메뉴 건너뛰기




Volumn 298, Issue 5, 2010, Pages

Ghrelin and PYY in the regulation of energy balance and metabolism: Lessons from mouse mutants

Author keywords

Ghrelin O acetyltransferase; Neuropeptide Y; Peptide YY

Indexed keywords

GHRELIN; GHRELIN RECEPTOR;

EID: 77950854036     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00191.2009     Document Type: Review
Times cited : (48)

References (134)
  • 1
    • 18144381593 scopus 로고    scopus 로고
    • The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JR, Ghatei MA, Bloom SR. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 1044: 127-131, 2005.
    • (2005) Brain Res , vol.1044 , pp. 127-131
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3    Sajedi, A.4    Smith, K.L.5    Parkinson, J.R.6    Ghatei, M.A.7    Bloom, S.R.8
  • 3
    • 9244224088 scopus 로고    scopus 로고
    • Effects of peptide YY[3-36] on short-term food intake in mice are not affected by prevailing plasma ghrelin levels
    • Adams SH, Won WB, Schonhoff SE, Leiter AB, Paterniti JR Jr. Effects of peptide YY[3-36] on short-term food intake in mice are not affected by prevailing plasma ghrelin levels. Endocrinology 145: 4967-4975, 2004.
    • (2004) Endocrinology , vol.145 , pp. 4967-4975
    • Adams, S.H.1    Won, W.B.2    Schonhoff, S.E.3    Leiter, A.B.4    Paterniti Jr., J.R.5
  • 4
  • 5
    • 0036083399 scopus 로고    scopus 로고
    • Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats
    • DOI 10.1046/j.1365-2826.2002.00811.x
    • Adeghate E, Ponery AS. Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats. J Neuroendocrinol 14: 555-560, 2002. (Pubitemid 34679218)
    • (2002) Journal of Neuroendocrinology , vol.14 , Issue.7 , pp. 555-560
    • Adeghate, E.1    Ponery, A.S.2
  • 8
    • 0031006827 scopus 로고    scopus 로고
    • Neuropeptide Y family of hormones: Receptor subtypes and antagonists
    • Balasubramaniam AA. Neuropeptide Y family of hormones: receptor subtypes and antagonists. Peptides 18: 445-457, 1997.
    • (1997) Peptides , vol.18 , pp. 445-457
    • Balasubramaniam, A.A.1
  • 10
    • 0038727630 scopus 로고    scopus 로고
    • The gut hormone peptide YY regulates appetite
    • Batterham RL, Bloom SR. The gut hormone peptide YY regulates appetite. Ann NY Acad Sci 994: 162-168, 2003.
    • (2003) Ann NY Acad Sci , vol.994 , pp. 162-168
    • Batterham, R.L.1    Bloom, S.R.2
  • 18
    • 0024339140 scopus 로고
    • Peptide YY: Intrapancreatic localization and effects on insulin and glucagon secretion in the mouse
    • Bottcher G, Ahren B, Lundquist I, Sundler F. Peptide YY: intrapancreatic localization and effects on insulin and glucagon secretion in the mouse. Pancreas 4: 282-288, 1989. (Pubitemid 19140827)
    • (1989) Pancreas , vol.4 , Issue.3 , pp. 282-288
    • Bottcher, G.1    Ahren, B.2    Lundquist, I.3    Sundler, F.4
  • 20
    • 0035089197 scopus 로고    scopus 로고
    • Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
    • Burcelin R, Brunner H, Seydoux J, Thorensa B, Pedrazzini T. Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice. Peptides 22: 421-427, 2001.
    • (2001) Peptides , vol.22 , pp. 421-427
    • Burcelin, R.1    Brunner, H.2    Seydoux, J.3    Thorensa, B.4    Pedrazzini, T.5
  • 23
    • 0042626304 scopus 로고    scopus 로고
    • Effects of ghrelin and other neuropeptides (CART, MCH, orexin a and B, and GLP-1) on the release of insulin from isolated rat islets
    • Colombo M, Gregersen S, Xiao J, Hermansen K. Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets. Pancreas 27: 161-166, 2003.
