Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: What is the evidence?

Molecular Nutrition and Food Research

Volumn 52, Issue 7, 2008, Pages 764-771

  Bone, Kerry Martin ^a,b  

^a UNIVERSITY OF NEW ENGLAND   (Australia)

^b MediHerb Pty Ltd   (Australia)

Author keywords

Aspirin; EGb 761; Ginkgo biloba; Herb drug interaction; Warfarin

Indexed keywords

GINKGO BILOBA;

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; GINKGO BILOBA EXTRACT 761; PLANT EXTRACT;

BLEEDING; CLINICAL TRIAL; GINKGO BILOBA; HERB DRUG INTERACTION; HUMAN; REPRODUCIBILITY; REVIEW;

ANTICOAGULANTS; CLINICAL TRIALS AS TOPIC; GINKGO BILOBA; HEMORRHAGE; HERB-DRUG INTERACTIONS; HUMANS; PLANT EXTRACTS; PLATELET AGGREGATION INHIBITORS; REPRODUCIBILITY OF RESULTS;

EID: 53249115785     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700098     Document Type: Review

References (53)

1. Mills, S., Bone, K., Principles and Practice of Phytotherapy: Modern Herbal Medicine. Churchill Livingstone, Edinburgh 2000, p. 404.
2. DeFeudis, F. V., Ginkgo biloba Extract (EGb 761): Pharmacological Activities and Clinical Applications. Elsevier, Amsterdam 1991, pp. 1-8.
3. Bensky, D., Clavey, S., Stoger, E., Chinese Herbal Medicine: Materia Medica, 3rd Edn. Eastland Press, Seattle 2004, p. 891.
4. Mills, S., Bone, K., Principles and Practice of Phytotherapy: Modern Herbal Medicine. Churchill Livingstone, Edinburgh 2000, pp. 408-409.
5. Rowin, J., Lewis, S. L., Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996, 46, 1775-1776.
6. Skidmore-Roth, L. (Ed.) Mosby's Handbook of Herbs & Natural Supplements. Mosby, St. Louis 2001, p. 377.
7. Chandler, F. (Ed.) Herbs Everyday Reference for Health Professionals. Canadian Pharmacists Association and Canadian Medical Association, Ottawa 2000, p. 129.
8. Graedon, J., Graedon, T. (Eds.) The People's Pharmacy Guide to Home and Herbal Remedies. St. Martin's Press, New York 1999, p. 9.
9. Peng, C. C., Glassman, P. A., Trilli, L. E., Hayes-Hunter, J., Good, C. B., Incidence and severity of potential drug-dietary supplement interactions in primary care patients. An exploratory study of 2 outpatient practices. Arch. Intern. Med. 2004, 164, 630-636.
10. Chung, K. F., Dent, G., McCusker, M., Guinot, P., et al. Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet 1987, 1, 248-251.
11. Guinot, P., Caffrey, E., Lambe, R., Darragh, A., Tanakan inhibits platelet-activating-factor-induced platelet aggregation in healthy male volunteers. Haemostasis 1989, 19, 219-223.
12. Dutta-Roy, A. K., Gordon, M. J., Kelly, C., Hunter, K., et al., Inhibitory effect of Ginkgo biloba extract on human platelet aggregation. Platelets 1999, 10, 298-305.
13. Koch, E., Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomed. 2005, 12, 10-16.
14. Kudolo, G. B., Dorsey, S., Blodgett, J., Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. Thromb. Res. 2003, 108, 151-160.
15. Kudolo, G., Wang, W., Barrientos, J., Elrod, R., Blodgett, J., The ingestion of Ginkgo biloba extract (EGb 761) inhibits arachidonic acid-mediated platelet aggregation and thromboxane B2 production in healthy volunteers. J. Herb. Pharmacother. 2004, 4, 13-26.
16. Kudolo, G. B., Delaney, D., Blodgett, J., Short-term oral ingestion of Ginkgo biloba extract (EGb 761) reduces malondialdehyde levels in washed platelets of type 2 diabetic subjects. Diabetes Res. Clin. Pract. 2005, 68, 29-38.
17. Ding, S., Dudley, E., Plummer, S., Tang, J., et al., Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry. Rapid Commun. Mass Spectrom. 2006, 20, 2753-2760.
18. Liu, C., Mandal, R., Li, X. F., Detection of fortification of ginkgo products using nanoelectrospray ionization mass spectrometry. Analyst 2005, 130, 325-329.
19. Jung, F., Mrowietz, C., Kiesewetter, H., Wenzel, E., Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculation in volunteers. Arzneimittelforschung 1990, 40, 589-593.
20. DeLoughery, T. G., Kaye, J. A., Morris, C. D., Oken, B., Zitzelberger, T. A., Ginkgo biloba does not affect platelet function in elderly patients. Blood 2002, 11, abstract 3809.
21. Halil, M., Cankurtaran, M., Yavuz, B. B., Ozkayar, N., et al., No alteration in the PFA-100 in vitro bleeding time induced by the Ginkgo biloba special extract, EGb 761, in elderly patients with mild cognitive impairment. Blood Coagul. Fibrinolysis 2005, 16, 349-353.
22. Sollier, C. B. D., Caplain, H., Drouet, L., No alteration in platelet function or coagulation induced by EGb761 in a controlled study. Clin. Lab. Haem. 2003, 25, 251-253.
