An update on drug interactions with the herbal medicine Ginkgo biloba

Current Drug Metabolism

Volumn 11, Issue 2, 2010, Pages 171-181

  Abad, María José ^a   Bedoya, Luis Miguel ^a   Bermejo, Paulina ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Ginkgo biloba; Herb drug interactions; Pharmacodynamic; Pharmacokinetic

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CILOSTAZOL; CLOPIDOGREL; CYCLOSPORIN; DICLOFENAC; DILTIAZEM; FEXOFENADINE; GINKGO BILOBA EXTRACT; GINKGOLIDE B; HERBACEOUS AGENT; LOPINAVIR; MEPHENYTOIN; MIDAZOLAM; NICARDIPINE; NIFEDIPINE; OMEPRAZOLE; PROPRANOLOL DERIVATIVE; PROTEINASE INHIBITOR; RITONAVIR; TALINOLOL; TANSHINONE; THEOPHYLLINE; TICLOPIDINE; TOLBUTAMIDE; UNINDEXED DRUG; VALPROIC ACID; WARFARIN; XENOBIOTIC AGENT;

BIOLOGICAL ACTIVITY; DRUG ACTIVITY; DRUG INTERACTION; DRUG MECHANISM; DRUG SAFETY; GINKGO BILOBA; HERBAL MEDICINE; HUMAN; MEDICAL LITERATURE; NONHUMAN; REVIEW; SYSTEMATIC REVIEW;

ANIMALS; DRUG INTERACTIONS; GINKGO BILOBA; HERB-DRUG INTERACTIONS; HUMANS; PHARMACEUTICAL PREPARATIONS; PLANT PREPARATIONS; RISK FACTORS;

EID: 77950842156     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920010791110818     Document Type: Review

References (287)

1. Elvin-Lewis, M. Should be concerned about herbal remedies. J. Ethnopharmacol., 2001, 75(2-3), 141-164.
2. Ernst, E. The efficacy of herbal medicines: an overview. Fund. Clin. Pharmacol., 2005, 19(4), 405-409.
3. Jarema, M. Herbal drug treatment. Neuroendocrinol. Lett., 2008, 29(1), 93-104.
4. Blumenthal, M. Systematic reviews and meta-analyses support the efficacy of numerous popular herbs and phytomedicines. Altern. Ther. Health Med., 2009, 15(2), 14-15.
5. Coxeter, P.D.; McLachlan, A.J.; Duke, C.C.; Roufogalis, B.D. Herb-drug interactions: an evidence based approach. Curr. Med. Chem., 2004, 11(11), 1513-1525. (Pubitemid 38735793)
6. Hu, Z.; Yang, X.; Ho, P.C.; Chan, S.Y.; Heng, P.W.; Chan, E.; Duan, W.; Koh, H.L.; Zhou, S. Herb-drug interactions: a literature review. Drugs, 2005, 65(9), 1239-1282.
7. Williamsom, E.M. Interactions between herbal and conventional medicines. Expert. Opin. Drug Saf., 2005, 4(2), 355-378.
8. Mills, E.; Wu, P.; Johnston, B.C.; Gallicano, K.; Clarke, M.; Guyatt, G. Natural health product-drug interactions: a systematic review of clinical trials. Ther. Drug Monit., 2005, 27(5), 549-557. (Pubitemid 41437629)
9. Chavez, M.L.; Jordan, M.A.; Chavez, P.I. Evidence-based drug-herbal interactions. Life Sci., 2006, 78(18), 2146-2157.
10. Venkataramanan, R.; Komoroski, B.; Strom, S. In vitro and in vivo assessment of herb drug interactions. Life Sci., 2006, 78(18), 2105-2115.
11. Gohil, K.J.; Patel, J.A. Herb-drug interactions: a review and study based on assessment of clinical case reports in literature. Indian J. Pharmacol., 2007, 39(3), 129-139.
12. Zhou, S.F.; Zhou, Z.W.; Li, C.G.; Chen, X.; Yu, X.; Xue, C.C.; Herington, A. Identification of drugs that interact with herbs in drug development. Drug Discov. Today, 2007, 12(15/16), 664-673. (Pubitemid 47238642)
13. Singh, S.R.; Levine, M.A.H. Potential interactions between pharmaceuticals and natural health products in Canada. J. Clin. Pharmacol., 2007, 47(2), 249-258.
14. Bush, T.M.; Rayburn, K.S.; Holloway, S.W.; Sanchez-Yamamoto, D.S.; Aller, B.L.; Lam, T.; So, B.K.; Tran, D.H.; Greyber, E.R.; Kantur, S.; Roth, L.W. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern. Ther. Health Med., 2007, 13(2), 30-35.
15. Skalli, S.; Zaid, A.; Soulaymani, R. Drug interactions with herbal medicines. Ther. Drug Monit., 2007, 29(6), 679-686.
16. Elmer, G.W.; Lafferty, W.E.; Tyree, P.T.; Lind, B.K. Potential interactions between complementary/alternative products and conventional medicines in a medicare population interactions. Ann. Pharmacother., 2007, 41(10), 1617-1624.
17. Tomlinson, B.; Hu, M.; Lee, V.W. In vivo assessment of herb-drug interactions: possible utility of a pharmacogenetic approach?. Mol. Nutr. Food Res., 2008, 52(7), 799-809.
18. Ulbricht, C.; Chao, W.; Costa, D.; Rusie-Seamon, E.; Weissner, W.; Woods, J. Clinical evidence of herb-drug interactions: a systematic review by the Natural Standard Research Collaboration. Curr. Drug Metab., 2008, 9(10), 1063-1120.
19. Izzo, A.A.; Ernst, E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs, 2009, 69(13), 1777-1798.
20. Hofbauer, R.; Frass, M. Ginkgo extract: a review. Herb. Complement. Med., 2002, 3(3), 74-80.
21. Sierpina, V.S.; Wollschlaeger, B.; Blumenthal, M. Ginkgo biloba. Complement. Altern. Med., 2003, 68(5), 923-926.
22. Boonkaew, T.; Camper, N.D. Biological activities of Ginkgo extracts. Phytomedicine, 2005, 12(4), 318-323.
23. Chan, P.C.; Xia, Q.S.; Fu, P.P. Ginkgo biloba leave extract: biological, medicinal and toxicological effects. J. Environ. Sci. Health Carcinog. Ecotoxicol. Rev., 2007, 25(3), 211-244. (Pubitemid 47347114)
24. Singh, B.; Kaur, P.; Gopichand, R.; Singh, R.D.; Ahuja, P.S. Biology and chemistry of Ginkgo biloba. Fitoterapia, 2008, 79(6), 401-418.
25. Mahadevan, S.; Park, Y.. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety and uses. J. Food Sci., 2008, 73(1), R14-R19.
26. Parsons, G. Ginkgo biloba did not prevent dementia or Alzheimer disease in elderly people. Evid. Based Nurs., 2009, 12(2), 56.
27. Perez, C.M. Can Ginkgo biloba combat diseases?. P. R. Health Sci. J., 2009, 28(1), 66-74.
28. Jacobs, B.P.; Browner, W.S. Ginkgo biloba: a living fossil. Am. J. Med., 2000, 108(4), 341-342.
29. Zhou, Z.; Zheng, S. Palaebiology: the missing link in Ginkgo evolution. Nature, 2003, 423(3), 821-822.
30. Di Renzo, G. Ginkgo biloba and the central nervous system. Fitoterapia, 2000, 71(1), S43-S47. (Pubitemid 30621694)
31. Diamond, B.J.; Shiflett, S.C.; Feiwel, N.; Matheis, R.J.; Noskin, O.; Richards, J.A.; Schoenberger, N.E. Ginkgo biloba extract: mechanism and clinical indications. Arch. Phys. Med. Rehabil., 2000, 81(5), 668-678. (Pubitemid 30257692)
32. Luo, Y. Ginkgo biloba neuroprotection: therapeutic implications in Alzheimer's disease. J. Alzheimer Dis., 2001, 3(3), 401-407. (Pubitemid 32843058)
33. Madennan, K.M.; Darlington, C.L.; Smith, P.E. The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog. Neurobiol., 2002, 67(3), 235-257. (Pubitemid 34880132)
34. Boles-Ponto, L.L.; Schultz, S.K. Ginkgo biloba extract: review of CNS effects. Ann. Clin. Psychiatry, 2003, 15(2), 109-119. (Pubitemid 38101802)
35. Ahlemeyer, B.; Krieglstein, J. Neuroprotective effect of Ginkgo biloba extract. Cell. Mol. Life Sci., 2003, 60(9), 1779-1792. (Pubitemid 37222578)
36. Smith, J.V.; Luo, Y. Studies on molecular mechanism of Ginkgo biloba extract. Appl. Microbiol. Biotechnol., 2004, 64(3), 465-472. (Pubitemid 38686154)
37. Dubey, A.K.; Shankar, P.R.; Upadhyaya, D.; Deshpande, V.Y. Ginkgo biloba: an appraisal. Kathmandu Univ. Med., 2004, 2(3), 225-229.
38. Christen, Y. Ginkgo biloba and neurodegenerative disorders. Front. Biosci., 2004, 9(1), 3091-3104.
39. Cass, H.; Herbs for the nervous system: Ginkgo, Kava, Valerian, Passion Flower. Semin. Integr. Med., 2004, 2(2), 82-88.
40. Zhu, S.F.; Yin, Y.C. Protective effects of Ginkgo biloba extract on brain tissue and activity of brain neural cells. Zhongguo Linchuang Kangfu, 2006, 10(23), 146-148. (Pubitemid 44236864)
41. Wang, J.; Li, H.T. Therapeutical effect of Ginkgo leaf extract on senile diseases. Zhongguo Linchuang Kangfu, 2006, 10(31), 181-184.
