Oxidative stress and cognitive longevity

Nutrition

Volumn 26, Issue 6, 2010, Pages 595-603

  Glade, Michael J ^a  

^a The Nutrition Doctor   (United States)

Author keywords

Cognitive function; Mitochondrial decay; Neuroprotection; Oxidative stress

Indexed keywords

BLUEBERRY EXTRACT; LEVACECARNINE; MITOCHONDRIAL PROTEIN; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; ACETYLCARNITINE;

AGING; AMNESIA; BERRY; BIOGENESIS; BRAIN METABOLISM; CELL NUCLEUS; CLINICAL TRIAL; COGNITION; DEGENERATIVE DISEASE; DIET SUPPLEMENTATION; HUMAN; LONGEVITY; MILD COGNITIVE IMPAIRMENT; MITOCHONDRIAL RESPIRATION; NEUROPROTECTION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SINGLE DRUG DOSE; SPINACH; STRAWBERRY; ANIMAL; CENTRAL NERVOUS SYSTEM; COGNITION DISORDERS; METABOLISM; MITOCHONDRION; NEURODEGENERATIVE DISEASES; PHYSIOLOGY;

ACETYLCARNITINE; AGING; ANIMALS; CENTRAL NERVOUS SYSTEM; COGNITION; COGNITION DISORDERS; HUMANS; LONGEVITY; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; PHOSPHATIDYLSERINES;

EID: 77952744134     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2009.09.014     Document Type: Review

References (185)

1. Wei Y.H., Lee H.C. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp Biol Med 2002, 227:671-682.
2. 2 sensing. J Biol Chem 2000, 275:25130-25138.
3. Di Lisa F., Bernardi P. Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition. Cardiovasc Res 2005, 66:222-232.
4. Pearlstein D.P., Ali M.H., Mungai P.T., Hynes K.L., Gewertz B.L., Schumacker P.T. Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia. Arterioscler Thromb Vasc Biol 2002, 22:566-573.
5. Chen Q., Moghaddas S., Hoppel C.L., Lesnefsky E.J. Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria. Am J Physiol Cell Physiol 2008, 294:C460-C466.
6. King M.S., Sharpley M.S., Hirst J. Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species. Biochemistry 2009, 48:2053-2062.
7. Murphy M.P. How mitochondria produce reactive oxygen species. Biochem J 2009, 417:1-13.
8. Liu J., Killilea D.W., Ames B.N. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-α-lipoic acid. Proc Natl Acad Sci U S A 2002, 99:1876-1881.
9. Davey G.P., Peuchen S., Clark J.B. Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration. J Biol Chem 1998, 273:12753-12757.
10. Butterfield D.A., Howard B.J., Yatin S., Allen K.L., Carney J.M. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone. Proc Natl Acad Sci U S A 1997, 94:674-678.
11. Stadtman E.R. Protein oxidation and aging. Free Radic Res 2006, 40:1250-1258.
12. Liu J., Head E., Gharib A.M., Yuan W., Ingersoll R.T., Hagen T.M., et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-α-lipoic acid. Proc Natl Acad Sci U S A 2002, 99:2356-2361.
13. Quiroz J.A., Singh J., Gould T.D., Denicoff K.D., Zarate C.A., Manji H.K. Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology. Mol Psychiatry 2004, 9:756-776.
14. Poon H.F., Calabrese V., Calvani M., Butterfield D.A. Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: Insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress. Antioxid Redox Signal 2006, 8:381-394.
15. Warner D.S., Sheng H., Batinić-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol 2004, 207:3221-3231.
16. Pryor W.A., Squadrito G.L. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol Lung Cell Mol Physiol 1995, 268:L699-L722.
17. Brown G.C., Cooper C.E. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 1994, 356:295-298.
18. Husain M., Bourret T.J., McCollister B.D., Jones-Carson J., Laughlin J., Vázquez-Torres A. Nitric oxide evokes an adaptive response to oxidative stress by arresting respiration. J Biol Chem 2008, 283:7682-7689.
