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Volumn 109, Issue 3, 2007, Pages 868-873

New agents that stimulate erythropoiesis

Author keywords

[No Author keywords available]

Indexed keywords

CONTINUOUS ERYTHROPOIETIN RECEPTOR ACTIVATOR; ERYTHROPOIETIN; ERYTHROPOIETIN ANTIBODY; ERYTHROPOIETIN RECEPTOR; FG 2216; FG 4592; GLYCYLGLYCYLTHREONYLTYROSYLSERYLCYSTEINYLHISTIDYLPHENYLALANYLGLYCYL PROLYLLEUCYLTHREONYLTRYPTOPHYLVALYLCYSTEINYLLYSYLPROLYLGLUTAMINYLGLYCYLGLYCINE; HEMATIDE; HEMATOLOGIC AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MACROGOL; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PEGYLATED ERYTHROPOIETIN; RECOMBINANT ERYTHROPOIETIN; SYNTHETIC ERYTHROPOIESIS PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

EID: 33846883294     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-08-019083     Document Type: Review
Times cited : (90)

References (63)
  • 1
    • 0022980521 scopus 로고
    • Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis
    • Winearls CG, Oliver DO, Pippard MJ, Reid C, Downing MR, Cotes PM. Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis. Lancet. 1986;2:1175-1178.
    • (1986) Lancet , vol.2 , pp. 1175-1178
    • Winearls, C.G.1    Oliver, D.O.2    Pippard, M.J.3    Reid, C.4    Downing, M.R.5    Cotes, P.M.6
  • 2
    • 0023120533 scopus 로고
    • Correction of the anemia of endstage renal disease with recombinant human erythropoietin
    • Eschbach JW, Ergie JC, Downing MR, Browne JK, Adamson JW. Correction of the anemia of endstage renal disease with recombinant human erythropoietin. N Engl J Med. 1987;316:73-78.
    • (1987) N Engl J Med , vol.316 , pp. 73-78
    • Eschbach, J.W.1    Ergie, J.C.2    Downing, M.R.3    Browne, J.K.4    Adamson, J.W.5
  • 3
    • 0037075272 scopus 로고    scopus 로고
    • Pure redcell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin
    • Casadevall N, Nataf J, Viron B, et al. Pure redcell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. N Engl J Med. 2002;346:469-475.
    • (2002) N Engl J Med , vol.346 , pp. 469-475
    • Casadevall, N.1    Nataf, J.2    Viron, B.3
  • 4
  • 5
    • 0027482752 scopus 로고
    • Hematopoietic growth factors: Understanding functional diversity in structural terms
    • Kaushansky K, Karplus PA. Hematopoietic growth factors: understanding functional diversity in structural terms. Blood. 1993;82:3229-3240.
    • (1993) Blood , vol.82 , pp. 3229-3240
    • Kaushansky, K.1    Karplus, P.A.2
  • 6
    • 0027133568 scopus 로고
    • Alanine scanning mutagenesis of human erythropoietin identifies four amino acids which are critical for biological activity
    • Grodberg J, Davis KL, Sytkowski AJ. Alanine scanning mutagenesis of human erythropoietin identifies four amino acids which are critical for biological activity. Euro J Biochem. 1993;218:597-601.
    • (1993) Euro J Biochem , vol.218 , pp. 597-601
    • Grodberg, J.1    Davis, K.L.2    Sytkowski, A.J.3
  • 7
    • 0028064871 scopus 로고
    • Erythropoietin structure-function relationships: Identification of functionally important domains
    • Wen D, Boissel J-P, Showers M, Ruch BC, Bunn HF. Erythropoietin structure-function relationships: identification of functionally important domains. J Biol Chem. 1994;269:22839-22846.