42. Baltasi, C. The benefits of Ginkgo biloba. J. Am. Diet. Assoc., 2007, 107(3), 432-433.
43. Mak, Y.T.; Wai, M.S.M.; Yew, D.T. The neuroprotective effect of Ginkgo biloba leaf extract and its possible mechanism. Cent. Nerv. Syst. Agent Med. Chem., 2007, 7(4), 230-235.
44. Ramassamy, C.; Longpre, F.; Christen, Y. Ginkgo biloba extract (EGb761) in Alzheimer's disease: is there any evidence. Curr. Alzheimer Res., 2007, 4(3), 253-262. (Pubitemid 47025423)
45. Canter, P.H.; Ernst, E. Ginkgo biloba is not a smart drug: an updated systematic trials testing the nootropic effects of G. biloba extracts in healthy people. Hum. Psycopharmacol., 2007, 22(5), 265-278. (Pubitemid 47180388)
46. Birks, J.; Grimley-Evans, J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst. Rev., 2009, 21(1), CD003120.
47. Hoerr, R. Ginkgo biloba does not reduce incidence of dementia in elderly people. Evid. Based Ment. Health, 2009, 12(3), 85.
48. Zhang, Z.J.; Tong, Y.; Zou, J.; Chen, P.J.; Yu, D.H. Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers. Chin. J. Integr. Med., 2009, 15(3), 177-183.
49. Kaschel, R. Ginkgo biloba: specificity of neuropsychological improvement, a selective review in search of different effects. Hum. Psycopharmacol., 2009, 24(5), 345-370.
50. Kasper, S.; Schubert, H. Ginkgo biloba extract EGb761 in the treatment of dementia: evidence of efficacy and tolerability. Fortschr. Neurol. Psychiatr., 2009, 77(9), 494-506.
51. Gertz, H.J.; Kiefer, M. Review about Ginkgo biloba special extract (EGb 761) (Ginkgo). Curr. Pharm. Design., 2004, 10(3), 261-264.
52. Stromgaard, K.; Nakanishi, K. Chemistry and biology of terpene trilactones from Ginkgo biloba. Angew. Chem. Int. Ed. Engl., 2004, 43(13), 1640-1658.
53. Nakanishi, K. Terpene trilactones from Ginkgo biloba: from ancient times to the 21st century. Bioorg. Med. Chem., 2005, 13(17), 4987-5000.
54. Van Beek, T.A.; Montoro, P. Chemical analysis and quality control of Ginkgo biloba leaves, extracts and phytopharmaceuticals. J. Chromatogr. A, 2009, 1216(11), 2002-2032.
55. De Feudis, F.V.; Drieu, K. "Stress-alleviating " and "vigilance-enhancing" actions of Ginkgo biloba extract (EGb761). Drug Develop. Res., 2004, 62(1), 1-25.
56. Hoffman, J.R.; Donato, A.; Robbins, S.J. Ginkgo biloba promotes short-term retention of spatial memory in rats. Pharmacol. Biochem., 2004, 77(3), 533-539.
57. Ahmad, M.; Saleem, S.; Ahmad, A.S.; Yousuf, S.; Ansari, M.A.; Khan, M.B.; Ishrat, T.; Chaturvedi, R.K.; Agrawal, A.K.; Islam, F. Ginkgo biloba afford dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioral, neurochemical and immunohistochemical evidence. J. Neurochem., 2005, 93(1), 94-104.
58. Wang, G.X.; Cao, F.L.; Chen, J. Progress in researches on the pharmaceutical mechanism and clinical application of Ginkgo biloba extract on various kinds of diseases. Chin. J. Integr. Med., 2006, 12(3), 234-239.
59. Lin, J.; Wei, L.; Xi, L.; Shu, L.Y. Effect of Ginkgo biloba leaf extract on the learning and memory and expression of glial fibrillary acidic protein in hippocampal astrocytes of type 2 diabetic rats. Zhongguo Linchuang Kangfo, 2006, 10(23), 176-179.
60. Xiao, Z.Y.; Sun, C.K.; Xiao, X.W.; Lin, Y.Z.; Fong, Y.Y.; Ma, H.; Song, G.R.; Cheng, R. Protective effect of Ginkgo biloba extract on cerebral ischemia and the responses of CD11b-immunoreactivity positive cells. Zhongguo Linchuang Kangfu, 2006, 10(43), 55-57.
61. Huang, X.; Whitworth, C.A.; Rybak, L.P. Ginkgo biloba extract (EGb761) protects against cisplatin-induced ototoxicity in rats. Otol. Neurotol., 2007, 28(6), 828-833.
62. Nooshinfar, E.; Lashgari, R.; Haghparast, A.; Sajjadi, S. NMDA receptors are involved in Ginkgo extract-induced facilitation on memory retention and passive avoidance learning in rats. Neurosci. Lett., 2008, 432(3), 206-211.
63. Zhang, X.; Liang, B.; Liang, Z.; Lin, J. Effect of Ginkgo biloba extract on learning, memory and hippocampal amyloid precursor protein mRNA expressions in diabetic rats. Neur. Reg. Res., 2008, 3(1), 29-32.
64. Satvat, E.; Mallet, P.E. Chronic administration of a Ginkgo biloba leaf extract facilitates acquisition but not performance of a working memory task. Psychopharmacology, 2009, 202(1-3), 173-183.
65. Walesiuk, A.; Braszko, J.J. Preventive action of Ginkgo biloba in stress- and corticosterone-induced impairment of spatial memory in rats. Phytomedicine, 2009, 16(1), 40-46.
66. Emir, H.; Kaptan, Z.K.; Samim, E.; Sungu, N.; Leglan, K.; Ustun, H. The preventive effect of Ginkgo biloba extract in myringosclerosis: study in rats. Otolaryngol. Head Neck Surg., 2009, 140(2), 171-176.
67. Yang, Y.L.; Hsieh, C.W.; Wo, Y.Y.P.; Yang, Y.C.; Lu, K.T. Intra-amygdaloid infusion of Ginkgo biloba leaf extract (EGb761) facilitates fear-potentiated startle in rats. Psycopharmacology, 2009, 202(1-3), 187-196.
68. Blecharz-Klin, K.; Piechal, A.; Joniec, I.; Pyrzanowska, J.; Widy-Tyskiewicz, E. Pharmacological and biochemical effects of Ginkgo biloba extract on learning, memory consolidation and motor activity in old rats. Acta Neurobiol. Exp., 2009, 69(2), 217-231.
69. Kim, Y.S.; Park, H.J.; Kim, T.K.; Moon, D.E.; Lee, H.J. The effect of Ginkgo biloba extract EGb761 on mechanical and cold allodynia in a rat model of neuropathic pain. Anesth. Analg., 2009, 108(6), 1958-1963.
70. Oliveira, D.R.; Sanada, P.F.; Saragossa Filho, A.C.; Inocenti, L.R.; Oler, G.; Cerutti, J.M.; Cerutti, S.M. Neuromodulatory property of standardized extract Ginkgo biloba (EGb761) on memory: behavioral and molecular evidence. Brain Res., 2009, 1269(7), 68-89.
71. Bäurle, P.; Suter, A.; Wormstall, H. Safety and effectiveness of a traditional Ginkgo fresh plant extract: results from a clinical trial. Forsch. Komplementmed., 2009, 16(3), 156-161.
72. Fontana, L.; Souza, A.S.; Del Bel, E.A.; Oliveira, R.M. Ginkgo biloba leaf extract (EGb761) enhances catalepsy induced by haloperidol and L-nitroarginine in mice. Braz. J. Med. Biol. Res., 2005, 38(11), 1649-1654.
73. Welt, K.; Weiss, J.; Martin, R.; Hermsdorf, T.; Drews, S.; Fitzl, G. Ginkgo biloba extract protect rat kidney from diabetic and hypoxic damage. Phytomedicine, 2007, 14(2-3), 196-203.
74. Zhou, Y.H.; Yu, J.P. Effects of Ginkgo biloba extract on the antioxidation in rats with TNBS-induced colitis. World Chin. J. Digestol., 2007, 15(15), 1701-1705.
75. Yang, X.; Li, Q.; Yang, R. Rivalry mechanism of Ginkgo in rat brain edema after intracerebral hemorrhage. J. Xi'An Jiatong University (Medical Sciences), 2007, 28(3), 297-299.
76. Boveris, A.D.; Galleano, M.; Puntarulo, S. In vivo supplementation with Ginkgo biloba protects.membranes against lipid peroxidation. Phytother. Res., 2007, 21(8), 735-740.
77. Mu, L.L.; Kuo, J.P.; Zhu, D.N.; Yu, B.Y. Antioxidant activities of the chemical constituents isolated from the leaves of Ginkgo biloba. Chin. J. Nat. Med., 2008, 6(1), 26-29.
78. Astolfi, L.; Simone, E.; Ciorba, A.; Martín, A. In vitro protective effects of Ginkgo biloba against cisplatin toxicity in mouse cell line OCK3. Audiolol. Med., 2008, 6(4), 251-258.
79. Wang, W.; Zhong, X.H.; Ma, A.; Shi, W.; Zhang, X.S.; Liu, Y. Effects of Ginkgo biloba on testicle injury induced by diethylstilbestrol in mice. Am. J. Chin. Med., 2008, 36(6), 1135-1144.
