Effect of Glutathione Depletion on Sites and Topology of Superoxide and Hydrogen Peroxide Production in Mitochondria

Molecular Pharmacology

Volumn 64, Issue 5, 2003, Pages 1136-1144

  Han, Derick ^a,b   Canali, Raffaella ^b   Rettori, Daniel ^b   Kaplowitz, Neil ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CITRININ; GLUTATHIONE; HYDROGEN PEROXIDE; MYXOTHIAZOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SEMIQUINONE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; SUPEROXIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFUSION; ELECTRON TRANSPORT; EXTRACELLULAR MATRIX; HEART MITOCHONDRION; HEART MUSCLE METABOLISM; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCAVENGING SYSTEM; STEADY STATE;

ACONITATE HYDRATASE; ANIMALS; ANTIMYCIN A; DINITROCHLOROBENZENE; FUMARATE HYDRATASE; GLUTATHIONE; HYDROGEN PEROXIDE; MALE; METHACRYLATES; MITOCHONDRIA, HEART; RATS; RATS, WISTAR; SUPEROXIDES; THIAZOLES;

EID: 0142210179     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.5.1136     Document Type: Article

References (47)

1. Anderson MF and Sims NR (2002) The effects of focal ischemia and reperfusion on the glutathione content of mitochondria from rat brain subregions. J Neurochem 81:541-549.
2. 2 detoxification in in vivo conditions. Free Rad Biol Med 33:1260-1267.
3. Boveris A and Cadenas E (1975) Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration. FEBS Lett 54:311-314.
4. Boveris A and Cadenas E (1997) Cellular sources and steady-state levels of reactive oxygen species, in Oxygen, Gene Expression and Cellular Function (Clerch LB and Massaro DJ eds), pp 1-26, Marcel Dekker, New York.
5. Boveris A and Chance B (1973) The mitochondrial generation of hydrogen peroxide. Biochem J 134:707-716.
6. Brandt U (1998) The chemistry and mechanics of ubihydroquinone oxidation at center P (Qo) of the cytochrome bc1 complex. Biochim Biophys Acta 1365:261-268.
7. Cadenas E and Boveris A (1980) Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria. Biochem J 188:31-37.
8. Cadenas E, Boveris A, Ragan CI, and Stoppani AO (1977) Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys 180:248-257.
9. Cadenas E and Davies KJ (2000) Mitochondrial free radical generation, oxidative stress and aging. Free Radic Biol Med 29:222-230.
10. Chance B, Sies H, and Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605.
11. de Vries S (1986) The pathway of electron transfer in the dimeric QH2: cytochrome c oxidoreductase. J Bioenerg Biomembr 18:195-224.
12. DeLeve LD and Kaplowitz N (1991) Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 52:287-305.
13. 1 complex of mitochondria. Biochemistry (Moscow) 63:755-772.
14. Fernandez-Checa JC, Ooktens M, and Kaplowitz N (1987) Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux and response to incubation with ethanol. J Clin Investig 80:57-62.
15. Finkelstein E, Rosen GM, and Rauckman EJ (1980) Spin trapping. Kinetics of the reaction of superoxide and hydroxyl radicals with nitrones. J Am Chem Soc 102:4994-4999.
16. Flohe L, Gunzler WA, and Ladenstein R (1976) Glutathione peroxidase, in Glutathione: Metabolism and Function (Arias IM and Jakoby WB eds) pp 115-138, Raven Press, New York.
17. Garcia-Ruiz C, Colell A, Mari M, Morales A, and Fernandez-Checa JC (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J Biol Chem 272:11369-77.
18. Garcia-Ruiz C, Colell A, Morales A, Kaplowitz N and Fernandez-Checa JC (1995) Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-κB: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol 48:825-834.
19. Gardner PR and White CW (1995) Application of the aconitase method to the assay of superoxide in the mitochondria matrices of cultured cells: Effects of oxygen, redox-cycling agents, TNF-α, IL-1, LPS and inhibitors of respiration, in The Oxygen Paradox (Davies KJA and Ursini F eds), Cleup University Press, Padova.
20. Han D, Antunes F, Canali R, Rettori D, and Cadenas E (2003) Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem 278:5557-5563.
21. Han D, Sen CK, Roy S, Kobayashi MS, Tritschler HJ and Packer L (1997) Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol 273:R1771-R1778.
