Circulating and vascular bioactive factors during hypertension in pregnancy

Current Bioactive Compounds

Volumn 6, Issue 1, 2010, Pages 60-75

  Tanbe, Alain F ^a   Khalil, Raouf A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Calcium; Cytokines; Endothelium; Nitric oxide; Preeclampsia; Vascular smooth muscle

Indexed keywords

2 METHOXY ESTRADIOL; ANGIOTENSIN II; CALCIUM; CALCIUM ION; CYTOKINE; ENDOGLIN; ENDOTHELIN; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ESTRADIOL; HYPOXIA INDUCIBLE FACTOR; LEAD; MAGNESIUM; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; POTASSIUM; PROSTACYCLIN; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; RHO KINASE; THROMBOXANE A2; UNCLASSIFIED DRUG; VASCULOTROPIN; VITAMIN D;

CYTOTROPHOBLAST; DIET SUPPLEMENTATION; DYSLIPIDEMIA; ENDOTHELIUM; ETHNICITY; FETUS GENE; GENETIC RISK; HUMAN; HYPERGLYCEMIA; MATERNAL GENE; MATERNAL HYPERTENSION; NONHUMAN; OXIDATIVE STRESS; PLACENTA DISORDER; PLACENTA HYPOXIA; PLACENTA ISCHEMIA; PREECLAMPSIA; PRIORITY JOURNAL; REVIEW; VASCULAR SMOOTH MUSCLE;

EID: 77949885485     PISSN: 15734072     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340710790711737     Document Type: Review

References (162)

1. Clausen, T., Slott, M., Solvoll, K., Drevon, C.A., Vollset, S.E., Henriksen, T. (2001) High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsia. Am. J. Obstet. Gynecol., 185, 451-458.
2. Roberts, J.M., Gammill, H.S. (2005) Preeclampsia: recent insights. Hypertension, 46(6), 1243-1249.
3. Villar, J., Carroli, G., Wojdyla, D., Abalos, E., Giordano, D., Ba'aqeel, H., Farnot, U., Bergsjø, P., Bakketeig, L., Lumbiganon, P., Campodónico, L., Al-Mazrou, Y., Lindheimer, M., Kramer, M., World Health Organization Antenatal Care Trial Research Group.
4. (2006) Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions? Am. J. Obstet. Gynecol., 194(4), 921-931.
5. Stennett, A.K., Khalil, R.A. (2006) Neurovascular mechanisms of hypertension in pregnancy. Curr. Neurovasc. Res., 3(2), 131-148.
6. Sholook, M.M., Gilbert, J.S., Sedeek, M.H., Huang, M., Hester, R.L., Granger, J.P. (2007) Systemic hemodynamic and regional blood flow changes in response to chronic reductions in uterine perfusion pressure in pregnant rats. Am. J. Physiol. Heart. Circ. Physiol., 293(4), H2080-H2084.
7. Skjaerven, R., Vatten, L.R., Wilcox, A.J., Ronning, T., Irgens, L.M., Lie, R.T. (2006) Recurrence of pre-eclampsia across generations: Exploring fetal and maternal genetic components in a population based cohort. Obstet. Gynecol. Surv., 61(3), 162-163.
8. Cross, J.C. (2003) The genetics of pre-eclampsia: a feto-placental or maternal problem? Clin. Genet., 64, 96-103.
9. Winn, V.D., Gormley, M., Paquet, A.C., Kjaer-Sorensen, K., Kramer, A., Rumer, K.K., Haimov-Kochman, R., Yeh, R.F., Overgaard, M.T., Varki, A., Oxvig, C., Fisher, S.J. (2009) Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology, 150(1), 452-62.
10. Kobashi, G. (2006) Genetic and environmental factors associated with the development of hypertension in pregnancy. J. Epidemiol., 16, 1-8.
11. Rosenberg, T.J., Garbers, S., Lipkind, H., Chiasson, M.A. (2005) Maternal obesity and diabetes as risk factors for adverse pregnancy outcomes: differences among 4 racial/ethnic groups. Am. J. Public Health, 95(9), 1545-1551.
12. Ray, J., Diamond, P., Singh, G., Bell, C. (2006) Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG, 113, 379-386.
13. Thomas, M., Weisman, S.M. (2006) Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus. Am. J. Obstet. Gynecol., 194(4), 937-945.
14. Prada, J.A., Tsang, R.C., Clark, K.E. (1994) Hypocalcemia and pregnancy-induced hypertension produced by low-calcium diet. Hypertension, 23(6), 695-702.
15. Oken, E., Ning, Y., Rifas-Shiman, S.L., Rich-Edwards, J.W., Olsen, S.F., Gillman, M.W. (2007) Diet during pregnancy and risk of preeclampsia or gestational hypertension. Ann. Epidemiol., 17(9), 663-668.