80. Ahmed, H.H.; Abdel-Rahman, M.; Ali, R.S.; Abdel-Moniem, A.E. Protective effect of Ginkgo biloba extract and pumpkin seed oil against neurotoxicity of rotenone in adult male rats. J. Appl. Sci. Res., 2009, 5(6), 622-635.
81. Feng, X.; Zhang, L.; Zhu, H. Comparative anticancer and antioxidants activities of different ingredients of Ginkgo biloba extract (EGb761). Planta Med., 2009, 75(8), 792-796.
82. Pinto Mda, S.; Kwon, Y.I.; Apostolidis, E.; Lajolo, F.M.; Genovese, M.I.; Shetty, K. Potential of Ginkgo biloba L. leaves in the management of hyperglycemia and hypertension using in vitro models. Bioresour. Technol., 2009, 100(24), 6599-6609.
83. Kaptan, Z.K.; Emir, H.; Gosmen, H.; Uzunkulaoglu, H.; Karakas, A.; Senes, M.; Samim, E. Ginkgo biloba, a free oxygen radical scavenger, affects inflammatory mediators to dimish the occurrence of experimental myringosclerosis. Acta Oto-Laryngol., 2009, 129(8), 826-831.
84. Posadas, F.A.; Chavez, R.M.; Rodriguez, M.L.; Jaramillo, F.; Martinez, M.C.; Olmos, C.E.; Reyes, M.A. Analysis of the therapeutic effects of Ginkgo biloba on liver damage produced by carbon tetrachloride in adult male rats. Toxicol. Lett., 2009, 189(1), S127.
85. Yang, S.J.; Xiu, J.Q.; Chen, Q.; Zhang, Y.J.; Li, C.; Ren, S.P. Protective effects of Ginkgo biloba extract on ECU304 cells exposed to high-level glucose. Jilin Daxue Xuebao Yixue Ban, 2009, 35(1), 131-134.
86. Liu, X.P.; Goldring, C.E.; Wang, H.Y.; Copple, I.M.; Kitteringham, N.R.; Park, B.K. Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro. Phytomedicine, 2009, 16(5), 451-455.
87. Shi, C.; Yao, Z.; Xu, J.; Yew, D.T. Effect of Ginkgo extract (EGb761) on oxidative damage under different conditions of serum supply. J. Bioenerg. Biomembr., 2009, 41(1), 61-69.
88. Mozet, C.; Martin, R.; Welt, K.; Filzl, G. Cardioprotective effect of EGb761 on myocardial ultrastructure of young and old rat heart and antioxidant status during acute hypoxia. Aging Clin. Exp. Res., 2009, 21(1), 14-21.
89. Tan, H.B.; He, Q. Protective effect of Ginkgo biloba extract on cardiovascular function. Zhongguo Linchuang Kangfu, 2006, 10(19), 155-157.
90. Yao, P.; Song, F.; Li, K.; Zhou, S.; Liu, S.; Sun, X.; Nussler, A.K.; Liu, L. Ginkgo biloba extract prevents ethanol induced dyslipemia. Am. J. Chinese Med., 2007, 35(4), 643-652.
91. Zhang, L.; Xie, Z.Q.; Song, H.G.; Song, K.; Ye, S.; Gu, X.M.; Zhao, G.P.; Zhang, Q.H. Effect of Ginkgo biloba extract (GBE50) on cholesterol metabolism in cultured cells. Chin. Pharm. Bull., 2008, 24(3), 313-317.
92. Tada, Y.; Kagota, S.; Kubota, Y.; Nejime, N.; Nakamura, K.; Kunitomo, M.; Shinozuka, K. Long-term feeding of Ginkgo biloba extract impairs peripheral circulation and hepatic function in aged spontaneously hypertensive rats. Biol. Pharm. Bull., 2008, 31(1), 68.
93. Ji, L.; Yin, X.X.; Wu, Z.M.; Wang, J.Y.; Lu, Q.; Gao, Y.Y. Ginkgo biloba prevents glucose-induced accumulation of ECM in rat mesangial cells. Phytother. Res., 2009, 23(4), 477-485.
94. Liu, H.J.; Wang, X.L.; Zhang, L.; Qiu, Y.; Li, T.J.; Li, R.; Wu, M.C.; Wei, L.X.; Rui, Y.L. Inhibition of vascular endothelial growth factor expression and foam cell formation by EGb761, a special extract of Ginkgo biloba, in oxidatively modified low-density lipoproteic-induced human THP-1 monocyte cells. Phytomedicine, 2009, 16(2-3), 138-145.
95. Gu, X.; Xie, Z.; Wang, Q.; Lu, G.; Qu, Y.; Zhang, L.; Pan, J.; Zhao, G.; Zhang, Q. Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet. FEBS J., 2009, 276(5), 1450-1458.
96. Yang, S.J.; Ren, S.P.; Chen, Q. Effect of Ginkgo biloba extract on serological indexes of diabetic rats. Zhongguo Shengwuzhipinxue Zszhi., 2009, 22(2), 171-173.
97. Li, R.; Chen, B.; Wu, W.; Bao, L.; Li, J.; Qi, R. Ginkgolide B suppresses intracellular adhesion molecule-1 expression via blocking nuclear factor-κB activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein. J. Pharmacol. Sci., 2009, 110(3), 362-369.
98. Xie, Z.Q.; Liang, G.; Zhang, L.; Wang, Q.; Qu, Y.; Gao, Y.; Lin, L.B.; Ye, S.; Zhang, J.; Wang, H.; Zhao, G.P.; Zhang, Q.H. Molecular mechanisms underlying the cholesterol-lowering effects of Ginkgo biloba extract in hepatocytes: a comparative study with lovastatin. Acta Pharmacol. Sin., 2009, 30(9), 1262-1275.
99. Koch, E. Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine, 2005, 12(1-2), 10-16.
100. Babayigit, A.; Olmez, D.; Karaman, O.; Ozugul, C.; Yilmaz, O.; Kivcak, B.; Erbil, G.; Uzuner, N. Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma. Allergy Asthma Proc., 2009, 30(2), 186-191.
101. Rojas, P.; Montes, S.; Serrano-Garcia, N.; Rojas-Castañeda, J. Effect of EGb761 supplementation on the content of copper in mouse brain in an animal model of Parkinson's disease. Nutrition, 2009, 25(4), 482-485.
102. Nishida, S.; Satoh, H. Comparative vasodilating actions among terpenoids and flavonoids contained in Ginkgo biloba extract. Clin. Chim. Acta, 2004, 339(1-2), 129-133.
103. Satoh, H.; Nishia, S. Electropharmacological actions of Ginkgo biloba extract on vascular smooth and heart muscles. Clin. Chim. Acta, 2004, 342(1-2), 13-22.
104. Yenilmez, A.; Kilic, F.S.; Sirmagul, B.; Isikli, B.; Aral, E.; Oner, S. Preventive effects of Ginkgo biloba extract on ischemia-reperfusion injury in rat bladder. Urol. Int., 2007, 78(2), 169-172.
105. Liu, X.; Wang, J.Y.; Lu, Q.; Dong, B.Z.; Yin, X.X. Inhibitory mechanism of Ginkgo biloba extract, captopril and valsartan on kidney fibrosis of diabetic nephropathy rats and their comparison. Chin. Trad. Herb. Drugs, 2008, 39(4), 560-561.
106. Kotil, K.; Uyar, R.; Bidge, T.; Ton, T.; Kucukhuseyin, C.; Koldas, M.; Atay, F. Investigation of the dose-dependent antivasospasmic effect of Ginkgo biloba extract (EGb761) in experimental subarachnoid hemorrhage. J. Clin. Neurosci., 2008, 15(12), 1382-1386.
107. Cho, J.H.; Song, J.H.; Cho, E.H.; Won, C.K.; Lee, H.J.; Kim, M.O.; Koh, P.O. Ginkgo biloba extract (EGb761) prevents ischemia brain injury by activation of the Akt signalling pathway. Am. J. Chin. Med., 2009, 37(3), 547-555.
108. Ou, H.C.; Lee, W.J.; Lee, I.T.; Chiu, T.H.; Tsai, K.L.; Lin, C.Y.; Sheu, W.H. Ginkgo biloba extract attenuates OXLDL.induced oxidative functional damages in endothelial cells. J. Appl. Physiol., 2009, 106(5), 1674-1685.
109. Schneider, R.; Welt, K.; Aust, W.; Löster, H.; Fitzi, G. Cardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb761. II. Interstitium and microvasculature. Histol. Histopathol., 2009, 24(5), 587-598.
110. Ding, F.; Wang, Y.; Liu, Y.; Yao, W.; Yu, S.; Xu, G. Effects of Ginkgo biloba extract (EGb) on acute myocardial ischemia induced by isoproterenol in rats. Zhongguo Zhong Yao Za Zhi, 2009, 34(7), 900-903.
111. Panda, V.S.; N, S.R. Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Altern. Med. Rev., 2009, 14(2), 161-171.
112. Hao Y.; Sun, Y.; Xu, C.; Jiang, X.; Sun, H.; Wu, Q.; Yan, C.; Gu, S. Improvement of contractile function in isolated cardiomyocites from ischemia-reperfusion rats by ginkgolide B pretreatment. J. Cardiovasc. Pharmacol., 2009, 54(1), 3-9.
113. Sun, B.L.; Hu, D.M.; Yuan, H.; Ye, W.J.; Wang, X.C.; Xia, Z.L.; Zhang, S.M.; Wang, L.X. Extract of Ginkgo biloba promotes the expression of VEGF following subarachnoid hemorrhage in rats. Int. J. Neurosci., 2009, 119(7), 995-1005.