    • (2003) Pancreas , vol.27 , pp. 161-166
    • Colombo, M.1    Gregersen, S.2    Xiao, J.3    Hermansen, K.4
  • 24
    • 27744451411 scopus 로고    scopus 로고
    • Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors
    • Costa T, Cotecchia S. Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors. Trends Pharmacol Sci 26: 618-624, 2005.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 618-624
    • Costa, T.1    Cotecchia, S.2
  • 26
    • 33846032275 scopus 로고    scopus 로고
    • Gastrointestinal regulation of food intake
    • Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 117: 13-23, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 13-23
    • Cummings, D.E.1    Overduin, J.2
  • 27
  • 28
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141: 4255-4261, 2000.
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 33
    • 9444264700 scopus 로고    scopus 로고
    • Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: Implication in the glycemic control in rodents
    • Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes 53: 3142-3151, 2004.
    • (2004) Diabetes , vol.53 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3    Hashiguchi, S.4    Watanabe, M.5    Kangawa, K.6    Yada, T.7
  • 36
    • 29344464362 scopus 로고    scopus 로고
    • Effects of a fixed meal pattern on ghrelin secretion: Evidence for a learned response independent of nutrient status
    • Drazen DL, Vahl TP, D'Alessio DA, Seeley RJ, Woods SC. Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. Endocrinology 147: 23-30, 2006.
    • (2006) Endocrinology , vol.147 , pp. 23-30
    • Drazen, D.L.1    Vahl, T.P.2    D'Alessio, D.A.3    Seeley, R.J.4    Woods, S.C.5
  • 37
    • 67349147951 scopus 로고    scopus 로고
    • Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- And gender-dependent manner
    • Edelsbrunner ME, Herzog H, Holzer P. Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- and gender-dependent manner. Behav Brain Res 203: 97-107, 2009.
    • (2009) Behav Brain Res , vol.203 , pp. 97-107
    • Edelsbrunner, M.E.1    Herzog, H.2    Holzer, P.3
  • 38
    • 70350705834 scopus 로고    scopus 로고
    • Evidence from knockout mice for distinct implications of neuropeptide-Y Y2 and Y4 receptors in the circadian control of locomotion, exploration, water and food intake
    • Edelsbrunner ME, Painsipp E, Herzog H, Holzer P. Evidence from knockout mice for distinct implications of neuropeptide-Y Y2 and Y4 receptors in the circadian control of locomotion, exploration, water and food intake. Neuropeptides 43: 491-497, 2009.
    • (2009) Neuropeptides , vol.43 , pp. 491-497
    • Edelsbrunner, M.E.1    Painsipp, E.2    Herzog, H.3    Holzer, P.4
  • 39
    • 0036161876 scopus 로고    scopus 로고
    • Distribution of pancreatic polypeptide and peptide YY
    • Ekblad E, Sundler F. Distribution of pancreatic polypeptide and peptide YY. Peptides 23: 251-261, 2002.
    • (2002) Peptides , vol.23 , pp. 251-261
    • Ekblad, E.1    Sundler, F.2
  • 40
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381: 415-421, 1996.
    • (1996) Nature , vol.381 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 41
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274: 1704-1707, 1996.
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 42
    • 74749103533 scopus 로고    scopus 로고
    • Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach
    • Gahete MD, Cordoba-Chacon J, Salvatori R, Castano JP, Kineman RD, Luque RM. Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach. Mol Cell Endocrinol 317: 154-160, 2009.
    • (2009) Mol Cell Endocrinol , vol.317 , pp. 154-160
    • Gahete, M.D.1    Cordoba-Chacon, J.2    Salvatori, R.3    Castano, J.P.4    Kineman, R.D.5    Luque, R.M.6
  • 44
    • 57749084282 scopus 로고    scopus 로고
    • Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa
    • Gonzalez CR, Vazquez MJ, Lopez M, Dieguez C. Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa. J Mol Endocrinol 41: 415-421, 2008.