19. Galkin A., Moncada S. S-nitrosation of mitochondrial complex I depends on its structural conformation. J Biol Chem 2007, 282:37448-37453.
20. Ames B.N., Shigmaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A 1993, 90:7915-7922.
21. Kelly D.P., Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 2004, 18:357-368.
22. Moyes C.D. Controlling muscle mitochondrial content. J Exp Biol 2003, 206:4385-4391.
23. Linton S., Davies M.J., Dean R.T. Protein oxidation and ageing. Exp Gerontol 2001, 36:1503-1518.
24. Davies K.J. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life 2000, 50:279-289.
25. Rhodes M.A., Carraway M.S., Piantadosi C.A., Reynolds C.M., Cherry A.D., Wester T.E., et al. Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans. Am J Physiol Heart Circ Physiol 2009, 297. H392-9.
26. Scarpulla R.C. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 2008, 88:611-638.
27. Virbasius J.V., Scarpulla R.C. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc Natl Acad Sci U S A 1994, 91:1309-1313.
28. Melov S. Modeling mitochondrial function in aging neurons. Trends Neurosci 2004, 27:601-606.
29. Borniquel S., Valle I., Cadenas S., Lamas S., Monsalve M. Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1α. FASEB J 2006, 20:1889-1891.
30. Bergeron R., Jian M.R., Cadman K.S., Moore I.K., Perret P., Pypaert M., et al. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am J Physiol Endocrinol Metab 2001, 281:E1340-E1346.
31. Ojuka E.O. Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. Proc Nutr Soc 2004, 63:275-278.
32. Wu H., Kanatous S.B., Thurmond F.A., Gallardo T., Isotani E., Bassel-Duby R., Williams R.S. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 2002, 296:349-352.
33. Altieri F., Grillo C., Maceroni M., Chichiarelli S. DNA damage and repair: From molecular mechanisms to health implications. Antioxid Redox Signal 2008, 10:891-937.
34. Perry J.J., Fan L., Tainer J.A. Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. Neuroscience 2007, 145:1280-1299.
35. Cassano P., Sciancalepore A.G., Pesce V., Fluck M., Hoppeler H., Calvani M., et al. Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis. Biochim Biophys Acta 2006, 1757:1421-1428.
36. Wittwer M., Flück M., Hoppeler H., Müller S., Desplanches D., Billeter R. Prolonged unloading of rat soleus muscle causes distinct adaptations of the gene profile. FASEB J 2002, 16:884-886.
37. Yajid F., Mercier J.G., Mercier B.M., Dubouchaud H., Préfaut C. Effects of 4 wk of hindlimb suspension on skeletal muscle mitochondrial respiration in rats. J Appl Physiol 1998, 84:479-485.
38. Sadrzadeh S.M., Eaton J.W. Hemoglobin-mediated oxidant damage to the central nervous system requires endogenous ascorbate. J Clin Invest 1988, 82:1510-1515.
39. Kao C.H., Kao T.Y., Huang W.T., Lin M.T. Lipopolysaccharide- and glutamate-induced hypothalamic hydroxyl radical elevation and fever can be suppressed by N-methyl-D-aspartate-receptor antagonists. J Pharmacol Sci 2007, 104:130-136.
40. Floyd R.A. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999, 222:236-245.
41. Qi Z., Miller G.W., Voit E.O. Computational systems analysis of dopamine metabolism. PLoS One 2008, 3:e2444.
42. Sokoloff L., Wechsler R.L., Mangold R., Balls K., Kety S.S. Cerebral blood flow and oxygen consumption in hyperthyroidism before and after treatment. J Clin Invest 1953, 32:202-208.
43. Sokoloff L., Mangold R., Wechsler R.L., Kenney C., Kety S.S. The effect of mental arithmetic on cerebral circulation and metabolism. J Clin Invest 1955, 34:1101-1108.
