메뉴 건너뛰기




Volumn 80, Issue 3, 2006, Pages 219-227

Inflammation markers predicting frailty and mortality in the elderly

Author keywords

Elderly; Frailty; Inflammation markers

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CELL MARKER; CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; SOMATOMEDIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

EID: 33646518593     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2005.11.004     Document Type: Review
Times cited : (302)

References (100)
  • 1
    • 12144291184 scopus 로고    scopus 로고
    • Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly
    • Abbatecola A.M., Ferrucci L., Grella R., et al. Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. J. Am. Geriatr. Soc. 52 (2004) 399-404
    • (2004) J. Am. Geriatr. Soc. , vol.52 , pp. 399-404
    • Abbatecola, A.M.1    Ferrucci, L.2    Grella, R.3
  • 2
    • 0142186132 scopus 로고    scopus 로고
    • Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention
    • Anisimov V.N. Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention. Exp. Gerontol. 38 (2003) 1041-1049
    • (2003) Exp. Gerontol. , vol.38 , pp. 1041-1049
    • Anisimov, V.N.1
  • 3
    • 0036899797 scopus 로고    scopus 로고
    • Premature ageing of the immune system: the cause of AIDS?
    • Appay V., and Rowland-Jones S.L. Premature ageing of the immune system: the cause of AIDS?. Trends Immunol. 23 (2002) 580-585
    • (2002) Trends Immunol. , vol.23 , pp. 580-585
    • Appay, V.1    Rowland-Jones, S.L.2
  • 4
    • 17044397719 scopus 로고    scopus 로고
    • Markers of inflammation and their clinical significance
    • Ballantyne C.M., Nambi V., et al. Markers of inflammation and their clinical significance. Atherosclerosis, Suppl. 6 (2005) 21-29
    • (2005) Atherosclerosis, Suppl. , vol.6 , pp. 21-29
    • Ballantyne, C.M.1    Nambi, V.2
  • 5
    • 0037372505 scopus 로고    scopus 로고
    • Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
    • Barbieri M., Ferrucci L., Ragno E., et al. Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am. J. Physiol.: Endocrinol. Metab. 284 (2003) 481-487
    • (2003) Am. J. Physiol.: Endocrinol. Metab. , vol.284 , pp. 481-487
    • Barbieri, M.1    Ferrucci, L.2    Ragno, E.3
  • 6
    • 17444432616 scopus 로고    scopus 로고
    • Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?
    • Bo S., Gambino R., Uberti B., et al. Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?. Eur. J. Clin. Invest. 35 (2005) 265-270
    • (2005) Eur. J. Clin. Invest. , vol.35 , pp. 265-270
    • Bo, S.1    Gambino, R.2    Uberti, B.3
  • 7
    • 12444338807 scopus 로고    scopus 로고
    • Fluctuating inflammatory markers in patients with stable ischemic heart disease
    • Bogaty P., Brophy J.M., Boyer L., et al. Fluctuating inflammatory markers in patients with stable ischemic heart disease. Arch. Intern. Med. 165 (2005) 221-226
    • (2005) Arch. Intern. Med. , vol.165 , pp. 221-226
    • Bogaty, P.1    Brophy, J.M.2    Boyer, L.3
  • 8
    • 0034849867 scopus 로고    scopus 로고
    • A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity
    • Bonafè M., Olivieri F., Cavallone L., et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur. J. Immunol. 31 (2001) 2357-2361
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2357-2361
    • Bonafè, M.1    Olivieri, F.2    Cavallone, L.3
  • 9
    • 3342995295 scopus 로고    scopus 로고
    • Inflamm-aging: autoimmunity, and the immune-risk phenotype
    • Boren E., and Gershwin M.E. Inflamm-aging: autoimmunity, and the immune-risk phenotype. Autoimmun. Rev. 3 (2004) 401-406
    • (2004) Autoimmun. Rev. , vol.3 , pp. 401-406
    • Boren, E.1    Gershwin, M.E.2
  • 11
    • 0033163270 scopus 로고    scopus 로고
    • A high plasma concentration of TNF-alpha is associated with dementia in centenarians
    • Bruunsgaard H., Andersen-Ranberg K., Jeune B., et al. A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J. Gerontol. Med. Sci. 54 (1999) 357-364
    • (1999) J. Gerontol. Med. Sci. , vol.54 , pp. 357-364
    • Bruunsgaard, H.1    Andersen-Ranberg, K.2    Jeune, B.3
  • 14
    • 0347367048 scopus 로고    scopus 로고
    • Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
    • Bruunsgaard H., Ladelund S., Pedersen A.N., et al. Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin. Exp. Immunol. 132 (2003) 24-31
    • (2003) Clin. Exp. Immunol. , vol.132 , pp. 24-31
    • Bruunsgaard, H.1    Ladelund, S.2    Pedersen, A.N.3
  • 15
    • 0041878545 scopus 로고    scopus 로고
    • Elevated levels of tumor necrosis factor alpha and mortality in centenarians
