Activation of JAK2-V617F by components of heterodimeric cytokine receptors

Journal of Biological Chemistry

Volumn 285, Issue 22, 2010, Pages 16651-16663

  Pradhan, Anuradha ^a   Lambert, Que T ^a   Griner, Lori N ^a,b   Reuther, Gary W ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; ETIOLOGIC FACTORS; HEMATOPOIETIC CELL; IN-CELL; INTERLEUKIN-3; TRANSFORMING ACTIVITY; TYROSINE KINASE; TYROSINE PHOSPHORYLATION;

PHOSPHATASES; PHOSPHORYLATION; TUMORS;

AMINO ACIDS;

CD123 ANTIGEN; CYTOKINE RECEPTOR; INTERLEUKIN 27; INTERLEUKIN 27 RECEPTOR ALPHA; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; STAT5 PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BETA CHAIN; CELL CULTURE; CELL GROWTH; CELL LINE; CONTROLLED STUDY; CROSS LINKING; EXPRESSION VECTOR; GENETIC TRANSFECTION; HEMATOPOIETIC CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETROVIRUS; RETROVIRUS INFECTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ANIMALS; CELL LINE; CELL PROLIFERATION; CYTOKINES; DIMERIZATION; ENZYME ACTIVATION; HUMANS; JANUS KINASE 2; MICE; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, INTERLEUKIN-3; TYROSINE;

EID: 77952774104     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.071191     Document Type: Article

References (66)

