Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against β-amyloid peptide-induced toxicity in SH-SY5Y cells

Chemico-Biological Interactions

Volumn 181, Issue 1, 2009, Pages 115-123

  Shi, Chun ^a,b   Zhao, Lina ^a   Zhu, Bilian ^a   Li, Qianxi ^a   Yew, David T ^b   Yao, Zhibin ^a   Xu, Jie ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

A (1 42); Apoptosis; EGb761; Ginkgolide B; Quercetin

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; GINKGO BILOBA EXTRACT; GINKGOLIDE B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; QUERCETIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ACTIVATION; FLOW CYTOMETRY; GINKGOLIDES; HUMANS; HYDROGEN PEROXIDE; LACTONES; PLANT EXTRACTS; PROTEIN KINASES; QUERCETIN; REACTIVE OXYGEN SPECIES;

GINKGO BILOBA;

EID: 67650690570     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.05.010     Document Type: Article

References (53)

1. Lee S.Y., Lee J.W., Lee H., Yoo H.S., Yun Y.P., Oh K.W., Ha T.Y., and Hong J.T. Inhibitory effect of green tea extract on beta-amyloid-induced PC12 cell death by inhibition of the activation of NF-kappaB and ERK/p38 MAP kinase pathway through antioxidant mechanisms. Brain Res. Mol. Brain Res. 140 (2005) 45-54
2. Mattson M.P., Goodman Y., Luo H., Fu W., and Furukawa K. Activation of NF-kappaB protects hippocampal neurons against oxidative stress induced apoptosis evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J. Neurosci. Res. 49 (1997) 681-697
3. Kaltschmidt B., Uherek M., Wellmann H., Volk B., and Kaltschmidt C. Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 9409-9414
4. Yao M., Nguyen T.V., and Pike C.J. Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J. Neurosci. 25 (2005) 1149-1158
5. Montine T.J., Montine K.S., McMahan W., Markesbery W.R., Quinn J.F., and Morrow J.D. F(2)-isoprostanes in Alzheimer and other neurodegenerative diseases. Antioxid. Redox Signal. 7 (2005) 269-275
6. Sayre L.M., Zagorski M.G., Surewicz W.K., Krafft G.A., and Perry G. Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease a critical appraisal. Chem. Res. Toxicol. 10 (1997) 518-526
7. Ramassamy C., Averill D., Beffert U., Theroux L., Lussier-Cacan S., Cohn J.S., Christen Y., Schoofs A., Davignon J., and Poirier J. Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain. Neurobiol. Dis. 7 (2000) 23-37
8. Ramassamy C., Averill D., Beffert U., Bastianetto S., Theroux L., Lussier-Cacan S., Cohn J.S., Christen Y., Davignon J., Quirion R., and Poirier J. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free Radic. Biol. Med. 27 (1999) 544-553
9. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23 (1997) 134-147
10. Sayre L.M., Zelasko D.A., Harris P.L., Perry G., Salomon R.G., and Smith M.A. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68 (1997) 2092-2097
11. Christen Y. Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 71 (2000) 621S-629S
12. Hensley K., Carney J.M., Mattson M.P., Aksenova M., Harris M., Wu J.F., Floyd R.A., and Butterfield D.A. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide relevance to Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 3270-3274
13. Monji A., Utsumi H., Ueda T., Imoto T., Yoshida I., Hashioka S., Tashiro K., and Tashiro N. The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides. J. Neurochem. 77 (2001) 1425-1432
14. Monji A., Utsumi H., Yoshida I., Hashioka S., Tashiro K., and Tashiro N. The relationship between Abeta-associated free radical generation and Abeta fibril formation revealed by negative stain electron microscopy and thioflavine-T fluorometric assay. Neurosci. Lett. 304 (2001) 65-68
15. Butterfield D.A., and Boyd-Kimball D. The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity. Biochim. Biophys. Acta 1703 (2005) 149-156
16. Cardoso S.M., Santos S., Swerdlow R.H., and Oliveira C.R. Functional mitochondria are required for amyloid beta-mediated neurotoxicity. FASEB J. 15 (2001) 1439-1441
17. C. Shi, L. Zhao, B. Zhu, Q. Li, D.T. Yew, Z. Yao, J. Xu, Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells, Chem. Biol. Interact. (2009) [Epub ahead of print].
18. Bastianetto S., Ramassamy C., Doré S., Christen Y., Poirier J., and Quirion R. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur. J. Neurosci. 12 (2000) 1882-1890
19. Yao Z., Drieu K., and Papadopoulos V. The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands. Brain Res. 889 (2001) 181-190
20. Xu Y., Cui C., Pang C., Christen Y., and Luo Y. Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells. Eur. J. Neurosci. 26 (2007) 2931-2939
21. Longpré F., Garneau P., Christen Y., and Ramassamy C. Protection by EGb 761 against beta-amyloid-induced neurotoxicity involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic. Biol. Med. 41 (2006) 1781-1794
22. Smith J.V., and Luo Y. Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761. J. Alzheimers Dis. 5 (2003) 287-300
