Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: A randomized clinical trial

Blood Coagulation and Fibrinolysis

Volumn 18, Issue 8, 2007, Pages 787-793

  Gardner, Christopher D ^a   Zehnder, James L ^a   Rigby, Alison J ^a   Nicholus, Joel R ^a   Farquhar, John W ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aspirin; Bleeding; Bruising; Ginkgo biloba; Platelet aggregation; Platelet function analysis

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; COLLAGEN; GINKGO BILOBA EXTRACT; PLACEBO; RISTOCETIN;

ADULT; AGED; ANALYZER; ARTERY DISEASE; ARTICLE; BLEEDING; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG WITHDRAWAL; EPISTAXIS; FEMALE; GASTROINTESTINAL SYMPTOM; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BRUISING; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; TREATMENT DURATION; TREATMENT OUTCOME; WALKING;

AGED; ASPIRIN; BLOOD PLATELETS; CARDIOVASCULAR AGENTS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; PERIPHERAL VASCULAR DISEASES; PLANT EXTRACTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS;

EID: 35848932988     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e3282f102b1     Document Type: Article

References (33)

1. Kelly JP, Kaufman DW, Kelley K, Rosenberg L, Anderson TE, Mitchell AA. Recent trends in use of herbal and other natural products. Arch Intern Med 2005; 165:281-286.
2. Laird SA, ten Kate K. The botanical medicine industry. The commercial use of biodiversity: access to genetic resources and benefit sharing. London: Earthscan; 1999.
3. Diamond BJ, Shiflett SC, Feiwel N, Matheis RJ, Noskin O, Richards JA, Schoenberger NE. Ginkgo biloba extract: mechanisms and clinical indications. Arch Phys Med Rehabil 2000; 81:668-678.
4. Pittler MH, Ernst E. Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials. Am J Med 2000; 108:276-281.
5. Sierpina VS, Wollschlaeger B, Blumenthal M. Ginkgo biloba. Am Fam Physician 2003; 68:923-926.
6. Mehlsen J, Drabaek H, Wiinberg N, Winther K. Effects of a Ginkgo biloba extract on forearm haemodynamics in healthy volunteers. Clin Physiol Funct Imaging 2002; 22:375-378.
7. Liebgott T, Miollan M, Berchadsky Y, Drieu K, Culcasi M, Pietri S. Complementary cardioprotective effects of flavonoid metabolites and terpenoid constituents of Ginkgo biloba extract (EGb 761) during ischemia and reperfusion. Basic Res Cardiol 2000; 95:368-377.
8. Kubota Y, Tanaka N, Umegaki K, Takenaka H, Mizuno H, Nakamura K, et al. Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level. Life Sci 2001; 69:2327-2336.
9. Akiba S, Kawauchi T, Oka T, Hashizume T, Sato T. Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation. Biochem Mol Biol Int 1998; 46:1243-1248.
10. Chung KF, Dent G, McCusker M, Guinot P, Page CP, Barnes PJ. Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet 1987; 1:248-251.
11. Guinot P, Caffrey E, Lambe R, Darragh A. Tanakan inhibits platelet-activating-factor-induced platelet aggregation in healthy male volunteers. Haemostasis 1989; 19:219-223.
12. Kudolo GB, Dorsey S, Blodgett J. Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and type 2 diabetic subjects. Thromb Res 2002; 108:151-160.
13. Bal Dit Sollier C, Caplain H, Drouet L. No alteration in platelet function or coagulation induced by EGb761 in a controlled study. Clin Lab Haematol 2003; 25:251-253.
14. Braquet P. Cedemin, a Ginkgo biloba extract, should not be considered as a PAF antagonist [response]. Am J Gastroenterol 1993; 88:2138.
15. Koch E. Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 2005; 12:10-16.
16. Kohler S, Funk P, Kieser M. Influence of a 7-day treatment with Ginkgo biloba special extract EGb 761 on bleeding time and coagulation: a randomized, placebo-controlled, double-blind study in healthy volunteers. Blood Coagul Fibrinolysis 2004; 15:303-309.
17. Le Bars PL, Kastelan J. Efficacy and safety of a Ginkgo biloba extract. Public Health Nutr 2000; 3:495-499.
18. Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996; 46:1775-1776.
19. Vale S. Subarachnoid haemorrhage associated with Ginkgo biloba [case report]. Lancet 1998; 352:36.
20. Benjamin J, Muir T, Briggs K, Pentland B. A case of cerebral haemorrhage - can Ginkgo biloba be implicated? Postgrad Med J 2001; 77:112-113.
21. Gilbert GJ. Ginkgo biloba [letter]. Neurology 1997; 48:1137.
22. Matthews MK Jr. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology 1998; 50:1933-1934.
23. Miller LG, Freeman B. Possible subdural hematoma associated with Ginkgo biloba. J Herb Pharmacother 2002; 2:57-63.
24. Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract [letter]. N Engl J Med 1997; 336:1108.
25. Fessenden JM, Wittenborn W, Clarke L. Gingko biloba: a case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy. Am Surg 2001; 67:33-35.
26. Hauser D, Gayowski T, Singh N. Bleeding complications precipitated by unrecognized Gingko biloba use after liver transplantation. Transpl Int 2002; 15:377-379.
27. Norred CL, Finlayson CA. Hemorrhage after the preoperative use of complementary and alternative medicines. Am Assoc Nurse Anesth J 2000; 68:217-220.
28. Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA 1997; 278:1327-1332.
29. Hiatt WR. Medical treatment of peripheral arterial disease and claudication. N Engl J Med 2001; 344:1608-1621.
30. World Medical Association Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA 1997; 277:925-926.
31. Maitra I, Marcocci L, Droy-Lefaix MT, Packer L. Peroxyl radical scavenging activity of Ginkgo biloba extract EGb 761. Biochem Pharmacol 1995; 49:1649-1655.
32. Braquet P. The ginkgolides: potent platelet-activating factor antagonists isolated from Gb L - chemistry, pharmacology and clinical applications. Drugs Future 1987; 12:643-699.
33. Kressmann S, Biber A, Wonnemann M, Schug B, Blume HH, Muller WE. Influence of pharmaceutical quality on the bioavailability of active components from Ginkgo biloba preparations. J Pharm Pharmacol 2002; 54:1507-1514.