Effect of topical Ginkgo biloba extract on steroid-induced changes in the trabecular meshwork and intraocular pressure

Archives of Ophthalmology

Volumn 126, Issue 12, 2008, Pages 1700-1706

  Jia, Li Yun ^a   Sun, Ling ^a,b   Fan, Dorothy S P ^a   Lam, Dennis S C ^a,b   Pang, Chi Pui ^a,b   Yam, Gary H F ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Shantou University Medical College   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; DEXAMETHASONE; DEXAMETHASONE PLUS TOBRAMYCIN; FAS LIGAND; GINKGO BILOBA EXTRACT; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MYOCILIN; STEROID; CYTOSKELETON PROTEIN; EYE PROTEIN; GINKGO BILOBA EXTRACT 761; GLUCOCORTICOID; GLYCOPROTEIN; MESSENGER RNA; PLANT EXTRACT; TRABECULAR MESHWORK-INDUCED GLUCOCORTICOID RESPONSE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRESS; CONTROLLED STUDY; DRUG EFFECT; ENUCLEATION; EXTRACELLULAR FLUID; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RABBIT; TRABECULAR MESHWORK; TREATMENT DURATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED DISORDER; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GINKGO BILOBA; METABOLISM; PHYTOTHERAPY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; CYTOSKELETAL PROTEINS; DEXAMETHASONE; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GINKGO BILOBA; GLUCOCORTICOIDS; GLYCOPROTEINS; INTRAOCULAR PRESSURE; MALE; OCULAR HYPERTENSION; PHYTOTHERAPY; PLANT EXTRACTS; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRABECULAR MESHWORK; TRANSFECTION;

EID: 58149214539     PISSN: 00039950     EISSN: 15383601     Source Type: Journal    
DOI: 10.1001/archophthalmol.2008.512     Document Type: Article

References (56)