44. Reiter R.J. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995, 9:526-533.
45. Loft S., Astrup A., Buemann B., Poulsen H.E. Oxidative DNA damage correlates with oxygen consumption in humans. FASEB J 1994, 8:534-537.
46. Smith A.J., Blumenfeld H., Behar K.L., Rothman D.L., Shulman R.G., Hyder F. Cerebral energetics and spiking frequency: The neurophysiological basis of fMRI. Proc Natl Acad Sci U S A 2002, 99:10765-10770.
47. Combs C.K., Karlo J.C., Kao S.C., Landreth G.E. β-Amyloid stimulation of microglia and monocytes results in TNFα-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 2001, 21:1179-1188.
48. 1-42- and lipopolysaccharide-activated microglia. J Neurosci 2002, 22:3484-3492.
49. Qin L., Liu Y., Wang T., Wei S.J., Block M.L., Wilson B., et al. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 2004, 279:1415-1421.
50. Calabrese V., Ravagna A., Colombrita C., Scapagnini G., Guagliano E., Calvani M., et al. Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2. J Neurosci Res 2005, 79:509-521.
51. Poon H.F., Vaishnav R.A., Getchell T.V., Getchell M.L., Butterfield D.A. Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice. Neurobiol Aging 2006, 27:1010-1019.
52. Poon H.F., Shepherd H.M., Reed T.T., Calabrese V., Stella A.M., Pennisi G., et al. Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis. Neurobiol Aging 2006, 27:1020-1034.
53. Bader Lange M.L., Cenini G., Piroddi M., Abdul H.M., Sultana R., Galli F., et al. Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease. Neurobiol Dis 2008, 29:456-464.
54. Wang J., Xiong S., Xie C., Markesbery W.R., Lovell M.A. Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J Neurochem 2005, 93:953-962.
55. Wang J., Markesbery W.R., Lovell M.A. Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment. J Neurochem 2006, 96:825-832.
56. Markesbery W.R., Lovell M.A. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol 2007, 64:954-956.
57. Kamat C.D., Gadal S., Mhatre M., Williamson K.S., Pye Q.N., Hensley K. Antioxidants in central nervous system diseases: Preclinical promise and translational challenges. J Alzheimers Dis 2008, 15:473-493.
58. Miyamoto Y., Yamauchi J., Tanoue A. Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. J Neurosci 2008, 28:8326-8337.
59. Qin J., Goswami R., Dawson S., Dawson G. Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress. J Neurosci Res 2008, 86:2414-2422.
60. Taddei S., Galetta F., Virdis A., Ghiadoni L., Salvetti G., Franzoni F., et al. Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 2000, 101:2896-2901.
61. Taddei S., Virdis A., Ghiadoni L., Salvetti G., Bernini G., Magagna A., Salvetti A. Age-related reduction of NO availability and oxidative stress in humans. Hypertension 2001, 38:274-279.
62. Matsumoto T., Kobayashi T., Kamata K. Relationships among ET-1, PPARγ, oxidative stress and endothelial dysfunction in diabetic animals. J Smooth Muscle Res 2008, 44:41-55.
63. Gerhard M., Roddy M.A., Creager S.J., Creager M.A. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 1996, 27:849-853.
64. Taddei S., Virdis A., Mattei P., Ghiadoni L., Gennari A., Fasolo C.B., et al. Aging and endothelial function in normotensive subjects and essential hypertensive patients. Circulation 1995, 91:1981-1987.
65. Taddei S., Virdis A., Mattei P., Ghiadoni L., Fasolo C.B., Sudano I., Salvetti A. Hypertension causes premature aging of endothelial function in humans. Hypertension 1997, 29:736-743.
66. Moriyama Y., Tsunoda R., Harada M., Miyao Y., Yoshimura M., Kugiyama K., et al. Nitric oxide-mediated vasodilatation is decreased in forearm resistance vessels in patients with coronary spastic angina. Jpn Circ J 2001, 65:81-86.
