Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels

Journal of Neurochemistry

Volumn 99, Issue 3, 2006, Pages 861-867

  Cao, Xu Qing ^a   Arai, Hiroyuki ^a   Ren, Yong Ri ^a   Oizumi, Hideki ^a   Zhang, Ning ^a   Seike, Shiho ^a   Furuya, Tsuyoshi ^a   Yasuda, Toru ^a   Mizuno, Yoshikuni ^a   Mochizuki, Hideki ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

Bax; Bcl 2; Granulocyte colony stimulating factor; MPTP; Neuroprotection; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; JANUS KINASE; PROTEIN BAX; PROTEIN BCL 2; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STAT PROTEIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HEMATOLOGIC DISEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL NECROSIS; NEUROCHEMISTRY; NEUROPROTECTION; NEUTROPENIA; NICK END LABELING; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SUBSTANTIA NIGRA; TREATMENT DURATION; WESTERN BLOTTING;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; DOPAMINE; GENE EXPRESSION; GENES, BCL-2; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; NEOSTRIATUM; PARKINSON DISEASE, SECONDARY; TYROSINE 3-MONOOXYGENASE;

EID: 33750043456     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04125.x     Document Type: Article

References (32)

1. Fukuda S., Kato F., Tozuka Y., Yamaguchi M., Miyamoto Y. and Hisatsune T. (2003) Two distinct subpopulations of nestin-positive cells in adult mouse gyrus. J. Neurosci. 23, 9357-9366.
2. Furuya T., Hayakawa H., Yamada M., Yoshimi K., Hisahara S., Miura M., Mizuno Y. and Mochizuki H. (2004) Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J. Neurosci. 24, 1865-1872.
3. Gavrieli Y., Sherman Y. and Ben-Sasson S. A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
4. Gorgen I., Hartung T., Leist M., Niehorster M., Tiegs G., Uhlig S., Weitzel F. and Wendel A. (1992) Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-α. J. Immunol. 149, 918-924.
5. Hartung T. (1998) Anti-inflammatory effects of granulocyte colony-stimulating factor. Curr. Opin. Hematol. 5, 222-225.
6. Hassouna I., Wickert H., Zimmermann M. and Gillardon F. (1996) Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment of mice. Neurosci. Lett. 204, 85-88.
7. Heard S. O. and Fink M. P. (1999) Counter-regulatory control of the acute inflammatory response: granulocyte colony-stimulating factor has anti-inflammatory properties. Crit. Care. Med. 27, 1019-1021.
8. Heard S. O., Fink M. P., Gamelli R. L., Solomkin J. S., Joshi M., Trask A. L., Fabian T. C., Hudson L. D., Gerold K. B. and Logan E. D. (1998) Effect of prophylactic administration of recombinant human granulocyte colony-stimulating factor (filgrastim) on the frequency of nosocomial infections in patient with acute traumatic brain injury or cerebral hemorrhage. The Filgrastim Study Group. Crit. Care. Med. 26, 748-754.
9. Hebert J. C., O'Reilly M., Barry B., Shatney L. and Sartorelli K. (1997) Effects of exogenous cytokines on intravascular clearance of bacteria in normal and splenectomized mice. J. Trauma 43, 875-879.
10. Henze C., Lescot T., Traver S., Salthun-Lassalle B., Hirsch E. C., Michel P. P. and Hartmann A. (2005) Granulocyte colony-stimulating factor is not protective against selective cell death in vitro. Neurosci. Lett. 383, 44-48.
11. Jung K. H., Chu K., Lee S. T., Kim S. J., Sinn D. I., Kim S. U., Kim M. and Roh J. K. (2006) Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation. Brain Res. 16, (published online ahead of print).
12. Kitabayashi A., Hirokawa M., Hatano Y., Lee M., Kuroki J., Niitsu H. and Miura A. B. (1995) Granulocyte colony-stimulating factor down-regulates allogeneic immune responses by post-transcriptional inhibition of tumor necrosis factor-α production. Blood 86, 2220-2227.
