Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery

Experimental Hematology

Volumn 37, Issue 1, 2009, Pages 10-18

  Maltby, Steven ^a   Hughes, Michael R ^a   Zbytnuik, Lori ^a   Paulson, Robert F ^b   McNagny, Kelly M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; PODOCALYXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL EXPANSION; CELL STRESS; CHIMERA; CONTROLLED STUDY; ERYTHROBLAST; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; HEMOLYTIC ANEMIA; HOMEOSTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETICULOCYTE; UPREGULATION;

ANEMIA; ANIMALS; ANTIGENS, DIFFERENTIATION; BONE MARROW; ERYTHROID PRECURSOR CELLS; ERYTHROPOIETIN; MICE; MICE, KNOCKOUT; OXIDANTS; PHENYLHYDRAZINES; RETICULOCYTES; SIALOGLYCOPROTEINS; SPLEEN; STAT5 TRANSCRIPTION FACTOR; STRESS, PHYSIOLOGICAL; TRANSPLANTATION CHIMERA; UP-REGULATION;

MUS;

EID: 57549101047     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2008.09.006     Document Type: Article

References (35)

1. Socolovsky M. Molecular insights into stress erythropoiesis. Curr Opin Hematol 14 (2007) 215-224
2. Ebert B.L., and Bunn H.F. Regulation of the erythropoietin gene. Blood 94 (1999) 1864-1877
3. Broudy V.C., Lin N.L., Priestley G.V., Nocka K., and Wolf N.S. Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen. Blood 88 (1996) 75-81
4. Perry J.M., Harandi O.F., and Paulson R.F. BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors. Blood 109 (2007) 4494-4502
5. Lenox L.E., Perry J.M., and Paulson R.F. BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood 105 (2005) 2741-2748
6. Bauer A., Tronche F., Wessely O., et al. The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev 13 (1999) 2996-3002
7. Kerjaschki D., Sharkey D.J., and Farquhar M.G. Identification and characterization of podocalyxin-the major sialoprotein of the renal glomerular epithelial cell. J Cell Biol 98 (1984) 1591-1596
8. Dekan G., Gabel C., and Farquhar M.G. Sulfate contributes to the negative charge of podocalyxin, the major sialoglycoprotein of the glomerular filtration slits. Proc Natl Acad Sci U S A 15 88 (1991) 5398-5402
9. Furness S.G., and McNagny K. Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunol Res 34 (2006) 13-32
10. Kershaw D.B., Thomas P.E., Wharram B.L., et al. Molecular cloning, expression, and characterization of podocalyxin-like protein 1 from rabbit as a transmembrane protein of glomerular podocytes and vascular endothelium. J Biol Chem 270 (1995) 29439-29446
11. Horvat R., Hovorka A., Dekan G., Poczewski H., and Kerjaschki D. Endothelial cell membranes contain podocalyxin-the major sialoprotein of visceral glomerular epithelial cells. J Cell Biol 102 (1986) 484-491
12. Hara T., Nakano Y., Tanaka M., et al. Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region. Immunity 11 (1999) 567-578
13. Doyonnas R., Kershaw D.B., Duhme C., et al. Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. J Exp Med 194 (2001) 13-27
14. McNagny K.M., Pettersson I., Rossi F., et al. Thrombomucin, a novel cell surface protein that defines thrombocytes and multipotent hematopoietic progenitors. J Cell Biol 138 (1997) 1395-1407
15. Doyonnas R., Nielsen J.S., Chelliah S., et al. Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Blood 105 (2005) 4170-4178
16. Kerosuo L., Juvonen E., Alitalo R., Gylling M., Kerjaschki D., and Miettinen A. Podocalyxin in human haematopoietic cells. Br J Haematol 124 (2004) 809-818
17. Somasiri A., Nielsen J.S., Makretsov N., et al. Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression. Cancer Res 64 (2004) 5068-5073
18. Casey G., Neville P.J., Liu X., et al. Podocalyxin variants and risk of prostate cancer and tumor aggressiveness. Hum Mol Genet 15 (2006) 735-741
19. Sizemore S., Cicek M., Sizemore N., Ng K.P., and Casey G. Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin. Cancer Res 67 (2007) 6183-6191
20. Drew E., Merzaban J.S., Seo W., Ziltener H.J., and McNagny K.M. CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. Immunity 22 (2005) 43-57
21. Blanchet M.R., Maltby S., Haddon D.J., Merkens H., Zbytnuik L., and McNagny K.M. CD34 facilitates the development of allergic asthma. Blood 110 (2007) 2005-2012
22. Gounaris E., Erdman S.E., Restaino C., et al. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A 104 (2007) 19977-19982
23. Porayette P., and Paulson R.F. BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development. Dev Biol 317 (2008) 24-35
24. Sathyanarayana P., Menon M.P., Bogacheva O., et al. Erythropoietin modulation of podocalyxin, and a proposed erythroblast niche. Blood 110 (2007) 509-518
25. Zang H., Sato K., Nakajima H., McKay C., Ney P.A., and Ihle J.N. The distal region and receptor tyrosines of the epo receptor are non-essential for in vivo erythropoiesis. EMBO J 20 (2001) 3156-3166
26. Riley R.S., Ben-Ezra J.M., Goel R., and Tidwell A. Reticulocytes and reticulocyte enumeration. J Clin Lab Anal 15 (2001) 267-294
27. Riley R.S., Ben-Ezra J.M., Tidwell A., and Romagnoli G. Reticulocyte analysis by flow cytometry and other techniques. Hematol Oncol Clin North Am 16 (2002) 373-420 vii
28. Liu Y., Pop R., Sadegh C., Brugnara C., Haase V.H., and Socolovsky M. Suppression of fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood 108 (2006) 123-133
29. Jackson C.W. Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood 42 (1973) 413-421
30. Socolovsky M., Nam H., Fleming M.D., Haase V.H., Brugnara C., and Lodish H.F. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood 98 (2001) 3261-3273
31. Miettinen A., Solin M.L., Reivinen J., Juvonen E., Vaisanen R., and Holthofer H. Podocalyxin in rat platelets and megakaryocytes. Am J Pathol 154 (1999) 813-822
32. Baumheter S., Singer M.S., Henzel W., et al. Binding of L-selectin to the vascular sialomucin CD34. Science 262 (1993) 436-438
33. Fieger C.B., Sassetti C.M., and Endoglycan R.SD. a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J Biol Chem 278 (2003) 27390-27398
34. Sarangapani K.K., Yago T., Klopocki A.G., et al. Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan. J Biol Chem 279 (2004) 2291-2298
35. Sassetti C., Tangemann K., Singer M.S., Kershaw D.B., and Rosen S.D. Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. J Exp Med 187 (1998) 1965-1975