    • (1994) J Biol Chem , vol.269 , pp. 22839-22846
    • Wen, D.1    Boissel, J.-P.2    Showers, M.3    Ruch, B.C.4    Bunn, H.F.5
  • 8
    • 0029930231 scopus 로고    scopus 로고
    • Fine-structure epitope mapping of anti-erythropoietin monoclonal antibodies reveals a model of recombinant human erythropoietin protein structure
    • Elliott S, Lorenzini T, Chang D, et al. Fine-structure epitope mapping of anti-erythropoietin monoclonal antibodies reveals a model of recombinant human erythropoietin protein structure. Blood. 1996;87:2702-2713.
    • (1996) Blood , vol.87 , pp. 2702-2713
    • Elliott, S.1    Lorenzini, T.2    Chang, D.3
  • 9
    • 0031026905 scopus 로고    scopus 로고
    • Mapping of the active site of recombinant human erythropoietin
    • Elliott S, Lorenzini T, Chang D, Barzilay J, Delorme E. Mapping of the active site of recombinant human erythropoietin. Blood. 1997;89:493-502.
    • (1997) Blood , vol.89 , pp. 493-502
    • Elliott, S.1    Lorenzini, T.2    Chang, D.3    Barzilay, J.4    Delorme, E.5
  • 10
    • 0032079563 scopus 로고    scopus 로고
    • Homodimerization restores biological activity to an inactive erythropoietin mutant
    • Qiu H, Belanger A, Yoon HW, Bunn HF. Homodimerization restores biological activity to an inactive erythropoietin mutant. J Biol Chem. 1998;273:11173-11176.
    • (1998) J Biol Chem , vol.273 , pp. 11173-11176
    • Qiu, H.1    Belanger, A.2    Yoon, H.W.3    Bunn, H.F.4
  • 11
    • 0032188942 scopus 로고    scopus 로고
    • Efficiency of signalling through cytokine receptors depends critically on receptor orientation
    • Syed RS, Reid SW, Li C, et al. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998;395:511-516.
    • (1998) Nature , vol.395 , pp. 511-516
    • Syed, R.S.1    Reid, S.W.2    Li, C.3
  • 12
    • 0033548259 scopus 로고    scopus 로고
    • Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
    • Livnah O, Stura EA, Middleton SA, Johnson DL, Jolliffe LK, Wilson IA. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science. 1999;283:987-990.
    • (1999) Science , vol.283 , pp. 987-990
    • Livnah, O.1    Stura, E.A.2    Middleton, S.A.3    Johnson, D.L.4    Jolliffe, L.K.5    Wilson, I.A.6
  • 13
    • 0033548048 scopus 로고    scopus 로고
    • Erythropoietin receptor activation by a ligand-induced conformation change
    • Remy I, Wilson IA, Michnick SW. Erythropoietin receptor activation by a ligand-induced conformation change. Science. 1999;283:990-993.
    • (1999) Science , vol.283 , pp. 990-993
    • Remy, I.1    Wilson, I.A.2    Michnick, S.W.3
  • 14
    • 0037490210 scopus 로고    scopus 로고
    • Hypoxia-inducible factor and its biomedical relevance
    • Huang LE, Bunn HF. Hypoxia-inducible factor and its biomedical relevance. J Biol Chem. 2003;278:19575-19578.
    • (2003) J Biol Chem , vol.278 , pp. 19575-19578
    • Huang, L.E.1    Bunn, H.F.2
  • 16
    • 2442693041 scopus 로고    scopus 로고
    • Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression
    • Fandrey J. Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression. Am J Physiol Regul Integr Comp Physiol. 2004;286:R977-R988.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Fandrey, J.1
  • 17
    • 0033104847 scopus 로고    scopus 로고
    • Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha
    • Yu AY, Shimoda LA, Iyer NV, et al. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest. 1999;103:691-696.
