Immunological synapses within context: Patterns of cell-cell communication and their application in T-T interactions

Current Topics in Microbiology and Immunology

Volumn 340, Issue 1, 2010, Pages 25-50

  Doh, Junsang ^b   Krummel, Matthew F ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; FAS ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; LIPID; MEMBRANE RECEPTOR; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR;

ANTIGEN PRESENTING CELL; APOPTOSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ADHESION; CELL COMMUNICATION; CELL FUNCTION; CELL INTERACTION; CELL MEMBRANE; CELL MIGRATION; CELL MOTILITY; CELL POLARITY; CELL SELECTION; CELL SURVIVAL; CELL TYPE; DENDRITIC CELL; EFFECTOR CELL; HELPER CELL; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL SYNAPSE; IMMUNOSTIMULATION; LIGAND BINDING; LIPID BILAYER; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUORUM SENSING; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; CHEMISTRY; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PHYSIOLOGY;

ANIMALS; CELL COMMUNICATION; HUMANS; IMMUNOLOGICAL SYNAPSES; LYMPHOCYTE ACTIVATION; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77950901884     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-03858-7_2     Document Type: Review

References (95)

1. Alexander C, Ishikawa S, Silverstein M(1977) A pattern language: towns, buildings, construction. Oxford University Press, New York
2. Anderson RGW, Jacobson K (2002) Cell biology - a role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296(5574):1821-1825 (Pubitemid 34596260)
3. Bajenoff M et al (2006) Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25(6):989-1001 (Pubitemid 44914055)
4. Bar JJ, Khanna KM, Lefrancois L (2008) Endogenous naive CD8(+) T cell precursor frequency regulates primary and memory responses to infection. Immunity 28(6):859-869
5. Batista FD, Iber D, Neuberger MS (2001) B cells acquire antigen from target cells after synapse formation. Nature 411(6836):489-494 (Pubitemid 32494396)
6. Bettelli E et al (2008) Induction and effector functions of T(H)17 cells. Nature 453 (7198):1051-1057 (Pubitemid 351871737)
7. Boisvert J, Edmondson S, Krummel MF (2004) Immunological synapse formation licenses CD40- CD40L accumulations at T-APC contact sites. J Immunol 173(6):3647-3652 (Pubitemid 39280724)
8. Bousso P, Robey E (2003) Dynamics of CD8(+) T cell priming by dendritic cells in intact lymph nodes. Nat Immunol 4(6):579-585 (Pubitemid 36701342)
9. Brossard C et al (2005) Multifocal structure of the T cell - dendritic cell synapse. Eur J Immunol 35(6):1741-1753 (Pubitemid 40862322)
10. Cahalan MD, Parker I (2008) Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol 26:585-626 (Pubitemid 351600386)
11. Campi G, Varma R, Dustin ML (2005) Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med 202(8):1031-1036 (Pubitemid 41540032)
12. Castellino F et al (2006) Chemokines enhance immunity by guiding naive CD8(+) T cells to sites of CD4 T cell-dendritic cell interaction. Nature 440(7086):890-895
13. Celli S, Lemaitre F, Bousso P (2007) Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4(+) T cell activation. Immunity 27 (4):625-634 (Pubitemid 47615508)
14. Cemerski S et al (2008) The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity 29 (3):414-422
15. Chirifu M et al (2007) Crystal structure of the IL-15-IL-15R alpha complex, a cytokine-receptor unit presented in trans. Nat Immunol 8(9):1001-1007 (Pubitemid 47300015)
16. Choudhuri K et al (2005) T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 436(7050):578-582 (Pubitemid 41112933)
17. Constant SL, Bottomly K (1997) Induction of TH1 and TH2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 15:297-322 (Pubitemid 27169283)
18. Dardalhon V et al (2008) IL-4 inhibits TGF-beta-induced Foxp3(+) T cells and, together with TGF-beta, generates IL-9(+) IL-10(+) Foxp3(-) effector T cells. Nat Immunol 9 (12):1347-1355
19. Delon J, Kaibuchi K, Germain RN (2001) Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 15(5):691-701 (Pubitemid 34008498)
20. DeMond AL et al (2006) Control of antigen presentation with a photoreleasable agonist peptide. J Am Chem Soc 128(48):15354-15355
21. Depoil D et al (2005) Immunological synapses are versatile structures enabling selective T cell polarization. Immunity 22(2):185-194 (Pubitemid 40255710)
22. Douglass AD, Vale RD (2005) Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell 121(6):937-950
23. Dubois S et al (2002) IL-15R alpha recycles and presents IL-15 in trans to neighboring cells. Immunity 17(5):537-547 (Pubitemid 35351500)