114. Song, X.P.; Chen, Z.W.; Fang, A.N.; Fang, P.F. Experimental study on effect of total flavone of Ginkgo biloba on delaying cell senescence. Zhong Yao Cai, 2009, 32(1), 100-102.
115. Su, S.Y.; Hsieh, C.L.; Wu, S.L.; Cheng, W.Y.; Li, C.C.; Lo, H.Y.; Ho, T.Y.; Hsiang, C.Y. Transcriptomic analysis of EGb761-regulated neuroactive receptor pathway in vivo. J. Ethnopharmacol., 2009, 123(1), 68-73.
116. Sloley, B.D.; Urichuk, L.J.; Morley, P.; Durkin, J.; Shan, J.J.; Pang, P.K.T.; Coutts, R.T. Identification of kaempferol as a monoamine oxidase inhibitor and potential neuroprotection in extracts of Ginkgo biloba leaves. J. Pharm. Pharmacol., 2000, 52(4), 451-459.
117. Ba, X.H.; Liu, Y. Effect of Ginkgo biloba extract and bilobalide on neuronal injury of substantia nigra of rats with Parkinson disease. Zhongguo Linchuang Kangfu, 2006, 10(11), 39-41.
118. Xiao, Z.Y.; Sun, C.K.; Xiao, X.W.; Lin, Y.Z.; Li, S.; Ma, H.; Song, G.R.; Cheng, R. Effect of Ginkgo biloba extract against excitotoxicity induced by NMDA receptors and mechanism thereof. Chin. Med. J., 2006, 86(35), 2479-2484.
119. Kiewert, C.; Kumar, V.; Hildmam, O.; Rueda, M.; Hartmann, J.; Naik, R.S.; Klein, J. Role of GABAergic antagonism in the neuroprotective effects of bilobalide. Brain Res., 2007, 1128(1), 70-78.
120. Szasz, B.K.; Lenkey, N.; Barth, A.M.I.; Mike, A.; Somogyvary, Z.; Farkas, O.; Lendvai, B. Converging effect of Ginkgo biloba extract at the level of transmitter release, NMDA and sodium currents and dendritic spìkes. Planta Med., 2008, 74(10), 1235-1239.
121. Gong, Q.H.; Huang, B.; Xie, X.L.; Liu, Q.; Chen, J.W.; Qin, N.; Ma, H.; Shi, J.S. Improvement of Ginkgo biloba leaf extract on memory deficit induced by bradykinin in rats. Chin. J. Pharmacol. Toxicol., 2008, 22(3), 170-174.
122. Fehske, C.J.; Leoner, K.; Müller, W.E. Ginkgo biloba extract (EGb761®) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacol. Res., 2009, 60(1), 68-73.
123. Yao, Z.X.; Drieu, K.; Papadopoulus, V. The Ginkgo biloba extract EGb761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands. Brain Res., 2001, 889(1-2), 181-190.
124. Colciaghi, F.; Borroni, B.; Zimmermann, M.; Bellone, C.; Longhi, A.; Padovani, A.; Cattabeni, F.; Christen, Y.; Di Luca, M. Amyloid precursor protein metabolism is regulated toward α-secretase pathway by Ginkgo biloba extracts. Neurobiol. Dis., 2004, 16(2), 454-460.
125. Liu, X.N.; Huo, T.T.; Wang, W.Z.; Dong, G.L.; Zhang, H.W.; Chen, D.L. Protective effect of Ginkgo biloba extract on pancreas transplantation in type 2 diabetic rats. Zhongguo Linchuang Kangfu, 2006, 10(27), 175-177.
126. Vitolo, O.; Gong, B.; Cao, Z.; Ishii, H.; Jaracz, S.; Nakanishi, K.; Arancio, O.; Dzyuba, S.V.; Lefort, R.; Shelanski, M. Protection against β-amyloid induced abnormal synaptic function and cell death by ginkgolide. J. Neurobiol. Aging, 2009, 30(2), 257-265.
127. Shi, C.; Zhao, L.; Zhu, B.; Li, Q.; Yew, D.T.; Yao, Z.; Xu, J. Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against β-amyloid peptide-induced toxicity in SH-SY5Y cells. Chem. Biol. Interact., 2009, 181(1), 115-123.
128. Perez, G.G.; Schneider, L.C.L.; Anttow, N.C. Ginkgo biloba (EGb761) extract: effects on the myenteric plexus of the large intestine in Wistar rats. Dig. Dis. Sci., 2009, 54(2), 232-237.
129. Augustin, S.; Rimbach, G.; Augustin, K.; Schliebs, R.; Wollram, S.; Lermak, R. Effects of a short-and long-term treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer's disease. Arch. Biochem. Biophys., 2009, 481(2), 177-182.
130. He, J.; Lin, J.; Li, J.; Zhang, J.H.; Sun, X.M.; Zeng, C.M. Dual effects of Ginkgo biloba leaf extract on human red blood cells. Basic Clin. Pharmacol. Toxicol., 2009, 104(2), 138-144.
131. Zou, W.; Kim, B.O.; Zhou, B.Y.; Liu, Y.; Messing, A.; He, J.J. Protection against human immunodeficiency virus type 1 Tat neurotoxicity by Ginkgo biloba extract EGb761 involving glial fibrillary acidic protein. Am. J. Pathol., 2007, 171(6), 1923-1935.
132. Yan, F.L.; Zheng, Y.; Zhao, F.D. Effects of Ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglucemia. Acta Neuropathol., 2008, 116(5), 529-535.
133. Guan, X.; Yan, F. Influence of Ginkgo biloba extract on β-secretase in rat hippocampal neuronal cultures following chronic hypoxic and hypoglycemic conditions. Neur. Reg. Res., 2008, 3(10), 1065-1069.
134. Xu, Y.; Cui, C.; Pang, C.; Christen, Y.; Luo, Y. Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb761 and its constituents in Abeta-expressing neuroblastoma cells. Eur. J. Neurosci., 2007, 26(10), 2931-2939.
135. Lin, H.; Wang, H.; Chen, D.; Gu, Y. A dose-effect relationship of Ginkgo biloba extract to nerve regeneration in a rat model. Microsurgery, 2007, 27(8), 673-677.
136. Fukuda, I.; Ito, A.; Hirai, G.; Nishimura, S.; Kawasaki, H.; Saitoh, H.; Kimura, K.I.; Sodeoka, M.; Yoshida, M. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem. Biol., 2009, 16(2), 133-140.
137. Wadsworth, T.L.; McDonald, T.L.; Koop, D.R. Effects of Ginkgo biloba extract (EGb761) and quercetin on lipopolysaccharide-induced signalling pathways involved in the release of tumor necrosis factor α. Biochem. Pharmacol., 2001, 62(7), 963-974.
138. Hedayat, I.; Abdel-Salam, O.M.E.; Baivomy, A.R. Effect of Ginkgo biloba extract on carrageenan-induced acute local inflammation in a γ irradiated rats. Pharmazie, 2005, 60(8), 614-619.
139. Lin, Y.P.; Li, C.C.; Hu, Y.; Li, M.R. ; Mao, Y.F. ; Chen, X.F. Effect of extract of Ginkgo biloba on signal pathway of Iκκ/NF-kappa B in asthma rats. Chin. Pharm. J., 2006, 41(9), 671-674.
140. Peng, H.; Li, Y.; Liu, X.J. Ginkgo biloba extract inhibits the expressions of cell adhesion molecules and nuclear factor-kappa B in arterial endothelial cells. J. Clin. Rehabilit. Tissue Eng. Res., 2007, 11(14), 2772-2775.
141. Kisli, E.; Ozdemit, H.; Kosem, M.; Surer, H.; Ciftci, A.; Kanter, M. Effect of Ginkgo biloba extract (EGb761) on the healing of left colonic anastomoses in rats. World J. Surg., 2007, 31(8), 1652-1657.
142. Zhou, Y.H.; He, X.F.; Bai, Y.T.; Gao, H. Effect of Ginkgo biloba extract on tumor necrosis factor-α expression in TNBS-induced colitis in rats. Chin. Pharm. Bull., 2007, 23(12), 1605-1608.
143. Tsao, T.P.; Lai, J.H.; Yang, S.P.; Ho, L.J.; Liou, J.T.; Cheng, C.C.; Cheng, S.M. Suppression of tissue necrosis factor-α or hydrogen peroxide-activated primary human T lymphocytes by Ginkgo biloba extract through down-regulation of activator protein-t signal transduction. Phytomedicine, 2008, 15(3), 170-176.
144. Xu, A.H.; Ren, L.; Zheng, Y.Y.; Chen, H.S. Immunomodulatory effect of Ginkgo biloba exocarp polysaccharides on immunosuppressive mice induced by cyclophosphamide. Chin. J. Pharmacol. Toxicol., 2008, 22(1), 69-72.
145. Kotakadi, V.S.; Jin, Y.; Hofseth, A.B.; Ying, L.; Cui, X.; Volate, S.; Chumanevich, A.; Wood, P.A.; Price, R.L.; McNeal, A.; Singh, V.P.; Singh, N.P.; Nagarkatti, M.; Nagarkatti, P.S.; Matesic, L.E.; Auclair, K.; Wargovich, M.S.; Hofseth, L.J. Ginkgo biloba extract EGb761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. Carcinogenesis, 2008, 29(9), 1799-1806.
146. Jiao, J.; Du, B. Ginkgo biloba leaf extract effects on inducible nitric oxide synthase, Bcl-2 and Bax expression in rat models of spinal cord injury. Neur. Reg. Res., 2008, 3(8), 875-880.