    • (1999) J Clin Invest , vol.103 , pp. 691-696
    • Yu, A.Y.1    Shimoda, L.A.2    Iyer, N.V.3
  • 18
    • 18444380862 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys
    • Rosenberger C, Mandriota S, Jurgensen JS, et al. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol. 2002;13:1721-1732.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1721-1732
    • Rosenberger, C.1    Mandriota, S.2    Jurgensen, J.S.3
  • 19
    • 0032737391 scopus 로고    scopus 로고
    • Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients
    • Macdougall IC, Gray SJ, Elston O, et al. Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients. J Am Soc Nephrol. 1999;10:2392-2395.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2392-2395
    • Macdougall, I.C.1    Gray, S.J.2    Elston, O.3
  • 20
    • 18744363354 scopus 로고    scopus 로고
    • Darbepoetin alfa administered once monthly maintains hemoglobin concentrations in patients with chronic kidney disease
    • Ling B, Walczyk M, Agarwal A, Carroll W, Liu W, Brenner R. Darbepoetin alfa administered once monthly maintains hemoglobin concentrations in patients with chronic kidney disease. Clin Nephrol. 2005;63:327-334.
    • (2005) Clin Nephrol , vol.63 , pp. 327-334
    • Ling, B.1    Walczyk, M.2    Agarwal, A.3    Carroll, W.4    Liu, W.5    Brenner, R.6
  • 21
    • 20144376223 scopus 로고    scopus 로고
    • Randomized cross-over comparison of intravenous and subcutaneous darbepoetin dosing efficiency in haemodialysis patients
    • Cervelli MJ, Gray N, McDonald S, Gentgall MG, Disney AP. Randomized cross-over comparison of intravenous and subcutaneous darbepoetin dosing efficiency in haemodialysis patients. Nephrology (Carlton). 2005;10:129-135.
    • (2005) Nephrology (Carlton) , vol.10 , pp. 129-135
    • Cervelli, M.J.1    Gray, N.2    McDonald, S.3    Gentgall, M.G.4    Disney, A.P.5
  • 22
    • 33744822764 scopus 로고    scopus 로고
    • Randomized comparison of every-2-week darbepoetin alfa and weekly epoetin alfa for the treatment of chemotherapy-induced anemia: The 20030125 Study Group Trial
    • Glaspy J, Vadhan-Raj S, Patel R, et al. Randomized comparison of every-2-week darbepoetin alfa and weekly epoetin alfa for the treatment of chemotherapy-induced anemia: the 20030125 Study Group Trial. J Clin Oncol. 2006;24:2290-2297.
    • (2006) J Clin Oncol , vol.24 , pp. 2290-2297
    • Glaspy, J.1    Vadhan-Raj, S.2    Patel, R.3
  • 23
    • 33646905411 scopus 로고    scopus 로고
    • Recombinant human erythropoietins and cancer patients: Updated meta-analysis of 57 studies including 9353 patients
    • Bohlius J, Wilson J, Seidenfeld J, et al. Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patients. J Natl Cancer Inst. 2006;98:708-714.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 708-714
    • Bohlius, J.1    Wilson, J.2    Seidenfeld, J.3
  • 24
    • 33744964192 scopus 로고    scopus 로고
    • Darbepoetin alfa: A review of its use in the treatment of anaemia in patients with cancer receiving chemotherapy
    • Siddiqui MA, Keating GM. Darbepoetin alfa: a review of its use in the treatment of anaemia in patients with cancer receiving chemotherapy. Drugs. 2006;66:997-1012.
    • (2006) Drugs , vol.66 , pp. 997-1012
    • Siddiqui, M.A.1    Keating, G.M.2
  • 25
    • 28444489284 scopus 로고    scopus 로고
    • Darbepoetin alfa for the treatment of anemic patients with low- and intermediate-1-risk myelodysplastic syndromes
    • Stasi R, Abruzzese E, Lanzetta G, Terzoli E, Amadori S. Darbepoetin alfa for the treatment of anemic patients with low- and intermediate-1-risk myelodysplastic syndromes. Ann Oncol. 2005;16:1921-1927.