16. Villar, J., Abdel-Aleem, H., Merialdi, M., Mathai, M., Ali, M.M., Zavaleta, N., Purwar, M., Hofmeyr, J., Nguyen, T.N., Campódonico, L., Landoulsi, S., Carroli, G., Lindheimer, M., World Health Organization Calcium Supplementation for the Prevention of Preeclampsia Trial Group. (2006) World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am. J. Obstet. Gynecol., 194(3), 639-649.
17. Bodnar, L.M., Catov, J.M., Simhan, H.N., Holick, M.F., Powers, R.W., Roberts, J.M. (2007) Maternal vitamin D deficiency increases the risk of preeclampsia. J. Clin. Endocrinol. Metab., 92(9), 3517-3522.
18. Li, Y.C., Kong, J., Wei, M., Chen, Z.F., Liu, S.Q., Cao, L.P. (2002) 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J. Clin. Invest., 110(2), 229-238.
19. Roberts, J.M., Balk, J.L., Bodnar, L.M., Belizan, J.M., Bergel, E., Martinez, A. (2003) Nutrition as a preventive strategy against adverse pregnancy outcomes. J. Nutr., 133, 1684S-1692S.
20. Frederick, I.O., Williams, M.A., Dashow, E., Kestin, M., Zhang, C., Leisenring, W.M. (2005) Dietary fiber, potassium, magnesium and calcium in relation to the risk of preeclampsia. J. Reprod. Med., 50, 332-344.
21. Holmes, V.A., McCance, D.R. (2005) Could antioxidant supplementation prevent pre-eclampsia? Proc. Nutr. Soc., 64, 491-501.
22. Chen, X.K., Yang, Q., Smith, G., Krewski, D., Walker, M., Wen, S.W. (2006) Environmental lead level and pregnancy-induced hypertension. Environ. Res., 100, 424-430.
23. Vigeh, M., Yokoyama, K., Mazaheri, M., Beheshti, S., Ghazizadeh, S., Sakai, T., Morita, Y., Kitamura, F., Araki, S. (2004) Relationship between increased blood lead and pregnancy hypertension in women without occupational lead exposure in Tehran, Iran. Arch. Environ. Health, 59(2), 70-75.
24. Fisher, S.J. (2004) The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod. Biol. Endocrinol., 2, 53.
25. McMaster, M.T., Zhou, Y., Fisher, S.J. (2004) Abnormal placentation and the syndrome of preeclampsia. Semin. Nephrol., 24(6), 540-547.
26. Alexander, B.T. (2006) Fetal programming of hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol., 290(1), R1-R10.
27. Ojeda, N.B., Grigore, D., Alexander, B.T. (2008) Intrauterine growth restriction: fetal programming of hypertension and kidney disease. Adv. Chronic Kidney Dis., 15(2), 101-106.
28. Gilbert, J.S., Ryan, M.J., LaMarca, B.B., Sedeek, M., Murphy, S.R., Granger, J.P. (2008) Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am. J. Physiol. Heart. Circ. Physiol., 294(2), H541-H550.
29. Shaarawy, M., Al-Sokkary, F., Sheba, M., Wahba, O., Kandil, H.O., Abdel-Mohsen, I. (2005) Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia. Int. J. Gynaecol. Obstet., 88, 112-117.
30. Stepan, H., Geide, A., Faber, R. (2004) Soluble fms-like tyrosine kinase 1. N. Engl. J. Med., 351(21), 2241-2242.
31. Levine, R.J., Lam, C., Qian, C., Yu, K.F., Maynard, S.E., Sachs, B.P., Sibai, B.M., Epstein, F.H., Romero, R., Thadhani, R., Karumanchi, S.A., CPEP Study Group. (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N. Engl. J. Med., 355(10), 992-1005.
32. Hayashi, M., Ueda, Y., Yamaguchi, T., Sohma, R., Shibazaki, M., Ohkura, T., Inaba, N. (2005) Tumor Necrosis Factor-α in the placenta is not elevated in the pre-eclamptic patients despite its elevation in peripheral blood. Am. J. Reprod. Immunol., 53, 113-119.
33. Casart, Y.C., Tarrazzi, K., Camejo, M.I. (2007) Serum levels of interleukin-6, interleukin-1beta and human chorionic gonadotropin in pre-eclamptic and normal pregnancy. Gynecol. Endocrinol., 23(5), 300-303.
34. Rajakumar, A., Whitelock, K.A., Weissfeld, L.A., Daftary, A.R., Markovic, N., Conrad, K.P. (2001) Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentas from women with preeclampsia. Biol. Reprod., 64, 499-506.
35. Tsukimori, K., Fukushima, K., Tsushima, A., Nakano, H. (2005) Generation of reactive oxygen species by neutrophils and endothelial cell injury in normal and preeclamptic pregnancies. Hypertension, 46, 696-700.
36. Narumiya, H., Zhang, Y., Fernandez-Patron, C., Guilbert, L.J., Davidge, S.T. (2001) Matrix metalloproteinase-2 is elevated in the plasma of women with preeclampsia. Hypertens. Pregnancy, 20(2), 185-194.
37. Kanasaki, K., Palmsten, K., Sugimoto, H., Ahmad, S., Hamano, Y., Xie, L., Parry, S., Augustin, H.G., Gattone, V.H., Folkman, J., Strauss, J.F., Kalluri, R. (2008) Deficiency in catechol-Omethyltransferase and 2-methoxyoestradiol is associated with preeclampsia. Nature, 453(7198), 1117-1121.
38. Ranta, V., Viinikka, L., Halmesmäki, E., Ylikorkala, O. (1999) Nitric oxide production with preeclampsia. Obstet. Gynecol., 93(3), 442-445.
39. Crews, J.K., Herrington, J.N., Granger, J.P., Khalil, R.A. (2000) Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat. Hypertension, 35, 367-372.
40. Kenny, L.C., Baker, P.N., Kendall, D.A., Randall, M.D., Dunn, W.R. (2002) Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsia. Clin. Sci. Lond., 103, 67-73.
41. Clark, B.A., Halvorson, L., Sachs, B., Epstein, F.H. (1992) Plasma endothelin levels in preeclampsia: elevation and correlation with uric acid levels and renal impairment. Am. J. Obstet. Gynecol., 166(3), 962-968.
42. Brosnihan, K.B., Neves, L.A., Anton, L., Joyner, J., Valdes, G., Merrill, D.C. (2004) Enhanced expression of Ang-(1-7) during pregnancy. Braz. J. Med. Biol. Res., 37,1255-1262.
43. Maynard, S.E., Min, J.Y., Merchan, J., Lim, K.H., Li, J., Mondal, S., Libermann, T.A., Morgan, J.P., Sellke, F.W., Stillman, I.E., Epstein, F.H., Sukhatme, V.P., Karumanchi, S.A. (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest., 111(5), 649-658
44. Gilbert, J.S., Babcock, S.A., Granger, J.P. (2007) Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression. Hypertension, 50(6), 1142-1147.
45. Purwosunu, Y., Sekizawa, A., Farina, A., Wibowo, N., Koide, K., Okazaki, S., Nakamura, M., Okai, T. (2008) Evaluation of physiological alterations of the placenta through analysis of cell-free messenger ribonucleic acid concentrations of angiogenic factors. Am. J. Obstet. Gynecol., 198(1), 124.e1-7.
46. LaMarca, B.B., Bennett, W.A., Alexander, B.T., Cockrell, K., Granger, J.P. (2005) Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of tumor necrosis factor-alpha. Hypertension, 46(4), 1022-1025.
47. LaMarca, B.D., Ryan, M.J., Gilbert, J.S., Murphy, S.R., Granger, J.P. (2007) Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia. Curr. Hypertens. Rep., 9(6), 480-485.
48. Alexander, B.T., Kassab, S.E., Miller, M.T., Abram, S.R., Reckelhoff, J.F., Bennett, W.A., Granger, J.P. (2001) Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide. Hypertension, 37(4), 1191-1195.
49. Wang, Y., Walsh, S., Guo, J., Zhang, J. (1991) The imbalance between thromboxane and prostacyclin in preeclampsia. Curr. Hypertens., 165, 1695-1700.
50. LaMarca, B.B., Cockrell, K., Sullivan, E., Bennett, W., Granger, J.P. (2005) Role of endothelin in mediating tumor necrosis factorinduced hypertension in pregnant rats. Hypertension, 46(1), 82-86.
51. Lamarca, B., Wallukat, G., Llinas, M., Herse, F., Dechend, R., Granger, J.P. (2008) Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor-alpha in pregnant rats. Hypertension, 52(6), 1168-1172.
52. Murphy, J.G., Fleming, J.B., Cockrell, K.L., Granger, J.P., Khalil, R.A. (2001) [Ca2+]i signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS. Am. J. Physiol. Regul. Integr. Comp. Physiol., 280(1), R87-R99.
53. Murphy, J.G., Herrington, J.N., Granger, J.P., Khalil, R.A. (2003) Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure. Am. J. Physiol. Heart Circ. Physiol., 284(1), H393-H403.
54. Sargent, I.L., Germain, S.J., Sacks, G.P., Kumar, S., Redman, C.W. (2003) Trophoblast deportation and the maternal inflammatory response in pre-eclampsia. J. Reprod. Immunol., 59(2), 153-160.
55. Kertesz, Z., Hurst, G., Ward, M., Willis, A.C., Caro, H., Linton, E.A., Sargent, I.L., Redman, C.W. (1999) Purification and characterization of a complex from placental syncytiotrophoblast microvillous membranes which inhibits the proliferation of human umbilical vein endothelial cells. Placenta, 20(1), 71-79.
56. Wang, Y., Lewis, D.F., Gu, Y., Zhang, Y., Alexander, J.S., Granger, D.N. (2004) Placental trophoblast-derived factors diminish endothelial barrier function. J. Clin. Endocrinol. Metab., 89(5), 2421-2428.
57. Van Wijk, M.J., Boer, K., Nisell, H., Smarason, A.K., Van Bavel, E., Kublickiene, K.R. (2001) Endothelial function in myometrial resistance arteries of normal pregnant women perfused with syncytiotrophoblast microvillous membranes. Br. J. Obstet. Gynecol., 108, 967-972.
58. Hayman, R., Warren, A., Johnson, I., Baker, P. (2001) The preliminary characterization of a vasoactive circulating factor(s) in preeclampsia. Am. J. Obstet. Gynecol., 184, 1196-1203.
59. Brownbill, P., Mills, T.A., Soydemir, D.F., Sibley, C.P. (2008) Vasoactivity to and endogenous release of vascular endothelial growth factor in the in vitro perfused human placental lobule from pregnancies complicated by preeclampsia. Placenta, 29(11), 950-955.
60. Munaut, C., Lorquet, S., Pequeux, C., Blacher, S., Berndt, S., Frankenne, F., Foidart, J.M. (2008) Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast. Hum. Reprod., 23(6), 1407-1415.
61. Akercan, F., Cirpan, T., Terek, M.C., Ozcakir, H.T., Giray, G., Sagol, S., Karadadas, N. (2008) The immunohistochemical evaluation of VEGF in placenta biopsies of pregnancies complicated by preeclampsia. Arch. Gynecol. Obstet., 277(2), 109-114.
62. Bosio, P.M., Wheeler, T., Anthony, F., Conroy, R., O'herlihy, C., McKenna, P. (2001) Maternal plasma vascular endothelial growth factor concentrations in normal and hypertensive pregnancies and their relationship to peripheral vascular resistance. Am. J. Obstet. Gynecol., 184, 146-152.
63. VanWijk, M.J., Kublickiene, K., Boer, K., VanBavel, E. (2000) Vascular function in preeclampsia. Cardiovasc. Res., 47(1), 38-48.
64. Serraf, A., Aznag, H., Baudet, B., Détruit, H., Séccatore, F., Mazmanian, M.G., Planché, C. (2003) Pulmonary vascular endothelial growth factor and nitric oxide interaction during total cardiopulmonary bypass in neonatal pigs. J. Thorac. Cardiovasc. Surg., 125,1050-1057.
65. Woolcock, J., Hennessy, A., Xu, B., Thornton, C., Tooher, J., Makris, A., Ogle, R. (2008) Soluble Flt-1 as a diagnostic marker of pre-eclampsia. Aust. NZ J Obstet. Gynecol., 48(1), 64-70.
66. Boyd, P.A., Lindenbaum, R.H., Redman, C. (1987) Pre-eclampsia and trisomy 13: a possible association. Lancet, 2, 425-427.
67. Tuohy, J.F., James, D.K. (1992) Pre-eclampsia and trisomy 13. Br. J. Obstet. Gynecol., 99, 891-894.
68. Hirashima, C., Ohkuchi, A., Matsubara, S., Suzuki, H., Takahashi, K., Usui, R., Suzuki, M. (2008) Alteration of serum soluble endoglin levels after the onset of preeclampsia is more pronounced in women with early-onset. Hypertens. Res., 31(8), 1541-1548.
69. Venkatesha, S., Toporsian, M., Lam, C., Hanai, J., Mammoto, T., Kim, Y.M., Bdolah, Y., Lim, K.H., Yuan, H.T., Libermann, T.A., Stillman, I.E., Roberts, D., D'Amore, P.A., Epstein, F.H., Sellke, F.W., Romero, R., Sukhatme, V.P., Letarte, M., Karumanchi, S.A. (2006) Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat. Med., 2, 642-649.
70. ten Dijke, P., Goumans, M.J., Pardali, E. (2008) Endoglin in angiogenesis and vascular diseases. Angiogenesis, 11(1), 79-89.
71. Conrad, K.P., Miles, T.M., Benyo, D.F. (1998) Circulating levels
72. of immunoreactive cytokines in women with preeclampsia. Am. J. Reprod. Immunol., 40, 102-111.
73. Hashii, K., Fujiwara, H., Yoshioka, S., Kataoka, N., Yamada, S., Hirano, T., Mori, T., Fujii, S., Maeda, M. (1998) Peripheral blood mononuclear cells stimulate progesterone production by luteal cells derived from pregnant and non-pregnant women: possible involvement of interleukin-4 and interleukin-10 in corpus luteum function and differentiation. Hum. Reprod., 13(1O), 2738-2744.
74. Gadonski, G., LaMarca, B.B., Sullivan, E., Bennett, W., Chandler, D., Granger, J.P. (2006) Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of interleukin 6. Hypertension, 48(4), 711-716.
75. Alexander, B.T., Cockrell, K.L., Massey, M.B., Bennett, W.A., Granger, J.P. (2002) Tumor necrosis factor-α-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression. Am. J. Hypertens., 15, 12-19.
76. Davis, J.R., Giardina, J.B., Green, G.M., Alexander, B.T., Granger, J.P., Khalil, R.A. (2002) Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-α-induced hypertension in pregnant rats. Am. J. Physiol. Reg. Int. Comp. Physiol., 282, R390-R399.
77. Orshal, J.M., Khalil, R.A. (2004) Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension, 43, 434-444.
78. Sedeek, M., Gilbert, J.S., LaMarca, B.B., Sholook, M., Chandler, D.L., Wang, Y., Granger, J.P. (2008) Role of reactive oxygen species in hypertension produced by reduced uterine perfusion in pregnant rats. Am. J. Hypertens., 21(10), 1152-1156.
79. Sato, H., Sato, M., Kanai, H., Uchiyama, T., Iso, T., Ohyama, Y., Sakamoto, H., Tamura, J., Nagai, R., Kurabayashi, M. (2005) Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells. Cardiovasc. Res., 67(4), 714-722.
80. Tyurin, V.A., Liu, S.X., Tyurina, Y.Y., Sussman, N.B., Hubel, C.A., Roberts, J.M., Taylor, R.N., Kagan, V.E. (2001) Elevated levels of S-nitrosoalbumin in preeclampsia plasma. Circ. Res., 88(11), 1210-1215.
81. Chambers, J.C., Fusi, L., Malik, I.S., Haskard, D.O., De Swiet, M., Kooner, J.S. (2001) Association of maternal endothelial dysfunction with preeclampsia. JAMA, 285, 1607-1612.
82. Roberts, J.M., Speer, P. (2004) Antioxidant therapy to prevent preeclampsia. Semin. Nephrol., 24, 557-564.
83. Parra, M., Rodrigo, R., Barja, P., Bosco, C., Fernández, V., Muñoz, H., Soto-Chacón, E. (2005) Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction. Am. J. Obstet. Gynecol., 193(4), 1486-1491.
84. Egi, K., Conrad, N.E., Kwan, J., Schulze, C., Schulz, R., Wildhirt, S.M. (2004) Inhibition of inducible nitric oxide synthase and superoxide production reduces matrix metalloproteinase-9 activity and restores coronary vasomotor function in rat cardiac allografts. Eur. J. Cardiothorac. Surg., 26, 262-269.
85. Chang, T.C., Huang, C.J., Tam, K., Chen, S.F., Tan, K.T., Tsai, M.S., Lin, T.N., Shyue, S.K. (2005) Stabilization of hypoxia-inducible factor-1{alpha} by prostacyclin under prolonged hypoxia via reducing reactive oxygen species level in endothelial cells. J. Biol. Chem., 280(44), 36567-36574.
86. Jin, L., Ying, Z., Webb, R.C. (2004) Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. Am. J. Physiol. Heart Circ. Physiol., 287, H1495-H1500.
87. Semenza, G.L., Agani, F., Iyer, N., Kotch, L., Laughner, E., Leung, S., Yu, A. (1999) Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1. Ann. NY. Acad. Sci., 874, 262-268.
88. Yamashita, K., Discher, D.J., Hu, J., Bishopric, N.H., Webster, K.A. (2001) Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. J. Biol. Chem. 276(16), 12645-12653.
89. Kelly, B.A., Bond, B.C., Poston, L. (2004) Aortic adaptation to pregnancy: elevated expression of matrix metalloproteinases-2 and -3 in rat gestation. Mol. Hum. Reprod., 10, 331-337.
90. Galewska, Z., Bańkowski, E., Romanowicz, L., Jaworski, S. (2003) Pre-eclampsia (EPH-gestosis)-induced decrease of MMP-s content in the umbilical cord artery. Clin. Chim. Acta, 335(1-2), 109-115.
91. 2+ entry mechanisms of vascular contraction. J. Vasc. Surg., 40, 1001-1010.
92. Wang, H., Olszewski, B., Rosebury, W., Wang, D., Robertson, A., Keiser, J.A. (2004) Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression. Biochem. Biophys. Res. Commun., 315, 363-368.
93. Faller, D.V. (1999) Endothelial cell responses to hypoxic stress. Clin. Exp. Pharmacol. Physiol., 26, 74-84.
94. Anumba, D.O., Robson, S.C., Boys, R.J., Ford, G.A. (1999) Nitric oxide activity in the peripheral vasculature during normotensive and preeclamptic pregnancy. Am. J. Physiol., 277, H848-H854.
95. Nelson, S.H., Steinsland, O.S., Wang, Y., Yallampalli, C., Dong, Y.L, Sanchez, J.M. (2000) Increased nitric oxide synthase activity and expression in the human uterine artery during pregnancy. Circ. Res., 87, 406-411.
96. Conrad, K.P., Kerchner, L.J., Mosher, M.D. (1999) Plasma and 24-h NO(x) and cGMP during normal pregnancy and preeclampsia in women on a reduced NO(x) diet. Am. J. Physiol., 277, F48-F57.
97. Mutlu-Turkoglu, U., Aykac-Toker, G., Ibrahimoglu, L., Ademoglu, E., Uysal, M. (1999) Plasma nitric oxide metabolites and lipid peroxide levels in preeclamptic pregnant women before and after delivery. Gynecol. Obstet. Invest., 48, 247-250.
98. Schiessl, B., Strasburger, C., Bidlingmaier, M., Mylonas, I., Jeschke, U., Kainer, F., Friese, K. (2006) Plasma- and urine concentrations of nitrite/nitrate and cyclic guanosinemonophosphate in intrauterine growth restricted and preeclamptic pregnancies. Arch. Gynecol. Obstet., 274(3), 150-154.
99. Conrad, K.P., Davis, A.K. (1995) Nitric oxide synthase activity in placentae from women with pre-eclampsia. Placenta, 16, 691-699.
100. Alexander, B.T., Miller, M.T., Kassab, S., Novak, J., Reckelhoff, J.F., Kruckeberg, W.C., Granger, J.P. (1999) Differential expression of renal nitric oxide synthase isoforms during pregnancy in rats. Hypertension, 33(1 Pt 2), 435-439.
101. Roberts, J.M. (1998) Endothelial dysfunction in preeclampsia. Semin. Reprod. Endocrinol., 16, 5-15.
102. Molnar, M., Suto, T., Toth, T., Hertelendy, F. (1994) Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation. Am. J. Obstet. Gynecol., 170, 1458-1466.
103. Khalil, R.A., Crews, J.K., Novak, J., Kassab, S., Granger, J.P. (1998) Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats. Hypertension, 31, 1065-1069.
104. Fike, C.D., Kaplowitz, M.R., Pfister, S.L. (2003) Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. Am. J. Physiol. Lung Cell Mol. Physiol., 284, L316-L323.
105. Suzuki, Y., Hattori, T., Kajikuri, J., Yamamoto, T., Suzumori, K., Itoh, T. (2002) Reduced function of endothelial prostacyclin in human omental resistance arteries in pre-eclampsia. J. Physiol., 545, 269-277.
106. Bowen, R.S., Zhang, Y., Gu, Y., Lewis, D.F., Wang, Y. (2005) Increased phospholipase A2 and thromboxane but not prostacyclin production by placental trophoblast cells from normal and preeclamptic pregnancies cultured under hypoxia condition. Placenta, 26(5), 402-409.
107. Scotland, R.S., Madhani, M., Chauhan, S., Moncada, S., Andresen, J., Nilsson, H., Hobbs, A.J., Ahluwalia, A. (2005) Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation, 111(6), 796-803.
108. Fulep, E.E., Vedernikov, Y.P., Saade, G.R., Garfield, R.E. (2001) The role of endothelium-derived hyperpolarizing factor in the regulation of the uterine circulation in pregnant rats. Am. J. Obstet. Gynecol., 185, 638-642.
109. Petersson, J., Zygmunt, P.M., Jonsson, P., Hogestatt, E.D. (1998) Characterization of endothelium- dependent relaxation in guinea pig basilar artery - effect of hypoxia and role of cytochrome P450 mono-oxygenase. J. Vasc. Res., 35, 285-294.
110. Resta, T.C., Walker, B.R. (1996) Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilation. Am. J. Physiol., 270, H888-H896.
111. Kenny, L.C., Baker, P.N., Kendall, D.A., Randall, M.D., Dunn, W.R. (2002) Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsia. Clin. Sci. Lond., 103, 67-73.
112. Luksha, L., Nisell, H., Luksha, N., Kublickas, M., Hultenby, K., Kublickiene, K. (2008) Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites. Am. J. Physiol. Regul. Integr. Comp. Physiol., 294(2), R510-R519.
113. Niwano, K., Arai, M., Tomaru, K., Uchiyama, T., Ohyama, Y., Kurabayashi, M. (2003) Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: close link between PGI2 signal and NO pathways. Circ. Res., 93(6), 523-530.
114. Orie, N.N., Fry, C.H., Clapp, L.H. (2006) Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism. Cardiovasc. Res., 69, 107-115.
115. Bernardi, F., Constantino, L., Machado, R., Petronilho, F., Dal-Pizzol, F. (2008) Plasma nitric oxide, endothelin-1, arginase and superoxide dismutase in pre-eclamptic women. J. Obstet. Gynaecol. Res., 34(6), 957-963.
116. Kourembanas, S., McQuillan, L.P., Leung, G.K., Faller, D.V. (1993) Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J. Clin. Invest., 92, 99-104.
117. Taylor, R.N., Varma, M., Teng, N.N., Roberts, J.M. (1990) Women with preeclampsia have higher plasma endothelin levels than women with normal pregnancies. J. Clin. Endocrinol. Metab., 71, 1675-1677.
118. Yao, L., Kobori, H., Rahman, M., Seth, D.M., Shokoji, T., Fan, Y., Zhang, G.X., Kimura, S., Abe, Y., Nishiyama, A. (2004) Olmesartan improves endothelin-induced hypertension and oxidative stress in rats. Hypertens. Res., 27(7), 493-500.
119. Giardina, J.B., Green, G.M., Rinewalt, A.N., Granger, J.P., Khalil, R.A. (2001) Role of endothelin B receptors in enhancing endothelium-dependent nitric oxide-mediated vascular relaxation during high salt diet. Hypertension, 37, 516-523.
120. Conrad, K.P., Gandley, R.E., Ogawa, T., Nakanishi, S., Danielson, L.A. (1999) Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats. Am. J. Physiol., 276, F767-F776.
121. Gandley, R.E., Conrad, K.P., McLaughlin, M.K. (2001) Endothelin and nitric oxide mediate reduced myogenic reactivity of small renal arteries from pregnant rats. Am. J. Physiol. Regul. Integr. Comp. Physiol., 280, R1-R7.
122. Weigand, L., Sylvester, J.T., Shimoda, L.A. (2006) Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. Am. J. Physiol. Lung Cell Mol. Physiol., 290(2), L284-L290.
123. Cheng, Z.J., Vapaatalo, H., Mervaala, E. (2005) Angiotensin II and vascular inflammation. Med. Sci. Monit., 11, RA194-RA205.
124. Chassagne, C., Eddahibi, S., Adamy, C., Rideau, D., Marotte, F., Dubois-Randé, J.L., Adnot, S., Samuel, J.L., Teiger, E. (2000) Modulation of angiotensin II receptor expression during development and regression of hypoxic pulmonary hypertension. Am. J. Respir. Cell Mol. Biol., 22(3), 323-332.
125. Merrill, D.C., Karoly, M., Chen, K., Ferrario, C.M., Brosnihan, K.B. (2002) Angiotensin-(1-7) in normal and preeclamptic pregnancy. Endocrine, 18, 239-245.
126. Wesselman, J.P., De Mey, J.G. (2002) Angiotensin and cytoskeletal proteins: role in vascular remodeling. Curr. Hypertens. Rep., 4, 63-70.
127. Mizutani, S., Tomoda, Y. (1996) Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsia. Am. J. Hypertens., 9(6), 591-597.
128. Dechend, R., Homuth, V., Wallukat, G., Kreuzer, J., Park, J.K., Theuer, J., Juepner, A., Gulba, D.C., Mackman, N., Haller, H., Luft, F.C. (2000) AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation, 101(20), 2382-2387.
129. Wijayagunawardane, M.P., Gabler, C., Killian, G., Miyamoto, A. (2003) Tumor necrosis factor alpha in the bovine oviduct during the estrous cycle: messenger RNA expression and effect on secretion of prostaglandins, endothelin-1, and angiotensin II. Biol. Reprod., 69, 1341-1346.
130. Wassmann, S., Stumpf, M., Strehlow, K., Schmid, A., Schieffer, B., Böhm, M., Nickenig, G. (2004) Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ. Res., 94(4), 534-541.
131. Cingolani, H.E., Villa-Abrille, M.C., Cornelli, M., Nolly, A., Ennis, I.L., Garciarena, C., Suburo, A.M., Torbidoni, V., Correa, M.V., Camiliónde Hurtado, M.C., Aiello, E.A. (2006) The positive inotropic effect of angiotensin II: role of endothelin-1 and reactive oxygen species. Hypertension, 47(4), 727-734.
132. Askari, B., Ferrerib, N.R. (2001) Regulation of prostacyclin synthesis by angiotensin II and TNF-α in vascular smooth muscle. Prostaglandins, 63, 175-187.
133. Wang, D., Chabrashvili, T., Borrego, L., Aslam, S., Umans, J.G. (2006) Angiotensin II infusion alters vascular function in mouse resistance vessels: roles of superoxide and endothelium. J. Vasc. Res., 43, 109-119.
134. Goto, K., Fujii, K., Kansui, Y., Iida, M. (2004) Changes in endothelium-derived hyperpolarizing factor in hypertension and ageing: Response to chronic treatment with renin-angiotensin system inhibitors. Clin. Exp. Pharmacol. Physiol., 31, 650-655.
135. Deja, M.A., Gołlba, K.S., Widenka, K., Mrozek, R., Biernat, J., Kolowca, M., Malinowski, M., Woś, S. (2005) Angiotensin-converting enzyme inhibitors reveal non-NO-, non-prostacycline-mediated endothelium-dependent relaxation in internal thoracic artery of hypertensive patients. Int. J. Cardiol., 102(3), 455-460.
136. Wang, Y., Walsh, S.W., Kay, H.H. (1999) Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia. Am. J. Obstet. Gynecol., 167, 946-949.
137. Llinás, M.T., Alexander, B.T., Seedek, M., Abram, S.R., Crell, A., Granger, J.P. (2002) Enhanced thromboxane synthesis during chronic reductions in uterine perfusion pressure in pregnant rats. Am. J. Hypertens., 15(9), 793-797.
138. Coomarasamy, A., Papaioannou, S., Gee, H., Khan, K.S. (2001) Aspirin for the prevention of preeclampsia in women with abnormal uterine artery doppler: a meta-analysis. Obstet. Gynecol., 98, 861-866.
139. Coomarasamy, A., Honest, H., Papaioannou, S., Gee, H., Khan, K.S. (2003) Aspirin for prevention of preeclampsia in women with historical risk factors: a systematic review. Obstet. Gynecol., 101(6), 1319-1332.
