-
1
-
-
0037398134
-
Historical perspective: Visceral obesity and related comorbidity in Joannes Baptista Morgagni's 'De sedibus et causis morborum per anatomen indagata'
-
Enzi, G., Busetto, L., Inelmen, E.M., Coin, A., and Sergi, G. 2003. Historical perspective: visceral obesity and related comorbidity in Joannes Baptista Morgagni's 'De sedibus et causis morborum per anatomen indagata.' Int. J. Obes. Relat. Metab. Disord. 27:534-535.
-
(2003)
Int. J. Obes. Relat. Metab. Disord.
, vol.27
, pp. 534-535
-
-
Enzi, G.1
Busetto, L.2
Inelmen, E.M.3
Coin, A.4
Sergi, G.5
-
2
-
-
50349109266
-
The mechanism of diabetes mellitus. III. Human diabetes mellitus
-
Himsworth, H. 1939. The mechanism of diabetes mellitus. III. Human diabetes mellitus. Lancet. 2:171-175.
-
(1939)
Lancet
, vol.2
, pp. 171-175
-
-
Himsworth, H.1
-
3
-
-
33745488817
-
Serum triglycerides in coronary artery disease
-
Albrink, M.J., and Mann, E.B. 1958. Serum triglycerides in coronary artery disease. Trans. Assoc. Am. Physicians. 71:162-173.
-
(1958)
Trans. Assoc. Am. Physicians
, vol.71
, pp. 162-173
-
-
Albrink, M.J.1
Mann, E.B.2
-
4
-
-
0000380542
-
Immunoassay of endogenous plasma insulin in man
-
Yalow, R.S., and Berson, S.A. 1960. Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39:1157-1175.
-
(1960)
J. Clin. Invest.
, vol.39
, pp. 1157-1175
-
-
Yalow, R.S.1
Berson, S.A.2
-
5
-
-
0006773319
-
Carbohydrate intolerance and hyperlipemia in patients with myocardial infarction without known diabetes mellitus
-
Reaven, G., Calciano, A., Cody, R., Lucas, C., and Miller, R. 1963. Carbohydrate intolerance and hyperlipemia in patients with myocardial infarction without known diabetes mellitus. J. Clin. Endocrinol. Metab. 23:1013-1023.
-
(1963)
J. Clin. Endocrinol. Metab.
, vol.23
, pp. 1013-1023
-
-
Reaven, G.1
Calciano, A.2
Cody, R.3
Lucas, C.4
Miller, R.5
-
6
-
-
0024160877
-
Banting lecture 1988. Role of insulin resistance in human disease
-
Reaven, G.M. 1988. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 37:1595-1607.
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
7
-
-
0037407403
-
NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older
-
Alexander, C.M., Landsman, P.B., Teutsch, S.M., and Haffner, S.M. 2003. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes. 52:1210-1214.
-
(2003)
Diabetes
, vol.52
, pp. 1210-1214
-
-
Alexander, C.M.1
Landsman, P.B.2
Teutsch, S.M.3
Haffner, S.M.4
-
8
-
-
4444222221
-
Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
-
Malik, S., et al. 2004. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation. 110:1245-1250.
-
(2004)
Circulation
, vol.110
, pp. 1245-1250
-
-
Malik, S.1
-
9
-
-
8744297386
-
Desnutrin, an adipocyte gene encoding a novel patratin domain-containing protein, is induced by fasting and glucocorticoids: Ectopic expression of desnutrin increases triglyceride hydrolysis
-
Villena, J.A., Roy, S., Sarkadi-Nagy, E., Kim, K.H., and Sul, H.S. 2004. Desnutrin, an adipocyte gene encoding a novel patratin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J. Biol. Chem. 279:47066-47075.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47066-47075
-
-
Villena, J.A.1
Roy, S.2
Sarkadi-Nagy, E.3
Kim, K.H.4
Sul, H.S.5
-
10
-
-
0026721574
-
Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus
-
Foley, J.E. 1992. Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus. Diabetes Care. 15:773-784.
-
(1992)
Diabetes Care
, vol.15
, pp. 773-784
-
-
Foley, J.E.1
-
11
-
-
32544443164
-
Review: Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia
-
Ginsberg, H.N. 2006. Review: efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia. J. Clin. Endocrinol. Metab. 91:383-392.
-
(2006)
J. Clin. Endocrinol. Metab.
, vol.91
, pp. 383-392
-
-
Ginsberg, H.N.1
-
12
-
-
4143058119
-
The triglyceride-high-density lipoprotein axis: An important target of therapy?
-
Szapary, P.O., and Rader, D.J. 2004. The triglyceride-high-density lipoprotein axis: an important target of therapy? Am. Heart J. 148:211-221.
-
(2004)
Am. Heart J.
, vol.148
, pp. 211-221
-
-
Szapary, P.O.1
Rader, D.J.2
-
13
-
-
0033842027
-
Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
-
Cavaghan, M.K., Ehrmann, D.A., and Polonsky, K.S. 2000. Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J. Clin. Invest. 106:329-333.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 329-333
-
-
Cavaghan, M.K.1
Ehrmann, D.A.2
Polonsky, K.S.3
-
14
-
-
0032902850
-
The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years
-
Coutinho, M., Gerstein, H.C., Wang, Y., and Yusuf, S. 1999. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care. 22:233-240.