    • (2005) Ann Oncol , vol.16 , pp. 1921-1927
    • Stasi, R.1    Abruzzese, E.2    Lanzetta, G.3    Terzoli, E.4    Amadori, S.5
  • 26
    • 33646237362 scopus 로고    scopus 로고
    • High-dose darbepoetin alpha in the treatment of anaemia of lower risk myelodysplastic syndrome results of a phase II study
    • Mannone L, Gardin C, Quarre MC, et al. High-dose darbepoetin alpha in the treatment of anaemia of lower risk myelodysplastic syndrome results of a phase II study. Br J Haematol. 2006;133:513-519.
    • (2006) Br J Haematol , vol.133 , pp. 513-519
    • Mannone, L.1    Gardin, C.2    Quarre, M.C.3
  • 27
    • 27844567934 scopus 로고    scopus 로고
    • Single-dose darbepoetin administration to anemic preterm neonates
    • Warwood TL, Ohls RK, Wiedmeier SE, et al. Single-dose darbepoetin administration to anemic preterm neonates. J Perinatol. 2005;25:725-730.
    • (2005) J Perinatol , vol.25 , pp. 725-730
    • Warwood, T.L.1    Ohls, R.K.2    Wiedmeier, S.E.3
  • 28
    • 0033609857 scopus 로고    scopus 로고
    • An erythropoietin fusion protein comprised of identical repeating domains exhibits enhanced biological properties
    • Sytkowski AJ, Lunn ED, Risinger MA, Davis KL. An erythropoietin fusion protein comprised of identical repeating domains exhibits enhanced biological properties. J Biol Chem. 1999;274:24773-24778.
    • (1999) J Biol Chem , vol.274 , pp. 24773-24778
    • Sytkowski, A.J.1    Lunn, E.D.2    Risinger, M.A.3    Davis, K.L.4
  • 30
    • 0037423148 scopus 로고    scopus 로고
    • Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein
    • Kochendoerfer GG, Chen SY, Mao F, et al. Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein. Science. 2003;299:884-887.
    • (2003) Science , vol.299 , pp. 884-887
    • Kochendoerfer, G.G.1    Chen, S.Y.2    Mao, F.3
  • 31
    • 10644276313 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of pegylated human erythropoietin in rats
    • Jolling K, Ruixo JJ, Hemeryck A, Piotrovskij V, Greway T. Population pharmacokinetic analysis of pegylated human erythropoietin in rats. J Pharm Sci. 2004;93:3027-3038.
    • (2004) J Pharm Sci , vol.93 , pp. 3027-3038
    • Jolling, K.1    Ruixo, J.J.2    Hemeryck, A.3    Piotrovskij, V.4    Greway, T.5
  • 32
    • 33644875091 scopus 로고    scopus 로고
    • (continuous erythropoietin receptor activator): A new erythropoiesis-stimulating agent for the treatment of anemia
    • Macdougall IC. CERA (continuous erythropoietin receptor activator): a new erythropoiesis-stimulating agent for the treatment of anemia. Curr Hematol Rep. 2005;4:436-440.
    • (2005) Curr Hematol Rep , vol.4 , pp. 436-440
    • Macdougall, I.C.1
  • 33
    • 33745050664 scopus 로고    scopus 로고
    • Dosing patterns, hematologic outcomes, and costs of erythropoietic agents in predialysis chronic kidney disease patients with anemia
    • Papatheofanis FJ, McKenzie RS, Mody SH, Suruki RY, Piech CT. Dosing patterns, hematologic outcomes, and costs of erythropoietic agents in predialysis chronic kidney disease patients with anemia. Curr Med Res Opin. 2006;22:837-842.
    • (2006) Curr Med Res Opin , vol.22 , pp. 837-842
    • Papatheofanis, F.J.1    McKenzie, R.S.2    Mody, S.H.3    Suruki, R.Y.4    Piech, C.T.5
  • 34
    • 9444236174 scopus 로고    scopus 로고
    • Small peptides as potent mimetics of the protein hormone erythropoietin
    • Wrighton NC, Farrell FX, Chang R, et al. Small peptides as potent mimetics of the protein hormone erythropoietin. Science. 1996;273:458-463.
