Effects of ghrelin on insulin and glucagon secretion: A study of isolated pancreatic islets and intact mice

Regulatory Peptides

Volumn 118, Issue 3, 2004, Pages 143-150

  Salehi, Albert ^a   De La Cour, Charlotta Dornonville ^a   Håkanson, Rolf ^a   Lundquist, Ingmar ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Ghrelin; Islet hormone secretion

Indexed keywords

ARGININE; CARBACHOL; GHRELIN; ISOBUTYLMETHYLXANTHINE; PHOSPHOLIPASE C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET CELL; PRIORITY JOURNAL;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ARGININE; BLOOD GLUCOSE; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCAGON; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; ISLETS OF LANGERHANS; MICE; PANCREAS; PEPTIDE HORMONES; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 1542270842     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2003.12.001     Document Type: Article

References (35)

1. Breuer R.I., Moses H., Hagen T.C., Zuckerman L. Gastric operations and glucose homeostasis. Gastroenterology. 62:1972;1109-1119.
2. Sudo T., Ishiyama K., Takemoto M., Kawamura M., Umemura H., Shiraha S, et al. Pancreatic endocrine function after total gastrectomy and truncal vagotomy. Am. J. Surg. 144:1982;539-544.
3. Salehi A., Chen D., Håkanson R., Nordin G., Lundquist I. Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice. J. Physiol. 514:1999;579-591.
4. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 402:1999;656-660.
5. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 141:2000;4255-4261.
6. Dornonville de la Cour C., Björkqvist M., Sandvik A.K., Bakke I., Zhao C.M., Chen D, et al. A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control. Regul. Pept. 99:2001;141-150.
7. Rindi G., Necchi V., Savio A., Torsello A., Zoli M., Locatelli V, et al. Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochem. Cell Biol. 117:2002;511-519.
8. Tschop M., Smiley D.L., Heiman M.L. Ghrelin induces adiposity in rodents. Nature. 407:2000;908-913.
9. Toshinai K., Mondal M.S., Nakazato M., Date Y., Murakami N., Kojima M, et al. Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem. Biophys. Res. Commun. 281:2001;1220-1225.
10. Date Y., Nakazato M., Hashiguchi S., Dezaki K., Mondal M.S., Hosoda H, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes. 51:2002;124-129.
11. Lee H.M., Wang G., Englander E.W., Kojima M., Greeley G.H. Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology. 143:2002;185-190.
12. Broglio F., Arvat E., Benso A., Gottero C., Muccioli G., Papotti M, et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J. Clin. Endocrinol. Metab. 86:2001;5083-5086.
13. Egido E.M., Rodriguez-Gallardo J., Silvestre R.A., Marco J. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur J. Endocrinol. 146:2002;241-244.
14. Kvist Reimer M., Pacini G., Ahren B. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology. 144:2003;916-921.
15. Lucidi P., Murdolo G., Di Loreto C., De Cicco A., Parlanti N., Fanelli C, et al. Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia. Diabetes. 51:2002;2911-2914.
16. McCowen K.C., Maykel J.A., Bistrian B.R., Ling P.R. Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents. J. Endocrinol. 175:2002;R7-R11.
17. Saad M.F., Bernaba B., Hwu C.M., Jinagouda S., Fahmi S., Kogosov E, et al. Insulin regulates plasma ghrelin concentration. J. Clin. Endocrinol. Metab. 87:2002;3997-4000.
18. Shiiya T., Nakazato M., Mizuta M., Date Y., Mondal M.S., Tanaka M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J. Clin. Endocrinol. Metab. 87:2002;240-244.
19. Flanagan D.E., Evans M.L., Monsod T.P., Rife F., Heptulla R.A., Tamborlane W.V, et al. The influence of insulin on circulating ghrelin. Am. J. Physiol. Endocrinol. Metab. 284:2003;E313-E316.
20. Caixas A., Bashore C., Nash W., Pi-Sunyer F., Laferrere B. Insulin, unlike food intake, does not suppress ghrelin in human subjects. J. Clin. Endocrinol. Metab. 87:2002;1902.
21. Gotoh M., Maki T., Kiyoizumi T., Satomi S., Monaco A.P. An improved method for isolation of mouse pancreatic islets. Transplantation. 40:1985;437-438.
22. Heding L. A simplified insulin radioimmunoassay method. Donato L., Milhaud G., Sircis J. Labelled Proteins in Tracer Studies. 1966;345-350 Euratom, Brussels.
23. Ahrén B., Lundquist I. Glucagon immunoreactivity in plasma from normal and dystrophic mice. Diabetologia. 22:1982;258-263.
24. Panagiotidis G., Salehi A.A., Westermark P., Lundquist I. Homologous islet amyloid polypeptide: effects on plasma levels of glucagon, insulin and glucose in the mouse. Diabetes Res. Clin. Pract. 18:1992;167-171.
25. Bruss M.L., Black A.L. Enzymatic microdetermination of glycogen. Anal. Biochem. 84:1978;309-312.
26. Lundquist I., Panagiotidis G., Salehi A. Islet acid glucan-1,4-alpha- glucosidase: a putative key enzyme in nutrient-stimulated insulin secretion. Endocrinology. 137:1996;1219-1225.
27. Lundquist I., Panagiotidis G. The relationship of islet amyloglucosidase activity and glucose-induced insulin secretion. Pancreas. 7:1992;352-357.
28. 2+ efflux. Endocrine. 11:1999;99-107.
29. Sundler F., Håkanson R. Gastric endocrine cell typing at the light microscopic level. Håkanson R., Sundler F. The Stomach as an Endocrine Organ. 1991;9-26 Elsevier, Amsterdam.
30. Håkanson R., Chen D., Sundler F. The ECL cells. Johnson L.R. Physiology of the Gastrointestinal Tract. 1994;1171-1184 Raven Press, New York.
31. 2+, cAMP and diacylglycerol. Mol. Cell. Endocrinol. 70:1990;119-137.
32. Svensson J., Lönn L., Jansson J.O., Murphy G., Wyss D., Krupa D, et al. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. J. Clin. Endocrinol. Metab. 83:1998;362-369.
33. Murata M., Okimura Y., Iida K., Matsumoto M., Sowa H., Kaji H, et al. Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J. Biol. Chem. 277:2002;5667-5674.
34. Beck B., Musse N., Stricker-Krongrad A. Ghrelin, macronutrient intake and dietary preferences in Long-Evans rats. Biochem. Biophys. Res. Commun. 292:2002;1031-1035.
35. Murakami N., Hayashida T., Kuroiwa T., Nakahara K., Ida T., Mondal M.S, et al. Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats. J. Endocrinol. 174:2002;283-288.