147. Li, G.H.; Lei, X.X.; Yi, Y.M.; Xu, B.L.; Wang, H.; Du, J. Studies on the effect of Ginkgo biloba extracts on NF-κB pathway. Zhong. Yao Cai., 2008, 31(9), 1357-1360.
148. Trivedi, R.; Kumar, A.; Gupta, V.; Kumar, S.; Nagar, G.K.; Romero, J.R.; Dwivedi, A.K.; Chattopadhyay, N. Effects of EGb761 on bone mineral density, bone microstructure and osteoblast function: possible roles of quercetin and kaempferol. Moll. Cell Endocrinol., 2009, 302(1), 86-91.
149. Zhang, J.; Su, H.M.; Bai, L.M.; Xu, H.; Wu, H.X.; Cui, L. Effect of Ginkgo biloba Pingchan Recipe on neuronal nitric oxide synthase mRNA expression in the brain of mouse model of Parkinson disease. Nan Fang Yi Ke Da Xue Bao, 2009, 29(8), 1735-1740.
150. Zhu, Q.X.; Shen, T.; Tu, D.Y.; Ding, R.; Liang, Z.Z.; Zhang, X.J. Protective effects of Ginkgo biloba leaf extracts on trichloroethylene-induced human keratinocyte cytotoxicity and apoptosis. Skin Pharmacol. Physiol., 2005, 18(4), 160-169.
151. Zhang, S.; Jiang, X.L.; Wei, T.T. Suppressive effect of Ginkgo biloba extract on H2O2-induced apoptosis in RAW 264.7 macrophages. Chin. Pharm. J., 2006, 41(10), 750-754.
152. Zhang, C.; Zhu, Y.; Wan, J.; Xu, H.; Shi, H.; Lu, X. Effect of Ginkgo biloba extract on cell proliferation, cytokines and extracellular matrix of hepatic stellate cells. Liver Int., 2006, 26(10), 1283-1290.
153. Song, H.J.; Liu, M.; Wang, D.Q. ; Lei, W.L.; He, H.N.; Yang, Y.M. Effects of extracts from Ginkgo biloba on neurons apoptosis after spinal cord injury in rats. Zhonghua Jizhen Yixue Zazhi, 2007, 16(1), 46-49.
154. Shen, Z.; Li, G.; Wang, J. Effect of Ginkgo biloba on adult human retinal nerve cells. Chin. Ophthalmic. Res., 2007, 25(6), 408-411.
155. Wai, M.S.M.; Rudd, J.A.; Chan, W.Y.; Antonio, G.E.; Yew, D.T. The effects of Ginkgo biloba on the cerebellum of aging SAMP mouse: a TUNEL, bcl-2 and fMRI study. Microsc. Res. Tech., 2007, 70(8), 671-676.
156. Dias, M.C.; Rodrigues, M.A.M.; Reimberg, M.C.H.; Barbisan, L.F. Protective effect of Ginkgo biloba against rat liver carcinogenesis. Chem. Biol. Interact., 2008, 173(1), 32-42.
157. Zhang, Y.; Chen, A.Y.; Li, M.; Chen, C.; Yao, Q. Ginkgo biloba extract kaempferol inhibits cell proliferation and induce apoptosis in pancreatic cancer cells. J. Surg. Res., 2008, 148(1), 17-23.
158. Wang, Y.; Pei, D.S.; Ji, H.X.; Xing, S.H. Protective effect of a standardized Ginkgo extract (ginaton) on renal ischemia/reperfusion injury via suppressing the activation of JNK signal pathway. Phytomedicine, 2008, 15(11), 923-931.
159. Jia, L.Y.; Sun, L.; Fan, D.S.P.; Lam, D.S.C.; Pang, C.P.; Yam, G.M.F. Effect of topical Ginkgo biloba extract on steroid-induced changes in the trabecular meshwork and intraocular pressure. Arch. Ophthalmol., 2008, 126(12), 1700-1706.
160. Yan, J.J.; Peng, H.L.; Wang, Y.F.; Wu, C.X.; Liu, Z.Y. Effects of Ginkgo biloba extract on proliferation and apoptosis of human retinal capillary endothelial cells in high glucose environment. Int. J. Ophthalmol., 2008, 8(12), 2417-2420.
161. Hsu, C.L.; Wu, Y.L.; Tang, G.J.; Lee, T.S.; Kou, Y.R. Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: role of heme oxygenase-1. Pulm. Pharmacol. Ther., 2009, 22(4), 286-296.
162. Hao, Y.R.; Yang, F.; Cao, J.; Ou, C.; Zhang, J.J.; Yang, C.; Duan, X.X.; Li, Y.; Su, J.J. Ginkgo biloba extracts (EGb761) inhibits aflatoxin B1-induced hepatocarcinogenesis in Wistar rats. Zhong. Yao Cai., 2009, 32(1), 92-96.
163. Vilar, J.B.; Leite, K.R.; Chen-Chen, L. Antimutagenicity protection of Ginkgo biloba extract (EGb761) against mitomycin C and cyclophosphamide in mouse bone marrow. Genet. Mol. Res., 2009, 8(1), 328-333.
164. Akgül, T.; Karagüzel, E.; Sürer, H.; Yagmurdur, H.; Ayyildiz, A.; Ustün, H.; Germiyanoglu, C. Ginkgo biloba (EGb761) affects apoptosis and nitric oxide synthases in testicular torsion: an experimental study. Int. Urol. Nephrol., 2009, 41(3), 531-536.
165. Yeh, Y.C.; Liu, T.J.; Wang, L.C.; Lee. H.W.; Ting, C.T.; Lee, W.L.; Hung, C.J.; Wang, K.Y.; Lai, H.C.; Lai, H.C. A standardized extract of Ginkgo biloba suppresses doxorubicin-induced oxidative stress and p53-mediated mitochondrial apoptosis in rat testes. Br. J. Pharmacol., 2009, 156(1), 48-61.
166. Hsuuw, Y.D.; Kuo, T.F.; Lee, K.H.; Liu, Y.C.; Huang, Y.T.; Lai, C.Y.; Chan, W.H. Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells. Ann. N. Y. Acad. Sci., 2009, 1171(2), 501-508.
167. Yeh, K.Y.; Pu, H.F.; Kaphle, K.; Lin, S.F.; Wu, L.; Lin, J.H.; Tsai, Y.F. Ginkgo biloba extract enhances male copulatory behaviour and reduces serum prolactin levels in rats. Horm. Behav., 2008, 53(1), 225-231.
168. Wang, H.; Ng, T.B. Ginkgolobin, a novel antifungal protein from Ginkgo biloba seeds with sequence similarity to embryo-abundant protein. Biochem. Biophys. Res. Common., 2000, 279(2), 407-411.
169. Huang, X.; Xie, W.J.; Gong, Z.Z. Characteristics and antifungal activity of a chitin binding protein from Ginkgo biloba. FEBS Lett., 2000, 478(1-2), 123-126.
170. Choi, J.G.; Jeong, S.I.; Ku, C.S.; Sathishkumar, M.; Lee, J.J.; Mun, S.P.; Kim, S.M. Antibacterial activity of hydroxyalkenyl salycilic acids from sarcotesta of Ginkgo biloba against vancomycin-resistant Enterococcus. Fitoterapia, 2009, 80(1), 18-20.
171. Horsch, S.; Waltheer, C. Ginkgo biloba special extract EGb761 in the treatment of peripheral arterial occlusive disease (PAOD): a review based on randomized, controlled studies. Int. J. Clin. Pharmacol. Ther., 2004, 42(2), 63-72.
172. Zhou, W.; Chai, H.; Lin, P.H.; Lumsden, A.B.; Yao, Q.; Chen, C. Clinical use and molecular mechanism of action of extract of Ginkgo biloba leaves in cardiovascular diseases. Cardiovasc. Drug Rev., 2004, 22(4), 309-319.
173. Johnson, S.K.; Diamond, B.J.; Raush, S.; Kaufman, M.; Shiflett, S.C.; Graves, L. The effect of Ginkgo biloba on functional measures in multiple sclerosis: a pilot randomized controlled trial. J. Sci. Heal., 2006, 2(1), 19-24.
174. Lovera, J.; Bagert, B.; Smoot, K.; Morris, C.D.; Frank, R.; Bogardus, K.; Wild, K.; Oken, B.; Whitham, R.; Bourdette, D. Ginkgo biloba for the improvement of cognitive performance in multiple sclerosis: a randomized, placebo-controlled trial. Multiple Sclerosis, 2007, 13(3), 376-385.
175. Wang, J.; Zhou, S.; Bronks, R.; Graham, J.; Myers, S. Supervised exercise training combined with Ginkgo biloba treatment for patients with peripheral arterial disease. Clin. Rehabil., 2007, 21(7), 579-586.
176. Gardner, C.D.; Zehnder, J.L.; Rigby, A.J.; Nicholus, J.R.; Farquhar, J.W. Effect of Ginkgo biloba (EGb761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular diseases: a randomized clinical trial. Blood Coagul. Fibrinolysis, 2007, 18(8), 787-793.
177. Galduroz, J.C.F.; Antunes, H.K.; Santos, R.F. Gender- and aged-related variation in blood viscosity in normal volunteers: a study of the effects of extract of Allium sativum and Ginkgo biloba. Phytomedicine, 2007, 14(7-8), 447-451.
178. Choi, W.S.; Choi, C.J.; Kim, K.S.; Lee, J.H.; Song, C.H.; Chung, J.H.; Ock, S.M.; Lee, J.B.; Kim, C.M. To compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud's phenomenon in South Korea; Korean Raynaud study (KOARA study). Clin. Rheumatol., 2009, 28(5), 553-559.
