Inhibitory mechanism of Ginkgo biloba extract, Captopril, and Valsartan on kidney fibrosis of diabetic nephropathy rats and their comparison

Chinese Traditional and Herbal Drugs

Volumn 39, Issue 4, 2008, Pages 560-565

  Liu, Xiao ^a   Wang, Jian Yun ^a   Lu, Qian ^a   Dong, Bing Zheng ^a   Yin, Xiao Xing ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Captopril; Combination of medication; Diabetic nephropathy (DN); Ginkgo biloba extracts (GBE); Kidney fibrosis; Valsartan

Indexed keywords

CAPTOPRIL; CARBOXYMETHYLCELLULOSE; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE A; GINKGO BILOBA EXTRACT; LAMININ; MESSENGER RNA; STREPTOZOCIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1; VALSARTAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG EFFICACY; EXTRACELLULAR MATRIX; GLOMERULUS BASEMENT MEMBRANE; IMMUNOHISTOCHEMISTRY; KIDNEY CORTEX; KIDNEY FIBROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RADIOIMMUNOASSAY; RANDOMIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; THICKNESS; TRANSMISSION ELECTRON MICROSCOPY;

EID: 45149102175     PISSN: 02532670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Sharma K, McGowan T A. TGF-beta in diabetic kidney disease: role of novel signaling pathways [J]. Cytokine Growth Factor Rev, 2000, 11: 115-123.
2. Sakharova O V, Taal M W, Brenner B M. Pathogenesis of diabetic nephropathy: focus on transforming growth factor-beta and connective tissue growth factor [J]. Curr Opin Nephrol Hypertens, 2001, 10: 727-738.
3. Lam S, van der Geest R N, Verhagen N A, et al. Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose [J]. Diabetes, 2003, 52: 2975-2983.
4. Woessner J F. Matrix metalloproteinases and their inhibitors in connective tissue remodeling [J]. FASEB J, 1991, 5: 2145-2154.
5. Akisu M, Kultursay N, Coker I, et al. Flunarizine and Ginkgo biloba extract reduce PAF concentration in the brain [J]. Biol Neonate, 1998, 74: 439-444.
6. Haines D D, Bak L, Ferdinandy P, et al. Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGB761, in isolated ischemic/reperfused rat hears [J]. J Cardioyasc Pharmacol, 2000, 35: 37-44.
7. Okada H, Watanabe Y, Kikuta T, et al. Bradykinin decreases plasminogen activitor inhibitor-1 expression and facilitates matrix degradation in the renal tubulointerstitium under angiotensin-converting enzyme blockade [J]. J Am Soc Nephrol, 2004, 15: 2404-2413.
8. Chinese source.
9. Chinese source.
10. Chinese source.
11. Wang J Y, Yin X X, Wu Y M, et al. Ginkgo biloba extract suppresses hypertrophy and extracellular matrix accumulation in rat mesangial cells [J]. Acta Pharmacol Sin, 2006, 27 (9): 1222-1230.
12. Chinese source.
13. Wahab N A, Weston B S, Mason R M. Modulation of the TGF-beta/Smad signaling pathway in mesangial cells by CT-GF/CCN2 [J]. Exp Cell Res, 2005, 307(2): 305-314.
14. Ruperez M, Ruiz-Ortega M, Esteban V, et al. Angiotensin II increases connective tissue growth factor in the kidney [J]. Am J Pathol, 2003, 163: 1937-1947.
15. Chinese source.
16. Chinese source.
17. Yu L, Border W A, Anderson I, et al. Combining TGF-beta inhibition and angiotensin II blockade results in endanced antifibrotic effect [J]. Kidney Int, 2004, 66: 1774-1784.