Ginkgo biloba (EGb 761) extract: Effects on the myenteric plexus of the large intestine in wistar rats

Digestive Diseases and Sciences

Volumn 54, Issue 2, 2009, Pages 232-237

  Perez, Glasiella Gonzalez ^a   Schneider, Larissa Carla Lauer ^a   Buttow, Nilza Cristina ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Ageing; Ginkgo biloba; Myenteric plexus; Neurotrophic effect

Indexed keywords

GINKGO BILOBA EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; LARGE INTESTINE; MALE; MYENTERIC PLEXUS; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; WISTAR RAT;

AGING; ANIMALS; COLON; MALE; MYENTERIC PLEXUS; NEURONS; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 59449107271     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0338-3     Document Type: Article

References (29)

1. R Kohen D Fanberstein O Tirosh 1997 Reducing equivalents in the aging process Arch Gerontol Geriatr 24 103 123 10.1016/S0167-4943(96)00744-3
2. PR Wade T Cowen 2004 Neurodegeneration: a key factor in the ageing gut Neurogastroenterol Motil 16 19 23 10.1111/j.1743-3150.2004.00469.x
3. RJ Phillips TL Powley 2007 Innervation of the gastrointestinal tract: patterns of aging Auton Neurosci 136 1 19 10.1016/j.autneu.2007.04.005
4. C Thrasivoulou V Soubeyre H Ridha D Giuliani C Giaroni GJ Michael GJ Saffrey T Cowen 2006 Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons Aging Cell 5 247 257 10.1111/j.1474-9726.2006.00214.x
5. Marroni NP (2002) Estresse Oxidativo e antioxidante. ULBRA, Canoas
6. S Yoon C Yun A Chung 2002 Dose effect of oxidative stress on signal transduction in aging Mech Ageing Dev 123 1539 1601 10.1016/S0047-6374(02)00095- 7
7. Signorini JL, Signorini SL (1993) Atividade física e radicais livres: aspectos biológicos, químicos, fisiopatológicos e preventivos. Ícone Editora, São Paulo
8. D Harman 2001 Aging: overview Ann N Y Acad Sci 928 1 21
9. OA Gomes RR Souza EA Liberti 1997 A preliminary investigation of the effects of aging on the nerve cell number in the myenteric ganglia of the human colon Gerontology 43 210 217
10. RM Santer DM Baker 1988 Enteric neuron numbers and sizes in Auerbach's plexus in the small and large intestine of adult and aged rats J Aut Nerv Syst 25 59 67 10.1016/0165-1838(88)90008-2
11. APN Majumdar R Jaszewski M Dubick 1997 Effect of aging on the gastrointestinal tract and the pâncreas Proc Soc Exp Biol Med 215 134 144
12. G Calapai A Crupi F Firenzuoli MC Marciano F Squadrito G Inferrera A Parisi A Rizzo C Crisafulli A Fiore AP Caputi 2000 Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis Life Sci 67 2673 2683 10.1016/S0024-3205(00)00858-4
13. Y Oyama L Chikahisa T Ueha K Kanemaru K Noda 1996 Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide Brain Res 712 349 352 10.1016/0006-8993(95)01440-3
14. LCL Schneider GG Peres SR Banzi JN Zanoni MRM Natali NC Buttow 2007 Evaluation of the effect of Ginkgo biloba extract (EGb 761) on the myenteric plexus of the small intestine of Wistar rats J Gastroenterol. 42 624 630 10.1007/s00535-006-1945-4
15. IW McLean PK Nakane 1974 Periodate-lysine-paraformaldehyde fixative. A new fixative for immunoelectron microscopy J Histochem Cytochem 22 1077 1083
16. NC Buttow S Zucoloto EM Espreafico P Gama EP Alvares 2003 Substance P enhances neuronal area and epithelial cell proliferation after colon denervation in rats Dig Dis Sci 48 2069 2076 10.1023/A:1026103311800
17. JN Zanoni P De Freitas RV Pereira MA Dos Santos Pereira MH De Miranda Neto 2005 Effects of supplementation with ascorbic acid for a period of 120 days on the myosin-V and NADPHd positive myenteric neurons of the ileum of rats Anat Histol Embryol. 34 149 153 10.1111/j.1439-0264.2005.00584.x
18. HJ Cooke 1986 Neurobiology of the intestinal mucosa Gastroenterology 90 1057 1081
19. RR Souza HB Moratelli N Borges EA Liberti 1993 Age-induced nerve cell loss in the myenteric plexus of the small intestine in man Gerontology 39 183 188
20. G Gabella 1989 Fall in the number of myenteric neurons in aging guinea pigs Gastroenterology 96 1487 1493
21. RJ Johnson M Schemann RM Santer T Cowen 1998 The effects of age on the overall population and on sub-populations of myenteric neurons in the rat small intestine J Anat 192 479 88 10.1046/j.1469-7580.1998.19240479.x
22. RJ Phillips EJ Kieffer TL Powley 2003 Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons Auton Neurosci 106 69 83 10.1016/S1566-0702(03)00072-9
23. ACM Marese P Freitas MRM Natali 2007 Alterations of the number and the profile of myenteric neurons of Wistar rats promoted by age Auton Neurosci 137 10 18 10.1016/j.autneu.2007.05.003
24. I Maitra L Marcocci MT Droylefaix L Packer 1995 Peroxyl radical scavenging activity of Ginkgo biloba extract EGb-761 Biochem Pharmacol 49 1649 1655 10.1016/0006-2952(95)00089-I
25. Y Ni B Zhao J Hou W Xin 1996 Preventive effect of Ginkgo biloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals Neurosci Lett 214 115 118 10.1016/0304-3940(96)12897-4
26. L Marcocci JJ Maguire MT Droy-Lefaix L Packer 1994 The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761 Biochem Biophys Res Commun 201 748 755 10.1006/bbrc.1994.1764
27. JL Dahl DD Bloom ML Epstein DA Fox P Bass 1987 Effect of chemical ablation of myenteric neurons on neurotransmitter levels in the rat jejunum Gastroenterology 92 338 344
28. SX Zheng LJ Zhou ZL Chen ML Yin XZ Zhu 2000 Bilobalide promotes expression of glial cell line-derived neurotrophic factor and vascular endothelial growth factor in rat astrocytes Acta Pharmacol Sin 21 151 155
29. W Li F Trovero J Cordier Y Wang K Drieu V Papadopoulos 2003 Prenatal exposure of rats to Ginkgo biloba extract (EGb 761) increases neuronal survival/growth and alters gene expression in the developing fetal hippocampus Brain Res Dev Brain Res 144 169 180 10.1016/S0165-3806(03)00168-8