    • Bruunsgaard H., Andersen-Ranberg K., Hjelmborg J.B., et al. Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am. J. Med. 115 (2003) 278-283
    • (2003) Am. J. Med. , vol.115 , pp. 278-283
    • Bruunsgaard, H.1    Andersen-Ranberg, K.2    Hjelmborg, J.B.3
  • 16
    • 0038369150 scopus 로고    scopus 로고
    • Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    • Cappola A.R., Xue Q.-L., Ferrucci L., et al. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J. Clin. Endocrinol. Metab. 88 (2003) 2019-2025
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2019-2025
    • Cappola, A.R.1    Xue, Q.-L.2    Ferrucci, L.3
  • 17
    • 13844280837 scopus 로고    scopus 로고
    • The G/C915 polymorphism of transforming growth factor beta 1 is associated with human longevity: a study in Italian centenarians
    • Carrieri G., Marzi E., Olivieri F., et al. The G/C915 polymorphism of transforming growth factor beta 1 is associated with human longevity: a study in Italian centenarians. Aging Cell 3 (2004) 443-448
    • (2004) Aging Cell , vol.3 , pp. 443-448
    • Carrieri, G.1    Marzi, E.2    Olivieri, F.3
  • 18
    • 0031667011 scopus 로고    scopus 로고
    • Cardiovascular risk factors in the elderly
    • Casiglia E., and Palatini P. Cardiovascular risk factors in the elderly. J. Hum. Hypertens. 12 (1998) 575-581
    • (1998) J. Hum. Hypertens. , vol.12 , pp. 575-581
    • Casiglia, E.1    Palatini, P.2
  • 19
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon R.M., Smith K.R., O'Brien E., et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361 (2003) 393-395
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3
  • 20
    • 0242610488 scopus 로고    scopus 로고
    • Inflammatory markers and onset of cardiovascular events: results from the Health ABC study
    • Cesari M., Penninx B.W., Newman A.B., et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation 108 (2003) 9049-9050
    • (2003) Circulation , vol.108 , pp. 9049-9050
    • Cesari, M.1    Penninx, B.W.2    Newman, A.B.3
  • 21
    • 1642316427 scopus 로고    scopus 로고
    • Inflammatory markers and physical performance in older persons: the InCHIANTI study
    • Cesari M., Penninx B.W., Pahor M., et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J. Gerontol., Ser. A, Biol. Sci. Med. Sci. 59 (2004) 242-248
    • (2004) J. Gerontol., Ser. A, Biol. Sci. Med. Sci. , vol.59 , pp. 242-248
    • Cesari, M.1    Penninx, B.W.2    Pahor, M.3
  • 22
    • 1642556843 scopus 로고    scopus 로고
    • Gene-environment interactions and the etiology of common complex disease
    • Cooper R.S. Gene-environment interactions and the etiology of common complex disease. Ann. Int. Med. 139 (2003) 445-449
    • (2003) Ann. Int. Med. , vol.139 , pp. 445-449
    • Cooper, R.S.1
  • 23
    • 0034555131 scopus 로고    scopus 로고
    • Adhesion molecules on peripheral blood lymphocyte subpopulations in the elderly
    • De Martinis M., Modesti M., Loreto M.F., et al. Adhesion molecules on peripheral blood lymphocyte subpopulations in the elderly. Life Sci. 68 (2000) 139-145
    • (2000) Life Sci. , vol.68 , pp. 139-145
    • De Martinis, M.1    Modesti, M.2    Loreto, M.F.3
  • 24
    • 0034434280 scopus 로고    scopus 로고
    • CD50 and CD62L adhesion receptor expression on naïve (CD45RA+) and memory (CD45RO+) T lymphocytes in the elderly
    • De Martinis M., Modesti M., Profeta V.F., et al. CD50 and CD62L adhesion receptor expression on naïve (CD45RA+) and memory (CD45RO+) T lymphocytes in the elderly. Pathobiology 68 (2000) 245-250
    • (2000) Pathobiology , vol.68 , pp. 245-250
    • De Martinis, M.1    Modesti, M.2    Profeta, V.F.3
  • 25
    • 4344658758 scopus 로고    scopus 로고
    • Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons
    • De Martinis M., Modesti M., and Ginaldi L. Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons. Immunol. Cell Biol. 82 (2004) 415-420
    • (2004) Immunol. Cell Biol. , vol.82 , pp. 415-420
    • De Martinis, M.1    Modesti, M.2    Ginaldi, L.3
  • 26
    • 16344376370 scopus 로고    scopus 로고
    • Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
    • De Martinis M., Franceschi C., Monti D., and Ginaldi L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett. 579 (2005) 2035-2039
    • (2005) FEBS Lett. , vol.579 , pp. 2035-2039
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3    Ginaldi, L.4
  • 27
    • 0041343008 scopus 로고    scopus 로고
    • Serum IL-1β levels in health and disease: a population-based study. The InCHIANTI study
    • Di Iorio A., Ferrucci L., Sparvieri E., et al. Serum IL-1β levels in health and disease: a population-based study. The InCHIANTI study. Cytokine 22 (2003) 198-205
    • (2003) Cytokine , vol.22 , pp. 198-205
    • Di Iorio, A.1    Ferrucci, L.2    Sparvieri, E.3
  • 28
    • 1642421853 scopus 로고    scopus 로고
    • Replicative senescence of CD8 T cells: effect on human ageing
    • Effros R.B. Replicative senescence of CD8 T cells: effect on human ageing. Exp. Gerontol. 39 (2004) 517-524
    • (2004) Exp. Gerontol. , vol.39 , pp. 517-524
    • Effros, R.B.1
  • 29
    • 20344373118 scopus 로고    scopus 로고
    • The role of CD8 T-cell replicative senescence in human aging
    • Effros R.B., Dagarag M., Spaulding C., and Man J. The role of CD8 T-cell replicative senescence in human aging. Immunol. Rev. 205 (2005) 147-157
    • (2005) Immunol. Rev. , vol.205 , pp. 147-157
    • Effros, R.B.1    Dagarag, M.2    Spaulding, C.3    Man, J.4
  • 30
    • 0034194058 scopus 로고    scopus 로고
    • Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging
    • Fagnoni F.F., Vescovini R., Passeri G., et al. Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging. Blood 95 (2000) 2860-2868
    • (2000) Blood , vol.95 , pp. 2860-2868
    • Fagnoni, F.F.1    Vescovini, R.2    Passeri, G.3
  • 31
    • 0028839467 scopus 로고
    • Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and non survivors
    • Ferguson F.G., Wikby A., Maxson P., et al. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and non survivors. J. Gerontol., Ser. A, Biol. Sci. Med. Sci. 50 (1995) 378-382
    • (1995) J. Gerontol., Ser. A, Biol. Sci. Med. Sci. , vol.50 , pp. 378-382
    • Ferguson, F.G.1    Wikby, A.2    Maxson, P.3
  • 32
    • 0037396614 scopus 로고    scopus 로고
    • Centenarians as a model for healthy aging
    • Franceschi C., and Bonafè M. Centenarians as a model for healthy aging. Biochem. Soc. Trans. 31 (2003) 457-461
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 457-461
    • Franceschi, C.1    Bonafè, M.2
  • 33
    • 0028891555 scopus 로고
    • The immunology of exceptional individuals: the lesson of centenarians
    • Franceschi C., Monti D., Sansoni P., and Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol. Today 16 (1995) 12-16
    • (1995) Immunol. Today , vol.16 , pp. 12-16
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossarizza, A.4
  • 34
    • 0032752273 scopus 로고    scopus 로고
    • Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load
    • Franceschi C., Valensin S., Fagnoni F., et al. Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load. Exp. Gerontol. 34 (1999) 911-921
    • (1999) Exp. Gerontol. , vol.34 , pp. 911-921
    • Franceschi, C.1    Valensin, S.2    Fagnoni, F.3
  • 35
    • 0033975581 scopus 로고    scopus 로고
    • Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
    • Franceschi C., Bonafè M., and Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 18 (2000) 1717-1720
    • (2000) Vaccine , vol.18 , pp. 1717-1720
    • Franceschi, C.1    Bonafè, M.2    Valensin, S.3
  • 36
    • 0033911488 scopus 로고    scopus 로고
    • Inflamm-aging. An evolutionary perspective on immunosenescence
    • Franceschi C., Bonafè M., Valensin S., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 908 (2000) 244-254
    • (2000) Ann. N. Y. Acad. Sci. , vol.908 , pp. 244-254
    • Franceschi, C.1    Bonafè, M.2    Valensin, S.3
  • 37
    • 0034962808 scopus 로고    scopus 로고
    • Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype
    • Franceschi C., Valensin S., Lescai F., et al. Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype. Aging Clin. Exp. Res. 13 (2001) 163-170
    • (2001) Aging Clin. Exp. Res. , vol.13 , pp. 163-170
    • Franceschi, C.1    Valensin, S.2    Lescai, F.3
  • 38
    • 19944392873 scopus 로고    scopus 로고
    • Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians
    • Franceschi C., Olivieri F., Marchegiani F., et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech. Ageing Dev. 126 (2005) 351-361
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 351-361
    • Franceschi, C.1    Olivieri, F.2    Marchegiani, F.3
  • 39
    • 0038241866 scopus 로고    scopus 로고
    • Increased circulating interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
    • Gangemi S., Basile G., Merendino R.A., et al. Increased circulating interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?. Exp. Gerontol. 38 (2003) 669-672
    • (2003) Exp. Gerontol. , vol.38 , pp. 669-672
    • Gangemi, S.1    Basile, G.2    Merendino, R.A.3
  • 40
    • 0344406880 scopus 로고    scopus 로고
    • Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology
    • Geenen V., Poulin J.F., Dion M.L., et al. Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology. J. Endocrinol. 176 (2003) 305-311
    • (2003) J. Endocrinol. , vol.176 , pp. 305-311
    • Geenen, V.1    Poulin, J.F.2    Dion, M.L.3
  • 42
    • 0033798392 scopus 로고    scopus 로고
    • Immunophenotypical changes of T lymphocytes in the elderly
    • Ginaldi L., De Martinis M., Modesti M., et al. Immunophenotypical changes of T lymphocytes in the elderly. Gerontology 46 (2000) 242-248
    • (2000) Gerontology , vol.46 , pp. 242-248
    • Ginaldi, L.1    De Martinis, M.2    Modesti, M.3
  • 43
    • 0035014855 scopus 로고    scopus 로고
    • Changes in the expression of surface receptors on lymphocyte subsets in the elderly: quantitative flow cytometric analysis
    • Ginaldi L., De Martinis M., D'Ostilio A., et al. Changes in the expression of surface receptors on lymphocyte subsets in the elderly: quantitative flow cytometric analysis. Am. J. Hematol. 67 (2001) 63-72
    • (2001) Am. J. Hematol. , vol.67 , pp. 63-72
    • Ginaldi, L.1    De Martinis, M.2    D'Ostilio, A.3
  • 44
    • 3242891953 scopus 로고    scopus 로고
    • The immune system in the elderly: activation-induced and damage-induced apoptosis
    • Ginaldi L., De Martinis M., Monti D., and Franceschi C. The immune system in the elderly: activation-induced and damage-induced apoptosis. Immunol. Res. 30 (2004) 81-94
    • (2004) Immunol. Res. , vol.30 , pp. 81-94
    • Ginaldi, L.1    De Martinis, M.2    Monti, D.3    Franceschi, C.4
  • 46
    • 0036422425 scopus 로고    scopus 로고
    • Anti-inflammatory interleukin-10 genotype protects dialysis patients from cardiovascular events
    • Girndt M., Kaul H., Sester U., et al. Anti-inflammatory interleukin-10 genotype protects dialysis patients from cardiovascular events. Kidney Int. 62 (2002) 949-955
    • (2002) Kidney Int. , vol.62 , pp. 949-955
    • Girndt, M.1    Kaul, H.2    Sester, U.3
  • 48
    • 0034740493 scopus 로고    scopus 로고
    • Influence of TNFalpha gene polymorphisms on TNFalpha production and disease
    • Hajeer A.H., and Hutchinson I.V. Influence of TNFalpha gene polymorphisms on TNFalpha production and disease. Hum. Immunol. 62 (2001) 1191-1199
    • (2001) Hum. Immunol. , vol.62 , pp. 1191-1199
    • Hajeer, A.H.1    Hutchinson, I.V.2
  • 49
    • 0033134682 scopus 로고    scopus 로고
    • Association of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
    • Harris T.B., Ferrucci L., Tracy R.P., et al. Association of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106 (1999) 506-512
    • (1999) Am. J. Med. , vol.106 , pp. 506-512
    • Harris, T.B.1    Ferrucci, L.2    Tracy, R.P.3
  • 50
    • 14144249221 scopus 로고    scopus 로고
    • Prognostic value of inflammatory markers alone and in combination with blood lipids in patients with stable coronary artery disease
    • Hoffmeister A., Rothenbacher D., Kunze M., et al. Prognostic value of inflammatory markers alone and in combination with blood lipids in patients with stable coronary artery disease. Eur. J. Intern. Med. 16 (2005) 47-52
    • (2005) Eur. J. Intern. Med. , vol.16 , pp. 47-52
    • Hoffmeister, A.1    Rothenbacher, D.2    Kunze, M.3
  • 51
    • 17144392613 scopus 로고    scopus 로고
    • Total and differential white blood cell counts and their associations with circulating interleukin-6 levels in community-dwelling older women
    • Leng S., Xue Q.L., Huang Y., et al. Total and differential white blood cell counts and their associations with circulating interleukin-6 levels in community-dwelling older women. J. Gerontol., Ser. A, Biol. Sci. Med. Sci. 60 (2005) 95-99
    • (2005) J. Gerontol., Ser. A, Biol. Sci. Med. Sci. , vol.60 , pp. 95-99
    • Leng, S.1    Xue, Q.L.2    Huang, Y.3
  • 52
    • 2942750881 scopus 로고    scopus 로고
    • Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain
    • Licastro F., Grimaldi L.M.E., Bonafè M., et al. Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol. Aging 5831 (2003) 1-6
    • (2003) Neurobiol. Aging , vol.5831 , pp. 1-6
    • Licastro, F.1    Grimaldi, L.M.E.2    Bonafè, M.3
  • 53
    • 0036481791 scopus 로고    scopus 로고
    • Gender-specific association between -1082 IL-10 promoter polymorphism and longevity
    • Lio D., Scola L., Crivello A., et al. Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun. 3 (2002) 30-33
    • (2002) Genes Immun. , vol.3 , pp. 30-33
    • Lio, D.1    Scola, L.2    Crivello, A.3
  • 54
    • 0037374849 scopus 로고    scopus 로고
    • Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-α-308 promoter SNP
    • Lio D., Scola L., Crivello A., et al. Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-α-308 promoter SNP. J. Med. Genet. 40 (2003) 496-499
    • (2003) J. Med. Genet. , vol.40 , pp. 496-499
    • Lio, D.1    Scola, L.2    Crivello, A.3
  • 55
    • 0035930860 scopus 로고    scopus 로고