-
(1999)
Diabetes Care
, vol.22
, pp. 233-240
-
-
Coutinho, M.1
Gerstein, H.C.2
Wang, Y.3
Yusuf, S.4
-
15
-
-
4644336398
-
Association of hemoglobin A1c with cardiovascular disease and mortality in adults: The European prospective investigation into cancer in Norfolk
-
Khaw, K.T., et al. 2004. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann. Intern. Med. 141:413-420.
-
(2004)
Ann. Intern. Med.
, vol.141
, pp. 413-420
-
-
Khaw, K.T.1
-
16
-
-
0028988890
-
Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension
-
Grekin, R.J., Vollmer, A.P., and Sider, R.S. 1995. Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension. Hypertension. 26:193-198.
-
(1995)
Hypertension
, vol.26
, pp. 193-198
-
-
Grekin, R.J.1
Vollmer, A.P.2
Sider, R.S.3
-
17
-
-
29244456775
-
Hypertension and the metabolic syndrome
-
Morse, S.A., Zhang, R., Thakur, V., and Reisin, E. 2005. Hypertension and the metabolic syndrome. Am. J. Med. Sci. 330:303-310.
-
(2005)
Am. J. Med. Sci.
, vol.330
, pp. 303-310
-
-
Morse, S.A.1
Zhang, R.2
Thakur, V.3
Reisin, E.4
-
18
-
-
0036078412
-
Respiratory uncoupling lowers blood pressure through a leptindependent mechanism in genetically obese mice
-
Bernal-Mizrachi, C., et al. 2002. Respiratory uncoupling lowers blood pressure through a leptindependent mechanism in genetically obese mice. Arterioscler. Thromb. Vasc. Biol. 22:961-968.
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 961-968
-
-
Bernal-Mizrachi, C.1
-
19
-
-
0031710787
-
Prevalence of insulin resistance in metabolic disorders: The Bruneck Study
-
Bonora, E., et al. 1998. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes. 47:1643-1649.
-
(1998)
Diabetes
, vol.47
, pp. 1643-1649
-
-
Bonora, E.1
-
20
-
-
0037031061
-
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomized placebo-controlled trial
-
Heart Protection Study Collaborative Group. 2002. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trial. Lancet. 360:7-22.
-
(2002)
Lancet
, vol.360
, pp. 7-22
-
-
-
21
-
-
0037840242
-
MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5,963 people with diabetes: A randomised placebo-controlled trial
-
Collins, R., Armitage, J., Parish, S., Sleigh, P., and Peto, R. 2003. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5,963 people with diabetes: a randomised placebo-controlled trial. Lancet. 361:2005-2016.
-
(2003)
Lancet
, vol.361
, pp. 2005-2016
-
-
Collins, R.1
Armitage, J.2
Parish, S.3
Sleigh, P.4
Peto, R.5
-
22
-
-
4344683381
-
Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomized placebo-controlled trial
-
Colhoun, H.M., et al. 2004. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomized placebo-controlled trial. Lancet. 364:685-696.
-
(2004)
Lancet
, vol.364
, pp. 685-696
-
-
Colhoun, H.M.1
-
23
-
-
10744228379
-
Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose
-
Keech, A., et al. 2003. Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose. Diabetes Care. 26:2713-2721.
-
(2003)
Diabetes Care
, vol.26
, pp. 2713-2721
-
-
Keech, A.1
-
24
-
-
0034688194
-
Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
-
Yusuf, S., et al. 2000. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N. Engl. J. Med. 342:145-153.
-
(2000)
N. Engl. J. Med.
, vol.342
, pp. 145-153
-
-
Yusuf, S.1
-
25
-
-
0033034404
-
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: The Captopril Prevention Project (CAPP) randomized trial
-
Hansson, L., et al. 1999. Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPP) randomized trial. Lancet. 353:611-616.
-
(1999)
Lancet
, vol.353
, pp. 611-616
-
-
Hansson, L.1
-
26
-
-
0037160969
-
Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): A randomized trial against atenolol
-
Lindholm, L.H., et al. 2002. Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. Lancet. 359:1004-1010.
-
(2002)
Lancet
, vol.359
, pp. 1004-1010
-
-
Lindholm, L.H.1
-
27
-
-
0018947555
-
Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population
-
Ducimetiere, P., et al. 1980. Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population. Diabetologia. 19:205-210.
-
(1980)
Diabetologia
, vol.19
, pp. 205-210
-
-
Ducimetiere, P.1
-
28
-
-
0018775947
-
Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: Results from two population studies in Finland
-
Pyorala, K. 1979. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes. 2:131-141.
-
(1979)
Diabetes
, vol.2
, pp. 131-141
-
-
Pyorala, K.1
-
29
-
-
0028273371
-
Insulin as a predictor of coronary heart disease: Interaction with apolipoprotein E phenotype. A report from the Multiple Risk Factor Intervention Trial
-
Orchard, T.J., et al. 1994. Insulin as a predictor of coronary heart disease: interaction with apolipoprotein E phenotype. A report from the Multiple Risk Factor Intervention Trial. Ann. Epidemiol. 4:40-45.
-
(1994)
Ann. Epidemiol.