23. Smith P.F., Maclennan K., and Darlington C.L. The neuroprotective properties of the Ginkgo biloba leaf a review of the possible relationship to platelet-activating factor (PAF). J. Ethnopharmacol. 50 (1996) 131-139
24. Nakanishi K. The ginkgolides. Pure Appl. Chem. 14 (1967) 89-113
25. Ivic L., Sands T.T., Fishkin N., Nakanishi K., Kriegstein A.R., and Strømgaard K. Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. J. Biol. Chem. 278 (2003) 49279-49285
26. Jaracz S., Malik S., and Nakanishi K. Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts. Phytochemistry 65 (2004) 2897-2902
27. Kobayashi M.S., Han D., and Packer L. Antioxidants and herbal extracts protect HT-4 neuronal cells against glutamate-induced cytotoxicity. Free Radic. Res. 32 (2000) 115-124
28. Shi C., Xu X.W., Forster E.L., Tang L.F., Ge Z., Yew D.T., and Xu J. Possible role of mitochondrial dysfunction in central neurodegeneration of ovariectomized rats. Cell Biochem. Funct. 26 (2008) 172-178
29. Behl C., Davis J.B., Lesley R., and Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77 (1994) 817-827
30. Bate C., Salmona M., Williams A., and Ginkgolide. B inhibits the neurotoxicity of prions or amyloid-beta1-42. J. Neuroinflammation 1 (2004) 4
31. Bate C., Salmona M., and Williams A. The role of platelet activating factor in prion and amyloid-beta neurotoxicity. Neuroreport 15 (2004) 509-513
32. Bate C., Tayebi M., and Williams A. Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro. Mol. Neurodegener. 3 (2008) 1
33. Bate C., Kempster S., and Williams A. Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death. Neuropharmacology 51 (2006) 173-181
34. Selkoe D.J. Alzheimer's disease genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
35. Reddy P.H. Amyloid precursor protein-mediated free radicals and oxidative damage implications for the development and progression of Alzheimer's disease. J. Neurochem. 96 (2006) 1-13
36. Takuma K., Yan S.S., Stern D.M., and Yamada K. Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease. J. Pharmacol. Sci. 97 (2005) 312-316
37. Casley C.S., Land J.M., Sharpe M.A., Clark J.B., Duchen M.R., and Canevari L. β-Amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol. Dis. 10 (2002) 258-267
38. Keil U., Bonert A., Marques C.A., Scherping I., Weyermann J., Strosznajder J.B., Müller-Spahn, Haass C., Czech C., Pradier L., Müller W.E., and Eckert A. Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J. Biol. Chem. 279 (2004) 50310-50320
39. Eckert A., Keil U., Kressmann S., Schindowski K., Leutner S., Leutz S., and Müller W.E. Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress. Pharmacopsychiatry 36 Suppl. (1) (2003) S15-S23
40. Dorta D.J., Pigoso A.A., Mingatto F.E., Rodrigues T., Pestana C.R., Uyemura S.A., Santos A.C., and Curti C. Antioxidant activity of flavonoids in isolated mitochondria. Phytother. Res. 22 (2008) 1213-1218
41. Kaplan D.R., and Miller F.D. Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10 (2000) 381-391
42. Skaper S.D., Floreani M., Negro A., Facci L., and Guisti P. Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway. J. Neurochem. 70 (1998) 1859-1868
43. Murray B., Alessandrini A., Cole A.J., Yee A.G., and Furshpan E.J. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 11975-11980
44. Satoh T., Nakatsuka D., Watanabe Y., Nagata I., Kikuchi H., and Namura S. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured neurons. Neurosci. Lett. 288 (2000) 163-166
45. Stanciu M., Wang Y., Kentor R., Burke N., Watkins S., Kress G., Reynolds I., Klann E., Angiolieri M.R., Johnson J.W., and DeFranco D.B. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J. Biol. Chem. 275 (2000) 12200-12206
46. Bonni A., Brunet A., West A.E., Datta S.R., Takasu M.A., and Greenberg M.E. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and independent mechanisms. Science 286 (1999) 1358-1362
47. Maroney A.C., Glicksman M.A., Basma A.N., Walton K.M., Knight E., Murphy C.A., Bartlett B.A., Finn J.P., Angeles T., Matsuda Y., Neff N.T., and Dionne C.A. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J. Neurosci. 18 (1998) 104-111
48. Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 103 (2000) 239-252
49. Mielke K., and Herdegen T. JNK and p38 stress kinases degenerative effectors of signal transduction-cascades in the nervous system. Prog. Neurobiol. 61 (2000) 45-60
50. Whitfield J., Neame S.J., Pacquet L., Bernard O., and Ham J. Dominant-negative c-jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29 (2001) 629-643
51. Wei W., Wang X., and Kusiak J.W. Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor protection. J. Biol. Chem. 277 (2002) 17649-17656
52. Butterfield D.A., Koppal T., Subramaniam R., and Yatin S. Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease. Rev. Neurosci. 10 (1999) 141-149
53. Castellani R.J., Lee H.G., Perry G., and Smith M.A. Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. Am. J. Alzheimers Dis. Other. Demen. 21 (2006) 126-130