23. Köhler, S., Funk, P., Kieser, M., Influence of a 7-day treatment with Ginkgo biloba special extract EGb 761 on bleeding time and coagulation: a randomized, placebo-controlled, double-blind study in healthy volunteers. Blood Coagul. Fibrinolysis 2004, 15, 303-309.
24. Pittler, M. H., Ernst, E., Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials. Am. J. Med. 2000, 108, 276-281.
25. DeFeudis, F. V., Ginkgo biloba extract (EGb 761): pharmacological activities and clinical applications. Elsevier, Amsterdam 1991, pp. 143-146.
26. Woerdenbag, H. J., Van Beek, T. A., In: De Smet, P. A. G. M., Keller, K., Hansel, R., Chandler, R. F. (Eds.). Adverse Effects of Herbal Drugs, vol 3. Springer-Verlag, Berlin 1997, pp. 57-60.
27. Ernst, E., Pittler, M. H., Ginkgo biloba for Dementia: A systematic review of double-blind, placebo-controlled trials. Clin. Drug Invest. 1999, 17, 301-308.
28. Le Bars, P. L., Kastelan, J., Efficacy and safety of a Ginkgo biloba extract. Public Health Nutr. 2000, 3, 495-499.
29. Birks, J., Grimley, E. V., Van Dongen, M., Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst. Rev. 2002, CD003120.
30. Bent, S., Goldberg, H., Padula, A., Avins, A. L., Spontaneous bleeding associated with Ginkgo biloba, A case report and systematic review of the literature. J. Gen. Intern. Med. 2005, 20, 657-661.
31. Gaus, W., Westendorf, J., Diebow, R., Kieser, M., Identification of adverse drug reactions by evaluation of a prescription database, demonstrated for "risk of bleeding". Methods Inf. Med. 2005, 44, 697-703.
32. Wolf, H. R. D., Does Ginkgo biloba special extract EGb7611 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500mg daily? Drugs R. D. 2006, 7, 163-172.
33. Engelsen, J., Nielsen, J. D., Winther, K., Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb. Haemost. 2002, 87, 1075-1076.
34. Jiang, X., Williams, K. M., Liauw, W. S., Ammit, A. J., et al., Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br. J. Clin. Pharmacol. 2005, 59, 425-432.
35. Yagmur, E., Piatkowski, A., Groger, A., Pallua, N., et al., Bleeding complication under Ginkgo biloba medication. Am. J. Hematol. 2005, 79, 343-345.
36. Matthews, M. K., Association of Ginkgo biloba with intracerebral hemorrhage. Neurology 1998, 50, 1933.
37. rd ed. John Wiley, Chichester 2000, pp. 525-538.
38. Gilbert, G. J., Ginkgo biloba. Neurology 1997, 48, 1137.
39. Rosenblatt, M., Mindel, J., Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N. Engl. J. Med. 1997, 336, 1108.
40. Vale, S., Subarachnoid haemorrhage associated with Ginkgo biloba. Lancet 1998, 352, 36.
41. Fessenden, J. M., Wittenboarn, W., Clarke, L., Ginkgo Biloba, A case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy. Am. Surg. 2001, 67, 33-35.
42. Hoffman, T., Ginko, Vioxx and excessive bleeding - Possible drug-herb interactions: Case Report. Hawaii Med. J. 2001, 60, 290.
43. Benjamin, J., Muir, T., Briggs, K., Pentland, B., A case of cerebral haemorrhage - can Ginkgo biloba be implicated? Postgrad. Med. J. 2001, 77, 112-113.
44. Miller, L. G., Freeman, B., Possible subdural hematoma associated with Ginkgo biloba. J. Herb. Pharmacother. 2002, 2, 57-63.
45. Schneider, C., Bord, C., Misse, P., Arnaud, B., Schmitt-Bernard, D.-F., Hyphéma spontané provoqué par l'extrait de Ginkgo biloba. Fr. Ophtalmol. 2002, 25, 731-732.
46. Garcia, F. P., Molina, C., Sabin, J. A., Hemorragia cerebelosa espontánea asociada a la ingestión de Ginkgo biloba. Med. Clin. (Barc). 2002, 119, 596-599.
47. Hauser, D., Gayowski, T., Singh, N., Bleeding complication precipitated by unrecognized Ginkgo biloba use after liver transplantation. Transpl. Int. 2002, 15, 377-379.
48. Fong, K. C. S., Kinnear, P. E., Retrobulbar haemorrhage associated with chronic Gingko biloba ingestion. Postgrad. Med. J. 2003, 79, 531-532.
49. Meisel, C., Johne, A., Roots, I., Fatal intracerebral mass bleeding associated with Ginkgo biloba and ibuprofen. Atherosclerosis 2003, 167, 367.
50. MacVie, O. P., Harney, B. A., Vitreous haemorrhage associated with Gingko biloba use in a patient with age related macular disease. Br. J. Ophthalmol. 2005, 89, 1378-1379.
51. Jayasekera, N., Moghal, A., Kashif, F., Herbal medicines and postoperative haemorrhage. Anaesthesia 2005, 60, 725-726.
52. Bebbington, A., Kulkarni, R., Roberts, P., Ginkgo Biloba. Persistent bleeding after total hip arthroplasty caused by herbal self-medication. J. Arthroplasty 2005, 20, 125-126.
53. Destro, M. W. B., Speranzini, M. B., Filho, C. C., Destro, T., Destro, C., Bilateral haematoma after rhytidoplasty and blepharoplasty following chronic use of Ginkgo biloba. Br. J. Plast. Surg. 2005, 58, 100-101.