, vol.4
, pp. 40-45
-
-
Orchard, T.J.1
-
30
-
-
0029102130
-
Is insulin really a heart disease risk factor?
-
Wingard, D.L., Barrett-Connor, E.L., and Ferrara, A. 1995. Is insulin really a heart disease risk factor? Diabetes Care. 18:1299-1304.
-
(1995)
Diabetes Care
, vol.18
, pp. 1299-1304
-
-
Wingard, D.L.1
Barrett-Connor, E.L.2
Ferrara, A.3
-
31
-
-
0343209773
-
Insulin sensitivity and atherosclerosis
-
The Insulin Resistance Atherosclerosis Study (IRAS) Investigators
-
Howard, G., et al. 1996. Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Circulation. 93:1809-1817.
-
(1996)
Circulation
, vol.93
, pp. 1809-1817
-
-
Howard, G.1
-
32
-
-
24144484876
-
The metabolic syndrome: Time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
-
Kahn, R., Buse, J., Ferrannini, E., and Stern, M. 2005. The metabolic syndrome: time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 28:2289-2304.
-
(2005)
Diabetes Care
, vol.28
, pp. 2289-2304
-
-
Kahn, R.1
Buse, J.2
Ferrannini, E.3
Stern, M.4
-
33
-
-
12844262139
-
The metabolic syndrome and 11-year risk of incident cardiovascular disease in the Atherosclerosis Risk in Communities study
-
McNeill, A.M., et al. 2005. The metabolic syndrome and 11-year risk of incident cardiovascular disease in the Atherosclerosis Risk in Communities study. Diabetes Care. 28:385-390.
-
(2005)
Diabetes Care
, vol.28
, pp. 385-390
-
-
McNeill, A.M.1
-
34
-
-
28944434431
-
Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus
-
Wannamethee, S.G., Shaper, A.G., Lennon, L., and Morris, R.W. 2005. Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus. Arch. Intern. Med. 165:2644-2650.
-
(2005)
Arch. Intern. Med.
, vol.165
, pp. 2644-2650
-
-
Wannamethee, S.G.1
Shaper, A.G.2
Lennon, L.3
Morris, R.W.4
-
35
-
-
18044376795
-
PPARs: Therapeutic targets for metabolic disease
-
Berger, J.P., Akiyama, T.E., and Meinke, P.T. 2005. PPARs: therapeutic targets for metabolic disease. Trends Pharmacol. Sci. 26:244-251.
-
(2005)
Trends Pharmacol. Sci.
, vol.26
, pp. 244-251
-
-
Berger, J.P.1
Akiyama, T.E.2
Meinke, P.T.3
-
36
-
-
0034595980
-
Peroxisome proliferative-activated receptor alpha activators improve insulin sensitivity and reduce adiposity
-
Guerre-Millo, M., et al. 2000. Peroxisome proliferative-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J. Biol. Chem. 275:16638-16642.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16638-16642
-
-
Guerre-Millo, M.1
-
37
-
-
0037025390
-
WY14,643, a peroxisome proliferative-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-Zip/F-1 mice
-
Chou, C.J., et al. 2002. WY14,643, a peroxisome proliferative-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-Zip/F-1 mice. J. Biol. Chem. 277:24484-24489.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 24484-24489
-
-
Chou, C.J.1
-
38
-
-
2242436246
-
Reduction of atherosclerosis by the peroxisome proliferative-activated receptor alpha agonist fenofibrate in mice
-
Duez, H., et al. 2002. Reduction of atherosclerosis by the peroxisome proliferative-activated receptor alpha agonist fenofibrate in mice. J. Biol. Chem. 277:48051-48057.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48051-48057
-
-
Duez, H.1
-
39
-
-
2442660528
-
Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease
-
Tenenbaum, A., et al. 2004. Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease. Circulation. 109:2197-2202.
-
(2004)
Circulation
, vol.109
, pp. 2197-2202
-
-
Tenenbaum, A.1
-
40
-
-
0033864582
-
Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
-
Li, A.C., et al. 2000. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. 106:523-531.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 523-531
-
-
Li, A.C.1
-
41
-
-
85047693466
-
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ
-
doi:10.1172/JCI200418730
-
Li, A.C., et al. 2004. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ. J. Clin. Invest. 114:1564-1576. doi:10.1172/JCI200418730.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1564-1576
-
-
Li, A.C.1
-
42
-
-
24144476576
-
PPARα, but not PPARγ, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia
-
Hennuyer, N., et al. 2005. PPARα, but not PPARγ, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia. Arterioscler. Thromb. Vasc. Biol. 25:1897-1902.
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 1897-1902
-
-
Hennuyer, N.1
-
43
-
-
0018117095
-
A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators
-
[Anonymous]. 1978. A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators. Br. Heart J. 40:1069-1118.
-
(1978)
Br. Heart J.
, vol.40
, pp. 1069-1118
-
-
-
44
-
-
0018838168
-
W.H.O. cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: Mortality follow-up. Report of the committee of principal investigators
-
Oliver, M.F., Heady, J.A., Morris, J.N., and Cooper, J. 1980. W.H.O. cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow-up. Report of the committee of principal investigators. Lancet. 316:379-385.
-
(1980)
Lancet
, vol.316
, pp. 379-385
-
-
Oliver, M.F.1
Heady, J.A.2
Morris, J.N.3
Cooper, J.4
-
45
-
-
84920245150
-
W.H.O. cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: Final mortality follow-up. Report of the committee of principal investigators
-
Oliver, M.F., Heady, J.A., Morris, J.N., and Cooper, J. 1984. W.H.O. cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report of the committee of principal investigators. Lancet. 324:600-604.
-
(1984)
Lancet
, vol.324
, pp. 600-604
-
-
Oliver, M.F.1
Heady, J.A.2
Morris, J.N.3
Cooper, J.4
-
46
-
-
0023232216
-
Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middleaged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
-
Frick, M.H., et al. 1987. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middleaged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N. Engl. J. Med. 317:1237-1245.
-
(1987)
N. Engl. J. Med.
, vol.317
, pp. 1237-1245
-
-
Frick, M.H.1
-
47
-
-
0033527030
-
Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol
-
Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
-
Rubins, H.B., et al. 1999. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N. Engl. J. Med. 341:410-418.
-
(1999)
N. Engl. J. Med.
, vol.341
, pp. 410-418
-
-
Rubins, H.B.1
-
48
-
-
0034604225
-
Secondary Prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. The Bezafibrate Infarction Prevention (BIP) study
-
The BIP Study Group. 2000. Secondary Prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. The Bezafibrate Infarction Prevention (BIP) study. Circulation. 102:21-27.
-
(2000)
Circulation
, vol.102
, pp. 21-27
-
-
-
49
-
-
28044452217
-
Effects of long-term fenofibrate therapy on cardiovascular events in 9,795 people with type 2 diabetes mellitus (the FIELD study): Randomised clinical trial
-
The FIELD study investigators. 2005. Effects of long-term fenofibrate therapy on cardiovascular events in 9,795 people with type 2 diabetes mellitus (the FIELD study): randomised clinical trial. Lancet. 366:1849-1861.
-
(2005)
Lancet
, vol.366
, pp. 1849-1861
-
-
-
50
-
-
26244453309
-
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial in macroVascular Events): A randomised controlled trial
-
Dormandy, J.A., et al. 2005. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet. 366:1279-1289.
-
(2005)
Lancet
, vol.366
, pp. 1279-1289
-
-
Dormandy, J.A.1
-
51
-
-
21544479710
-
Collecting duct specific deletion of peroxisome proliferator-activated receptor blocks thiazolidinedione-induced fluid retention
-
Zhang, H., et al. 2005. Collecting duct specific deletion of peroxisome proliferator-activated receptor blocks thiazolidinedione-induced fluid retention. Proc. Natl. Acad. Sci. U. S. A. 102:9406-9411.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 9406-9411
-
-
Zhang, H.1
-
52
-
-
23844472901
-
Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption
-
Guan, Y., et al. 2005. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat. Med. 11:861-866.
-
(2005)
Nat. Med.
, vol.11
, pp. 861-866
-
-
Guan, Y.1
-
53
-
-
23844461797
-
TZDs and diabetes: Testing the waters
-
Semenkovich, C.F. 2005. TZDs and diabetes: testing the waters. Nat. Med. 11:822-824.
-
(2005)
Nat. Med.
, vol.11
, pp. 822-824
-
-
Semenkovich, C.F.1
-
54
-
-
28144451163
-
Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus
-
Nissen, S.E., Wolski, K., and Topol, E.J. 2005. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA. 294:2581-2586.
-
(2005)
JAMA
, vol.294
, pp. 2581-2586
-
-
Nissen, S.E.1
Wolski, K.2
Topol, E.J.3
-
55
-
-
0032511566
-
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
-
UK Prospective Diabetes Study (UKPDS) Group. 1998. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 352:854-865.
-
(1998)
Lancet
, vol.352
, pp. 854-865
-
-
-
56
-
-
32644441249
-
Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients. RIO-North America: A randomized controlled trial
-
Pi-Sunyer, F.X., et al. 2006. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients. RIO-North America: a randomized controlled trial. JAMA. 295:761-775.
-
(2006)
JAMA
, vol.295
, pp. 761-775
-
-
Pi-Sunyer, F.X.1
-
57
-
-
0031861372
-
Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors
-
MacLennan, S.J., Reynen, P.H., Kwan, J., and Bonhaus, D.W. 1998. Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors. Br. J. Pharmacol. 124:619-622.
-
(1998)
Br. J. Pharmacol.
, vol.124
, pp. 619-622
-
-
MacLennan, S.J.1
Reynen, P.H.2
Kwan, J.3
Bonhaus, D.W.4
-
58
-
-
17144400758
-
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
-
Steffens, S., et al. 2005. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature. 434:782-786.
-
(2005)
Nature
, vol.434
, pp. 782-786
-
-
Steffens, S.1
-
59
-
-
0033559691
-
MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B
-
Gosling, J., et al. 1999. MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. J. Clin. Invest. 103:773-778.
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 773-778
-
-
Gosling, J.1
-
60
-
-
0032572719
-
Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
-
Boring, L., Gosling, J., Cleary, M., and Charo, I.F. 1998. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 394:894-897.
-
(1998)
Nature
, vol.394
, pp. 894-897
-
-
Boring, L.1
Gosling, J.2
Cleary, M.3
Charo, I.F.4
-
61
-
-
0029079926
-
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
-
Smith, J.D., et al. 1995. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc. Natl. Acad. Sci. U. S. A. 92:8264-8268.
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 8264-8268
-
-
Smith, J.D.1
-
62
-
-
17644424349
-
Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/- mice
-
Haj, F.G., Zabolotny, J.M., Kim, Y.B., Kahn, B.B., and Neel, B.G. 2005. Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/- mice. J. Biol. Chem. 280:15038-15046.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 15038-15046
-
-
Haj, F.G.1
Zabolotny, J.M.2
Kim, Y.B.3
Kahn, B.B.4
Neel, B.G.5
-
63
-
-
33644504478
-
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling
-
Heinonen, K.M., Dube, N., Bourdeau, A., Lapp, W.S., and Tremblay, M.L. 2006. Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc. Natl. Acad. Sci. U. S. A. 103:2776-2781.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 2776-2781
-
-
Heinonen, K.M.1
Dube, N.2
Bourdeau, A.3
Lapp, W.S.4
Tremblay, M.L.5
-
64
-
-
0028808236
-
Altered thyroid function in non-thyroidal illness and surgery. to treat or not to treat?
-
Utiger, R.D. 1995. Altered thyroid function in non-thyroidal illness and surgery. To treat or not to treat? N. Engl. J. Med. 333:1562-1563.
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 1562-1563
-
-
Utiger, R.D.1
-
65
-
-
0022576606
-
Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration
-
Brent, G.A., and Hershman, J.M. 1986. Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration. J. Clin. Endocrinol. Metab. 63:1-8.
-
(1986)
J. Clin. Endocrinol. Metab.
, vol.63
, pp. 1-8
-
-
Brent, G.A.1
Hershman, J.M.2
-
66
-
-
0018415335
-
Effect of triiodothyronine replacement on the metabolic and pituitary responses to starvation
-
Gardner, D.F., Kaplan, M.M., Stanley, C.A., and Utiger, R.D. 1979. Effect of triiodothyronine replacement on the metabolic and pituitary responses to starvation. N. Engl. J. Med. 300:579-584.
-
(1979)
N. Engl. J. Med.
, vol.300
, pp. 579-584
-
-
Gardner, D.F.1
Kaplan, M.M.2
Stanley, C.A.3
Utiger, R.D.4
-
67
-
-
0028587742
-
Tumor necrosis factor alpha: A key component of the obesity-diabetes link
-
Hotamisligil, G.S., and Spiegelman, B.M. 1994. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes. 43:1271-1278.
-
(1994)
Diabetes
, vol.43
, pp. 1271-1278
-
-
Hotamisligil, G.S.1
Spiegelman, B.M.2
-
68
-
-
0029955427
-
Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55
-
Schreyer, S.A., Peschon, J.J., and LeBoeuf, R.C. 1996. Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55. J. Biol. Chem. 271:26174-26178.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 26174-26178
-
-
Schreyer, S.A.1
Peschon, J.J.2
LeBoeuf, R.C.3
-
69
-
-
33644746231
-
TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells
-
Gerbod-Giannone, M.-C., et al. 2006. TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells. Proc. Natl. Acad. Sci. U. S. A. 103:3112-3117.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 3112-3117
-
-
Gerbod-Giannone, M.-C.1
-
70
-
-
0346727295
-
Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
-
doi:10.1172/JCI200318580
-
Kanters, E., et al. 2003. Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. 112:1176-1185. doi:10.1172/JCI200318580.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1176-1185
-
-
Kanters, E.1
-
71
-
-
0036796875
-
Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
-
Evans, J.L., Goldfine, I.D., Maddux, B.A., and Grodsky, G.M. 2002. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 23:599-622.
-
(2002)
Endocr. Rev.
, vol.23
, pp. 599-622
-
-
Evans, J.L.1
Goldfine, I.D.2
Maddux, B.A.3
Grodsky, G.M.4
-
72
-
-
0037166236
-
Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes
-
Ugi, S., Sharma, P.M., Ricketts, W., Imamura, T., and Olefsky, J.M. 2002. Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes. J. Biol. Chem. 277:18592-18597.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18592-18597
-
-
Ugi, S.1
Sharma, P.M.2
Ricketts, W.3
Imamura, T.4
Olefsky, J.M.5
-
73
-
-
3843092569
-
Protein-tyrosine phosphatase 1B associates with insulin receptor and negatively regulates insulin signaling without receptor internalization
-
Shi, K., et al. 2004. Protein-tyrosine phosphatase 1B associates with insulin receptor and negatively regulates insulin signaling without receptor internalization. J. Biochem. (Tokyo). 136:89-96.
-
(2004)
J. Biochem. (Tokyo)
, vol.136
, pp. 89-96
-
-
Shi, K.1
-
74
-
-
0042421854
-
Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates
-
Whiteman, E.L., Chen, J.J., and Birnbaum, M.J. 2003. Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates. Endocrinology. 144:3811-3820.
-
(2003)
Endocrinology
, vol.144
, pp. 3811-3820
-
-
Whiteman, E.L.1
Chen, J.J.2
Birnbaum, M.J.3
-
75
-
-
0037432766
-
LRP: Role in vascular wall integrity and protection from atherosclerosis
-
Boucher, P., Gotthardt, M., Li, W.P., Anderson, R.G., and Herz, J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science. 300:329-332.
-
(2003)
Science
, vol.300
, pp. 329-332
-
-
Boucher, P.1
Gotthardt, M.2
Li, W.P.3
Anderson, R.G.4
Herz, J.5
-
76
-
-
33645563765
-
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis
-
Baumgartl, J., et al. 2006. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab. 3:247-256.
-
(2006)
Cell Metab.
, vol.3
, pp. 247-256
-
-
Baumgartl, J.1
-
77
-
-
33645567816
-
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions
-
Han, S., et al. 2006. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab. 3:257-266.
-
(2006)
Cell Metab.
, vol.3
, pp. 257-266
-
-
Han, S.1
-
78
-
-
24744435115
-
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
Camps, M., et al. 2005. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. 11:936-943.
-
(2005)
Nat. Med.
, vol.11
, pp. 936-943
-
-
Camps, M.1
-
79
-
-
24744449495
-
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
-
Barber, D.F., et al. 2005. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. 11:933-935.
-
(2005)
Nat. Med.
, vol.11
, pp. 933-935
-
-
Barber, D.F.1
-
80
-
-
0037324321
-
Mismatch repair activity in mammalian mitochondria
-
Mason, P.A., Matheson, E.C., Hall, A.G., and Lightowlers, R.N. 2003. Mismatch repair activity in mammalian mitochondria. Nucleic Acids Res. 31:1052-1058.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 1052-1058
-
-
Mason, P.A.1
Matheson, E.C.2
Hall, A.G.3
Lightowlers, R.N.4
-
81
-
-
0037477855
-
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
-
Patti, M.E., et al. 2003. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U. S. A. 100:8466-8471.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 8466-8471
-
-
Patti, M.E.1
-
82
-
-
1642377274
-
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
-
Petersen, K.F., Dufour, S., Befroy, D., Garcia, R., and Shulman, G.I. 2004. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 350:664-671.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Garcia, R.4
Shulman, G.I.5
-
83
-
-
33645509709
-
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
-
doi:10.1172/JCI23354
-
Du, X., et al. 2006. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J. Clin. Invest. 116:1071-1080. doi:10.1172/JCI23354.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1071-1080
-
-
Du, X.1
-
84
-
-
0037199466
-
Mitochondrial integrity and function in atherogenesis
-
Ballinger, S.W., et al. 2002. Mitochondrial integrity and function in atherogenesis. Circulation. 106:544-549.
-
(2002)
Circulation
, vol.106
, pp. 544-549
-
-
Ballinger, S.W.1
-
85
-
-
17344375456
-
Mapping of ATP, glucose, glycogen, and lactate concentrations within the arterial wall
-
Levin, M., et al. 2003. Mapping of ATP, glucose, glycogen, and lactate concentrations within the arterial wall. Arterioscler. Thromb. Vasc. Biol. 23:1801-1807.
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
, pp. 1801-1807
-
-
Levin, M.1
-
86
-
-
0016250762
-
Respiratory control in preatherosclerotic susceptible and resistant pigeon aortas
-
Santerre, R.F., Nicolosi, R.J., and Smith, S.C. 1974. Respiratory control in preatherosclerotic susceptible and resistant pigeon aortas. Exp. Mol. Pathol. 20:397-406.
-
(1974)
Exp. Mol. Pathol.
, vol.20
, pp. 397-406
-
-
Santerre, R.F.1
Nicolosi, R.J.2
Smith, S.C.3
-
87
-
-
19544368178
-
f 0-12 lipoprotein in normal and hypercholesterolaemic serum
-
f 0-12 lipoprotein in normal and hypercholesterolaemic serum. Lancet. 2:530-534.
-
(1962)
Lancet
, vol.2
, pp. 530-534
-
-
Smith, E.B.1
-
88
-
-
0011735042
-
Phosphorus metabolism in unsaturated fatty acid-deficient rats
-
Klein, P.D., and Johnson, R.M. 1954. Phosphorus metabolism in unsaturated fatty acid-deficient rats. J. Biol. Chem. 211:103-110.
-
(1954)
J. Biol. Chem.
, vol.211
, pp. 103-110
-
-
Klein, P.D.1
Johnson, R.M.2
-
89
-
-
0019762493
-
Atherosclerosis: An intracellular deficiency in essential fatty acids
-
Cornwell, D.G., and Panganamala, R.V. 1981. Atherosclerosis: an intracellular deficiency in essential fatty acids. Prog. Lipid Res. 20:365-376.
-
(1981)
Prog. Lipid Res.
, vol.20
, pp. 365-376
-
-
Cornwell, D.G.1
Panganamala, R.V.2
-
90
-
-
21144450045
-
Vascular respiratory uncoupling increases blood pressure and atherosclerosis
-
Bernal-Mizrachi, C., et al. 2005. Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature. 435:502-506.
-
(2005)
Nature
, vol.435
, pp. 502-506
-
-
Bernal-Mizrachi, C.1
-
91
-
-
8444228909
-
A cluster of metabolic defects caused by mutation in a mitochondrial tRNA
-
Wilson, F.H., et al. 2004. A cluster of metabolic defects caused by mutation in a mitochondrial tRNA. Science. 306:1190-1194.
-
(2004)
Science
, vol.306
, pp. 1190-1194
-
-
Wilson, F.H.1
-
92
-
-
0015332110
-
The distribution of brown adipose tissue in the human
-
Heaton, J.M. 1972. The distribution of brown adipose tissue in the human. J. Anat. 112:35-39.
-
(1972)
J. Anat.
, vol.112
, pp. 35-39
-
-
Heaton, J.M.1
-
93
-
-
0034744590
-
PPARα deficiency reduces insulin resistance and atherosclerosis in apoE null mice
-
Tordjman, K., et al. 2001. PPARα deficiency reduces insulin resistance and atherosclerosis in apoE null mice. J. Clin. Invest. 107:1025-1034.
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 1025-1034
-
-
Tordjman, K.1
-
94
-
-
0042967650
-
Dexamethasone induction of hypertension and diabetes is PPARα-dependent in LDL receptor null mice
-
Bernal-Mizrachi, C., et al. 2003. Dexamethasone induction of hypertension and diabetes is PPARα-dependent in LDL receptor null mice. Nat. Med. 9:1069-1075.
-
(2003)
Nat. Med.
, vol.9
, pp. 1069-1075
-
-
Bernal-Mizrachi, C.1
-
95
-
-
26844558334
-
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
-
Nisoli, E., et al. 2005. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science. 310:314-317.
-
(2005)
Science
, vol.310
, pp. 314-317
-
-
Nisoli, E.1
-
96
-
-
31944452442
-
Mitochondrial transfer between cells can rescue aerobic respiration
-
Spees, J.L., Olson, S.D., Whitney, M.J., and Prockop, D.J. 2006. Mitochondrial transfer between cells can rescue aerobic respiration. Proc. Natl. Acad. Sci. U. S. A. 103:1283-1288.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 1283-1288
-
-
Spees, J.L.1
Olson, S.D.2
Whitney, M.J.3
Prockop, D.J.4
-
97
-
-
3042631024
-
Gene regulation and DNA damage in the ageing human brain
-
Lu, T., et al. 2004. Gene regulation and DNA damage in the ageing human brain. Nature. 429:883-891.
-
(2004)
Nature
, vol.429
, pp. 883-891
-
-
Lu, T.1
-
98
-
-
0015319601
-
The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature
-
DeBusk, F.L. 1972. The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature. J. Pediatr. 80:697-724.
-
(1972)
J. Pediatr.
, vol.80
, pp. 697-724
-
-
DeBusk, F.L.1
-
99
-
-
0020659334
-
Progeria: Insulin resistance and hyperglycemia
-
Rosenbloom, A.L., et al. 1983. Progeria: insulin resistance and hyperglycemia. J. Pediatr. 102:400-402.
-
(1983)
J. Pediatr.
, vol.102
, pp. 400-402
-
-
Rosenbloom, A.L.1
-
100
-
-
33644770201
-
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome
-
Varga, R., et al. 2006. Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. U. S. A. 103:3250-3255.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 3250-3255
-
-
Varga, R.1
-
101
-
-
22544466685
-
Genomic instability in laminopathy-based premature aging
-
Liu, B., et al. 2005. Genomic instability in laminopathy-based premature aging. Nat. Med. 11:780-785.
-
(2005)
Nat. Med.
, vol.11
, pp. 780-785
-
-
Liu, B.1
-
102
-
-
33645060977
-
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
-
Fong, L.G., et al. 2006. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science. 311:1621-1623.
-
(2006)
Science
, vol.311
, pp. 1621-1623
-
-
Fong, L.G.1
-
103
-
-
0030751354
-
The Werner syndrome protein is a DNA helicase
-
Gray, M.D., et al. 1997. The Werner syndrome protein is a DNA helicase. Nat. Genet. 17:100-103.
-
(1997)
Nat. Genet.
, vol.17
, pp. 100-103
-
-
Gray, M.D.1
-
104
-
-
0033361074
-
All patients with Werner's syndrome are insulin resistant, but only those who also have impaired insulin secretion develop overt diabetes
-
Yamada, K., Ikegami, H., Yoneda, H., Miki, T., and Ogihara, T. 1999. All patients with Werner's syndrome are insulin resistant, but only those who also have impaired insulin secretion develop overt diabetes. Diabetes Care. 22:2094-2095.
-
(1999)
Diabetes Care
, vol.22
, pp. 2094-2095
-
-
Yamada, K.1
Ikegami, H.2
Yoneda, H.3
Miki, T.4
Ogihara, T.5
-
105
-
-
0013907774
-
Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process
-
Epstein, C.J., Martin, G.M., Schultz, A.L., and Motulsky, A.G. 1966. Werner's syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore). 45:177-221.
-
(1966)
Medicine (Baltimore)
, vol.45
, pp. 177-221
-
-
Epstein, C.J.1
Martin, G.M.2
Schultz, A.L.3
Motulsky, A.G.4
-
106
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C.J., and Kastan, M.B. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
107
-
-
0031875104
-
Co-expression of p53 and MDM2 in human atherosclerosis: Implications for the regulation of cellularity of atherosclerotic lesions
-
Ihling, C., et al. 1998. Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions. J. Pathol. 185:303-312.
-
(1998)
J. Pathol.
, vol.185
, pp. 303-312
-
-
Ihling, C.1
-
108
-
-
0035853398
-
Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering
-
Martinet, W., Knaapen, M.W., De Meyer, G.R., Herman, A.G., and Kockx, M.M. 2001. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ. Res. 88:733-739.
-
(2001)
Circ. Res.
, vol.88
, pp. 733-739
-
-
Martinet, W.1
Knaapen, M.W.2
De Meyer, G.R.3
Herman, A.G.4
Kockx, M.M.5
-
109
-
-
0032978142
-
The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
-
Guevara, N.V., Kim, H.S., Antonova, E.I., and Chan, L. 1999. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat. Med. 5:335-339.
-
(1999)
Nat. Med.
, vol.5
, pp. 335-339
-
-
Guevara, N.V.1
Kim, H.S.2
Antonova, E.I.3
Chan, L.4
-
110
-
-
0035957575
-
Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice
-
Van Vlijmen, B.J., et al. 2001. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice. Circ. Res. 88:780-786.
-
(2001)
Circ. Res.
, vol.88
, pp. 780-786
-
-
Van Vlijmen, B.J.1
-
111
-
-
0346101496
-
Cockayne syndrome group B cellular and biochemical functions
-
Licht, C.L., Stevnsner, T., and Bohr, V.A. 2003. Cockayne syndrome group B cellular and biochemical functions. Am. J. Hum. Genet. 73:1217-1239.
-
(2003)
Am. J. Hum. Genet.
, vol.73
, pp. 1217-1239
-
-
Licht, C.L.1
Stevnsner, T.2
Bohr, V.A.3
-
112
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan, U., et al. 2004. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 306:457-461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
-
113
-
-
9444277846
-
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
-
Ricci, R., et al. 2004. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science. 306:1558-1561.
-
(2004)
Science
, vol.306
, pp. 1558-1561
-
-
Ricci, R.1
-
114
-
-
26444524411
-
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
-
Devries-Seimon, T., et al. 2005. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J. Cell Biol. 171:61-73.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 61-73
-
-
Devries-Seimon, T.1
-
115
-
-
30944451788
-
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
-
Wang, D., Wei, Y., and Pagliassotti, M.J. 2006. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology. 147:943-951.
-
(2006)
Endocrinology
, vol.147
, pp. 943-951
-
-
Wang, D.1
Wei, Y.2
Pagliassotti, M.J.3
-
116
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
Zhang, K., et al. 2006. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell. 124:587-599.
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
-
117
-
-
29144453326
-
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
-
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. 2005. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N. Engl. J. Med. 353:2643-2653.
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2643-2653
-
-
-
118
-
-
33646380879
-
Periodontal changes in children and adolescents with diabetes: A case-control study
-
Lalla, E., et al. 2006. Periodontal changes in children and adolescents with diabetes: a case-control study. Diabetes Care. 29:295-299.
-
(2006)
Diabetes Care
, vol.29
, pp. 295-299
-
-
Lalla, E.1
-
119
-
-
0035571671
-
Relationship of periodontal disease to carotid artery intima-media wall thickness: The Atherosclerosis Risk in Communities (ARIC) study
-
Beck, J.D., et al. 2001. Relationship of periodontal disease to carotid artery intima-media wall thickness: the Atherosclerosis Risk in Communities (ARIC) study. Arterioscler. Thromb. Vasc. Biol. 21:1816-1822.
-
(2001)
Arterioscler. Thromb. Vasc. Biol.
, vol.21
, pp. 1816-1822
-
-
Beck, J.D.1
-
120
-
-
2942544238
-
Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice
-
Gibson, F.C., 3rd, et al. 2004. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 109:2801-2806.
-
(2004)
Circulation
, vol.109
, pp. 2801-2806
-
-
Gibson III, F.C.1
-
121
-
-
8144226856
-
The gut microbiota as an environmental factor that regulates fat storage
-
Backhed, F., et al. 2004. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U. S. A. 101:15718-15723.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 15718-15723
-
-
Backhed, F.1
-
122
-
-
24644491335
-
Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice
-
doi:10.1172/JCI24819
-
Vikramadithyan, R.K., et al. 2005. Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. J. Clin. Invest. 115:2434-2443. doi:10.1172/JCI24819.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2434-2443
-
-
Vikramadithyan, R.K.1
-
123
-
-
0033927563
-
Involvement of aldose reductase in vascular smooth muscle cell growth and lesion formation after arterial injury
-
Ruef, J., et al. 2000. Involvement of aldose reductase in vascular smooth muscle cell growth and lesion formation after arterial injury. Arterioscler. Thromb. Vasc. Biol. 20:1745-1752.
-
(2000)
Arterioscler. Thromb. Vasc. Biol.
, vol.20
, pp. 1745-1752
-
-
Ruef, J.1
-
124
-
-
2442545151
-
Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease
-
Aprahamian, T., et al. 2004. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J. Exp. Med. 199:1121-1131.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1121-1131
-
-
Aprahamian, T.1
-
125
-
-
27144481169
-
Apolipoprotein-mediated pathways of lipid antigen presentation
-
van den Elzen, P., et al. 2005. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 437:906-910.
-
(2005)
Nature
, vol.437
, pp. 906-910
-
-
Van Den Elzen, P.1
|