Fatal seizures due to potential herb-drug interactions with Ginkgo biloba

Journal of Analytical Toxicology

Volumn 29, Issue 7, 2005, Pages 755-758

  Kupiec, Thomas ^a   Raj, Vishnu ^a  

^a Analytical Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; GINKGO BILOBA EXTRACT; HERBACEOUS AGENT; NUTRACEUTICAL; PHENYTOIN; VALPROATE SEMISODIUM;

ADULT; ARTICLE; CASE REPORT; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INDUCTION; FATALITY; GINKGO BILOBA; HERB DRUG INTERACTION; HUMAN; MALE; PATIENT COMPLIANCE; PRESCRIPTION; SEIZURE; SELF MEDICATION;

GINKGO BILOBA;

EID: 29144432784     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/29.7.755     Document Type: Article

References (21)

1. A.S. Granger. Ginkgo biloba precipitating epileptic seizures. Age Ageing 30: 523-525 (2001).
2. S. Zhou, Y. Gao, W. Jiang, M. Huang, A. Xu, and J.W. Paxton. Interactions of herbs with cytochrome P450. Drug Metab. Rev. 35(1): 35-98 (2003).
3. J. Rowin and S.L. Lewis. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 46(6): 1775-1776 (1996).
4. J. Kleijnen and P. Knipschild. Ginkgo biloba. Lancet 340: 1136-1139 (1992).
5. M.K. Kottke. Scientific and regulatory aspects of nutraceutical products in the United States. Drug Dev. Ind. Pharm. 24(12): 1177-1195 (1998).
6. E.P. Elovic and R.D. Zafonte. Ginkgo biloba: applications in traumatic brain injury. J. Head Trauma Rehabil. 16(6): 603-607 (2001).
7. X.F. Yang, N.P. Wang, W.H. Lu, and F.D. Zeng. Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats. Acta Pharmacol. Sin. 24(10): 1033-1038 (2003).
8. L. Miller. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch. Intern. Med. 158(20): 2200-2211 (1998).
9. M.J. Cupp. Herbal remedies: adverse effects and drug interactions. Am. Fam. Physician 59(5): 1239-1245 (1999).
10. P.J. Gregory. Seizure associated with Ginkgo biloba? Ann. Intern. Med 134(4): 344 (2001).
11. H. Miwa, M. Iijima, S. Tanaka, and Y. Mizuno. Generalized convulsions after consuming a large amount of ginkgo nuts. Epilepsia 42(2): 280-281 (2001).
12. M. Shannon, E.A. McElroy, and E.L. Liebelt. Toxic seizures in children: case scenarios and treatment strategies. Pediatr. Emerg. Care 19(3): 206-210 (2003).
13. Drugdex Drug Evaluations (MICROMEDEX) - Dilantin®, Depakote® and Strychnine.
14. A. Arenz, M. Klein, K. Fiehe, J. Gros, C. Drewke, T. Hemscheidt, and E. Leistner. Occurrence of neurotoxic 4′-O-methylpyridoxine in Ginkgo biloba leaves, ginkgo medications and Japanese ginkgo food. Planta Medica 62: 548-551 (1996).
15. A. Manocha, K.K. Pillai, and S.Z. Husain. Influence of ginkgo biloba on the effect of anti-convulsants. Indian J. Pharmacol. 28: 84-87 (1996).
16. A. Manocha, K.K. Pillai, S.Z. Husain. Effect of ginkgo biloba on chemoshock in mice. Indian J. Pharmacol. 29: 198-200 (1997).
17. E.M. Williamson. Drug interactions between herbal and prescription medicines. Drug Saf. 26(15): 1075-1092 (2003).
18. The Worldwide Physiologist: cytochrome P450. http://www.anaesthetist. com/physiol/basics/metabol/cyp/p.htm#phenytoin.
19. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed., J.G. Hardman, L.E. Limbird, and A.G. Gilman, Eds. McGraw-Hill, New York, NY, 2001.
20. O.Q. Yin, B. Tomlinson, M.M. Waye, A.H. Chow, and M.S. Chow. Pharmacogenetics and herb-drug interactions: experience with ginkgo biloba and omeprazole. Pharmacogenetics 14 (12): 841-850 (2004).
21. A. Tyagi and N. Delanty. Herbal remedies, dietary supplements, and seizures. Epilepsia 44(2): 228-235 (2003).