neurosci. (in press).
  • 34
    • 0034659835 scopus 로고    scopus 로고
    • Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    • (2000) J. Neurosci. , vol.20 , pp. 4686-4700
    • Kirik, D.1    Rosenblad, C.2    Bjorklund, A.3    Mandel, R.J.4
  • 37
    • 0006827561 scopus 로고    scopus 로고
    • J.H. Kordower, M. Emborg, J. Bloch, S.Y. Ma, Y. Chu, L. Leventhal, J. McBride, E.-Y. Chen, S. Palfi, B.Z. Roitberg, W.D. Brown, J.E. Holden, R. Pyzalski, M.D. Taylor, P. Carvey, Z. Ling, D. Trono, P. Hantraye, N. Deglon, P. Aebischer, Lentiviral vector-mediated expression of GDNF prevents motor deficits and nigrostriatal degeneration in nonhuman primate models of Parkinson's disease, Science (in press).
  • 39
    • 0031550611 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats
    • (1997) Neuroscience , vol.77 , pp. 745-752
    • Lapchak, P.A.1    Miller, P.J.2    Jiao, S.3
  • 44
    • 0032708890 scopus 로고    scopus 로고
    • Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease
    • (1999) Exp. Neurol. , vol.160 , pp. 205-214
    • Mandel, R.J.1    Snyder, R.O.2    Leff, S.E.3
  • 59
    • 0034097605 scopus 로고    scopus 로고
    • Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    • (2000) Exp. Neurol. , vol.161 , pp. 503-516
    • Rosenblad, C.1    Kirik, D.2    Bjorklund, A.3
  • 61
    • 0000609138 scopus 로고    scopus 로고
    • Adeno-associated viral vectors
    • Friedmann T. (Ed.), The Development of Human Gene Therapy, New York: Cold Spring Harbor
    • (1999) , pp. 131-172
    • Samulski, R.J.1    Sally, M.2    Muzyczka, N.3
  • 63
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde and immunocytochemical study in the rat
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 64
    • 0033972740 scopus 로고    scopus 로고
    • Lentiviral vectors: turning a deadly foe into a therapeutic agent
    • (2000) Gene Ther. , vol.7 , pp. 20-23
    • Trono, D.1
  • 67


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.