Active conformation of the erythropoietin receptor: Random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains

Journal of Biological Chemistry

Volumn 281, Issue 11, 2006, Pages 7002-7011

  Lu, Xiaohui ^a   Gross, Alec W ^a   Lodish, Harvey F ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELLS; CONFORMATIONS; DIMERIZATION; DIMERS; MUTAGENESIS;

ACTIVE CONFORMATION; ERYTHROPOIETIN RECEPTOR; EXTRACELLULAR JUXTAMEMBRANE; TRANSMEMBRANE DOMAINS;

CYTOLOGY;

CYSTEINE; CYTOKINE; DIMER; DISULFIDE; ERYTHROPOIETIN RECEPTOR; LIGAND; MUTANT PROTEIN; GLYCOSIDASE;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; MOUSE; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CELL MEMBRANE; CHEMISTRY; CONFORMATION; DIMERIZATION; DOSE RESPONSE; GENE LIBRARY; IMMUNOBLOTTING; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PLASMID; PROTEIN TERTIARY STRUCTURE; TIME;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; CYSTEINE; CYTOSOL; DIMERIZATION; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE LIBRARY; GLYCOSIDE HYDROLASES; IMMUNOBLOTTING; MICE; MODELS, BIOLOGICAL; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PHOSPHORYLATION; PLASMIDS; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ERYTHROPOIETIN; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 33646381647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512638200     Document Type: Article

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