1. Campbell, P. J., and Green, A. R. (2006) N. Engl. J. Med. 355, 2452-2466
2. Tefferi, A., Thiele, J., and Vardiman, J. W. (2009) Cancer 115, 3842-3847
3. Tefferi, A., and Vardiman, J. W. (2008) Leukemia 22, 14-22
4. Dameshek, W. (1951) Blood 6, 372-375
5. Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., Scott, M. A., Erber, W. N., and Green, A. R. (2005) Lancet 365, 1054-1061
6. James, C., Ugo, V., Le Couédic, J. P., Staerk, J., Delhommeau, F., Lacout, C., Garçon, L., Raslova, H., Berger, R., Bennaceur-Griscelli, A., Villeval, J. L., Constantinescu, S. N., Casadevall, N., and Vainchenker, W. (2005) Nature 434, 1144-1148
7. Jones, A. V., Kreil, S., Zoi, K., Waghorn, K., Curtis, C., Zhang, L., Score, J., Seear, R., Chase, A. J., Grand, F. H., White, H., Zoi, C., Loukopoulos, D., Terpos, E., Vervessou, E. C., Schultheis, B., Emig, M., Ernst, T., Lengfelder, E., Hehlmann, R., Hochhaus, A., Oscier, D., Silver, R. T., Reiter, A., and Cross, N. C. (2005) Blood 106, 2162-2168
8. Kralovics, R., Passamonti, F., Buser, A. S., Teo, S. S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., and Skoda, R. C. (2005) N. Engl. J. Med. 352, 1779-1790
9. Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., Adelsperger, J., Koo, S., Lee, J. C., Gabriel, S., Mercher, T., D'Andrea, A., Fröhling, S., Döhner, K., Marynen, P., Vandenberghe, P., Mesa, R. A., Tefferi, A., Griffin, J. D., Eck, M. J., Sellers, W. R., Meyerson, M., Golub, T. R., Lee, S. J., and Gilliland, D. G. (2005) Cancer Cell 7, 387-397
10. Zhao, R., Xing, S., Li, Z., Fu, X., Li, Q., Krantz, S. B., and Zhao, Z. J. (2005) J. Biol. Chem. 280, 22788-22792
11. Haan, C., Kreis, S., Margue, C., and Behrmann, I. (2006) Biochem. Pharmacol. 72, 1538-1546
12. Ihle, J. N. (1995) Nature 377, 591-594
13. Rane, S. G., and Reddy, E. P. (2000) Oncogene 19, 5662-5679
14. Yamaoka, K., Saharinen, P., Pesu, M., Holt, V. E., 3rd, Silvennoinen, O., and O'Shea, J. J. (2004) Genome Biol. 5, 253
15. Baker, S. J., Rane, S. G., and Reddy, E. P. (2007) Oncogene 26, 6724-6737
16. Lindauer, K., Loerting, T., Liedl, K. R., and Kroemer, R. T. (2001) Protein Eng. 14, 27-37
17. Luo, H., Rose, P., Barber, D., Hanratty, W. P., Lee, S., Roberts, T. M., D'Andrea, A. D., and Dearolf, C. R. (1997) Mol. Cell. Biol. 17, 1562-1571
18. Malinge, S., Ben-Abdelali, R., Settegrana, C., Radford-Weiss, I., Debre, M., Beldjord, K., Macintyre, E. A., Villeval, J. L., Vainchenker, W., Berger, R., Bernard, O. A., Delabesse, E., and Penard-Lacronique, V. (2007) Blood 109, 2202-2204
19. Saharinen, P., and Silvennoinen, O. (2002) J. Biol. Chem. 277, 47954-47963
20. Saharinen, P., Takaluoma, K., and Silvennoinen, O. (2000) Mol. Cell. Biol. 20, 3387-3395
21. Lee, T. S., Ma, W., Zhang, X., Giles, F., Kantarjian, H., and Albitar, M. (2009) Cancer 115, 1692-1700
22. Lee, T. S., Ma, W., Zhang, X., Kantarjian, H., and Albitar, M. (2009) BMC Struct. Biol. 9, 58
23. Bumm, T. G., Elsea, C., Corbin, A. S., Loriaux, M., Sherbenou, D., Wood, L., Deininger, J., Silver, R. T., Druker, B. J., and Deininger, M. W. (2006) Cancer Res. 66, 11156-11165
24. Lacout, C., Pisani, D. F., Tulliez, M., Gachelin, F. M., Vainchenker, W., and Villeval, J. L. (2006) Blood 108, 1652-1660
25. Tiedt, R., Hao-Shen, H., Sobas, M. A., Looser, R., Dirnhofer, S., Schwaller, J., and Skoda, R. C. (2008) Blood 111, 3931-3940
26. Wernig, G., Mercher, T., Okabe, R., Levine, R. L., Lee, B. H., and Gilliland, D. G. (2006) Blood 107, 4274-4281