    • (2008) J Mol Endocrinol , vol.41 , pp. 415-421
    • Gonzalez, C.R.1    Vazquez, M.J.2    Lopez, M.3    Dieguez, C.4
  • 45
    • 0028173653 scopus 로고
    • Two molecular forms of peptide YY (PYY) are abundant in human blood: Characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36
    • Grandt D, Schimiczek M, Beglinger C, Layer P, Goebell H, Eysselein VE, Reeve JR Jr. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36. Regul Pept 51: 151-159, 1994.
    • (1994) Regul Pept , vol.51 , pp. 151-159
    • Grandt, D.1    Schimiczek, M.2    Beglinger, C.3    Layer, P.4    Goebell, H.5    Eysselein, V.E.6    Reeve Jr., J.R.7
  • 51
    • 2542444495 scopus 로고    scopus 로고
    • Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism
    • Halatchev IG, Ellacott KL, Fan W, Cone RD. Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology 145: 2585-2590, 2004.
    • (2004) Endocrinology , vol.145 , pp. 2585-2590
    • Halatchev, I.G.1    Ellacott, K.L.2    Fan, W.3    Cone, R.D.4
  • 53
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist
    • Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW. High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist. Mol Endocrinol 17: 2201-2210, 2003.
    • (2003) Mol Endocrinol , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 54
    • 33644658516 scopus 로고    scopus 로고
    • Ghrelin receptor mutations-too little height and too much hunger
    • Holst B, Schwartz TW. Ghrelin receptor mutations-too little height and too much hunger. J Clin Invest 116: 637-641, 2006.
    • (2006) J Clin Invest , vol.116 , pp. 637-641
    • Holst, B.1    Schwartz, T.W.2
  • 59
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660, 1999. (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 62
    • 0041859272 scopus 로고    scopus 로고
    • To eat or not to eat - How the gut talks to the brain
    • DOI 10.1056/NEJMp038114
    • Korner J, Leibel RL. To eat or not to eat-how the gut talks to the brain. N Engl J Med 349: 926-928, 2003. (Pubitemid 37064764)
    • (2003) New England Journal of Medicine , vol.349 , Issue.10 , pp. 926-928
    • Korner, J.1    Leibel, R.L.2
  • 64
    • 0029867643 scopus 로고    scopus 로고
    • Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide
    • DOI 10.1016/0167-0115(95)00169-7
    • Larhammar D. Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide. Regul Pept 62: 1-11, 1996. (Pubitemid 26146193)
    • (1996) Regulatory Peptides , vol.62 , Issue.1 , pp. 1-11
    • Larhammar, D.1
  • 68
  • 69
    • 33646129214 scopus 로고    scopus 로고
    • Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain
    • Lin S, Boey D, Lee N, Schwarzer C, Sainsbury A, Herzog H. Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain. Neuropeptides 40: 115-123, 2006.
    • (2006) Neuropeptides , vol.40 , pp. 115-123
    • Lin, S.1    Boey, D.2    Lee, N.3    Schwarzer, C.4    Sainsbury, A.5    Herzog, H.6
  • 71
    • 0024376346 scopus 로고
    • Neuropeptide Y receptor binding sites in rat brain: Differential autoradiographic localizations with 125I-peptide YY and 125I-neuropeptide Y imply receptor heterogeneity
    • Lynch DR, Walker MW, Miller RJ, Snyder SH. Neuropeptide Y receptor binding sites in rat brain: differential autoradiographic localizations with 125I-peptide YY and 125I-neuropeptide Y imply receptor heterogeneity. J Neurosci 9: 2607-2619, 1989.
    • (1989) J Neurosci , vol.9 , pp. 2607-2619
    • Lynch, D.R.1    Walker, M.W.2    Miller, R.J.3    Snyder, S.H.4
  • 72
    • 0031779336 scopus 로고    scopus 로고
    • Role of the Y5 neuropeptide Y receptor in feeding and obesity
    • Marsh DJ, Hollopeter G, Kafer KE, Palmiter RD. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med 4: 718-721, 1998.
