The effect of Ginkgo biloba on the cerebellum of aging SAMP mouse - A TUNEL, bcl-2, and fMRI study

Microscopy Research and Technique

Volumn 70, Issue 8, 2007, Pages 671-676

  Wai, Maria S M ^a   Rudd, John A ^a   Chan, W Y ^a   Antonio, Gregory E ^a   Yew, David T ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Aging; Apoptosis; bcl 2; Cerebellum; fMRI; Ginkgo; SAMP mouse

Indexed keywords

BRAIN; FUNCTIONAL NEUROIMAGING; MAMMALS; PLANT EXTRACTS;

AGE-MATCHED CONTROLS; AGING MOUSE; BCL-2; CEREBELLUM; CONTROL GROUPS; FMRI; GINKGO; GINKGO BILOBA; PROPERTY; SAMP MOUSE;

CELL DEATH;

GINKGO BILOBA EXTRACT; PROTEIN BCL 2;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DENSITY; CEREBELLUM; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GINKGO BILOBA; IMAGE ANALYSIS; MALE; MOUSE; MOUSE STRAIN; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SYNAPSE;

EPICOCCUM; GINKGO BILOBA; MUS;

EID: 34547897601     PISSN: 1059910X     EISSN: 10970029     Source Type: Journal    
DOI: 10.1002/jemt.20452     Document Type: Article

References (30)

1. Ahlemeyer B, Junker V, Huhne R, Krieglstein J. 2001. Neuroprotective effects of NV-31, a bilobalide-derived compound: Evidence for an antioxidative mechanism. Brain Res 890:338-342.
2. Akcali KC, Sahiner M, Sahiner T. 2005. The role of bcl-2 family of genes during kindling. Epilepsia 46:217-223.
3. Barkats M, Venault P, Christen Y, Cohen-Salmon C. 1995. Effect of long-term treatment with EGb 761 on age-dependent structural changes in the hippocampi of three inbred mouse strains. Life Sci 56:213-222.
4. Braun DP, Ding J, Shaheen F, Willey JC, Rana N, Dmowski WP. 2007. Quantitative expression of apoptosis-regulating genes in endometrium from women with and without endometriosis. Fertil Steril 87:263-268.
5. Chen C, Wei T, Gao Z, Zhao B, Hou J, Xu H, Xin W, Packer L. 1999. Different effects of the constituents of EGb761 on apoptosis in rat cerebellar granule cells induced by hydroxyl radicals. Biochem Mol Biol Int 47:397-405.
6. Chen JW, Chen YH, Lin FY, Chen YL, Lin SJ. 2003. Ginkgo biloba extract inhibits tumor necrosis factor-α-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells. Arterioscler Thromb Vasc Biol 23:1559-1566.
7. Chopin P, Briley M. 1992. Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology (Berl) 106:26-30.
8. Ge Y, Belcher SM, Pierce DR, Light KE. 2004. Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9. Brain Res Mol Brain Res 129:124-134.
9. Gertz HJ, Kiefer M. 2004. Review about Ginkgo biloba extract EGb 761 (Ginkgo). Curr Pharm Des 10:261-264.
10. Guidetti C, Paracchini S, Lucchini S, Cambieri M, Marzatico F. 2001. Prevention of neuronal cell damage induced by oxidative stress invitro: Effect of different Ginkgo biloba extracts. J Pharm Pharmacol 53:387-392.
11. Kawamata T, Akiguchi I, Yagi H, Irino M, Sugiyama H, Akiyama H, Shimada A, Takemura M, Ueno M, Kitabayashi T, Ohnishi K, Seriu N, Higuchi K, Hosokawa M, Takeda T. 1997. Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory. Exp Gerontol 32:161-169.
12. Kobayashi K, Hayashi M, Nakano H, Shimazaki M, Sugimori K, Koshino Y. 2004. Correlation between astrocyte apoptosis and Alzheimer changes in gray matter lesions in Alzheimer's disease. J Alzheimers Dis 6:623-632; discussion 673-681.
13. Langley LK, Madden DJ. 2000. Functional neuroimaging of memory: Implications for cognitive aging. Microsc Res Tech 51:75-84.
14. Li ZG, Zhang W, Sima AA. 2003. C-peptide enhances insulin-mediated cell growth and protection against high glucose-induced apoptosis in SH-SY5Y cells. Diabetes Metab Res Rev 19:375-385.
15. Lu G, Wu Y, Mak YT, Wai SM, Feng ZT, Rudd JA, Yew DT. 2006. Molecular evidence of the neuroprotective effect of Ginkgo biloba (EGb761) using bax/bcl-2 ratio after brain ischemia in senescence-accelerated mice, strain prone-8. Brain Res 1090:23-28.
16. Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, Khan I, Netzer WJ, Xu H, Butko P. 2002. Inhibition of amyloid-β aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci USA 99:12197-12202.
17. Mak YT, Chan WY, Lam WP, Yew DT. 2006. Immunohistological evidences of Ginkgo biloba extract altering Bax to Bcl-2 expression ratio in the hippocampus and motor cortex of senescence accelerated mice. Microsc Res Tech 69:601-605.
18. Manji HK, Moore GJ, Chen G. 2000. Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: A role for neurotrophic and neuroprotective effects in manic depressive illness. J Clin Psychiatry 61 (Suppl 9):82-96.
19. Mendlin A, Martin FJ, Rueter LE, Jacobs BL. 1996. Neuronal release of serotonin in the cerebellum of behaving rats: An in vivo microdialysis study. J Neurochem 67:617-622.
20. Miyamoto M. 1997. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10. Exp Gerontol 32:139-148.
21. Pardon MC, Hanoun N, Perez-Diaz F, Joubert C, Launay JM, Christen Y, Hamon M, Cohen-Salmon C. 2004. Long-term treatment with the antioxidant drug EGb 761 at senescence restored some neurobehavioral effects of chronic ultramild stress exposure seen in young mice. Neurobiol Aging 25:1067-1083.
22. Perianayagam MC, Balakrishnan VS, Guo D, Pereira BJ, Jaber BL. 2003. Quantification of Bax and Bcl2 in polymorphonuclear leukocytes from haemodialysis patients: Relation to hydrogen peroxide. Eur J Clin Invest 33:905-911.
23. Smith JV, Luo Y. 2004. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol 64:465-472.
24. Takeda T. 1999. Senescence-accelerated mouse (SAM): A biogerontological resource in aging research. Neurobiol Aging 20:105-110.
25. Veurink G, Liu D, Taddei K, Perry G, Smith MA, Robertson TA, Hone E, Groth DM, Atwood CS, Martins RN. 2003. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radic Biol Med 34:1070-1077.
26. Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. 2004. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci 24:10963-10973.
27. Warburton DM. 1993. Ginkgo biloba extract and cognitive decline. Br J Clin Pharmacol 36:137.
28. Williams B, Watanabe CM, Schultz PG, Rimbach G, Krucker T. 2004. Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability. Neurobiol Aging 25:955-962.
29. Yao ZX, Han Z, Drieu K, Papadopoulos V. 2004. Ginkgo biloba extract (Egb 761) inhibits β-amyloid production by lowering free cholesterol levels. J Nutr Biochem 15:749-756.
30. Zhang WR, Hayashi T, Kitagawa H, Sasaki C, Sakai K, Warita H, Wang JM, Shiro Y, Uchida M, Abe K. 2000. Protective effect of ginkgo extract on rat brain with transient middle cerebral artery occlusion. Neurol Res 22:517-521.