67. Mosconi L., Pupi A., De Leon M.J. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci 2008, 1147:180-195.
68. Erecinska M., Silver I. ATP and brain function. J Cereb Blood Flow Metab 1989, 9:2-12.
69. Manczak M., Anekonda T.S., Henson E., Park B.S., Quinn J., Reddy P.H. Mitochondria are a direct site of A β accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 2006, 15:1437-1449.
70. Volterra A., Trotti D., Tromba C., Floridi S., Racagni G. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci 1994, 14:2924-2932.
71. Sorg O., Horn T.F., Yu N., Gruol D.L., Bloom F.E. Inhibition of astrocyte glutamate uptake by reactive oxygen species: role of antioxidant enzymes. Mol Med 1997, 3:431-440.
72. van der Flier W.M., van Straaten E.C., Barkhof F., Verdelho A., Madureira S., Pantoni L., et al. Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. Stroke 2005, 36:2116-2120.
73. de la Torre J.C. Cerebral hypoperfusion, capillary degeneration, and development of Alzheimer disease. Alzheimer Dis Assoc Disord 2000, 14(suppl 1):S72-S81.
74. Ohmine T., Miwa Y., Yao H., Yuzuriha T., Takashima Y., Uchino A., et al. Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects. Hypertens Res 2008, 31:75-81.
75. Martin L.J. DNA damage and repair: relevance to mechanisms of neurodegeneration. J Neuropathol Exp Neurol 2008, 67:377-387.
76. Fishel M.L., Vasko M.R., Kelley M.R. DNA repair in neurons: so if they don't divide what's to repair?. Mutat Res 2007, 614:24-36.
77. Subba Rao K. Mechanisms of disease: DNA repair defects and neurological disease. Nat Clin Pract Neurol 2007, 3:162-172.
78. Serra J.A., Domínguez R.O., Marschoff E.R., Guareschi E.M., Famulari A.L., Boveris A. Systemic oxidative stress associated with the neurological diseases of aging. Neurochem Res 2009.
79. Andreazza A.C., Kauer-Sant'anna M., Frey B.N., Bond D.J., Kapczinski F., Young L.T., Yatham L.N. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord 2008, 111:135-144.
80. Venters H.D., Bonilla L.E., Jensen T., Garner H.P., Bordayo E.Z., Najarian M.M., et al. Heme from Alzheimer's brain inhibits muscarinic receptor binding via thiyl radical generation. Brain Res 1997, 764:93-100.
81. Holmgren A. Bovine thioredoxin system. Purification of thioredoxin reductase from calf liver and thymus and studies of its function in disulfide reduction. J Biol Chem 1977, 252:4600-4606.
82. Stemme S., Hansson H.A., Holmgren A., Rozell B. Axoplasmic transport of thioredoxin and thioredoxin reductase in rat sciatic nerve. Brain Res 1985, 359:140-146.
83. Watson W.H., Yang X., Choi Y.E., Jones D.P., Kehrer J.P. Thioredoxin and its role in toxicology. Toxicol Sci 2004, 78:3-14.
84. Berndt C., Lillig C.H., Holmgren A. Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system. Am J Physiol Heart Circ Physiol 2007, 292:H1227-H1236.
85. Björnstedt M., Hamberg M., Kumar S., Xue J., Holmgren A. Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. J Biol Chem 1995, 270:11761-11764.
86. Zhong L., Arnér E.S., Holmgren A. Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. Proc Natl Acad Sci U S A 2000, 97:5854-5859.
87. Kalinina E.V., Chernov N.N., Saprin A.N. Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes. Biochemistry 2008, 73:1493-1510.
88. Lundberg M., Johansson C., Chandra J., Enoksson M., Jacobsson G., Ljung J., et al. Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. J Biol Chem 2001, 276:26269-26275.
89. Björnstedt M., Xue J., Huang W., Akesson B., Holmgren A. The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase. J Biol Chem 1994, 269:29382-29384.