    • (1996) Science , vol.273 , pp. 458-463
    • Wrighton, N.C.1    Farrell, F.X.2    Chang, R.3
  • 35
    • 0029798402 scopus 로고    scopus 로고
    • Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 A
    • Livnah O, Stura EA, Johnson DL, et al. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science. 1996;273:464-471.
    • (1996) Science , vol.273 , pp. 464-471
    • Livnah, O.1    Stura, E.A.2    Johnson, D.L.3
  • 36
    • 33747601907 scopus 로고    scopus 로고
    • Preclinical evaluation of Hematide, a novel erythropoietin receptor agonist for the treatment of anemia caused by kidney disease [abstract]
    • Abstract no. 2094
    • Woodburn KW, Fan Q, Leuther KK, et al. Preclinical evaluation of Hematide, a novel erythropoietin receptor agonist for the treatment of anemia caused by kidney disease [abstract]. Blood. 2004;104. Abstract no. 2094.
    • (2004) Blood , pp. 104
    • Woodburn, K.W.1    Fan, Q.2    Leuther, K.K.3
  • 37
    • 33748679131 scopus 로고    scopus 로고
    • Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose escalation study in healthy volunteers
    • Stead RB, Lambert J, Wessels D, et al. Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose escalation study in healthy volunteers. Blood. 2006;108:1830-1834.
    • (2006) Blood , vol.108 , pp. 1830-1834
    • Stead, R.B.1    Lambert, J.2    Wessels, D.3
  • 38
    • 85006458247 scopus 로고    scopus 로고
    • Hematide, a synthetic peptide-based erythropoiesis stimulating agent (ESA) demonstrates erythropoietic activity in a phase 2 single dose escalating study in patients with chronic kidney disease (CKD) [abstract]
    • Abstract no. 3532
    • Duliege A-M, Macdougall I, Duncan N, et al. Hematide, a synthetic peptide-based erythropoiesis stimulating agent (ESA) demonstrates erythropoietic activity in a phase 2 single dose escalating study in patients with chronic kidney disease (CKD) [abstract]. Blood. 2005;106. Abstract no. 3532.
    • (2005) Blood , pp. 106
    • Duliege, A.-M.1    Macdougall, I.2    Duncan, N.3
  • 39
    • 17944375360 scopus 로고    scopus 로고
    • Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107:43-54.
    • Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107:43-54.
  • 40
    • 33745820018 scopus 로고    scopus 로고
    • Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure
    • Bernhardt WM, Campean V, Kany S, et al. Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol. 2006;17:1970-1978.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1970-1978
    • Bernhardt, W.M.1    Campean, V.2    Kany, S.3
  • 41
    • 33646123187 scopus 로고    scopus 로고
    • Novel and beneficial pharmacodynamic properties of endogenous EPO and 'complete erythropoiesis' induced by selective HIF prolyl hydroxylase inhibitors [abstract]
    • Liu DY, Neff TB, Guenzler V, et al. Novel and beneficial pharmacodynamic properties of endogenous EPO and 'complete erythropoiesis' induced by selective HIF prolyl hydroxylase inhibitors [abstract]. J Am Soc Nephrol. 2005;16:761A.
    • (2005) J Am Soc Nephrol , vol.16
    • Liu, D.Y.1    Neff, T.B.2    Guenzler, V.3
  • 42
    • 33746609948 scopus 로고    scopus 로고
    • FG-2216 corrects anemia and improves iron utilization in a rat model of anemia of chronic disease: Comparison to darbepoetin [abstract]
    • Langsetmo I, Nichols B, Seeley T, et al. FG-2216 corrects anemia and improves iron utilization in a rat model of anemia of chronic disease: comparison to darbepoetin [abstract]. J Am Soc Nephrol. 2005;16:481A.
    • (2005) J Am Soc Nephrol , vol.16
    • Langsetmo, I.1    Nichols, B.2    Seeley, T.3
  • 43
    • 33846882723 scopus 로고    scopus 로고
    • Günzler V, Muthukrishnan E, H.H. Neumayer KS, et al. FG-2216 increases hemoglobin concentration in anemic patients with chronic kidney disease [abstract]. J Am Soc Nephrol. 2005;16:758A.
