Aging: Overview

Annals of the New York Academy of Sciences

Volumn 928, Issue , 2001, Pages 1-21

  Harman, D ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Aging; Evolution; Free radical reactions; Mitochondria; Retirement and care of the elderly

Indexed keywords

FREE RADICAL;

AGING; CONFERENCE PAPER; DEATH; ELDERLY CARE; FERTILITY; HUMAN; LIFE EXPECTANCY; LIFESTYLE; RETIREMENT;

EID: 0035033142     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb05631.x     Document Type: Conference Paper

References (108)

1. The aging process
2. Aging and age-related diseases: Normal processes
3. Pathology
4. Prospects for future increases in average longevity
5. Aging, natural death, and the compression of morbidity
6. In search of Methuselah: Estimating the upper limits to human longevity
7. Aging: Phenomena and theories
8. The life table as a record of progress to the end of the nineteenth century
9. Aging: Prospects for further increases in the functional life span
10. The relation of human health to age, place and time
11. Aging: A theory based on free radical and radiation chemistry
12. Free radical theory of aging: History
13. The biologic clock: The mitochondria?
14. Free radical theory of aging: Consequences of mitochondrial aging
15. Free radical involvement in aging: Pathophysiology and therapeutic implications
16. Free radical theory of aging: Role of free radicals in the origination and evolution of life, aging, and diseases processes
17. Free radical theory of aging: The "free radical" diseases
18. Genetically determined conidial longevity is positively correlated with superoxide dismutase, catalase, glutathione peroxidase, cytochrome c peroxidase, and ascorbate free radical reductase activities in Neurospora crassa
19. Extended longevity and enhanced antioxidant defenses in Drosophila
20. The search for the genetic basis of aging: The identification of gerontogenes in the nematode Caenorhabditis elegans
21. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
22. 1 mice
23. Effect of ethoxyquin on the longevity of C3H mice
24. Studies of mitochondria in oxidative embryo toxicity
25. High oestrogen excretion in pregnancy
26. Genotoxic effects of estrogens
27. Protective effect of vitamin E on fetal distress induced by ischemia of the uteroplacental system in pregnant rats
28. Free radical theory of aging: Beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring: Possible explanation of the sex difference in longevity
29. Iron and the sex difference in longevity
30. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
31. Does superoxide underlie the pathogenesis of hypertension?
32. Aging: Minimizing free radical damage
33. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men
34. 1 mice
35. Free radicals and the action of inhibitors of radical processes under pathological states and aging in living organisms and man
36. Drug for prophylaxis of aging and prolongation of lifetime
37. Free radical theory of aging: Nutritional implications
38. Does blood donation prolong life expectancy?
39. Metal chelation therapy, oxygen radicals, and human disease
40. A pilot double-blind study of sodium-magnesium EDTA in peripheral vascular disease
41. Antioxidant therapy in the aging process
42. Hydroperoxide metabolism in mammalian organs
43. Do mitochondria produce oxygen radicals in vivo?
44. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species
45. Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
46. Hydrogen peroxide release by mitochondria increases during aging
47. Is cell aging caused by respiratory-dependent injury to the mitochondrial genome?
48. Mitochondrial role in cell aging
49. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
50. Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: Possible basis of variation in longevity and metabolic potential
51. 2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds
52. Biochemical correlates of longevity in two closely related rodent species
53. Mitochondrial geno-type associated with longevity
54. Siblings of centenarians live longer
55. Oxidative stress and advancing age: Results in healthy centenarians
56. Oxidative stress, caloric restriction, and aging
57. Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease
58. Dietary restriction and aging: The initiation of a primate study
59. A critical review of spin trapping in biological systems
60. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-″-phenylnitrone
61. Oxidative damage to behavior during aging
62. Covalent modification reactions are marking steps in protein turnover
63. Protein oxidation and aging
64. Surface localization of sites of reduction of nitroxide spin-labeled molecules in mitochondria
65. An electron paramagnetic resonance study of the antioxidant properties of the nitroxide free radical tempo
66. Biologically active metal-independent superoxide dismutase mimics
67. A spin trap, N-tert-butyl-α-phenylnitrone extends the life span of mice
68. Antioxidant treatment with phenyl-α-tert-butyl nitrone (PBN) improves cognitive performance anti survival of aging rats
69. The spin-trap N-tert-α-butylnitrone prolongs the life span of the senescence accelerated mouse
70. Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity anti reduced glutathione level in the brain and liver in senescence accelerated mice (SAM): A comparison with ddY mice
71. Buckyballs: Wide open playing field for chemists
72. Carboxyfullerenes as neuroprotective agents
73. The toxicologic and pharmacologic properties of amantadine hydrochloride
74. Mode of action of the antiviral activity of amantadine in tissue culture
75. 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
76. Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles
77. 10 tissues concentrations and life span of male rats and mice
78. α-lipoic acid in liver metabolism and disease
79. (R)-α-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
80. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA
81. A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress
82. Glutathione-ascorbic acid antioxidant system in animals
83. Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice
84. Aminoethylcysteine ketimine decarboxylated dimer protects submitochondrial particles from lipid peroxidation at a concentration not inhibitory of electron transport
85. Resolution of NADH:ubiquinone oxidoreductase from bovine heart mitochondria into two subcomplexes, one of which contains the redox centers of the enzyme
86. Superoxide, neuroleptics and the ubiquinone and cytochrome b5 reductases in brain and lymphocytes from normals and schizophrenic patients
87. Mitochondrial involvement in schizophrenia and other functional psychoses
88. shc adaptor protein controls oxidative stress response and life span in mammals
89. Hypothesis: Does breast cancer originate in utero?
90. Intrauterine environment and breast cancer risk in women: A population-based study
91. A maternal diet high in n-6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring
92. The oldest old
93. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats