Inhibition of inducible nitric oxide synthase and superoxide production reduces matrix metalloproteinase-9 activity and restores coronary vasomotor function in rat cardiac allografts

European Journal of Cardio-thoracic Surgery

Volumn 26, Issue 2, 2004, Pages 262-269

  Egi, Koso ^a   Conrad, Nicole E ^a   Kwan, Jennifer ^b   Schulze, Costas ^a   Schulz, Richard ^b   Wildhirt, Stephen M ^a,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF ALBERTA   (Canada)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Endothelium; Matrix metalloproteinases; Nitric oxide synthase; Superoxide; Transplantation

Indexed keywords

ACETAMIDINE DERIVATIVE; BRADYKININ; GELATINASE B; N [3 (AMINOMETHYL)BENZYL]ACETAMIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CORONARY ARTERY BLOOD FLOW; ENDOTHELIUM CELL; ENZYME ACTIVITY; HEART FUNCTION; HEART TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; VASOMOTOR REFLEX;

AMIDINES; ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; BENZYLAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; HEART; HEART TRANSPLANTATION; HEMODYNAMIC PROCESSES; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, INBRED BN; RATS, WISTAR; SUPEROXIDE DISMUTASE; SUPEROXIDES; VASOMOTOR SYSTEM;

EID: 3543118893     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2004.04.037     Document Type: Article

References (25)

1. Drexler H., Fischell T., Pinto F., Chenzbraun A., Botas J., Cooke J., Alderman E. Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Circulation. 89:1994;1615-1623
2. Schächtinger V., Britten M., Zeiher A. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 101:2000;1899-1906
3. Loscalzo J. Inducible NO synthesis in the vasculature. Molecular context defines physiological response. Arterioscler Thromb Vasc Biol. 21:2001;1259-1260
4. Kessler P., Bauersachs J., Busse R., Schini-Kerth V. Inhibition of inducible nitric oxide synthase resotres endothelium-dependent relaxations in proinflammatory mediator-induced blood vessels. Arterioscler Thromb Vasc Biol. 17:1997;1746-1755
5. Wildhirt S., Weis M., Schulze C., Conrad N., Pehlivanli S., Rieder G., Enders G., von Scheidt W., Reichart B. Expression of endomyocardial nitric oxide synthase and coronary endothelial function in human cardiac allografts. Circulation. 104:2001;I336-I343
6. Cai H., Harrison D. Endothelial dysfunction in cardiovascular disease: the role of oxidant stress. Circ Res. 87:2000;840-844
7. Gunnett C., Lund D., Chu Y., Brooks R., Faraci F., Heistad D. NO-dependent vasorelaxation is impaired after gene transfer of inducible nitric oxide synthase. Arterioscler Thromb Vasc Biol. 21:2001;1281-1287
8. Rajagopalan S., Meng X., Ramasamy S., Harrison D., Galis Z. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matric metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest. 98:1996;2572-2579
9. Takahashi S., Barry A., Factor S. Collagen degradation in ischemic rat hearts. Biochem J. 265:1990;233-241
10. Dollery C., McEwan J., Henney A. Matrix metalloproteinases and cardiovascular disease. Circ Res. 77:1995;863-868
11. Danielsen C., Wiggers H., Andersen H. Increased amounts of collagenase and gelatinase in porcine myocardium following ischemia and reperfusion. J Mol Cell Cardiol. 30:1998;1431-1442
12. Siwik D., Pagano P., Colucci W. Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am J Physiol Cell Physiol. 280:2001;C53-C60
13. Okamoto I., Akaike T., Nagano T., Miyajima S., Suga M., Ando M., Ichimori K., Maeda H. Activation of human neutrophil procollagenase by nitrogen dioxide and peroxynitrite: a novel mechanism for procollagenase activation involving nitric oxide. Arch Biochem Biophys. 342:1997;261-274
14. Cheung P., Sawicki G., Wozniak M., Wang W., Radomski M., Schulz R. Matrix metalloprteinase-2 contributes to ischemia-reperfusion injury in the heart. Circulation. 101:2000;1833-1839
15. Ono K., Lindsey E. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 57:1969;225-229
16. Garvey E., Oplonger J., Furfine E., Kiff R., Laszlo F., Whittle B., Knowles R. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric oxide synthase inhibitor in vitro and in vivo. J Biol Chem. 272:1997;4959-4963
17. Tarpey M., Fridovich I. Methods of detection of vascular reactive species. Nitric oxide, superoxide, hydrogen peroxyde, and peroxynitrite. Circ Res. 89:2001;224-236
18. Khadour F., Panas D., Ferdinandy P., Schulze C., Csont C., Lalu M., Wildhirt S., Schulz R. Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats. Am J Physiol. 283:2002;H1108-H1115
19. Vos I., Joles J., Schurink M., Weckbecker G., Stojanovic T., Rabelink T., Grone H. Inhibition of inducible nitric oxide synthase improves graft function and reduces tubulointerstitial injury in renal allograft rejection. Eur J Pharmacol. 391:2000;31-38
20. Xia Y., Zweier J. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proc Natl Acad Sci USA. 94:1997;6954-6958
21. Bouloumie A., Bauersachs J., Linz W., Schoelkens B., Wiemer G., Fleming I., Busse R. Endothelial dysfunction coincides with an enhanced nitric oxide expression and superoxide anion production. Hypertension. 30:1997;934-941
22. Bhagat K.R.M., Collier J., Vallance P. Endothelial stunning following a brief exposure to endotoxin: a mechanism to link infection and infarction? Cardiovasc Res. 32:1996;822-829
23. Ruetten H., Thiemermann C. Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochem Biophys Res Commun. 225:1996;525-530
24. Eberhardt W., Huwiler A., Beck K., Walpen S., Pfeilschifter J. Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways. J Immunol. 165:2000;5788-5797
25. Gurjar M., DeLeon J., Sharma R., Bhalla R. Mechanism of inhibition of matrixmetalloproteinase-9 induction by NO in vascular smooth muscle cells. J Appl Physiol. 91:2001;1380-1386