24. Dustin ML, Colman DR (2002) Neural and immunological synaptic relations. Science 298 (5594):785-789
25. Dustin ML et al (1997) Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc Natl Acad Sci USA 94(8):3909-3913
26. Dustin ML et al (1998) A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell 94(5):667-677
27. Dustin ML et al (2006) T cell-dendritic cell immunological synapses. Curr Opin Immunol 18 (4):512-516
28. Eicher DM, Waldmann TA (1998) IL-2R alpha on one cell can present IL-2 to IL-2R beta/gamma (c) on another cell to augment IL-2 signaling. J Immunol 161(10):5430-5437
29. Faroudi M et al (2003) Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling. J Immunol 171(3):1128-1132 (Pubitemid 36900039)
30. Gaffen SL (2001) Signaling domains of the interleukin 2 receptor. Cytokine 14(2):63-77
31. Gaffen SL, Liu KD (2004) Overview of interleukin-2 function, production and clinical applications. Cytokine 28(3):109-123 (Pubitemid 39313082)
32. Garcia Z et al (2007) Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion. Proc Natl Acad Sci USA 104(11):4553-4558 (Pubitemid 47186263)
33. Germain RN et al (2006) Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol 6(7):497-507
34. Grakoui A et al (1999) The immunological synapse: a molecular machine controlling T cell activation. Science 285(5425):221-227 (Pubitemid 29329988)
35. Gunzer M et al (2000) Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13(3):323-332
36. Hataye J et al (2006) Naive and memory CD4(+) T cell survival controlled by clonal abundance. Science 312(5770):114-116
37. Hemar A et al (1995) Endocytosis of interleukin-2 receptors in human T-lymphocytes - distinct intracellular-localization and fate of the receptor alpha-chain, beta-chain, and gamma-chain. J Cell Biol 129(1):55-64
38. Henrickson SE et al (2008) T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol 9(3):282-291
39. Hommel M, Kyewski B (2003) Dynamic changes during the immune response in T cell-antigenpresenting cell clusters isolated from lymph nodes. J Exp Med 197(3):269-280 (Pubitemid 36184234)
40. Hugues S et al (2007) Dynamic imaging of chemokine-dependent CD8(+) T cell help for CD8(+) T cell responses. Nat Immunol 8(9):921-930 (Pubitemid 47300006)
41. Hurez V et al (2003) Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells. J Exp Med 198(1):123-132 (Pubitemid 36870192)
42. Huse M et al (2006) T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol 7(3):247-255
43. Huse M et al (2007) Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity 27(1):76-88 (Pubitemid 47089024)
44. Ingulli E et al (1997) In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J Exp Med 185(12):2133-2141 (Pubitemid 27265997)
45. Kim HP, Imbert J, Leonard WJ (2006) Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev 17(5):349-366 (Pubitemid 44604346)
46. Krummel MF et al (2000) Differential clustering of CD4 and CD3 zeta during T cell recognition. Science 289(5483):1349-1352
47. Kupfer A, Mosmann TR, Kupfer H (1991) Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc Natl Acad Sci USA 88(3):775-779 (Pubitemid 21916106)
48. Kupfer H, Monks CR, Kupfer A (1994) Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions. J Exp Med 179(5):1507-1515 (Pubitemid 24129568)
49. Laurence A et al (2007) Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26(3):371-381 (Pubitemid 46413906)
50. Lee KH et al (2002) T cell receptor signaling precedes immunological synapse formation. Science 295(5559):1539-1542
51. Lenardo MJ (1991) Interleukin-2 programs mouse alpha-beta-lymphocytes-T for apoptosis. Nature 353(6347):858-861
52. LiaoWet al (2008) Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol 9(11):1288-1296
53. Lillemeier BF et al (2006) Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. Proc Natl Acad Sci USA 103(50):18992-18997
54. Lin JX, Leonard WJ (2000) The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19(21):2566-2576
55. Lindquist RL et al (2004) Visualizing dendritic cell networks in vivo. Nat Immunol 5 (12):1243-1250 (Pubitemid 41057739)
56. Long MX, Adler AJ (2006) Cutting edge: paracrine, but not autocrine, IL-2 signaling is sustained during early antliviiral. CD4 T cell response. J Immunol 177(7):4257-4261
57. Maldonado RA et al (2004) A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431(7008):527-532
58. McCann FE et al (2003) The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses. J Immunol 170(6):2862-2870
59. Mempel TR, Henrickson SE, von Andrian UH (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427(6970):154-159
60. Miller MJ et al (2004) Imaging the single cell dynamics of CD4(+) T cell activation by dendritic cells in lymph nodes. J Exp Med 200(7):847-856