90. Seo M.S., Kang S.W., Kim K., Baines I.C., Lee T.H., Rhee S.G. Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. J Biol Chem 2000, 275:20346-20354.
91. Bayir H., Kagan V.E., Clark R.S., Janesko-Feldman K., Rafikov R., Huang Z., et al. Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury. J Neurochem 2007, 101:168-181.
92. Watabe S., Makino Y., Ogawa K., Hiroi T., Yamamoto Y., Takahashi S.Y. Mitochondrial thioredoxin reductase in bovine adrenal cortex. Its purification, properties, nucleotide/amino acid sequences, and identification of selenocysteine. Eur J Biochem 1999, 264:74-84.
93. Spyrou G., Enmark E., Miranda-Vizuete A., Gustafsson J. Cloning and expression of a novel mammalian thioredoxin. J Biol Chem 1997, 272:2936-2941.
94. Chen Y., Cai J., Murphy T.J., Jones D.P. Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. J Biol Chem 2002, 277:33242-33248.
95. Damdimopoulos A.E., Miranda-Vizuete A., Pelto-Huikko M., Gustafsson J.A., Spyrou G. Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. J Biol Chem 2002, 277:33249-33257.
96. Johansson C., Lillig C.H., Holmgren A. Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase. J Biol Chem 2004, 279:7537-7543.
97. Beer S.M., Taylor E.R., Brown S.E., Dahm C.C., Costa N.J., Runswick M.J., Murphy M.P. Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant defense. J Biol Chem 2004, 279:47939-47951.
98. Lillig C.H., Berndt C., Vergnolle O., Lönn M.E., Hudemann C., Bill E., Holmgren A. Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor. Proc Natl Acad Sci USA 2005, 102:8168-8173.
99. Arnér E.S., Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem 2000, 267:6102-6109.
100. Tanaka T., Hosoi F., Yamaguchi-Iwai Y., Nakamura H., Masutani H., Ueda S., et al. Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J 2002, 21:1695-1703.
101. Rybnikova E., Damdimopoulos A.E., Gustafsson J.A., Spyrou G., Pelto-Huikko M. Expression of novel antioxidant thioredoxin-2 in the rat brain. Eur J Neurosci 2000, 12:1669-1678.
102. Gladyshev V.N., Liu A., Novoselov S.V., Krysan K., Sun Q.A., Kryukov V.M., Kryukov G.V., Lou M.F. Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. J Biol Chem 2001, 276:30374-30380.
103. Townsend D.M. S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response. Mol Interv 2007, 7:313-324.
104. Imai H., Nakagawa Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic Biol Med 2003, 34:145-169.
105. Chang T.S., Cho C.S., Park S., Yu S., Kang S.W., Rhee S.G. Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. J Biol Chem 2004, 279:41975-41984.
106. Banmeyer I., Marchand C., Clippe A., Knoops B. Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide. FEBS Lett 2005, 579:2327-2333.
107. Wickens A.P. Ageing and the free radical theory. Respir Physiol 2001, 128:79-391.
108. Castro L., Freeman B.A. Reactive oxygen species in human health and disease. Nutrition 2001, 17:161-165.
109. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956, 11:298-300.
110. Han D., Canali R., Rettori D., Kaplowitz N. Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria. Mol Pharmacol 2003, 64:1136-1144.
111. Dringen R., Pfeiffer B., Hamprecht B. Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. J Neurosci 1999, 19:562-569.
112. Calabrese V., Colombrita C., Sultana R., Scapagnini G., Calvani M., Butterfield D.A., Stella A.M. Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function. Antioxid Redox Signal 2006, 8:404-416.
113. Shih A.Y., Johnson D.A., Wong G., Kraft A.D., Jiang L., Erb H., et al. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci 2003, 23:3394-3406.
114. Takeda A., Perry G., Abraham N.G., Dwyer B.E., Kutty R.K., Laitinen J.T., et al. Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau. J Biol Chem 2000, 275:5395-5399.