    • A stochastic model for CD8+ T cell dynamics in human immunosenescence: implications for survival and longevity
    • Luciani F., Valensin S., Vescovini R., et al. A stochastic model for CD8+ T cell dynamics in human immunosenescence: implications for survival and longevity. J. Theor. Biol. 213 (2001) 587-597
    • (2001) J. Theor. Biol. , vol.213 , pp. 587-597
    • Luciani, F.1    Valensin, S.2    Vescovini, R.3
  • 56
    • 20044383742 scopus 로고    scopus 로고
    • Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study
    • Margolis K.L., Manson J.E., Greenland P., et al. Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study. Arch. Intern. Med. 165 (2005) 500-508
    • (2005) Arch. Intern. Med. , vol.165 , pp. 500-508
    • Margolis, K.L.1    Manson, J.E.2    Greenland, P.3
  • 57
    • 0037011794 scopus 로고    scopus 로고
    • RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects
    • Mariani E., Pulsatelli L., Neri S., et al. RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects. Exp. Gerontol. 37 (2002) 219-226
    • (2002) Exp. Gerontol. , vol.37 , pp. 219-226
    • Mariani, E.1    Pulsatelli, L.2    Neri, S.3
  • 58
    • 4344625914 scopus 로고    scopus 로고
    • Evidence for C-reactive protein (CRP)'s role in vascular disease: atherothrombosis, immuno-regulation and CRP
    • Mazer S.P., and Rabbani L.E. Evidence for C-reactive protein (CRP)'s role in vascular disease: atherothrombosis, immuno-regulation and CRP. J. Thromb. Thrombolysis 17 (2004) 95-105
    • (2004) J. Thromb. Thrombolysis , vol.17 , pp. 95-105
    • Mazer, S.P.1    Rabbani, L.E.2
  • 59
    • 0026005830 scopus 로고
    • Detectable serum levels of tumor necrosis factor alpha may predict early mortality in elderly institutionalized patients
    • Mooradian A.D., Reed R.L., Osterweil D., and Scuderi P. Detectable serum levels of tumor necrosis factor alpha may predict early mortality in elderly institutionalized patients. J. Am. Geriatr. Soc. 39 (1991) 891-894
    • (1991) J. Am. Geriatr. Soc. , vol.39 , pp. 891-894
    • Mooradian, A.D.1    Reed, R.L.2    Osterweil, D.3    Scuderi, P.4
  • 60
    • 17644384896 scopus 로고    scopus 로고
    • CD4+CD25+T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
    • Mottonen M., Heikkinen J., Mustonen L., et al. CD4+CD25+T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin. Exp. Immunol. 140 (2005) 360-367
    • (2005) Clin. Exp. Immunol. , vol.140 , pp. 360-367
    • Mottonen, M.1    Heikkinen, J.2    Mustonen, L.3
  • 61
    • 0037396188 scopus 로고    scopus 로고
    • Morbidity does not influence the T cell immune risk phenotype in the elderly: findings in the Swedish NONA immune study using sample selection protocols
    • Nilsson B.O., Ernerudh J., Johansson B., et al. Morbidity does not influence the T cell immune risk phenotype in the elderly: findings in the Swedish NONA immune study using sample selection protocols. Mech. Ageing Dev. 124 (2003) 469-476
    • (2003) Mech. Ageing Dev. , vol.124 , pp. 469-476
    • Nilsson, B.O.1    Ernerudh, J.2    Johansson, B.3
  • 62
    • 0242585029 scopus 로고    scopus 로고
    • In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging
    • Olivieri F., Bonafè M., Giovagnetti S., et al. In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging. Mech. Ageing Dev. 124 (2003) 549-553
    • (2003) Mech. Ageing Dev. , vol.124 , pp. 549-553
    • Olivieri, F.1    Bonafè, M.2    Giovagnetti, S.3
  • 63
    • 0035915757 scopus 로고    scopus 로고
    • Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study
    • Olsson J., Wikby A., Johansson B., et al. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev. 121 (2000) 187-201
    • (2000) Mech. Ageing Dev. , vol.121 , pp. 187-201
    • Olsson, J.1    Wikby, A.2    Johansson, B.3
  • 64
    • 0042206627 scopus 로고    scopus 로고
    • Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)
    • Ouyang Q., Wagner W.M., Voehringer D., et al. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp. Gerontol. 38 (2003) 911-920
    • (2003) Exp. Gerontol. , vol.38 , pp. 911-920
    • Ouyang, Q.1    Wagner, W.M.2    Voehringer, D.3
  • 66
    • 0036644685 scopus 로고    scopus 로고
    • Is human immunosenescence clinically relevant? Looking for "immunological risk phenotype"
    • Pawelec G., Ouyang Qin, Colonna-Romano G., et al. Is human immunosenescence clinically relevant? Looking for "immunological risk phenotype". Trends Immunol. 23 (2002) 330-332
    • (2002) Trends Immunol. , vol.23 , pp. 330-332
    • Pawelec, G.1    Ouyang Qin2    Colonna-Romano, G.3
  • 67
    • 20344396835 scopus 로고    scopus 로고
    • Human immunosenescence: is it infectious?