61. Monks CRF et al (1998) Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395(6697):82-86
62. Mossman KD et al (2005) Altered TCR signaling from geometrically repatterned immunological synapses. Science 310(5751):1191-1193
63. Norcross MA (1984) A synaptic basis for T-lymphocyte activation. Ann Immunol (Paris) 135D:113-134
64. Oddos S et al (2008) High-speed high-resolution imaging of intercellular immune synapses using optical tweezers. Biophys J 95:L66-L68
65. Pandiyan P et al (2007) CD4(+) CD25(+) Foxp3(+) regulatory T cells induce cytokine deprivationmediated apoptosis of effector CD4(+) T cells. Nat Immunol 8(12):1353-1362
66. Purbhoo MA et al (2004) T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol 5(5):524-530
67. Reichert P et al (2001) Cutting edge: in vivo identification of TCR redistribution and polarized IL- 2 production by naive CD4 T cells. J Immunol 166(7):4278-4281 (Pubitemid 32233707)
68. Rittirsch D, Flierl MA, Ward PA (2008) Harmful molecular mechanisms in sepsis. Nat Rev Immunol 8(10):776-787
69. Robb RJ et al (1987) Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors. Proc Natl Acad Sci USA 84:2002-2006
70. Rothlein R, Springer TA (1986) The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester. J Immunol 163(5):1132-1149 (Pubitemid 16000413)
71. Rothlein R et al (1986) A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137(4):1270-1274 (Pubitemid 16041114)
72. Sabatos CA et al (2008) A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity 29(2):238-248
73. Saparov A et al (1999) Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function. Immunity 11(3):271-280 (Pubitemid 29463235)
74. Scholer A et al (2008) Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8(+) T cell memory. Immunity 28(2):258-270 (Pubitemid 351222655)
75. Shaw AS, Dustin ML (1997) Making the T cell receptor go the distance: a topological view of T cell activation. Immunity 6(4):361-369
76. Sims TN et al (2007) Opposing effects of PKC theta and WASp on symmetry breaking and relocation of the immunological synapse. Cell 129(4):773-785
77. Skokos D et al (2007) Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol 8(8):835-844 (Pubitemid 47099036)
78. Stauber DJ et al (2006) Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci USA 103(8):2788-2793 (Pubitemid 43306627)
79. Stinchcombe JC et al (2001) The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 15(5):751-761
80. Sytwu HK, Liblau RS, McDevitt HO (1996) The roles of Fas/APO-1 (CD95) and TNF in antigeninduced programmed cell death in T cell receptor transgenic mice. Immunity 5(1):17-30
81. Tang QZ et al (2006) Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 7(1):83-92
82. Tohma S, Ramberg JE, Lipsky PE (1992) Expression and distribution of CD11a/CD18 and CD54 during human T cell-B cell interactions. J Leukoc Biol 52:97-103
83. van der Merwe PA, Davis SJ (2003) Molecular interactions mediating T cell antigen recognition. Annu Rev Immunol 21:659-684 (Pubitemid 37174544)
84. van Kooyk Y et al (1989) Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature 342(6251):811-813 (Pubitemid 20023816)
85. Varma R et al (2006) T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 25(1):117-127 (Pubitemid 44066825)
86. Veldhoen M et al (2008) Transforming growth factor-beta "reprograms" the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 9(12):1341-1346
87. Villarino AV et al (2007) Helper T cell IL-2 production is limited by negative feedback and STATdependent cytokine signals. J Exp Med 204(1):65-71
88. Waldmann TA (2006) The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol 6(8):595-601 (Pubitemid 44134092)
89. Wang XQ, Rickert M, Garcia KC (2005) Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gamma(c) receptors. Science 310(5751):1159-1163
90. Whyte WH (1988) City: rediscovering the center. Doubleday, New York
91. Wiedemann A et al (2006) Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses. Proc Natl Acad Sci USA 103 (29):10985-10990 (Pubitemid 44148405)
92. Williams MA, Tyznik AJ, Bevan MJ (2006) Interleukin-2 signals during priming are required for secondary expansion of CD8(+) memory T cells. Nature 441(7095):890-893 (Pubitemid 43910424)
93. Wulfing C, Davis MM (1998) A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282(5397):2266-2269 (Pubitemid 29004077)
94. Yokosuka T et al (2005) Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol 6(12):1253-1262 (Pubitemid 43045637)
95. Yokosuka T et al (2008) Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity 29(4):589-601