Cutting edge: Paracrine, but not autocrine, IL-2 signaling is sustained during early antiviral CD4 T cell response

Journal of Immunology

Volumn 177, Issue 7, 2006, Pages 4257-4261

  Long, Meixiao ^a   Adler, Adam J ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; STAT5 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FLOW CYTOMETRY; KINETICS; MOUSE; NONHUMAN; PARACRINE SIGNALING; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; STEADY STATE; TRANSCRIPTION INITIATION; VIRUS INFECTION;

EID: 33749134189     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.7.4257     Document Type: Article

References (27)

1. Davis, M. M., J. J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y. Chien. 1998. Ligand recognition by αβ T cell receptors. Annu. Rev. Immunol. 16: 525-544.
2. Jenkins, M. K. 1994. The ups and downs of T cell costimulation. Immunity 1: 443-446.
3. Croft, M. 2003. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat. Rev. Immunol. 3: 609-620.
4. von Freeden-Jeffry, U., P. Vieira, L. A. Lucian, T. McNeil, S. E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181: 1519-1526.
5. Marrack, P., and J. Kappler. 2004. Control of T cell viability. Annu. Rev. Immunol. 22: 765-787.
6. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7: 145-173.
7. Schluns, K. S., and L. Lefrancois. 2003. Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3: 269-279.
8. Smith, K. A. 1988. Interleukin-2: inception, impact, and implications. Science 240: 1169-1176.
9. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261.
10. Cousens, L. P., J. S. Orange, and C. A. Biron. 1995. Endogenous IL-2 contributes ro T cell expansion and IFN-γ production during lymphocytic choriomeningiris virus infection. J Immunol. 155: 5690-5699.
11. D'Souza, W. N., K. S. Schluns, D. Masopust, and L. Lefrancois. 2002. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J. Immunol. 168: 5566-5572.
12. + T cell numbers. J. Immunol. 169: 4850-4860.
13. + regulatory T cell function. J. Exp. Med. 196: 851-857.
14. + regulatory T cells by peripheral expansion. J. Immunol. 173: 7259-7268.
15. Leonard, W. J. 2003. Type I cytokines and interferons and their receptors. In Fundamental Immunology, 5 Ed. W. E. Paul, ed. Lippincott Williams & Wilkins, Philadelphia, pp. 706-708.
16. Lin, J. X., and W. J. Leonard. 2000. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19: 2566-2576.
17. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180: 25-34.
18. Higgins, A. D., M. A. Mihalyo, P. W. McGary, and A. J. Adler. 2002. CD4 cell priming and tolerization are differentially programmed by APCs upon initial engagement. J. Immunol. 168: 5573-5581.
19. Krutzik, P. O., M. R. Clutter, and G. P. Nolan. 2005. Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry. J. Immunol. 175: 2357-2365.
20. Maxwell, J. R., R. J. Rossi, S. J. McSorley, and A. T. Vella. 2004. T cell clonal conditioning: a phase occurring early after antigen presentation but before clonal expansion is impacted by Toll-like receptor stimulation. J. Immunol. 172: 248-259.
21. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
22. Thornton, A. M., and E. M. Shevach. 1998. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
23. + regulatory T cells. Nat. Immunol. 4: 330-336.
24. Utermohlen, O., A. Tarnok, L. Bonig, and F. Lehmann-Grube. 1994. T lymphocyte-mediated antiviral immune responses in mice are diminished by treatment with monoclonal antibody directed against the interleukin-2 receptor. Eur. J. Immunol. 24: 3093-3099.
25. Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353: 858-861.
26. + T cell responses. J. Exp. Med. 198: 889-901.
27. Zhou, G., C. G. Drake, and H. I. Levitsky. 2006. Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood 107: 628-636.