    • Günzler V, Muthukrishnan E, H.H. Neumayer KS, et al. FG-2216 increases hemoglobin concentration in anemic patients with chronic kidney disease [abstract]. J Am Soc Nephrol. 2005;16:758A.
  • 44
    • 18744373593 scopus 로고    scopus 로고
    • Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
    • Ang SO, Chen H, Hirota K, et al. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet. 2002;32:614-621.
    • (2002) Nat Genet , vol.32 , pp. 614-621
    • Ang, S.O.1    Chen, H.2    Hirota, K.3
  • 45
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830-5835.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 46
    • 33846642095 scopus 로고    scopus 로고
    • FG-2216: Tumor progression studies and correction of anemia of chronic disease in xenograft models [abstract]
    • Seeley TW, Langsetmo I, Stephenson R, et al. FG-2216: tumor progression studies and correction of anemia of chronic disease in xenograft models [abstract]. J Am Soc Nephrol. 2005;16:481A.
    • (2005) J Am Soc Nephrol , vol.16
    • Seeley, T.W.1    Langsetmo, I.2    Stephenson, R.3
  • 47
    • 0027136260 scopus 로고
    • Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
    • Wang GL, Semenza GL. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood. 1993;82:3610-3615.
    • (1993) Blood , vol.82 , pp. 3610-3615
    • Wang, G.L.1    Semenza, G.L.2
  • 48
    • 7444253390 scopus 로고    scopus 로고
    • Beneficial and ominous aspects of the pleiotropic action of erythropoietin
    • Jelkmann W, Wagner K. Beneficial and ominous aspects of the pleiotropic action of erythropoietin. Ann Hematol. 2004;83:673-686.
    • (2004) Ann Hematol , vol.83 , pp. 673-686
    • Jelkmann, W.1    Wagner, K.2
  • 49
    • 0037974734 scopus 로고    scopus 로고
    • Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
    • Erbayraktar S, Grasso G, Sfacteria A, et al. Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci U S A. 2003;100:6741-6746.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6741-6746
    • Erbayraktar, S.1    Grasso, G.2    Sfacteria, A.3
  • 50
    • 13844320400 scopus 로고    scopus 로고
    • A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury
    • Fiordaliso F, Chimenti S, Staszewsky L, et al. A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2005;102:2046-2051.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2046-2051
    • Fiordaliso, F.1    Chimenti, S.2    Staszewsky, L.3
  • 51
    • 6944237300 scopus 로고    scopus 로고
    • Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor
    • Brines M, Grasso G, Fiordaliso F, et al. Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci U S A. 2004;101:14907-14912.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14907-14912
    • Brines, M.1    Grasso, G.2    Fiordaliso, F.3
  • 53
    • 0028260228 scopus 로고
    • Erythropoietin receptor mRNA expression in human endothelial cells
    • Anagnostou A, Liu Z, Steiner M, et al. Erythropoietin receptor mRNA expression in human endothelial cells. Proc Natl Acad Sci U S A. 1994;91:3974-3978.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3974-3978
    • Anagnostou, A.1    Liu, Z.2    Steiner, M.3
  • 54
    • 23944523376 scopus 로고    scopus 로고
    • Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy
    • Watanabe D, Suzuma K, Matsui S, et al. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med. 2005;353:782-792.
    • (2005) N Engl J Med , vol.353 , pp. 782-792
    • Watanabe, D.1    Suzuma, K.2    Matsui, S.3
  • 55
    • 0030669135 scopus 로고    scopus 로고
    • Erythropoietin administration increases production and reactivity of platelets in dogs
    • Wolf RF, Peng J, Friese P, Gilmore LS, Burstein SA, Dale GL. Erythropoietin administration increases production and reactivity of platelets in dogs. Thromb Haemost. 1997;78:1505-1509.