115. Colombrita C., Calabrese V., Stella A.M., Mattei F., Alkon D.L., Scapagnini G. Regional rat brain distribution of heme oxygenase-1 and manganese superoxide dismutase mRNA: Relevance of redox homeostasis in the aging processes. Exp Biol Med 2003, 228:517-524.
116. Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A 2002, 99:11908-11913.
117. Balogun E., Hoque M., Gong P., Killeen E., Green C.J., Foresti R., et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 2003, 371:887-895.
118. Wu G., Fang Y.Z., Yang S., Lupton J.R., Turner N.D. Glutathione metabolism and its implications for health. J Nutr 2004, 134:489-492.
119. Björnstedt M., Kumar S., Holmgren A. Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase. J Biol Chem 1992, 267:8030-8034.
120. Casagrande S., Bonetto V., Fratelli M., Gianazza E., Eberini I., Massignan T., et al. Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems. Proc Natl Acad Sci U S A 2002, 99:9745-9749.
121. Calabrese V., Guagliano E., Sapienza M., Mancuso C., Butterfield D.A., Stella A.M. Redox regulation of cellular stress response in neurodegenerative disorders. Ital J Biochem 2006, 55:244-263.
122. Siems W.G., Zollner H., Grune T., Esterbauer H. Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product. J Lipid Res 1997, 38:6126-6132.
123. Aoyama K., Watabe M., Nakaki T. Regulation of neuronal glutathione synthesis. J Pharmacol Sci 2008, 108:227-238.
124. Dröge W., Schipper H.M. Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell 2007, 6:361-370.
125. Biterova E.I., Turanov A.A., Gladyshev V.N., Barycki J.J. Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. Proc Natl Acad Sci U S A 2005, 102:15018-15023.
126. Mustacich D., Powis G. Thioredoxin reductase. Biochem J 2000, 346:1-8.
127. Sun Q.A., Wu Y., Zappacosta F., Jeang K.T., Lee B.J., Hatfield D.L., Gladyshev V.N. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J Biol Chem 1999, 274:24522-24530.
128. Taylor E.R., Hurrell F., Shannon R.J., Lin T.K., Hirst J., Murphy M.P. Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem 2003, 278:19603-19610.
129. Bedard K., Krause K.H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007, 87:245-313.
130. Block M.L. NADPH oxidase as a therapeutic target in Alzheimer's disease. BMC Neurosci 2008, 9(suppl 2):S8.
131. Spolarics Z. Endotoxemia, pentose cycle, and the oxidant/antioxidant balance in the hepatic sinusoid. J Leukoc Biol 1998, 63:534-541.
132. Warner D.S., Sheng H., Batinic-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol 2004, 207:3221-3231.
133. Ames B.N. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci U S A 2006, 103:17589-17594.
134. Corbetta M., Patel G., Shulman G.L. The reorienting system of the human brain: From environment to theory of mind. Neuron 2008, 58:306-324.
135. Radak Z., Kumagai S., Nakamoto H., Goto S. 8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats. J Appl Physiol 2007, 102:1696-1701.
136. Weiler J.A., Bellebaum C., Daum I. Aging affects acquisition and reversal of reward-based associative learning. Learn Mem 2008, 15:190-197.
137. Harman D. Aging: overview. Ann N Y Acad Sci 2001, 928:1-21.
138. Calabrese V., Bates T.E., Stella A.M. NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochem Res 2000, 25:1315-1341.
139. Rottenberg H. Exceptional longevity in songbirds is associated with high rates of evolution of cytochrome b, suggesting selection for reduced generation of free radicals. J Exp Biol 2007, 210:2170-2180.
140. da Fonseca R.R., Johnson W.E., O'Brien S.J., Ramos M.J., Antunes A. The adaptive evolution of the mammalian mitochondrial genome. BMC Genomics 2008, 9:119.