    • Pawelec G., Akbar A., Caruso C., et al. Human immunosenescence: is it infectious?. Immunol. Rev. 205 (2005) 257-268
    • (2005) Immunol. Rev. , vol.205 , pp. 257-268
    • Pawelec, G.1    Akbar, A.2    Caruso, C.3
  • 68
    • 20344396835 scopus 로고    scopus 로고
    • Is immunosenescence infectious?
    • Pawelec G., Akbar A., Caruso C., et al. Is immunosenescence infectious?. Trends Immunol. 205 (2005) 257-268
    • (2005) Trends Immunol. , vol.205 , pp. 257-268
    • Pawelec, G.1    Akbar, A.2    Caruso, C.3
  • 69
    • 0037469232 scopus 로고    scopus 로고
    • Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association
    • Pearson T.A., Mensah G.A., Alexander R.W., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 177 (2003) 499-511
    • (2003) Circulation , vol.177 , pp. 499-511
    • Pearson, T.A.1    Mensah, G.A.2    Alexander, R.W.3
  • 70
    • 1642556821 scopus 로고    scopus 로고
    • Understanding the determinants of exceptional longevity
    • Perls T., and Terry D. Understanding the determinants of exceptional longevity. Ann. Int. Med. 139 (2003) 445-449
    • (2003) Ann. Int. Med. , vol.139 , pp. 445-449
    • Perls, T.1    Terry, D.2
  • 71
    • 1342265405 scopus 로고    scopus 로고
    • Ageing in the 21st century. Where to and how will we get there? Report on the 10th congress of the international association of biomedical gerontology, the geriatrician's view
    • Rea I.M. Ageing in the 21st century. Where to and how will we get there? Report on the 10th congress of the international association of biomedical gerontology, the geriatrician's view. Exp. Gerontol. 39 (2004) 283-284
    • (2004) Exp. Gerontol. , vol.39 , pp. 283-284
    • Rea, I.M.1
  • 72
    • 0242500485 scopus 로고    scopus 로고
    • Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants
    • Rea I.M., Ross O.A., Armstrong M., et al. Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants. Mech. Ageing Dev. 124 (2003) 555-561
    • (2003) Mech. Ageing Dev. , vol.124 , pp. 555-561
    • Rea, I.M.1    Ross, O.A.2    Armstrong, M.3
  • 73
    • 12244256100 scopus 로고    scopus 로고
    • An inflammation score is better associated with basal than stimulated surrogate indexes of insulin resistance
    • Recasens M., Lopez-Bermejo A., Ricart W., et al. An inflammation score is better associated with basal than stimulated surrogate indexes of insulin resistance. J. Clin. Endocrinol. Metab. 90 (2005) 112-116
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 112-116
    • Recasens, M.1    Lopez-Bermejo, A.2    Ricart, W.3
  • 74
    • 0031938266 scopus 로고    scopus 로고
    • C-reactive protein and risks of future myocardial infarction and thrombotic stroke
    • Ridker P.M. C-reactive protein and risks of future myocardial infarction and thrombotic stroke. Eur. Heart J. 19 (1998) 1-3
    • (1998) Eur. Heart J. , vol.19 , pp. 1-3
    • Ridker, P.M.1
  • 75
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker P.M., Hennekens C.H., Buring J.E., et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N. Engl. J. Med. 342 (2000) 836-843
    • (2000) N. Engl. J. Med. , vol.342 , pp. 836-843
    • Ridker, P.M.1    Hennekens, C.H.2    Buring, J.E.3
  • 76
    • 0037291273 scopus 로고    scopus 로고
    • Study of age-association with cytokine gene polymorphisms in an aged Irish population
    • Ross O.A., Curran M.D., Meenagh A., et al. Study of age-association with cytokine gene polymorphisms in an aged Irish population. Mech. Ageing Dev. 124 (2003) 199-206
    • (2003) Mech. Ageing Dev. , vol.124 , pp. 199-206
    • Ross, O.A.1    Curran, M.D.2    Meenagh, A.3
  • 77
    • 0037927688 scopus 로고    scopus 로고
    • Catabolism of aging: is it an inflammatory process?