140. de Berrazueta, J.R. (1999) The role of calcium in the regulation of normal vascular tone and in arterial hypertension. Rev. Esp. Cardiol., 52(3), 25-33.
141. Wimalasundera, R.C., Thom, S.A., Regan, L., Hughes, A.D. (2005) Effects of vasoactive agents on intracellular calcium and force in myometrial and subcutaneous resistance arteries isolated from preeclamptic, pregnant, and nonpregnant woman. Am. J. Obstet. Gynecol., 192(2), 625-632.
142. Magness, R.R., Rosenfeld, C.R., Carr, B.R. (1991) Protein kinase C in uterine and systemic arteries during ovarian cycle and pregnancy. Am. J. Physiol., 260(3), E464-E470.
143. Kanashiro, C.A., Cockrell, K.L., Alexander, B.T., Granger, J.P., Khalil, R.A. (2000) Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. Am. J. Physiol. Regul. Integr. Comp. Physiol., 278(2), R295-R303.
144. 2+-insensitive vascular protein kinase C during pregnancy and NOS inhibition. Hypertension, 34(4 Pt 2), 924-930.
145. Horowitz, A., Menice, C.B., Laporte, R., Morgan, K.G. (1996) Mechanisms of smooth muscle contraction. Physiol. Rev., 76(4), 967-1003.
146. Salamanca, D.A., Khalil, R.A. (2005) Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem. Pharmacol., 70(11), 1537-1547.
147. VanWijk, M.J., Boer, K., van der Meulen, E.T., Bleker, O.P., Spaan, J.A., VanBavel, E. (2002) Resistance artery smooth muscle function in pregnancy and preeclampsia. Am. J. Obstet. Gynecol., 186(1), 148-154.
148. Wallukat, G., Homuth, V., Fischer, T., Lindschau, C., Horstkamp, B., Jüpner, A., Baur, E., Nissen, E., Vetter, K., Neichel, D., Dudenhausen, J.W., Haller, H., Luft, F.C. (1999) Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J. Clin. Invest., 103, 945-952.
149. Hu, E. (2006) Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases. Recent Pat. Cardiovasc. Drug Discov., 1(3), 249-263.
150. Kataoka, C., Egashira, K., Inoue, S., Takemoto, M., Ni, W., Koyanagi, M., Kitamoto, S., Usui, M., Kaibuchi, K., Shimokawa, H., Takeshita, A. (2002) Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension, 39(2), 245-250.
151. Friel, A.M., Sexton, D.J., O'reilly, M.W., Smith, T.J., Morrison, J.J. (2006) Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction. Reproduction, 132(1), 169-176.
152. Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.E., Karandikar, M., Berman, K., Cobb, M.H. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev., 22(2), 153-183.
153. Khalil, R.A., Menice, C.B., Wang, C.L., Morgan, K.G. (1995) Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ. Res., 76(6), 1101-1108.
154. D'Angelo, G., Graceffa, P., Wang, C.A., Wrangle, J., Adam, L.P. (1999) Mammal-specific, ERK-dependent, caldesmon phosphorylation in smooth muscle. Quantitation using novel anti-phosphopeptide antibodies. J. Biol. Chem., 274(42), 30115-30121.
155. Hedges, J.C., Oxhorn, B.C., Carty, M., Adam, L.P., Yamboliev, I.A., Gerthoffer, W.T. (2000) Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am. J. Physiol. Cell Physiol., 278(4), C718-C726.
156. Kyaw, M., Yoshizumi, M., Tsuchiya, K., Izawa, Y., Kanematsu, Y., Tamaki, T. (2004) Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases. Acta Pharmacol. Sin., 25(8), 977-985.
157. Lee, D.L., Sturgis, L.C., Labazi, H., Osborne, J.B.Jr., Fleming, C., Pollock, J.S., Manhiani, M., Imig, J.D., Brands, M.W. (2006) Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. Am. J. Physiol. Heart Circ. Physiol., 290(3), H935-H940.
158. Zhao, Q., Ishibashi, M., Hiasa, K., Tan, C., Takeshita, A., Egashira, K. (2004) Essential role of vascular endothelial growth factor in angiotensin II-induced vascular inflammation and remodeling. Hypertension, 44(3), 264-270.
159. Brilla, C.G., Zhou, G., Rupp, H., Maisch, B., Weber, K.T. (1995) Role of angiotensin II and prostaglandin E2 in regulating cardiac fibroblast collagen turnover. Am. J. Cardiol., 76(13), 8D-13D.
160. Ergul, A., Portik-Dobos, V., Giulumian, A.D., Molero, M.M., Fuchs, L.C. (2003) Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation. Am. J. Physiol. Heart Circ. Physiol., 285(5), H2225-H2232.
161. Salani, D., Taraboletti, G., Rosano, L., Di Castro, V., Borsotti, P., Giavazzi, R., Bagnato, A. (2000) Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Am. J. Pathol., 157(5), 1703-1711.
162. Abalos, E., Duley, L., Steyn, D.W., Henderson-Smart, D.J. (2007) Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst. Rev., (1), CD002252.