STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5296-5307

  Funakoshi Tago, Megumi ^a   Tago, Kenji ^b   Abe, Miyuki ^a   Sonoda, Yoshiko ^a   Kasahara, Tadashi ^a  

^a KEIO UNIVERSITY   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COEXPRESSED; CONSTITUTIVELY ACTIVES; ERYTHROPOIETIN RECEPTORS; INTRACELLULAR DOMAIN; MOLECULAR MECHANISM; MYELOPROLIFERATIVE DISORDERS; SHORT HAIRPIN RNA; STABLE TRANSFECTANT; TRANSFORMING ACTIVITY;

GROWTH KINETICS; PHOSPHORYLATION; RNA; TRANSCRIPTION FACTORS;

SIGNALING;

ERYTHROPOIETIN RECEPTOR; JANUS KINASE 2; MUTANT PROTEIN; SHORT HAIRPIN RNA; STAT5 PROTEIN; TYROSINE; JAK2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL STRAIN; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; GENE MUTATION; GROWTH DISORDER; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; JANUS KINASE 2; MICE; MUTATION, MISSENSE; MYELOPROLIFERATIVE DISORDERS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ERYTHROPOIETIN; STAT5 TRANSCRIPTION FACTOR;

EID: 77949331464     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.040733     Document Type: Article

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