179. Leong, E.M.; Semple, S.J.; Angley, M.; Siebert, W.; Petkov, J.; McKimon, R.A. Complementary and alternative medicine and dietary interventions in multiple sclerosis: what is being used in South Australia and why?. Complement. Ther. Med., 2009, 17(4), 216-223.
180. Tang, D.; Zhang, Z.; Gao, Y.; Wei, Y.; Han, L. Protective effect of serum containing Ginkgo biloba extract on glomerulosclerosis in rat mesangial cells. J. Ethnopharmacol., 2009, 124(1), 26-33.
181. Nicolai, S.P.; Kruidenier, L.M.; Bendermacher, B.L.; Prins, M.H.; Tejink, J.A. Ginkgo biloba for intermittent claudication. Cochrane Databases Syst. Rev., 2009, 15(2), CD006888.
182. Moulton, P.L.; Boyko, L.N.; Fitzpatrick, J.L.; Petros, T.V. The effect of Ginkgo biloba on memory in healthy male volunteers. Physiol. Behav., 2001, 13(4), 659-665.
183. Maidment, I. The use of Ginkgo biloba in the treatment of dementia. Psychiatr. Bull., 2001, 25(4), 353-356.
184. Kurz, A.; Van Baelen, B. Ginkgo biloba compared with cholinesterase inhibitors in the treatment of dementia: a review based on meta-analyses by the Cochrane Collaboration. Dement. Geriatr. Cogn Disord., 2004, 18(2), 217-226.
185. Ren, F.; Gong, S.Y. Ginkgo biloba extract for senile dementia. Zhongguo Linchuang Kangfu, 2005, 9(32), 166-168.
186. Dekoski, S.T.; Fitzpatrick, A.; Ives, D.G.; Saxton, J.; Williamson, J.; Lopez, O.L.; Burke, G.; Fried, L.; Kuller, L.H.; Robbins, J.; Tracy, R.; Woolard, N.; Dunn, L.; Kronmal, R.; Nahin, R.; Furberg, C. The Ginkgo evaluation of memory (GEM) study: design and baseline data of a randomised trial of Ginkgo biloba extract in prevention of dementia. Contemp. Clin. Trials, 2006, 27(3), 238-253.
187. Nahin, R.L.; Fitzpatrick, A.L.; Williamson, J.D.; Burke, G.L.; Dekosky, S.T.; Furberg, C. Use of herbal medicines and other dietary supplements in community-dwelling older people: baseline data from the Ginkgo evaluation of memory study. JAGS, 2006, 54(5), 1725-1735.
188. Burns, N.R.; Bryan, J.; Nettelbeck, T. Ginkgo biloba: no robust effect on cognitive abilities or mood in healthy young or older adults. Hum. Psycopharmacol., 2006, 21(1), 27-37.
189. Scripnikov, A.; Khomemko, A.; Napryeyenko, O. Effect of Ginkgo biloba extract EGb761 on neuropsychiatric symptoms of dementia: findings from a randomised controlled trial. Wien. Med. Wochenschr., 2007, 157(13-14), 295-300.
190. Napryeyenko, O.; Borzenko, I. Ginkgo biloba special extract in dementia with neuropsychiatric features: a randomised, placebo-controlled, double-blind clinical trial. Arzneim. Forsch., 2007, 57(1), 4-11.
191. Kennedy, D.O.; Jackson, P.A.; Haskell, C.F.; Scholey, A.B. Modulation of cognitive performance following single doses of 120 mg of Ginkgo biloba extract administered to healthy young volunteers. Hum. Psycopharmacol., 2007, 22(8), 559-566.
192. Napreyeyenko, O.; Sonnik, G.; Tartakovsky, I. Efficacy and tolerability of Ginkgo biloba extract EGb761 by type of dementia: analyses of a randomised controlled trial. J. Neurol. Sci., 2009, 283(1-2), 224-229.
193. Snitz, B.E.; Saxon, J.; Lopez, O.L.; Ives, D.G.; Dunn, L.O.; Rapp, S.R.; Carlson, M.C.; Fitzpatrick, A.L.; Dekosky, S.T. GEM Study Investigators. Identifying mild cognitive impairment at baseline in the Ginkgo evaluation of memory (GEM) study. Aging Ment. Health, 2009, 13(2), 171-182.
194. De Feudis, F.V.; Papadopoulus, V.; Drieu, K. Ginkgo biloba extracts and cancer : a research area in its infancy. Fund. Clin. Pharmacol., 2003, 17(4), 405-417.
195. Schneider, L.S.; Dekosky, S.T.; Farlow, M.R.; Tariot, P.N.; Hoerr, R.; Kieser, M. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. Curr. Alzheimer Res., 2005, 2(5), 541-551.
196. Zeng, X.; Liu, M.; Yang, Y.; Li, Y.; Asplund, K. Ginkgo biloba for acute ischaemic stroke. Cochrane Databases Syst. Rev., 2005, 19(4), CD003691.
197. Vellos, B.; Andriev, S.; Ousset, P.J.; Ouzid, M.; Mathiex-Fortunet, H. The Guidage study : methodological issues : a 5-year double-blind randomized trial of the efficacy of EGb761 for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology, 2006, 67(9), S6-S11.
198. Dardano, A.; Ballardin, M.; Ferdeghini, M.; Lazzeri, E.; Traino, C.; Caraccio, N.; Mariani, G.; Barale, R.; Manzani, F. Brief report: anticlastogenic effect of Ginkgo biloba extract in Grave's disease patients receiving radioiodine therapy. J. Clin. Endocrinol. Metab., 2007, 92(11), 4286-4289.
199. Ye, B.; Aponte, M.; Dai, Y.; Li, L.; Ho, M.C.D.; Vitonis, A.; Edwards, D.; Huang, T.N.; Craner, D.W. Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Cancer Lett., 2007, 251(1), 43-52.
200. Rodriguez, M.; Ringstad, L.; Schafer, P.; Just, S.; Hofer, H.W.; Malmsten, M.; Siegel, G. Reduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb761) in cardiovascular high-risk patients. Atherosclerosis, 2007, 192(2), 438-444.
201. Wu, Y.; Li, S.; Cui, W.; Zu, X.; Du, J.; Wang, F. Ginkgo biloba extract improves coronary blood flow in healthy elderly adults: role of endothelium-dependent vasodilatation. Phytomedicine, 2008, 15(3), 164-169.
202. Yancheva, S.; Ihl, R.; Nikolova, G.; Panayotov, P.; Schlaefke, S.; Hoerr, R.; GINDON Study Group. Ginkgo biloba extract EGb761 (R), donezepil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trial. Aging Mental Health, 2009, 13(2), 183-190.
203. Deng, Y.K.; Wei, F.; An, B.Q. Effect of Ginkgo biloba extract on plasma vascular endothelial growth factor during peri-operative period of cardiac surgery. Zhongguo Zhong Xi Ji Jie He Za Zhi, 2009, 29(1), 40-42.
204. Russo, V.; Stella, A.; Appezzati, L.; Barone, A.; Stagui, E.; Roszkowska, A.; Delle Noci, N. Clinical efficacy of a Ginkgo biloba extract in the topical treatment of allergic conjunctivitis. Eur. J. Ophthalmol., 2009, 19(3), 331-336.
205. Atmaca, M.; Tezcan, E.; Kuloglu, M.; Ustundag, B.; Kirtas, O. The effect of extract of Ginkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophrenia. Psychiatr. Clin. Neurosci., 2005, 59(6), 652-656.
206. Guo, K.F.; Guo, S.; Yan, K.L. Therapeutic effect of Ginkgo leaves tablets combined with paroxetine on the treatment of depression. Zhongguo Linchuang Kangfu, 2006, 10(2), 43-45.
207. Harms, S.L.; Garrard, J.; Schwinghammer, P.; Eberly, L.E.; Chang, Y.; Leppik, I.E. Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorders. Epilepsia, 2006, 47(2), 323-329.
208. Kaschel, R.; Horr, R.; Wesimon, J.; Rychlik, R. Effect of the of Ginkgo biloba extract EGb761 on the cognitive performance in healthy volunteers doing computer work: an open clinical trial in pre-post-design with the control group. J. Pharmakol. Ther., 2007, 16(1), 3-9.
209. Quaranta, L.; Bettelli, S.; Wa, M.G.; Semeraro, F.; Turano, R.; Gandolfo, E. Effect of Ginkgo biloba extract on preeexisting visual field damage in normal tension glaucoma. Ophthalmology, 2003, 110(2), 359-362.
210. Gertsch, J.H.; Basnyat, B.; Johnson, E.W.; Onopa, J. Randomised, double blind, placebo controlled comparison of Ginkgo biloba and acetozolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT). Br. Med. J., 2004, 328(3), 797.
211. D'Andrea, G.; Bussone, G.; Allais, G.; Aquqqia, M.; D'Onofrio, F.; Maqqio, M.; Moschiano, F.; Saracco, M.G.; Terzi, M.G.; Petretta, V.; Benedetto, C. Efficacy of ginkgolide B in the prophylaxis of migraine with aura. Neurol. Sci., 2009, 30(1), 5121-5124.
212. Moeller, C.K.; Kurt, S.; Scheich, H.; Schulze, H. Improvement of auditory discrimination learning by Ginkgo biloba extract EGb761®. Neurosci. Lett., 2009, 463(3), 219-222.
213. Leadbetter, G.; Keyes, L.E.; Maakestad, K.M.; Olson, S.; Tissot van Patot, M.C.; Hackett, P.H. Ginkgo biloba does- and does not-prevent acute mountain sickness. Wilderness Environ. Med., 2009, 20(1), 66-71.