22. Han D, Williams E, and Cadenas E (2001) Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space. Biochem J 353:411-416.
23. 2 formation by rat heart mitochondria on substrate availability and donor age. J Bioenerg Biomembr 29:89-95.
24. Harvey PR, Ilson RG, and Strasberg SM (1989) The simultaneous determination of oxidized and reduced glutathiones in liver tissue by ion pairing reverse phase high performance liquid chromatography with a coulometric electrochemical detector. Clin Chim Acta 180:203-212.
25. Hensley K, Pye QN, Maidt ML, Stewart CA, Robinson KA, Jaffrey F, and Floyd RA (1998) Interaction of α-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site. J Neurochem 71:2549-2557.
26. Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, and Fernandez-Checa JC (1992) Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 16:1423-1427.
27. Hofmann B, Hecht HJ, and Flohe L (2002) Peroxiredoxins. Biol Chem 383:347-364.
28. Hyslop PA and Sklar LA (1984) A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: its use in the simultaneous fluorimetric assay of cellular activation processes. Anal Biochem 141:280-286.
29. Inarrea P (2002) Purification and determination of activity of mitochondrial cyanide-sensitive superoxide dismutase in rat tissue extract. Methods Enzymol 349:106-114.
30. Iwata S, Lee JW, Okada K, Lee JK, Iwata M, Rasmussen B, Link TA, Ramaswamy S, and Jap B (1998) Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex. Science (Wash DC) 281:64-71.
31. Jocelyn PC and Cronshaw A (1985) Properties of mitochondria treated with 1-chloro-2,4-dinitrobenzene. Biochem Pharmacol 34:1588-1590.
32. Nagai H, Matsumaru K, Feng G, and Kaplowitz N (2002) Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-α-induced apoptosis in cultured mouse hepatocytes. Hepatology 36:55-64.
33. Nigam D, Shukla GS, and Agarwal AK (1999) Glutathione depletion and oxidative damage in mitochondria following exposure to cadmium in rat liver and kidney. Toxicol Lett 106:151-157.
34. Nohl H and Hegner D (1978) Evidence for the existence of catalase in the matrix space of rat-heart mitochondria. FEBS Lett 89:126-130.
35. Nulton-Persson AC and Szweda LI (2001) Modulation of mitochondrial function by hydrogen peroxide. J Biol Chem 276:23357-23361.
36. Okado-Matsumoto A and Fridovich I (2001) Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria. J Biol Chem 276:38388-93.
37. Radi R, Turrens JF, Chang LY, Bush KM, Crapo JD, and Freeman BA (1991) Detection of catalase in rat heart mitochondria. J Biol Chem 266:22028-34.
38. 2 production from mitochondrial respiratory chain. Biochem Biophys Res Commun 281:645-650.
39. Taylor ER, Hurrell F, Shannon RJ, Lin TK, Hirst J, and Murphy MP (2003) Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem 278:19603-10.
40. Turrens JF, Alexandre A, and Lehninger AL (1985) Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch Biochem Biophys 237:408-414.
41. Turrens JF and Boveris A (1980) Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J 191:421-427.
42. Uhlig S and Wendel A (1992) The physiological consequences of glutathione variations. Life Sci 51:1083-1094.
43. Vendemiale G, Guerrieri F, Grattagliano I, Didonna D, Muolo L, and Altomare E (1995) Mitochondrial oxidative phosphorylation and intracellular glutathione compartmentation during liver regeneration. Hepatology 21:1450-1454.
44. Walker JE (1992) The NADH: ubiquinone oxidoreductase (complex I) of respiratory chains. Q Rev Biophys 25:253-324.
45. Young TA, Cunningham CC, and Bailey SM (2002) Reactive oxygen species production by the mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria: studies with myxothiazol. Arch Biochem Biophys 405:65-72.
46. Zoccarato F, Cavallini L, Deana R, and Alexandre A (1988) Pathways of hydrogen peroxide generation in guinea pig cerebral cortex mitochondria. Biochem Biophys Res Commun 154:727-734.
47. Zoccarato F, Cavallini L, Deana R, and Alexandre A (1990) The action of the glutathione transferase substrate, 1-chloro-2,4-dinitrobenzene on synaptosomal glutathione content and the release of hydrogen peroxide. Arch Biochem Biophys 282:244-247.