The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor

Journal of Biological Chemistry

Volumn 283, Issue 27, 2008, Pages 18522-18529

  Gakovic, Milica ^a   Ragimbeau, Josiane ^a   Francois, Véronique ^a   Constantinescu, Stefan N ^b   Pellegrini, Sandra ^a  

^a INSTITUT PASTEUR   (France)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; GLYCOPROTEINS;

CATALYTIC POTENTIALS; CYTOKINE; ECTODOMAIN; ERYTHROPOIETIN RECEPTORS; FAMILY MEMBERS; IN CELLS; IN VITRO; IN-VIVO; MUTANT ENZYMES; MYELOPROLIFERATIVE DISORDERS; RECEPTOR CHIMERAS;

LIGANDS;

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; HOMODIMER; INTERFERON RECEPTOR; INTERFERON REGULATORY FACTOR 1; JANUS KINASE 1; LIGAND; MUTANT PROTEIN; PHENYLALANINE; PROTEIN KINASE TYK2; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; VALINE; ALPHA BETA INTERFERON RECEPTOR; HYBRID PROTEIN; IFNAR2 PROTEIN, HUMAN; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; STAT3 PROTEIN, HUMAN; TYK2 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; CHIMERA; CONTROLLED STUDY; ENZYME MECHANISM; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; DIMERIZATION; GENETICS; METABOLISM; MISSENSE MUTATION; PHOSPHORYLATION; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; DIMERIZATION; ERYTHROPOIETIN; HUMANS; JANUS KINASE 2; LIGANDS; MUTATION, MISSENSE; PHOSPHORYLATION; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TYK2 KINASE;

EID: 49649113446     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801427200     Document Type: Article

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