13. Komine-Kobayashi M., Zhang N., Liu M., Tanaka R., Hara H., Osaka A., Mochizuki H., Mizuno Y. and Urabe T. (2006) Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice. J. Cereb. Blood Flow. Metab. 26, 402-413.
14. Liberatore G. T., Jackson-Lewis V., Vukosavic S., Mandir A. S., Vila M., McAuliffe W. G., Dawson V. L., Dawson T. M. and Przedborski S. (1999) Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 5, 1403-1409.
15. Maianski N. A., Roos D. and Kuijpers T. W. (2004) Bid truncation, Bid/Bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor. J. Immunol. 172, 7024-7030.
16. Mandir A. S., Przedborski S., Jackson-Iewis V., Wang Z. Q., Simbulan-Rosental. C. M., Smulson M. E., Hoffman B. E., Guastella D. B. and Dawson V. L. (1999) Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,.3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc. Natl Acad. Sci. USA 96, 5774-5779.
17. Meuer K., Pitzer C., Teismann P. et al. (2006) Granulocyte-colony stimulating factor is neuroprotective in a model of. Parkinson's disease. J. Neurochem. 97, 675-686.
18. Mochizuki H., Nakamura N., Nishi K. and Mizuno Y. (1994) Apoptosis induced by 1-methyl-4-phenyloyridium ion (MPP+) in ventral mesencephalic- striatal co-culture in rat. Neurosci. Lett. 170, 191-194.
19. Mochizuki H., Hayakawa H., Migita M. et al. (2001) An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as anti-apoptotic gene therapy for Parkinson's disease. Proc. Natl Acad. Sci. USA 98, 10 918-10 923.
20. Offen D., Beart P. M., Cheung N. S., Pascoe C. J., Hochman A., Gorodin S., Melamed E., Bernard R. and Bernard O. (1998) Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine neurotoxicity. Proc. Natl Acad. Sci. USA 95, 5789-5794.
21. Oltvai Z. N., Milliman C. L. and Korsmeyer S. J. (1993) Bel-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-619.
22. Przedborski S., Jackson-Lewis V., Djaldetti R., Liberatore G., Vila M., Vukosavic S. and Almer G. (2000) The parkinsonian toxin MPTP: cation and mechanism. Restor. Neurol. Neurosci. 16, 135-142.
23. Reed J. C. (1997) Double identity for proteins of the Bcl-2 family. Nature 387, 773-776.
24. Schabitz W. R., Kollmar R., Schwaninger M., Juettler E., Bardutzky J., Scholzke M. N., Sommer C. and Schwab S. (2003) Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 34, 745-751.
25. Schneider A., Kruger C., Steigleder T. et al. (2005) The hematopoitic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J. Clin. Invest. 115, 2083-2098.
26. Seki T. and Arai Y. (1993) Highly polysialylated neural cell adhesion molecule (UCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat. J. Neurosci. 13, 2351-2358.
27. Six I., Gassan G., Mura E. and Bordet R. (2003) Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia. Eur. J. Pharmacol. 458, 327-328.
28. Tatton N. A. and Kish S. J. (1997) In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labeling and acridine orange staining. Neuroscience 77, 1037-1048.
29. Wu D. C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., Choi D. K., Ischiropoulos H. and Przedborski S. (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of Parkinson disease. J. Neurosci. 22, 1763-1771.
30. Yoshimi K., Ren Y. R., Seki T. et al. (2005) Possibility for neurogenesis in substantia nigra of parkinsonian brain. Ann. Neurol. 58, 31-40.
31. Youdim M. B. and Arraf Z. (2004) Prevention of MPTP (N-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax. Neuropharmacology 46, 1130-1140.
32. Zavala F., Abad S., Ezine S., Taupin V., Masson A. and Bach F. J. (2002) G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine- and cytokine-based immune deviation. J. Immunol. 168, 2011-2019.