1. Goulding NJ, Euzger HS, Butt SK, Perretti M. Novel pathways for glucocorticoid effects on neutrophils in chronic inflammation. Inflamm Res. 1998;47(suppl 3):S158-S165.
2. Adcock IM, Caramori G. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol Cell Biol. 2001;79(4):376-384.
3. Wordinger RJ, Clark AF. Effects of glucocorticoids on the trabecular meshwork. Prog Retin Eye Res. 1999;18(5):629-667.
4. Ishibashi T, Takagi Y, Mori K, et al. cDNA microarray analysis of gene expression changes induced by dexamethasone in cultured human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2002;43(12):3691-3697.
5. Leung YF, Tam PO, Lee WS, et al. The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells. Mol Vis. 2003;9:425-439.
6. Tamm ER. Myocilin and glaucoma. Prog Retin Eye Res. 2002;21(4):395-428.
7. Lütjen-Drecoll E, Shimizu T, Rohrbach M, Rohen JW. Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes. Exp Eye Res. 1986;42(5):443-455.
8. Rohen JW, Lütjen-Drecoll E, Flügel C, Meyer M, Grierson I. Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma. Exp Eye Res. 1993;56(6):683-692.
9. Johnson D, Gottanka J, Flügel C, Hoffmann F, Futa R, Lütjen-Drecoll E. Ultra-structural changes in the trabecular meshwork of human eyes treated with corticosteroids. Arch Ophthalmol. 1997;115(3):375-383.
10. Ueda J, Wentz-Hunter K, Yue BY. Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes. Invest Ophthalmol Vis Sci. 2002;43(4):1068-1076.
11. Cracknell KP, Grierson I, Hogg P, Appleton P, Pfeiffer N. Latanoprost-induced iris darkening. Exp Eye Res. 2003;77(6):721-730.
12. Acott TS, Westcott M, Passo MS, van Buskirk EM. Trabecular meshwork glycosaminoglycans in human and cynomolgus monkey eye. Invest Ophthalmol Vis Sci. 1985;26(10):1320-1329.
13. Buller C, Johnson DH, Tschumper RC. Human trabecular meshwork phagocytosis. Invest Ophthalmol Vis Sci. 1990;31(10):2156-2163.
14. Lütjen-Drecoll E, May CA, Polansky JR, Johnson DH, Bloemendal H, Nguyen TD. Localization of the stress proteins alpha B-crystallin and trabecular meshwork inducible glucocorticoid response protein in normal and glaucomatous trabecular meshwork. Invest Ophthalmol Vis Sci. 1998;39(3):517-525.
15. Clark AF, Kawase K, English-Wright S, et al. Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues. Invest Ophthalmol Vis Sci. 2001;42(8):1769-1780.
16. Nguyen TD, Chen P, Huang WD, et al. Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells. J Biol Chem. 1998;273(11):6341-6350.
17. Shepard AR, Jacobson N, Fingert JH, et al. Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2001;42(13):3173-3181.
18. Yam GHF, Gaplovska-Kysela K, Zuber C, Roth J. Aggregated myocilin induces russell bodies and causes apoptosis. Am J Pathol. 2007;170(1):100-109.
19. Alvarado J, Murphy C, Juster R. Trabecular meshwork cellularity in primary openangle glaucoma and nonglaucomatous normals. Ophthalmology. 1984;91(6):564-579.
20. Tan JC, Peters DM, Kaufman PL. Recent developments in understanding the pathophysiology of elevated intraocular pressure. Curr Opin Ophthalmol. 2006;17(2):168-174.
21. Ritch R. Potential role for Ginkgo biloba extract in the treatment of glaucoma. Med Hypotheses. 2000;54(2):221-235.
22. Thiagarajan G, Chandani S, Rao SH, et al. Molecular and cellular assessment of gingko biloba extract as a possible ophthalmic drug. Exp Eye Res. 2002;75(4):421-430.
23. Ritch R. Complementary therapy for the treatment of glaucoma: a perspective. Ophthalmol Clin North Am. 2005;18(4):597-609.
24. Clostre F. Ginkgo biloba extract (EGb 761): state of knowledge in the dawn of the year 2000 [in French]. Ann Pharm Fr. 1999;57(suppl 1):1S8-1S88.
25. Kim SY, Kwak JS, Shin JP, Lee SH. The protection of the retina from ischemic injury by the free radical scavenger EGb 761 and zinc in the cat retina. Ophthalmologica. 1998;212(4):268-274.
26. Polansky JR, Weinreb RN, Baxter JD, Alvarado J. Human trabecular cells I: establishment in tissue culture and growth characteristics. Invest Ophthalmol Vis Sci. 1979;18(10):1043-1049.
27. Yam GHF, Gaplovska-Kysela K, Zuber C, Roth J. Sodium 4-phenylbutyrate acts as chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis. Invest Ophthalmol Vis Sci. 2007;48(4):1683-1690.
28. Yam GHF, Zuber Ch, Roth J. A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder. FASEB J. 2005;19(1):12-18.
29. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402-408.
30. Chen LW, Wang YQ, Wei LC, Shi M, Chan YS. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS Neurol Disord Drug Targets. 2007;6(4):273-281.
31. Takuma K, Hoshina Y, Arai S, et al. Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. Neuroscience. 2007;149(2):256-262.
32. Eckert A, Keil U, Kressmann S, et al. Effects of EGb761 Gingko biloba extract on mitochondrial functions and oxidative stress. Pharmacopsychiatry. 2003;36(suppl 1):S15-S23.
33. Sierpina VS, Wollschlaeger B, Blumenthal M. Ginkgo biloba. Am Fam Physician. 2003;68(5):923-926.
34. Zhou W, Chai H, Lin PH, et al. Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases. Cardiovasc Drug Rev. 2004;22(4):309-319.
35. Maurer K, Ihl R, Dierks T, Frolich L. Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type. J Psychiatr Res. 1997;31(6):645-655.
36. Le Bars PL, Katz MM, Berman N, et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia: North American EGb Study Group. JAMA. 1997;278(16):1327-1332.
37. Tang Y, Xu Y, Xiong S, et al. The effect of Ginkgo biloba extract on the expression of PKCalpha in the inflammatory cells and the level of IL-5 in inducedsputumof asthmatic patients. J Huazhong Univ Sci Technolog Med Sci. 2007;27(4):375-380.
38. Mozaffarieh M, Flammer J. A novel perspective on natural therapeutic approaches in glaucoma therapy. Expert Opin Emerg Drugs. 2007;12(2):195-198.
39. Paasche G, Gartner U, Germer A, Grosche J, Reichenbach A. Mitochondria of retinal Muller (glial) cells: the effects of aging and of application of free radical scavengers. Ophthalmic Res. 2000;32(5):229-236.
40. Chung HS, Harris A, Kristinsson JK, et al. Ginkgo biloba extract increases ocular blood flow velocity. J Ocul Pharmacol Ther. 1999;15(3):233-240.
41. Hirooka K, Tokuda M, Miyamoto O, et al. The Ginkgo biloba extract (EGb 761) provides a neuroprotective effect on retinal ganglion cells in a rat model of chronic glaucoma. Curr Eye Res. 2004;28(3):153-157.
42. Polansky JR, Fauss DJ, Chen P, et al. Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product. Ophthalmologica. 1997;211(3):126-139.
43. Tamm ER, Russell P, Epstein DL, Johnson DH, Piatigorsky J. Modulation of myocilin/TIGR expression in human trabecular meshwork. Invest Ophthalmol Vis Sci. 1999;40(11):2577-2582.
44. Borrás T. Gene expression in the trabecular meshwork and the influence of intraocular pressure. Prog Retin Eye Res. 2003;22(4):435-463.
45. Bartlett H, Eperjesi F. An ideal ocular nutritional supplement? Ophthalmic Physiol Opt. 2004;24(4):339-349.
46. Agarwal R, Talati M, Lambert W, et al. Fas-activated apoptosis and apoptosis mediators in human trabecular meshwork cells. Exp Eye Res. 1999;68(5):583-590.
47. Wentz-Hunter K, Shen X, Okazaki K, Tanihara H, Yue BY. Overexpression of myocilin in cultured human trabecular meshwork cells. Exp Cell Res. 2004;297(1):39-48.
48. Gu Y, Zeng S, Qiu P, Peng D, Yan G. Apoptosis of bovine trabecular meshwork cells induced by dexamethasone [in Chinese]. Zhonghua Yan Ke Za Zhi. 2002;38(5):302-304.
49. Chrysis D, Zaman F, Chagin AS, Takigawa M, Savendahl L. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3′-kinase signaling pathway. Endocrinology. 2005;146(3):1391-1397.
50. Tamm ER, Russell P, Johnson DH, Piatigorsky J. Human and monkey trabecular meshwork accumulate alpha B-crystallin in response to heat shock and oxidative stress. Invest Ophthalmol Vis Sci. 1996;37(12):2402-2413.
51. Ganea E. Chaperone-like activity of alpha-crystallin and other small heat-shock proteins. Curr Protein Pept Sci. 2001;2(3):205-225.
52. Young JC, Agashe VR, Siegers K, Hartl FU. Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol. 2004;5(10):781-791.
53. Haq F, Mahoney M, Koropatnich J. Signaling events for metallothionein induction. Mutat Res. 2003;533(1-2):211-226.
54. Maier CM, Chan PH. Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist. 2002;8(4):323-334.
55. Sastre J, Lloret A, Borras C, et al. Ginkgo biloba extract EGb761 protects against mitochondrial aging in the brain and in the liver. Cell Mol Biol (Noisy-le-grand). 2002;48(6):685-692.
56. Shirato S, Murphy CG, Bloom E, et al. Kinetics of phagocytosis in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1989;30(12):2499-2511.