214. Van Patot, M.C.; Keyes, L.E.; Leadbetter, G.; Hackett, P.H. Ginkgo biloba for prevention of acute mountain sickness: does it work?. High Alt. Med. Biol., 2009, 10(1), 33-43.
215. Ritch, R. Potential role of Ginkgo biloba extract in the treatment of glaucoma. Med. Hypotheses, 2000, 54(2), 221-235.
216. Wimpissinger, B.; Berischa, F.; Garhoefer, G.; Polak, K.; Schmeterer, L. Influence of Ginkgo biloba on ocular blood flow. Acta Ophthalmol. Scand., 2007, 85(4), 445-449.
217. Donfrancesco, R.; Ferrante, L. Ginkgo biloba in dyslexia: a pilot study. Phytomedicine, 2007, 14(6), 367-370.
218. Liu, W.; Li, H. Pharmacological functions of Ginkgo biloba extract and its clinical research progress in eye diseases. Int. J. Ophthalmol., 2008, 8(8), 1647-1649.
219. Ozgoli, G.; Selselei, E.A.; Mojab, F.; Majd, H.D. A randomized, placebo-controlled trial of Ginkgo biloba L. in the treatment of premenstrual syndrome. J. Altern. Complement. Med., 2009, 15(8), 845-851.
220. Li, X.S.; Zheng, W.Y.; Lou, S.X.; Lu, X.W.; Ye, S.H. Effect of Ginkgo biloba extract on vascular endothelial function in patients with early stage diabetic nephropathy. Chin. J. Integr. Med., 2009, 15(1), 26-29.
221. Lee, G.S.; Cho, J.H.; Park, C.S.; Jung, S.H.; Lee, D.H.; Jun, B.C.; Song, C.E.; Cho, K.J. The effect of Ginkgo biloba on the expression of intermediate-early antigen (c-fos) in the experimentally induced anosmic mouse. Aur. Nasus Larynx., 2009, 36(3), 287-291.
222. Granger, A.S. Ginkgo biloba precipitating epilectic seizures. Age Ageing, 2001, 30(2), 523-525.
223. Kajiyama, Y.; Fujii, K.; Takeuchi, H.; Manabe, Y. Ginkgo seeds poisoning. Pediatrics, 2002, 109(2), 325-327.
224. Kupiec, T.; Raj, V. Fatal seizures due to the potential herb-drug interactions with Ginkgo biloba. J. Anal. Toxicol., 2005, 29(7), 755-758.
225. Salamon, N.; Gurgui, C.; Leistner, E.; Drewke, C. Influence of antivitamins ginkgotoxin 5'-phosphate and deoxypyridoxine 5'-phosphate on human pyridoxine 5'-phosphate oxidase. Planta Med., 2009, 75(3), 563-567.
226. Dugova, J.J.; Mills, E.; Perri, D.; Koren, G. Safety and efficacy of Ginkgo (Ginkgo biloba) during pregnancy and lactation. Can. J. Clin. Pharmacol., 2006, 13(3), 277-284.
227. De Faria D.E.P.; Borges, L.V.; Peters, V.M.; Reis, J.E.D.P.; Ribeiro, L.C.; Sa, R.D.C.D.S.; Guerra, M.D.O. Postnatal development of pups from nursing rats treated with Ginkgo biloba. Phytother. Res., 2008, 22(2), 185-189.
228. Tirona, R.G.; Bailey, D.G. Herbal product-drug interactions mediated by induction. Br. J. Clin. Pharmacol., 2006, 61(6), 677-681.
229. Pal, D.; Mitra, A.K. MDR-and CYP3A4-mediated drug-herbal interactions. Life Sci., 2006, 78(18), 2131-2145.
230. Yarnell, E.; Abascal, K. Interaction of herbal constituents with cytochrome P450 enzymes. Altern. Complement. Ther., 2007, 13(5), 239-247.
231. Hellum, B.H.; Nilsen, O.G. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transporter by trade herbal products. Basic Clin. Pharmacol. Toxicol., 2008, 102(5), 466-475.
232. Hellum, B.H.; Hu, Z.; Nilsen, O.G. Trade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytes. Basic Clin. Pharmacol. Toxicol., 2009, 105(1), 58-63.
233. Ernst, E. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St.John's Wort, Ginseng, Echinacea, Saw Palmetto and Kava. Ann. Intern. Med., 2002, 136(1), 42-53.
234. Sugiyama, T.; Kubota, Y.; Shinozuka, K.; Yamada, S.; Yamada, K.; Umegaki, K. Induction and recovery of hepatic drug metabolizing enzymes in rats treated with Ginkgo biloba extract. Food Chem. Toxicol., 2004, 42(6), 953-957.
235. Bressler, R. Herb-drug interactions: Interactions between Ginkgo biloba and prescription medications. Geriatrics, 2005, 60(4), 30-33. (Pubitemid 40529448)
236. Alexandre, R.F.; Bagatini, F.; Simoes, C.M.O. Interaçoes entre fármacos e medicamentos fitoterapicos a base de Ginkgo ou Ginseng. Rev. Bras. Farmacogn., 2008, 18(1), 117-126.
237. Taki, Y.; Yamazaki, Y.; Shimura, F.; Yamada, S.; Umegaki, K. Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. J. Pharm. Sci., 2009, 109(3), 459-462.
238. Meisel, C.; Johne, A.; Roots, I. Fatal intracerebral mass bleeding associated with Ginkgo biloba and ibuprofen. Atherosclerosis, 2003, 167(2), 367. (Pubitemid 36773536)
239. Bent, S.; Goldberg, H.; Padula, A.; Avins, A.L. Spontaneous bleeding associated with Ginkgo biloba: a case report and systematc review of the literature. J. Gen. Intern. Med., 2005, 20(3), 657-661.
240. Jiang, X.; Williams, K.M.; Liauw, W.S.; Roufogalis, A.; Duke, C.C.; Day, R.O.; Mclachlan, A.J. Effect of ginkgo and ginger on the pharmacokinetic and pharmacodynamics of warfarin in healthy subjects. Br. J. Clin. Pharmacol., 2005, 59(4), 425-432. (Pubitemid 40523886)
241. Savovic, J.; Wider, B.; Ernst, E. Effect of Ginkgo biloba on blood coagulation parameters: a systematic review of randomised clinical trials. Evid. Based Integrt. Med., 2005, 2(3), 167-176.
242. Aruna, D.; Maidu, M.V. Pharmacodynamic interactions studies of Ginkgo biloba with cilostazol and clopidogrel in healthy subjects. Br. J. Clin. Pharmacol., 2007, 63(3), 333-338. (Pubitemid 46257069)
243. Bone, K.M. Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence?. Mol. Nutr. Food Res., 2008, 52(7), 764-771.
244. Huang, J.; Xu, H.X.; Cai, H.P. Dypyridamol/Ginkgo biloba overdose: anaphylaxis in a elderly patient: case report. Reactions, 2009, 1(1253), 15.
245. Ryu, K.H.; Han, H.Y.; Lee, S.Y.; Jeon, S.D.; Im, G.J.; Lee, B.Y.; Kim, K.; Lim, K.N.; Chung, J.H. Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time. Thromb. Res., 2009, 124(3), 328-334.
246. Kudolo, G.B.; Dorsey, S.; Blodgett, J. Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and type 2 diabetic subjects. Thromb. Res., 2002, 108(2-3), 151-160. (Pubitemid 36184651)
247. Kohler, S.; Funk, P.; Kieser, M. Influence of a 7-day treatment with Ginkgo biloba special extract EGb761 on bleeding time and coagulation: randomized, placebo-controlled, double-blind study in healthy volunteers. Blood Coagul. Fibrinolysis, 2004, 15(4), 303-309. (Pubitemid 38757057)
248. Lu, W.J.; Huang, J.D.; Lai, M.L. The effects of ergoloid mesylates and Ginkgo biloba on the pharmacokinetics of ticlopidine. J. Clin. Pharmacol., 2006, 46(6), 628-634. (Pubitemid 43920227)
249. Wolf, H.R.D. Does Ginkgo biloba special extract EGb761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily?. Drugs, 2006, 7(3), 163-172.
250. Von Moltke, L.L.; Weemhoff, J.L.; Bedir, E.; Khan, I.A.; Harmatz, J.S.; Goldman, P.; Greenblatt, D.J. Inhibition of human cytochrome P459 by components of Ginkgo biloba. J. Pharm. Pharmacol., 2004, 56(8), 1039-1044.
251. Yale, S.H.; Olurich, I. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6 and 2C9. J. Altern. Complement. Med., 2005, 11(3), 433-439.
252. Etheridge, A.S.; Black, S.R.; Patel, P.R.; So, J.; Mathews, J.M. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle and ginseng extracts and their constituents. Planta Med., 2007, 73(8), 731-741.
253. Ribonnet, L.; Callebaut, A.; Scippo, M.L.; Muller, M.; Robbens, J.; De Saeger, S.; Schneider, Y.J.; Pussemier, L.; Larondelle, Y. Modulation of cytochrome P450 1A1 expression and activity in intestinal Caco-2 cells by components of Ginkgo biloba-based dietary supplements. Toxicol. Lett., 2009, 189(1), S73.
254. Shinozuka, K.; Umegaki, K.; Kubota, Y.; Tanaka, N.; Mizuno, H.; Yamauchi, J.; Nakamura, K.; Kunimoto, M. Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life Sci., 2002, 70(23), 2783-2792.