141. Barja G., Herrero A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J 2000, 14:312-318.
142. Barja G. Mitochondrial free radical production and aging in mammals and birds. Ann N Y Acad Sci 1998, 854:224-238.
143. Joseph J.A., Shukitt-Hale B., Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 2005, 81(suppl). 313S-6.
144. Cotman C.W., Head E., Muggenburg B.A., Zicker S., Milgram N.W. Brain aging in the canine: A diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging 2002, 23:809-818.
145. Pop V., Head E., Nistor M., Milgram N.W., Muggenburg B.A., Cotman C.W. Reduced Aβ deposition with long-term antioxidant diet treatment in aged canines. Program no. 525.4. Abstract Viewer/Itinerary Planner 2003, Society for Neuroscience, Washington, DC.
146. Siwak-Tapp C.T., Head E., Muggenburg B.A., Milgram N.W., Cotman C.W. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem 2007, 88:249-259.
147. Joseph J.A., Shukitt-Hale B., Denisova N.A., Prior R.L., Cao G., Martin A., et al. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci 1998, 18:8047-8055.
148. Joseph J.A., Shukitt-Hale B., Denisova N.A., Bielinski D., Martin A., McEwen J.J., Bickford P.C. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 1999, 19:8114-8121.
149. Longo N., Amat di San Filippo C., Pasquali M. Disorders of carnitine transport and the carnitine cycle. Am J Med Genet C Semin Med Genet 2006, 142C:77-85.
150. Stephens F.B., Constantin-Teodosiu D., Greenhaff P.L. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol 2007, 581:431-444.
151. Siliprandi N., Siliprandi D., Ciman M. Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine. Biochem J 1965, 96:777-780.
152. Fritz I.B., Schultz S.K., Srere P.A. Properties of partially purified carnitine acetyltransferase. J Biol Chem 1963, 238:2509-2517.
153. Chase J.F., Tubbs P.K. Some kinetic studies on the mechanism of action of carnitine acetyltransferase. Biochem J 1966, 99:32-40.
154. Tanaka Y., Sasaki R., Fukui F., Waki H., Kawabata T., Okazaki M., et al. Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats. J Lipid Res 2004, 45:729-735.
155. Gadaleta M.N., Petruzzella V., Renis M., Fracasso F., Cantatore P. Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine. Eur J Biochem 1990, 187:501-506.
156. Gadaleta M.N., Petruzzella V., Daddabbo L., Olivieri C., Fracasso F., Loguercio Polosa P., Cantatore P. Mitochondrial DNA transcription and translation in aged rat. Effect of acetyl-L-carnitine. Ann N Y Acad Sci 1994, 717:150-160.
157. Carta A, Calvani M. Acetyl-L-carnitine: a drug able to slow the progress of Alzheimer's disease? Ann N Y Acad Sci 19191;640:228-232.
158. Liu J., Head E., Gharib A.M., Yuan W., Ingersoll R.T., Hagen T.M., et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-α-lipoic acid. Proc Natl Acad Sci U S A 2002, 99:2356-2361.
159. Sharman E.H., Vaziri N.D., Ni Z., Sharman K.G., Bondy S.C. Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine. Brain Res 2002, 957:223-230.
160. Ramacci M.T., De Rossi M., Lucreziotti M.R., Mione M.C., Amenta F. Effect of long-term treatment with acetyl-L-carnitine on structural changes of ageing rat brain. Drugs Exp Clin Res 1988, 14:593-601.
161. Cassano P., Sciancalepore A.G., Pesce V., Fluck M., Hoppeler H., Calvani M., et al. Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis. Biochim Biophys Acta 2006, 1757:1421-1428.
162. Petruzzella V., Baggetto L.G., Penin F., Cafagna F., Ruggiero F.M., Cantatore P., Gadaleta M.N. In vivo effect of acetyl-L-carnitine on succinate oxidation, adenine nucleotide pool and lipid composition of synaptic and non-synaptic mitochondria from cerebral hemispheres of senescent rats. Arch Gerontol Geriatr 1992, 14:131-144.