    • (1997) Thromb Haemost , vol.78 , pp. 1505-1509
    • Wolf, R.F.1    Peng, J.2    Friese, P.3    Gilmore, L.S.4    Burstein, S.A.5    Dale, G.L.6
  • 56
    • 0030978397 scopus 로고    scopus 로고
    • Erythropoietin potentiates thrombus development in a canine arterio-venous shunt model
    • Wolf RF, Gilmore LS, Friese P, Downs T, Burstein SA, Dale GL. Erythropoietin potentiates thrombus development in a canine arterio-venous shunt model. Thromb Haemost. 1997;77:1020-1024.
    • (1997) Thromb Haemost , vol.77 , pp. 1020-1024
    • Wolf, R.F.1    Gilmore, L.S.2    Friese, P.3    Downs, T.4    Burstein, S.A.5    Dale, G.L.6
  • 57
    • 0034192225 scopus 로고    scopus 로고
    • Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans
    • Stohlawetz PJ, Dzirlo L, Hergovich N, et al. Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans. Blood. 2000;95:2983-2989.
    • (2000) Blood , vol.95 , pp. 2983-2989
    • Stohlawetz, P.J.1    Dzirlo, L.2    Hergovich, N.3
  • 58
    • 0033562371 scopus 로고    scopus 로고
    • The effect of recombinant human erythropoietin on platelet counts is strongly modulated by the adequacy of iron supply
    • Loo M, Beguin Y. The effect of recombinant human erythropoietin on platelet counts is strongly modulated by the adequacy of iron supply. Blood. 1999;93:3286-3293.
    • (1999) Blood , vol.93 , pp. 3286-3293
    • Loo, M.1    Beguin, Y.2
  • 59
    • 17744398006 scopus 로고    scopus 로고
    • Inhibition of erythropoietin signalling destroys xenografts of ovarian and uterine cancers in nude mice
    • Yasuda Y, Musha T, Tanaka H, et al. Inhibition of erythropoietin signalling destroys xenografts of ovarian and uterine cancers in nude mice. Br J Cancer. 2001;84:836-843.
    • (2001) Br J Cancer , vol.84 , pp. 836-843
    • Yasuda, Y.1    Musha, T.2    Tanaka, H.3
  • 60
    • 0036318603 scopus 로고    scopus 로고
    • Functional significance of erythropoietin receptor expression in breast cancer
    • Arcasoy MO, Amin K, Karayal AF, et al. Functional significance of erythropoietin receptor expression in breast cancer. Lab Invest. 2002;82:911-918.
    • (2002) Lab Invest , vol.82 , pp. 911-918
    • Arcasoy, M.O.1    Amin, K.2    Karayal, A.F.3
  • 61
    • 0041976976 scopus 로고    scopus 로고
    • Breast cancer trial with erythropoietin terminated unexpectedly
    • Leyland-Jones B. Breast cancer trial with erythropoietin terminated unexpectedly. Lancet Oncol. 2003;4:459-460.
    • (2003) Lancet Oncol , vol.4 , pp. 459-460
    • Leyland-Jones, B.1
  • 62
    • 0142186283 scopus 로고    scopus 로고
    • Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial
    • Henke M, Laszig R, Rube C, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet. 2003;362:1255-1260.
    • (2003) Lancet , vol.362 , pp. 1255-1260
    • Henke, M.1    Laszig, R.2    Rube, C.3
  • 63
    • 27244443556 scopus 로고    scopus 로고
    • Darbepoetin alfa for the treatment of chemotherapy-induced anemia: Disease progression and survival analysis from four randomized, double-blind, placebo-controlled trials
    • Hedenus M, Vansteenkiste J, Kotasek D, Austin M, Amado RG. Darbepoetin alfa for the treatment of chemotherapy-induced anemia: disease progression and survival analysis from four randomized, double-blind, placebo-controlled trials. J Clin Oncol. 2005;23:6941-6948.
    • (2005) J Clin Oncol , vol.23 , pp. 6941-6948
    • Hedenus, M.1    Vansteenkiste, J.2    Kotasek, D.3    Austin, M.4    Amado, R.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.