27. Zaleskas, V. M., Krause, D. S., Lazarides, K., Patel, N., Hu, Y., Li, S., and Van Etten, R. A. (2006) PLoS ONE 1, e18
28. Lu, X., Levine, R., Tong, W., Wernig, G., Pikman, Y., Zarnegar, S., Gilliland, D. G., and Lodish, H. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 18962-18967
29. Staerk, J., Kallin, A., Demoulin, J. B., Vainchenker, W., and Constantinescu, S. N. (2005) J. Biol. Chem. 280, 41893-41899
30. Lu, X., Huang, L. J., and Lodish, H. F. (2008) J. Biol. Chem. 283, 5258-5266
31. Wernig, G., Gonneville, J. R., Crowley, B. J., Rodrigues, M. S., Reddy, M. M., Hudon, H. E., Walz, C., Reiter, A., Podar, K., Royer, Y., Constantinescu, S. N., Tomasson, M. H., Griffin, J. D., Gilliland, D. G., and Sattler, M. (2008) Blood 111, 3751-3759
32. Pradhan, A., Lambert, Q. T., and Reuther, G. W. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 18502-18507
33. Reuther, G. W. (2008) Cell Cycle 7, 714-719
34. Morgenstern, J. P., and Land, H. (1990) Nucleic Acids Res. 18, 3587-3596
35. Hayashida, K., Kitamura, T., Gorman, D. M., Arai, K., Yokota, T., and Miyajima, A. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 9655-9659
36. Chatti, K., Farrar, W. L., and Duhé, R. J. (2004) Biochemistry 43, 4272-4283
37. Palacios, R., and Steinmetz, M. (1985) Cell 41, 727-734
38. Thompson, J. E., Cubbon, R. M., Cummings, R. T., Wicker, L. S., Frankshun, R., Cunningham, B. R., Cameron, P. M., Meinke, P. T., Liverton, N., Weng, Y., and DeMartino, J. A. (2002) Bioorg. Med. Chem. Lett. 12, 1219-1223
39. Feng, J., Witthuhn, B. A., Matsuda, T., Kohlhuber, F., Kerr, I. M., and Ihle, J. N. (1997) Mol. Cell. Biol. 17, 2497-2501
40. Bercovich, D., Ganmore, I., Scott, L. M., Wainreb, G., Birger, Y., Elimelech, A., Shochat, C., Cazzaniga, G., Biondi, A., Basso, G., Cario, G., Schrappe, M., Stanulla, M., Strehl, S., Haas, O. A., Mann, G., Binder, V., Borkhardt, A., Kempski, H., Trka, J., Bielorei, B., Avigad, S., Stark, B., Smith, O., Dastugue, N., Bourquin, J. P., Tal, N. B., Green, A. R., and Izraeli, S. (2008) Lancet 372, 1484-1492
41. Mullighan, C. G., Zhang, J., Harvey, R. C., Collins-Underwood, J. R., Schulman, B. A., Phillips, L. A., Tasian, S. K., Loh, M. L., Su, X., Liu, W., Devidas, M., Atlas, S. R., Chen, I. M., Clifford, R. J., Gerhard, D. S., Carroll, W. L., Reaman, G. H., Smith, M., Downing, J. R., Hunger, S. P., and Willman, C. L. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 9414-9418
42. Hashimoto, Y., Kurita, M., Aiso, S., Nishimoto, I., and Matsuoka, M. (2009) Mol. Biol. Cell 20, 2864-2873
43. Takeda, A., Hamano, S., Yamanaka, A., Hanada, T., Ishibashi, T., Mak, T. W., Yoshimura, A., and Yoshida, H. (2003) J. Immunol. 170, 4886-4890
44. Hunter, C. A. (2005) Nat. Rev. Immunol. 5, 521-531
45. Geijsen, N., Koenderman, L., and Coffer, P. J. (2001) Cytokine Growth Factor Rev. 12, 19-25
46. Klingmüller, U., Bergelson, S., Hsiao, J. G., and Lodish, H. F. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 8324-8328
47. Okuda, K., Smith, L., Griffin, J. D., and Foster, R. (1997) Blood 90, 4759-4766
48. Sakamaki, K., Miyajima, I., Kitamura, T., and Miyajima, A. (1992) EMBO J. 11, 3541-3549
49. Fisher, G. M., Iqball, S., and Knight, S. C. (1999) Cytokine 11, 111-117
50. Grohmann, U., Belladonna, M. L., Vacca, C., Bianchi, R., Fallarino, F., Orabona, C., Fioretti, M. C., and Puccetti, P. (2001) J. Immunol. 167, 221-227
