Hemodynamic and hormonal effects of human ghrelin in healthy volunteers

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 280, Issue 5 49-5, 2001, Pages

  Nagaya, Noritoshi ^a   Kojima, Masayasu ^a   Uematsu, Masaaki ^b   Yamagishi, Masakazu ^a   Hosoda, Hiroshi ^a   Oya, Hideo ^a   Hayashi, Yujiro ^c   Kangawa, Kenji ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c SUNTORY LTD   (Japan)

Author keywords

Hemodynamics; Hormones; Vasodilation

Indexed keywords

GHRELIN; GROWTH HORMONE RELEASING FACTOR; HORMONE RECEPTOR; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARDIOVASCULAR EFFECT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HEART AFTERLOAD; HEART INDEX; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASODILATATION;

EID: 0035026511     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2001.280.5.r1483     Document Type: Article

References (20)

1. Amato G, Carella C, Fazio S, La Montagna G, Cittadini A, Sabatini D, Marciano-Mone C, Sacca L, and Bellastella A. Body composition, bone metabolism, heart structure and function in growth hormone deficient adults before and after growth hormone replacement therapy at low doses. J Clin Endocrinol Metab 77: 1671-1676, 1993.
2. Bisi G, Podio V, Valetto MR, Broglio F, Bertuccio G, Del Rio G, Arvat E, Boghen MF, Deghenghi R, Muccioli G, Ong H, and Ghigo E. Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans. J Endocrinol Invest 22: 266-272, 1999.
3. Boger RH, Skamira C, Bode-Boger SM, Brabant G, Muhlen A, and Frolich J. Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency: a double-blind, placebo-controlled study. J Clin Invest 98: 2706-2713, 1996.
4. De Marinis L, Mancini A, Valle D, Izzi D, Bianchi A, Gentilella R, Giampietro A, Desenzani P, and Giustina A. Role of food intake in the modulation of hexarelin-induced growth hormone release in normal human subjects. Harm Metab Res 32: 152-156, 2000.
5. Deghenghi R, Cananzi MM, Torsello A, Battisti C, Muller EE, and Locatelli V. GH-releasing activity of hexarelin. A new growth hormone releasing peptide, in infants and adult rats. Life Sci 54: 1321-1328, 1994.
6. Fazio S, Sabatini D, Capaldo B, Vigorito C, Giordano A, Guida R, Pardo F, Biondi B, and Sacca L. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. N Engl J Med 334: 809-814, 1996.
7. Ganz W, Donoso R, Marcus HS, Forrester JS, and Swan HJ. A new technique for measurement of cardiac output by thermodilution in man. Am J Cardiol 27: 392-396, 1971.
8. Ghigo E, Arvat E, Broglio F, Giordano R, Gianotti L, Muccioli G, Papotti M, Graziani A, Bisi G, Deghenghi R, and Camanni F. Endocrine and nonendocrine activities of growth hormone secretagogues in humans. Harm Res 51: 9-15, 1999.
9. Heinrichs C, Colli M, Yanovski JA, Laue L, Gerstl NA, Kramer AD, Uyeda JA, and Baron J. Effects of fasting on the growth plate: systemic and local mechanisms. Endocrinology 138: 5359-5365, 1997.
10. Hosoda H, Kojima M, Matsuo H, and Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 279: 909-913, 2000.
11. Howard AD, Fieghner SD, Cully DF, Arena JP, Liberator PA, and Rosenblum CI. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273: 974-977, 1996.
12. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660, 1999.
13. Locatelli V and Torsello A. Growth hormone secretagogues: focus on the growth hormone releasing peptides. Pharmacol Res 36: 415-423, 1997.
14. Massoud AF, Hindmarsh PC, and Brook CGD. Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study. J Clin Endocrinol Metab 81: 4338-4341, 1996.
15. Petersenn S and Schulte HM. Structure and function of the growth-hormone-releasing hormone receptor. Vitam Harm 59: 35-69, 2000.
16. Smith RG, Cheng K, Schoen WR, Pong SS, Hickey G, and Jacks T. A nonpeptidyl growth hormone secretagogue. Science 260: 1640-1643, 1993.
17. Smith RG, Van der Ploeg LH, Howard AD, Feighner SD, Cheng K, Hickey GJ, Wyvratt MJ Jr, Fisher MH, Nargund RP, and Patchett AA. Peptidomimetic regulation of growth hormone secretion. Endocr Rev 18: 621-645, 1997.
18. Tajima M, Weinberg EO, Bartunek J, Jin H, Yang R, Paoni NF, and Lorell BH. Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure. Circulation 99: 127-134, 1999.
19. Tschop M, Smiley DL, and Heiman ML. Ghrelin induces adiposity in rodents. Nature 407: 908-913, 2000.
20. Volterrani M, Desenzani P, Lorusso R, d'Aloia A, Manelli F, and Giustina A. Hemodynamic effects of intravenous growth hormone in congestive heart failure. Lancet 349: 1067-1068, 1997.