Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration

American Journal of Ophthalmology

Volumn 134, Issue 2, 2002, Pages 220-227

  Holekamp, Nancy M ^a   Bouck, Noel ^b   Volpert, Olga ^b  

^a BARNES RETINA INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PIGMENT EPITHELIUM DERIVED FACTOR; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION; TISSUE LEVEL; VITREOUS BODY;

AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CHEMOTAXIS; CHOROIDAL NEOVASCULARIZATION; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE PROTEINS; FEMALE; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; PROSPECTIVE STUDIES; PROTEINS; SERPINS; VITREOUS BODY;

EID: 0036329579     PISSN: 00029394     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9394(02)01549-0     Document Type: Article

References (26)

1. PEDF. A pigment epithelium-derived factor with potent neuronal differentiative activity
2. Structure-function studies on PEDF a noninhibitory serpin with neurotrophic activity
3. PEDF: Raising both hopes and questions in controlling angiogenesis
4. Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
5. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations
6. Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal
7. In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor
8. Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
9. Treatment of diabetic retinopathy
10. Low IGF suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity
11. More weapons in the arsenal against ischemic retinopathy
12. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization
13. Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues
14. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
15. Inhibitor of neovascularization by an extract of vitreous
16. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
17. Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study Group
18. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes
19. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor
20. Natural history of choroidal neovascularization induced by vascular endothelial growth factor in the primate
21. Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium lead to the development of choroidal neovascularization
22. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth facto in the retinal pigment epithelium
23. VEGF is major stimulator in model of choroidal neovascularization
24. Oxidative damage and protection of the RPE
25. Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF