Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women

Journal of the American Geriatrics Society

Volumn 53, Issue 5, 2005, Pages 747-754

  Schmaltz, Heidi N ^a,e   Fried, Linda P ^b,c,d   Xue, Qian Li ^b,c   Walston, Jeremy ^b   Leng, Sean X ^b   Semba, Richard D ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e Peter Lougheed Hospital   (Canada)

Author keywords

Aged; Cytomegalovirus; Frailty; Inflammation; Interleukin 6

Indexed keywords

INTERLEUKIN 6;

AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DEMOGRAPHY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXHAUSTION; FEMALE; GERIATRICS; GRIP STRENGTH; HEALTH STATUS; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; PHYSICAL ACTIVITY; PREVALENCE; SMOKING HABIT; VIRUS DETECTION; WALKING SPEED; WEIGHT REDUCTION; BLOOD; CHRONIC DISEASE; CROSS-SECTIONAL STUDY; CYTOMEGALIC INCLUSION BODY DISEASE; FRAIL ELDERLY;

AGED; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; CYTOMEGALOVIRUS INFECTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FRAIL ELDERLY; HUMANS; INFLAMMATION; INTERLEUKIN-6; RESIDENCE CHARACTERISTICS;

EID: 20444481012     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2005.53250.x     Document Type: Article

References (45)

1. Fried LP, Ferrucci L, Darer J et al. Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004;59A:255-263.
2. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56A:M146-M156.
3. Fried LP, Walston J. Frailty and failure to thrive. In: Hazzard WR, Blass JP, Ettinger WH Jr. et al., eds. Principles of Geriatric Medicine and Gerontology, 5th Ed. New York: McGraw-Hill, 2003, pp 1387-1402.
4. Leng S, Chaves P, Koenig K et al. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: A pilot study. J Am Geriatr Soc 2002;50:1268-1271.
5. Walston J, McBurnie MA, Newman AB et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Result from the Cardiovascular Health Study. Arch Intern Med 2002; 162:2333-2341.
6. Ferrucci L, Harris TB, Guralnik JM et al. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 1999;47:639-756.
7. Crumpacker CS. Cytomegalovirus. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases, 5th Ed. Philadelphia: Churchill Livingstone Inc., 2000, pp 1586-1596.
8. Frosch S, Docke W-D, Reinke P et al. Human cytomegalovirus reactivation in bone-marrow-derived granulocyte/monocyte progenitor cells and mature monocytes. Intervirology 1999;42:308-313.
9. Söderberg-Naucler C, Nelson JA. Human cytomegalovirus latency and reactivation-a delicate balance between the virus and its host's immune system. Intervirology 1999;42:314-321.
10. Mogensen TH, Paludan SR. Molecular pathways in virus-induced cytokine production. Microbiol Molec Biol Rev 2001;65:131-150.
11. Tong CY, Bakran A, Williams H et al. Association of tumor necrosis factor alpha and interleukin 6 with cytomegalovirus DNA detection and disease after renal transplantation. J Med Virol 2001;64:29-34.
12. Gillespie GMA, Wills MR, Appay V et al. Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8+ T lymphocytes in healthy seropositive donors. J Virol 2000;74:8140-8150.
13. Khan N, Shariff N, Cobbold M et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002;169:1984-1992.
14. Olsson J, Wikby A, Johansson B et al. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000;121:187-201.
15. Wikby A, Johansson B, Olsson J et al. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study. Exp Gerontol 2002;37:445-453.
16. Zhu J, Shearer GM, Marincola FM et al. Discordant cellular and humoral immune responses to cytomegalovirus infection in healthy blood donors: Existence of a Th1-type dominant response. Int Immmunol 2001;13:785-790.
17. Trzonkowski P, Mysliwska J, Szmit E et al. Association between cytomegalovirus infection, enhanced promflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence. Vaccine 2003;21:3826-3836.
18. Espinola-Klein C, Rupprecht H-J, Blankenburg S et al. Are morphological or functional changes in the carotid artery wall associated with Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, or herpes simplex virus infection? Stroke 2000;31:2127-2133.
19. Streblow DN, Orloff SL, Nelson JA. Do pathogens accelerate atherosclerosis? J Nutr 2001;131:2789S-2804S.
20. Zhu J, Quyyumi AA, Norman JE et al. Cytomegalovirus in the pathogenesis of atherosclerosis: The role of inflammation as reflected by elevated C-reactive protein levels. J Am Coll Cardiol 1999;34:1738-1743.
21. Blankenberg S, Rupprecht HJ, Bickel C et al. Cytomegalovirus infection with interleukin-6 response predicts cardiac mortality in patients with coronary artery disease. Circulation 2001;103:2915-2921.
22. Muhlestein JB, Home BD, Carlquist JF et al. Cytomegalovirus seropositivity and C-reactive protein have independent and combined predictive value for mortality in patients with angiographically demonstrated coronary artery disease. Circulation 2000;102:1917-1923.
23. Fried LP, Kasper JD, Guralnik JM et al. The Women's Health and Aging Study: An introduction. In: Guralnik JM, Fried LP, Simonsick EM et al., eds. The Women's Health and Aging Study: Health and Social Characteristics of old Women with Disability (NIH Publication no, 95-4009), Bethesda, MD: National Institute on Aging, 1995, pp 1-8.
24. Fried LP, Bandeen-Roche K, Chaves PH et al. Preclinical mobility disability predicts incident mobility disability in older women. J Gerontol A Biol Sci Med Sci 2000;55A:M43-M52.
25. Guralnik JM, Fried LP, Simonsick EM et al. Screening the community for disability. In: Guralnik JM, Fried LP, Simonsick EM et al., eds. The Women's Health and Aging Study: Health and Social Characteristics of old Women with Disability (NIH Publication no, 95-4009), Bethesda, MD: National Institute on Aging, 1995, pp 9-27.
26. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
27. Ferrucci L, Penninx BWJH, Volpato S et al. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc 2002;50:1947-1954.
28. Mohamed-Ali V, Goodrick S, Rawesh A et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α in vivo. J Clin Endocrinol Metab 1997;82:4196-4200.
29. Pickup JC, Mattock MB, Chusney GD et al. NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 1997;40:1286-1292.
30. Aukrust P, Ueland T, Lien E et al. Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 1999;83:376-382.
31. Cappola AR, Bandeen-Roche K, Wand GS et al. Association of IGF-1 levels with muscle strength and mobility in older women. J Clin Endocrinol Metab 2001;86:4139-4146.
32. Chu A, Maffeo CE, Lo A et al. Sample design, weighting and estimation procedures, and computation of sampling errors. In: Guralnik JM, Fried LP, Simonsick EM et al., eds. The Women's Health and Aging Study: Health and Social Characteristics of old Women with Disability (NIH Publication no, 95-4009), Bethesda, MD: National Institute on Aging, 1995, pp A1-A13.
33. Visser M, Pahor M, Taaffe DR et al. Relationship of interleukin-6 and tumor necrosis factor-α with muscle mass and muscle strength in elderly men and women: The Health ABC Study. J Gerontol A Biol Sci Med Sci 2002;57A:M326-M332.
34. Vanltallie TB. Frailty in the elderly: Contributions of sarcopenia and visceral protein depletion. Metabolism 2003;52:22-26.
35. Newman AB, Gottbiener JS, McBurnie MA et al. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci 2001;56A:M158-M166.
36. Hummel M, Abecassis MM. A model for reactivation of CMV from latency. J Clin Virol 2002;25(Suppl 2):S123-S136.
37. Wouters-Wesseling W, Rozendaal M, Snijder M et al. Effect of a complete nutritional supplement on antibody response to influenza vaccine in elderly people. J Gerontol A Biol Sci Med Sci 2002;57A:M563-M566.
38. Vedhara K, Cox HKM, Wilcock GK et al. Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet 1999;353:627-631.
39. Hosaka T, Sugiyama Y. Structured intervention in family caregivers of the demented elderly and changes in their immune function. Psychiatry Clin Neurosci 2003;57:147-151.
40. Pedersen BK, Bruunsgaard H. Possible beneficial role of exercise in modulating low-grade inflammation in the elderly. Scand J Med Sci Sports 2003;13:56-62.
41. Miszko TA, Cress E, Slade JM et al. Effect of strength and power training on physical function in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2003;58A:M171-M175.
42. Greiwe JS, Cheng B, Rubin DC et al. Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans. FASEB J 2001;15:475-482.
43. Roback JD, Drew WL, Laycock M et al. CMV DNA is rarely detected in healthy blood donors using validated PCR assays. Transfusion 2003;43:314-321.
44. Ljungman P. Risk of cytomegalovirus transmission by blood products to immunocompromised patients and means for reduction. Br J Haematol 2004;125:107-116.
45. Miller DK, Carter ME, Sigmund RH et al. Nutritional risk in inner city-dwelling older black Americans. J Am Geriatr Soc 1996;44:959-962.