163. Passeri M., Cucinotta D., Bonati P.A., Iannuccelli M., Parnetti L., Senin U. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Int J Clin Pharmacol Res 1990, 10:75-79.
164. Sano M., Bell K., Cote L., Dooneief G., Lawton A., Legler L., et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's disease. Arch Neurol 1992, 49:1137-1141.
165. Schneiter R., Brugger B., Sandhoff R., Zellnig G., Leber A., Lampl M., et al. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane. J Cell Biol 1999, 146:741-754.
166. Svennerholm L. Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res 1968, 9:570-579.
167. Hayes L.W., Jungalwala F.B. Synthesis and turnover of cerebrosides and phosphatidylserine of myelin and microsomal fractions of adult and developing rat brain. Biochem J 1976, 160:195-204.
168. Martin O.C., Pagano R.E. Transbilayer movement of fluorescent analogs of phosphatidylserine and phosphatidylethanolamine at the plasma membrane of cultured cells. Evidence for a protein-mediated and ATP-dependent process(es). J Biol Chem 1987, 262:5890-5898.
169. Seigneuret M., Devaux P.F. ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes. Proc Natl Acad Sci USA 1984, 81:3751-3755.
170. Vance J.E., Steenbergen R. Metabolism and functions of phosphatidylserine. Prog Lipid Res 2005, 44:207-234.
171. Mozzi R., Buratta S., Goracci G. Metabolism and functions of phosphatidylserine in mammalian brain. Neurochem Res 2003, 28:195-214.
172. Takai Y., Kishimoto A., Iwasa Y., Kawahara Y., Mori T., Nishizuka Y. Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem 1979, 254:3692-3695.
173. Purdon A.D., Rapoport S.I. Energy requirements for two aspects of phospholipid metabolism in mammalian brain. Biochem J 1998, 335:313-318.
174. Aporti F., Borsato R., Calderini G., Rubini R., Toffano G., Zanotti A., et al. Age-dependent spontaneous EEG bursts in rats: effects of brain phosphatidylserine. Neurobiol Aging 1986, 7:115-120.
175. Rosadini G., Sannita W.G., Nobili F., Cenacchi T. Phosphatidylserine: quantitative EEG effects in healthy volunteers. Neuropsychobiol 1990-1991, 24:42-48.
176. Daleke D.L. Phospholipid flippases. J Biol Chem 2007, 282:821-825.
177. Zeisel S. Choline phospholipids: Signal transduction and carcinogenesis. FASEB J 1993, 7:551-557.
178. Giorgione J.R., Lin J.H., McCammon J.A., Newton A.C. Increased membrane affinity of the C1 domain of protein kinase Cδ compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem 2006, 281:1660-1669.
179. Wrenn R.W., Katoh N., Wise B.C., Kuo J.F. Stimulation by phosphatidylserine and calmodulin of calcium-dependent phosphorylation of endogenous proteins from cerebral cortex. J Biol Chem 1980, 255:12042-12046.
180. Petersen R.C., Jack C.R., Xu Y.C., Waring S.C., O'Brien P.C., Smith G.E., et al. Memory and MRI-based hippocampal volumes in aging and AD. Neurology 2000, 54:581-587.
181. Villardita C., Grioli S., Salmeri G., Nicoletti F., Pennisi G. Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clin Trials J 1987, 24:84-93.
182. Palmieri G., Palmieri R., Inzoli M.R., Lombardi G., Sottini C., Tavolato B., Giometto B. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J 1987, 24:73-83.
183. Cenacchi T., Bertoldin T., Farina C., Fiori M.G., Crepaldi G. Cognitive decline in the elderly: a double blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging Clin Exp Res 1993, 5:123-133.
184. Delwaide P.J., Gyselynck-Mambourg A.M., Hurlet A., Ylieff M. Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta Neurol Scand 1986, 73:136-140.
185. Taylor C.L. Letter regarding phosphatidylserine and cognitive dysfunction and dementia 2003, Bethesda, MD: US Food and Drug Administration.