    • (1998) Nat Med , vol.4 , pp. 718-721
    • Marsh, D.J.1    Hollopeter, G.2    Kafer, K.E.3    Palmiter, R.D.4
  • 74
    • 11144310116 scopus 로고    scopus 로고
    • Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus
    • DOI 10.1016/j.regpep.2004.08.038, PII S0167011504002964
    • Mondal MS, Date Y, Yamaguchi H, Toshinai K, Tsuruta T, Kangawa K, Nakazato M. Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul Pept 126: 55-59, 2005. (Pubitemid 40037743)
    • (2005) Regulatory Peptides , vol.126 , Issue.1-2 SPEC. ISS , pp. 55-59
    • Mondal, M.S.1    Date, Y.2    Yamaguchi, H.3    Toshinai, K.4    Tsuruta, T.5    Kangawa, K.6    Nakazato, M.7
  • 76
    • 33646769934 scopus 로고    scopus 로고
    • Direct stimulation of ghrelin secretion by sympathetic nerves
    • Mundinger TO, Cummings DE, Taborsky GJ Jr. Direct stimulation of ghrelin secretion by sympathetic nerves. Endocrinology 147: 2893-2901, 2006.
    • (2006) Endocrinology , vol.147 , pp. 2893-2901
    • Mundinger, T.O.1    Cummings, D.E.2    Taborsky Jr., G.J.3
  • 82
    • 0035996844 scopus 로고    scopus 로고
    • Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation
    • Naveilhan P, Svensson L, Nystrom S, Ekstrand AJ, Ernfors P. Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation. Peptides 23: 1087-1091, 2002.
    • (2002) Peptides , vol.23 , pp. 1087-1091
    • Naveilhan, P.1    Svensson, L.2    Nystrom, S.3    Ekstrand, A.J.4    Ernfors, P.5
  • 83
    • 0028108628 scopus 로고
    • Mechanisms underlying the insulinostatic effect of peptide YY in mouse pancreatic islets
    • Nieuwenhuizen AG, Karlsson S, Fridolf T, Ahren B. Mechanisms underlying the insulinostatic effect of peptide YY in mouse pancreatic islets. Diabetologia 37: 871-878, 1994.
    • (1994) Diabetologia , vol.37 , pp. 871-878
    • Nieuwenhuizen, A.G.1    Karlsson, S.2    Fridolf, T.3    Ahren, B.4
  • 86
    • 0036164442 scopus 로고    scopus 로고
    • Multiple regulation of peptide YY secretion in the digestive tract
    • DOI 10.1016/S0196-9781(01)00609-X, PII S019697810100609X
    • Onaga T, Zabielski R, Kato S. Multiple regulation of peptide YY secretion in the digestive tract. Peptides 23: 279-290, 2002. (Pubitemid 34127966)
    • (2002) Peptides , vol.23 , Issue.2 , pp. 279-290
    • Onaga, T.1    Zabielski, R.2    Kato, S.3
  • 89
  • 93
    • 0026756760 scopus 로고
    • Differential expression of mRNAs for neuropeptide Y-related peptides in rat nervous tissues: Possible evolutionary conservation
    • Pieribone VA, Brodin L, Friberg K, Dahlstrand J, Soderberg C, Larhammar D, Hokfelt T. Differential expression of mRNAs for neuropeptide Y-related peptides in rat nervous tissues: possible evolutionary conservation. J Neurosci 12: 3361-3371, 1992.
    • (1992) J Neurosci , vol.12 , pp. 3361-3371
    • Pieribone, V.A.1    Brodin, L.2    Friberg, K.3    Dahlstrand, J.4    Soderberg, C.5    Larhammar, D.6    Hokfelt, T.7
  • 97
    • 0037372044 scopus 로고    scopus 로고
    • Dose-dependent inhibition by ghrelin of insulin secretion in the mouse
    • Reimer MK, Pacini G, Ahren B. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology 144: 916-921, 2003.
    • (2003) Endocrinology , vol.144 , pp. 916-921
    • Reimer, M.K.1    Pacini, G.2    Ahren, B.3
  • 98
    • 15444374354 scopus 로고    scopus 로고
    • Peptide YY: A potential therapy for obesity
    • Renshaw D, Batterham RL. Peptide YY: a potential therapy for obesity. Curr Drug Targets 6: 171-179, 2005.