    • Roubenoff R. Catabolism of aging: is it an inflammatory process?. Curr. Opin. Clin. Nutr. Metab. Care 6 (2003) 295-299
    • (2003) Curr. Opin. Clin. Nutr. Metab. Care , vol.6 , pp. 295-299
    • Roubenoff, R.1
  • 78
    • 0141892842 scopus 로고    scopus 로고
    • Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham heart study
    • Roubenoff R., Parise H., Payette H.A., et al. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham heart study. Am. J. Med. 115 (2003) 429-435
    • (2003) Am. J. Med. , vol.115 , pp. 429-435
    • Roubenoff, R.1    Parise, H.2    Payette, H.A.3
  • 79
    • 0037261078 scopus 로고    scopus 로고
    • High circulating levels of tumor necrosis factor-α in centenarians are not associated with increased production in T lymphocytes
    • Sandmand M., Bruunsgaard H., Kemp K., et al. High circulating levels of tumor necrosis factor-α in centenarians are not associated with increased production in T lymphocytes. Gerontology 49 (2003) 155-160
    • (2003) Gerontology , vol.49 , pp. 155-160
    • Sandmand, M.1    Bruunsgaard, H.2    Kemp, K.3
  • 80
    • 9144232352 scopus 로고    scopus 로고
    • Statin and fibrate treatment of combined hyperlipidemia: the effects on some novel risk factors
    • Sebestjen M., Keber I., Zegura B., et al. Statin and fibrate treatment of combined hyperlipidemia: the effects on some novel risk factors. Thromb. Haemost. 92 (2004) 1129-1135
    • (2004) Thromb. Haemost. , vol.92 , pp. 1129-1135
    • Sebestjen, M.1    Keber, I.2    Zegura, B.3
  • 81
    • 12344265789 scopus 로고    scopus 로고
    • T cell subsets and mortality in older community-dwelling women
    • Semba R.D., Margolick J.B., Leng S., et al. T cell subsets and mortality in older community-dwelling women. Exp. Gerontol. 40 (2005) 81-87
    • (2005) Exp. Gerontol. , vol.40 , pp. 81-87
    • Semba, R.D.1    Margolick, J.B.2    Leng, S.3
  • 82
    • 0036198286 scopus 로고    scopus 로고
    • Sustained high frequencies of specific CD4 T cells restricted to a single persistent virus
    • Sester M., Sester U., Gartner B., et al. Sustained high frequencies of specific CD4 T cells restricted to a single persistent virus. J. Virol. 76 (2002) 3748-3755
    • (2002) J. Virol. , vol.76 , pp. 3748-3755
    • Sester, M.1    Sester, U.2    Gartner, B.3
  • 83
    • 7244219899 scopus 로고    scopus 로고
    • Sudden unexpected death in heart failure may be preceded by short term, intraindividual increases in inflammation and in autonomic dysfunction: a pilot study
    • Shehab A.M., MacFadyen R.J., McLaren M., et al. Sudden unexpected death in heart failure may be preceded by short term, intraindividual increases in inflammation and in autonomic dysfunction: a pilot study. Heart 90 (2004) 1263-1268
    • (2004) Heart , vol.90 , pp. 1263-1268
    • Shehab, A.M.1    MacFadyen, R.J.2    McLaren, M.3
  • 84
    • 4644305250 scopus 로고    scopus 로고
    • Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes
    • Shetty G.K., Economides P.A., Horton E.S., et al. Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care 27 (2004) 2450-2457
    • (2004) Diabetes Care , vol.27 , pp. 2450-2457
    • Shetty, G.K.1    Economides, P.A.2    Horton, E.S.3
  • 85
    • 4444285836 scopus 로고    scopus 로고
    • Plasma levels of inflammatory C-reactive protein and interleukin-6 predict outcome in elderly patients with stroke
    • Silvestri A., Vitale C., Ferretti F., et al. Plasma levels of inflammatory C-reactive protein and interleukin-6 predict outcome in elderly patients with stroke. J. Am. Geriatr. Soc. 52 (2004) 1586-1587
    • (2004) J. Am. Geriatr. Soc. , vol.52 , pp. 1586-1587
    • Silvestri, A.1    Vitale, C.2    Ferretti, F.3
  • 86
    • 13844298724 scopus 로고    scopus 로고
    • Endothelial inflammation in insulin resistance
    • Sjoholm A., and Nystrom T. Endothelial inflammation in insulin resistance. Lancet 365 (2005) 610-612
    • (2005) Lancet , vol.365 , pp. 610-612
    • Sjoholm, A.1    Nystrom, T.2
  • 87
    • 0142055947 scopus 로고    scopus 로고
    • New markers of inflammation and endothelial cell activation
    • Szmitko P.E., Wang C.-H., and Weisel R.D. New markers of inflammation and endothelial cell activation. Circulation 108 (2003) 1917-1923
    • (2003) Circulation , vol.108 , pp. 1917-1923
    • Szmitko, P.E.1    Wang, C.-H.2    Weisel, R.D.3
  • 88
    • 0040780540 scopus 로고    scopus 로고
    • Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation
    • Terry C.F., Loukaci V., and Green F.R. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J. Biol. Chem. 275 (2000) 18138-18144
    • (2000) J. Biol. Chem. , vol.275 , pp. 18138-18144
    • Terry, C.F.1    Loukaci, V.2    Green, F.R.3
  • 89