51. Huang, H. M., Lin, Y. L., Chen, C. H., and Chang, T. W. (2005) J. Cell. Biochem. 96, 361-375
52. Quelle, F. W., Sato, N., Witthuhn, B. A., Inhorn, R. C., Eder, M., Miyajima, A., Griffin, J. D., and Ihle, J. N. (1994) Mol. Cell. Biol. 14, 4335-4341
53. Funakoshi-Tago, M., Tago, K., Abe, M., Sonoda, Y., and Kasahara, T. (2010) J. Biol. Chem. 285, 5296-5307
54. Carr, P. D., Gustin, S. E., Church, A. P., Murphy, J. M., Ford, S. C., Mann, D. A., Woltring, D. M., Walker, I., Ollis, D. L., and Young, I. G. (2001) Cell 104, 291-300
55. Murphy, J. M., and Young, I. G. (2006) Vitam. Horm. 74, 1-30
56. Muto, A., Watanabe, S., Miyajima, A., Yokota, T., and Arai, K. (1996) J. Exp. Med. 183, 1911-1916
57. Martinez-Moczygemba, M., and Huston, D. P. (2003) J. Allergy Clin. Immunol. 112, 653-665; quiz 666
58. Hornakova, T., Staerk, J., Royer, Y., Flex, E., Tartaglia, M., Constantinescu, S. N., Knoops, L., and Renauld, J. C. (2009) J. Biol. Chem. 284, 6773-6781
59. Hertzberg, L., Vendramini, E., Ganmore, I., Cazzaniga, G., Schmitz, M., Chalker, J., Shiloh, R., Iacobucci, I., Shochat, C., Zeligson, S., Cario, G., Stanulla, M., Strehl, S., Russell, L. J., Harrison, C. J., Bornhauser, B., Yoda, A., Rechavi, G., Bercovich, D., Borkhardt, A., Kempski, H., te Kronnie, G. T., Bourquin, J. P., Domany, E., and Izraeli, S. (2010) Blood 115, 1006-1017
60. Mullighan, C. G., Collins-Underwood, J. R., Phillips, L. A., Loudin, M. G., Liu, W., Zhang, J., Ma, J., Coustan-Smith, E., Harvey, R. C., Willman, C. L., Mikhail, F. M., Meyer, J., Carroll, A. J., Williams, R. T., Cheng, J., Heerema, N. A., Basso, G., Pession, A., Pui, C. H., Raimondi, S. C., Hunger, S. P., Downing, J. R., Carroll, W. L., and Rabin, K. R. (2009) Nat. Genet. 41, 1243-1246
61. Russell, L. J., Capasso, M., Vater, I., Akasaka, T., Bernard, O. A., Calasanz, M. J., Chandrasekaran, T., Chapiro, E., Gesk, S., Griffiths, M., Guttery, D. S., Haferlach, C., Harder, L., Heidenreich, O., Irving, J., Kearney, L., Nguyen-Khac, F., Machado, L., Minto, L., Majid, A., Moorman, A. V., Morrison, H., Rand, V., Strefford, J. C., Schwab, C., Tönnies, H., Dyer, M. J., Siebert, R., and Harrison, C. J. (2009) Blood 114, 2688-2698
62. Yoda, A., Yoda, Y., Chiaretti, S., Bar-Natan, M., Mani, K., Rodig, S. J., West, N., Xiao, Y., Brown, J. R., Mitsiades, C., Sattler, M., Kutok, J. L., DeAngelo, D. J., Wadleigh, M., Piciocchi, A., Dal Cin, P., Bradner, J. E., Griffin, J. D., Anderson, K. C., Stone, R. M., Ritz, J., Foa, R., Aster, J. C., Frank, D. A., and Weinstock, D. M. (0000) Proc. Natl. Acad. Sci. U.S.A. 107, 252-257
63. Gakovic, M., Ragimbeau, J., Francois, V., Constantinescu, S. N., and Pellegrini, S. (2008) J. Biol. Chem. 283, 18522-18529
64. Seita, J., Asakawa, M., Ooehara, J., Takayanagi, S., Morita, Y., Watanabe, N., Fujita, K., Kudo, M., Mizuguchi, J., Ema, H., Nakauchi, H., and Yoshimoto, T. (2008) Blood 111, 1903-1912
65. Pardanani, A. D., Levine, R. L., Lasho, T., Pikman, Y., Mesa, R. A., Wadleigh, M., Steensma, D. P., Elliott, M. A., Wolanskyj, A. P., Hogan, W. J., McClure, R. F., Litzow, M. R., Gilliland, D. G., and Tefferi, A. (2006) Blood 108, 3472-3476
66. Pikman, Y., Lee, B. H., Mercher, T., McDowell, E., Ebert, B. L., Gozo, M., Cuker, A., Wernig, G., Moore, S., Galinsky, I., DeAngelo, D. J., Clark, J. J., Lee, S. J., Golub, T. R., Wadleigh, M., Gilliland, D. G., and Levine, R. L. (2006) PLoS Med. 3, e270