    • (2005) Curr Drug Targets , vol.6 , pp. 171-179
    • Renshaw, D.1    Batterham, R.L.2
  • 102
    • 0036894201 scopus 로고    scopus 로고
    • Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice
    • Sainsbury A, Schwarzer C, Couzens M, Herzog H. Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice. Diabetes 51: 3420-3427, 2002.
    • (2002) Diabetes , vol.51 , pp. 3420-3427
    • Sainsbury, A.1    Schwarzer, C.2    Couzens, M.3    Herzog, H.4
  • 104
    • 1542270842 scopus 로고    scopus 로고
    • Effects of ghrelin on insulin and glucagon secretion: A study of isolated pancreatic islets and intact mice
    • Salehi A, Dornonville de la Cour C, Hakanson R, Lundquist I. Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice. Regul Pept 118: 143-150, 2004.
    • (2004) Regul Pept , vol.118 , pp. 143-150
    • Salehi, A.1    Dornonville De La Cour, C.2    Hakanson, R.3    Lundquist, I.4
  • 109
    • 34047216695 scopus 로고    scopus 로고
    • Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, and glucose and fat metabolism in obese and lean subjects
    • Sloth B, Holst JJ, Flint A, Gregersen NT, Astrup A. Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, and glucose and fat metabolism in obese and lean subjects. Am J Physiol Endocrinol Metab 292: E1062-E1068, 2007.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Sloth, B.1    Holst, J.J.2    Flint, A.3    Gregersen, N.T.4    Astrup, A.5
  • 110
    • 36549050805 scopus 로고    scopus 로고
    • Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging
    • Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Ann NY Acad Sci 1119: 147-164, 2007.
    • (2007) Ann NY Acad Sci , vol.1119 , pp. 147-164
    • Smith, R.G.1    Sun, Y.2    Jiang, H.3    Albarran-Zeckler, R.4    Timchenko, N.5
  • 111
    • 75049085779 scopus 로고    scopus 로고
    • Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa
    • Stengel A, Goebel M, Wang L, Tache Y, Sachs G, Lambrecht NW. Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa. Biochem Biophys Res Commun 392: 67-71, 2010.
    • Biochem Biophys Res Commun , vol.392 , Issue.67-71 , pp. 2010
    • Stengel, A.1    Goebel, M.2    Wang, L.3    Tache, Y.4    Sachs, G.5    Lambrecht, N.W.6
  • 112
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of Ghrelin Impairs neither Growth nor Appetite
    • DOI 10.1128/MCB.23.22.7973-7981.2003
    • Sun Y, Ahmed S, Smith RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 23: 7973-7981, 2003. (Pubitemid 37377491)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.22 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 113
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3: 379-386, 2006.
    • (2006) Cell Metab , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3    Chan, L.4    Smith, R.G.5
  • 118
    • 0000613769 scopus 로고
    • Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion
    • Tatemoto K. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci USA 79: 2514-2518, 1982.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 2514-2518
    • Tatemoto, K.1
  • 120
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 407: 908-913, 2000.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 122
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25: 426-457, 2004.
    • (2004) Endocr Rev , vol.25 , pp. 426-457
    • Van Der Lely, A.J.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4
  • 131
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132: 387-396, 2008.
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 132
    • 67650904962 scopus 로고    scopus 로고
    • Peptide YY induces intestinal proliferation in peptide YY knockout mice with total enteral nutrition after massive small bowel resection
    • Zhu W, Zhang W, Gong J, Huang Q, Shi Y, Li Q, Li N, Li J. Peptide YY induces intestinal proliferation in peptide YY knockout mice with total enteral nutrition after massive small bowel resection. J Pediatr Gastroenterol Nutr 48: 517-525, 2009.
    • (2009) J Pediatr Gastroenterol Nutr , vol.48 , pp. 517-525
    • Zhu, W.1    Zhang, W.2    Gong, J.3    Huang, Q.4    Shi, Y.5    Li, Q.6    Li, N.7    Li, J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.