    • 0036604205 scopus 로고    scopus 로고
    • Differentiation of human CD8+ T cells from a memory to memory/effector phenotype
    • Tomiyama H., Matsuda T., and Takiguchi M. Differentiation of human CD8+ T cells from a memory to memory/effector phenotype. J. Immunol. 168 (2002) 5538-5550
    • (2002) J. Immunol. , vol.168 , pp. 5538-5550
    • Tomiyama, H.1    Matsuda, T.2    Takiguchi, M.3
  • 90
    • 0347511004 scopus 로고    scopus 로고
    • Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging
    • Tracy R.P. Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging. Int. J. Obes. Relat. Metab. Disord. 27 (2003) 29-34
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , pp. 29-34
    • Tracy, R.P.1
  • 91
    • 0036867423 scopus 로고    scopus 로고
    • Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus
    • Valenzuela H.F., and Effros R.B. Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin. Immunol. 105 (2002) 117-125
    • (2002) Clin. Immunol. , vol.105 , pp. 117-125
    • Valenzuela, H.F.1    Effros, R.B.2
  • 92
    • 0037465808 scopus 로고    scopus 로고
    • Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study
    • Vasan R.S., Sullivan L.M., Roubenoff R., et al. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation 107 (2003) 1486-1491
    • (2003) Circulation , vol.107 , pp. 1486-1491
    • Vasan, R.S.1    Sullivan, L.M.2    Roubenoff, R.3
  • 93
    • 2442422177 scopus 로고    scopus 로고
    • C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function
    • Verma S., Kuliszewski M.A., Li S.H., et al. C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function. Circulation 109 (2004) 2058-2067
    • (2004) Circulation , vol.109 , pp. 2058-2067
    • Verma, S.1    Kuliszewski, M.A.2    Li, S.H.3
  • 94
    • 0035916309 scopus 로고    scopus 로고
    • Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study
    • Volpato S., Guralnik J.M., Ferrucci L., et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation 103 (2001) 947-953
    • (2001) Circulation , vol.103 , pp. 947-953
    • Volpato, S.1    Guralnik, J.M.2    Ferrucci, L.3
  • 95
    • 0032524932 scopus 로고    scopus 로고
    • Changes in CD8 and CD4 lymphocyte subsets, T cell proliferative responses and non-survival in the very old: the Swedish longitudinal OCTO immune study
    • Wikby A., Maxson P., Olsson J., et al. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferative responses and non-survival in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev. 102 (1998) 187-198
    • (1998) Mech. Ageing Dev. , vol.102 , pp. 187-198
    • Wikby, A.1    Maxson, P.2    Olsson, J.3
  • 96
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    • Wikby A., Johansson B., Olsson J., et al. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp. Gerontol. 37 (2002) 445-453
    • (2002) Exp. Gerontol. , vol.37 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3
  • 97
    • 0036604316 scopus 로고    scopus 로고
    • Identification of naive or antigen-experienced human CD8+ T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8+ T cell response
    • Wills M.R., Okecha G., Weekes M.P., et al. Identification of naive or antigen-experienced human CD8+ T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8+ T cell response. J. Immunol. 168 (2002) 5155-5161
    • (2002) J. Immunol. , vol.168 , pp. 5155-5161
    • Wills, M.R.1    Okecha, G.2    Weekes, M.P.3
  • 98
    • 6944249060 scopus 로고    scopus 로고
    • Risk factors relating blood markers of inflammation and nutritional status to survival in cachectic geriatric patients in a randomized clinical trial
    • Yeh S.S., Hafner A., Chang C.K., et al. Risk factors relating blood markers of inflammation and nutritional status to survival in cachectic geriatric patients in a randomized clinical trial. J. Am. Geriatr. Soc. 52 (2004) 1708-1712
    • (2004) J. Am. Geriatr. Soc. , vol.52 , pp. 1708-1712
    • Yeh, S.S.1    Hafner, A.2    Chang, C.K.3
  • 99
    • 10744223612 scopus 로고    scopus 로고
    • Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence
    • Zanni F., Vescovini R., Biasini C., et al. Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp. Gerontol. 38 (2003) 981-987
    • (2003) Exp. Gerontol. , vol.38 , pp. 981-987
    • Zanni, F.1    Vescovini, R.2    Biasini, C.3
  • 100
    • 0037017378 scopus 로고    scopus 로고
    • Aging leads to disturbed homeostasis of memory phenotype CD8+ cells
    • Zhang X., Fujii H., Kishimoto H., et al. Aging leads to disturbed homeostasis of memory phenotype CD8+ cells. J. Exp. Med. 195 (2002) 283-293
    • (2002) J. Exp. Med. , vol.195 , pp. 283-293
    • Zhang, X.1    Fujii, H.2    Kishimoto, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.