255. Kubota, Y.; Kobayashi, K.; Tanaka, N.; Nakamura, K.; Kunitomo, M.; Umegaki, K.; Shinozuka, K. Interactions of Ginkgo extract (GBE) with hypotensive agent, nicardipine, in rats. In vivo, 2003, 17(5), 409-412. (Pubitemid 37328044)
256. Yoshioka, M.; Ohnishi, N.; Sone, N.; Egami, S.; Takara, K.; Yokoyama, T.; Kuroda, K. Studies on interactions between functional foods or dietary supplements and medicines. III. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of nifedipine in rats. Biol. Pharm. Bull., 2004, 27(12), 2042-2045. (Pubitemid 41701588)
257. Yoshioka, M.; Ohnishi, N.; Koishi, T.; Obata, Y.; Nakagawa, M.; Matsumoto, T.; Tagagi, K.; Takara, K.; Ohkuni, T.; Yokoyama, T.; Kuroda, K. Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of Ginkgo biloba leaf extract on the pharmacokinetics and pharmacodymamics of nifedipine in healthy volunteers. Biol. Pharm. Bull., 2004, 27(12), 2006-2009. (Pubitemid 41701579)
258. Zhu, M.; Yao, T.W.; Zeng, S. Glucuronidation and in vitro interaction of Ginkgo flavonoids with other drugs. Zhejiang Da Xue Bao Yi Xue Ban, 2004, 33(1), 15-20.
259. Fan, L.; Tao, G.Y.; Wang, G.; Chen, Y.; Zhang, W.; He, Y.J.; Li, Q.; Lei, H.P.; Jiang, F.; Hu, D.L.; Huang, Y.F.; Zhou, H.N. Effect of Ginkgo biloba extract ingestion on the pharmacokinetics of talinolol in healthy Chinese volunteers. Ann. Pharmacother., 2009, 43(5), 944-949.
260. Fan, L.; Mao, X.Q.; Tao, G.Y.; Wang, G.; Jiang, F.; Chen, Y.; Li, Q.; Zhang, W.; Lei, H.P.; Hu, D.L.; Huang, Y.F.; Wang, D.; Zhou, H.H. Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers. Xenobiotica, 2009, 39(3), 249-254.
261. Yang, C.Y.; Chao, P.D.; Hou, Y.C.; Tsai, S.Y.; Wen, K.C.; Hsiu, S.L. Marked decrease of cyclosporine bioavailability caused by co-administration of Ginkgo and onion in rats. Food Chem. Toxicol., 2006, 44(9), 1572-1578.
262. Ohnishi, N.; Kusuhara, M.; Yoshioka, M.; Kuroda, K.; Soga, A.; Nishikawa Koishi, T.; Nakagawa, M.; Hori, S.; Matsumoto, T.; Yamashita, M.; Ohta, S.; Takara, K.; Yokoyama, T. Studies on interaction between functional foods and dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats. Biol. Pharm. Bull., 2003, 26(9), 1315-1320.
263. Robertson, S.M.; Davey, R.T.; Voell, J.; Formentini, E.; Alfaro, R.M.; Penzak, S.R. Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects. Curr. Med. Res. Opin., 2008, 24(2), 591-599.
264. Uchida, S.; Yamada, H.; Li, X.D.; Maruyama, S.; Ohmori, Y.; Oki, T.; Watanabe, H.; Umegaki, K.; Ohashi, K.; Yamada, S. Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. J. Clin. Pharmacol., 2006, 46(11), 1290-1298.
265. Sugiyama, T.; Kubota, Y.; Shinozuka, K.; Yamada, S.; Wu, J.; Umegaki, K. Ginkgo biloba extract modifies hypoglycaemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats. Life Sci., 2004, 75(9), 1113-1122. (Pubitemid 38780993)
266. Chatterjee, S.S.; Doelman, C.J.; Nöldner, M.; Biber, A.; Koch, E. Influence of the Ginkgo extract on rat liver cytochrome P450 and steroid metabolism and excretion in rats and man. J. Pharm. Pharmacol., 2005, 57(5), 641-650. (Pubitemid 40562403)
267. Numa, A.M.; Abbott, F.S.; Chang, T.K.H. Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotypes. Can. J. Physiol. Pharmacol., 2007, 85(9), 848-855.
268. Zou, L.; Harkey, M.R.; Henderson, G.L. Effects of herbal components in cDNA-expressed cytochrome P450 enzyme catalytic activity. Life Sci., 2002, 71(13), 1579-1589.
269. Gaudineau, C.; Beckerman, R.; Welbourn, S. Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. Biochem. Biophys. Res. Comm., 2004, 318(4), 1072-1078. (Pubitemid 38625885)
270. Rajaraman, G.; Chen, J.; Chang, T.K. Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. Toxicol. Appl. Pharmacol., 2006, 217(2), 225-233.
271. He, N.; Cai, H.B.; Xie, H.G.; Collins, X.; Edeki, T.I.; Strom, S. Induction of CYP3A4 in primary cultures of human hepatocytes by ginkgolides A and B. Clin. Exper. Pharmacol. Toxicol., 2007, 34(7), 632-635. (Pubitemid 46953110)
272. Deng, Y.; Bi, H.C.; Zhao, L.Z.; Wang, X.D.; Chen, J.; Ou, Z.M.; Ding, L.; Xu, L.J.; Guan, S.; Chen, X.; Zhou, S.F.; Huang, M. Induction of cytochrome P4503A by the Ginkgo biloba extract and bilobalide in human and rat primary hepatocytes. Drug Metab. Lett., 2008, 2(1), 60-66.
273. Deng, Y.; Bi, H.C.; Zhao, L.Z.; He, F.; Liu, Y.Q.; Yu, J.J.; Ou, Z.M.; Ding, L.; Chen, X.; Huang, Z.Y.; Huang, M.; Zhou, S.F. Induction of cytochrome P450 by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb761 in rats. Xenobiotica, 2008, 38(5), 465-481.
274. Yang, X.F.; Wang, N.P.; Lu, W.H.; Zeng, F.D. Effects of Ginkgo biloba extract and tanshinone on cytochrome P450 isoenzymes and glutathione transferase in rats. Acta Pharmacol. Sin., 2003, 24(10), 1033-1038.
275. Zhao, L.Z.; Huang, M.; Chen, J.; Ee, P.L.; Chan, E.; Duan, W.; Guan, Y.Y.; Hong, Y.H.; Chen, X.; Zhou, S. Induction of propanolol metabolism by Ginkgo biloba extract EGb761 in rats. Curr. Drug Metab., 2006, 7(6), 577-587.
276. Tang, J.; Sun, J.; Zhang, Y.; Li, L.; Cui, F.; He, Z. Herb-drug interactions: effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats. Food Chem. Toxicol., 2007, 45(12), 2441-2445. (Pubitemid 47600451)
277. Yin, O.; Tomlinson, B.; Waye, M.; Chow, A.; Chow, M. Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole. Pharmacogenetics, 2004, 14(12), 841-850. (Pubitemid 40054339)
278. Lei, H.P.; Wang, G.; Wang, L.S.; Ou-Jang, D.S.; Chen, H.; Li, Q.; Zhang, W.; Tan, Z.R.; Fan, L.; He, Y.J.; Zhou, H.H. Lack of effect of Ginkgo biloba on voriconazole pharmacokinetics in Chinese volunteers identified as CYP2C19 poor and extensive metabolizers. Ann. Pharmacother., 2009, 43(4), 726-731.
279. Yeung, E.Y.H.; Sueyoshi, T.; Negishi, M.; Chang, T.K.H. Identification of Ginkgo biloba as a novel activator of pregnane X. Drug Metab. Dispos., 2008, 36(11), 2270-2276.
280. Li, L.; Stanton, J.D.; Tolson, A.H.; Luo, Y.; Wang, H. Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharmacol. Res., 2009, 26(4), 872-882.
281. Markowitz, J.S.; Donovan, J.L.; Lindsay, D.V.; Sipkes, L.B.S.; Chavin, K.D. Multiple-dose administration Ginkgo biloba did not affect cytochrome P450 2D6 and 3A4 activity in normal volunteers. J. Clin. Psycopharmacol., 2003, 23(6), 576-581. (Pubitemid 37443189)
282. Mauro, V.F.; Mauro, L.S.; Kleshinski, J.F.; Khuder, S.A.; Wang, Y.; Erhardt, P.W. Impact of Ginkgo biloba on the pharmacokinetics of digoxin. Am. J. Ther., 2003, 10(4), 247-251.
283. Yasui-Furukori, N.; Furukori, H.; Kaneda, A.; Kaneko, S.; Tateishi, T. The effects of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donezepil. J. Clin. Pharmacol., 2004, 44(5), 538-542. (Pubitemid 38509723)
284. Greenblatt, D.J.; Von Moltke, L.L.; Luo, Y.; Perloff, E.S.; Horan, K.A.; Bruce, A.; Reynolds, R.C.; Harmatz, J.S.; Avula, B.; Khan, I.A.; Goldman, P. Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate. J. Clin. Pharmacol., 2006, 46(2), 214-221.
285. Wiegman, D.J.; Brinkman, K.; Franssen, E.J. Interaction of Ginkgo biloba with efavirenz. AIDS, 2009, 23(9), 1184-1185.
286. Lau, A.J.; Chang, T.K. Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: effect of terpene trilactones and flavonols. Drug Metab. Dispos., 2009, 37(9), 1931-1937.
287. Lei, H.P.; Ji, W.; Lin, J.; Chen, H.; Tan, Z.R.; Hu, D.L.; Liu, L.J.; Zhou, H.H. Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers. Br. J. Clin. Pharmacol., 2009, 68(2), 201-206.