Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats

American Journal of Physiology - Renal Physiology

Volumn 276, Issue 5 45-5, 1999, Pages

  Conrad, Kirk P ^a   Gandley, Robin E ^a   Ogawa, Tatsuhiro ^b   Nakanishi, Satoshi ^b   Danielson, Lee A ^c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelin receptors; Glomerular filtration; Guanosine 3',5' cyclic monophosphate; N( ) nitro L arginine methyl ester; Nitric oxide; Renal circulation; RES 701 1; SB 209670; Small renal arteries

Indexed keywords

3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; ENDOTHELIN; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; RES 701 1;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GLOMERULUS FILTRATION RATE; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; RENAL ARTERY; VASODILATATION;

EID: 0033043767     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1999.276.5.f767     Document Type: Article

References (52)

1. Baylis, C. Renal effects of cyclooxygenase inhibition in the pregnant rat. Am. J. Physiol. 253 (Renal Fluid Electrolyte Physiol. 22): F158-F163, 1987.
2. Bogaert, G. A., B. A. Kogan, R. A. Mevorach, J. Wong, G. R. Gluckman, J. R. Fineman, M. A. Heymann. Exogenous endothelin-1 causes renal vasodilation in the fetal lamb. J. Urol. 156: 847-853, 1996.
3. Brown, G. P., and R. C. Venuto. Eicosanoid production in rabbit vascular tissues and placentas. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E418-E422, 1990.
4. Brown, G. P., and R. C. Venuto. Renal blood flow response to angiotensin II infusions in conscious pregnant rabbits. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F51-F59, 1991.
5. Chou, S.-Y., S. Dahal, K. Parvaiz, F. Tefera, and J. G. Porush. Endothelin-1 (ET-1) activates nitric oxide synthase and induces renal vasodilation (Abstract). J. Am. Soc. Nephrol. 9: 1560, 1996.
6. Conrad, K. P. Renal hemodynamics during pregnancy in chronically catheterized, conscious rats. Kidney Int. 26: 24-29, 1984.
7. Conrad, K. P. Possible mechanisms for changes in renal hemodynamics during pregnancy: studies from animal models. Am. J. Kidney Dis. 9: 253-259, 1987.
8. Conrad, K. P. Renal changes in pregnancy. Urol. Ann. 6: 313-340, 1992.
9. Conrad, K. P., and M. C. Colpoys. Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious rats. J. Clin. Invest. 77: 236-245, 1986.
10. Conrad, K. P., and A. K. Davis. Nitric oxide synthase activity in placentas from women with preeclampsia. Placenta 16: 691-699, 1995.
11. Conrad, K. P., and M. J. Dunn. Renal synthesis and urinary excretion of eicosanoids during pregnancy in rats. Am. J. Physiol. 253 (Renal Fluid Electrolyte Physiol. 22): F1197-F1205, 1987.
12. Conrad, K. P., G. M. Joffe, H. Kruszyna, R. Kruszyna, L. G. Rochelle, R. P. Smith, J. E. Chavez, and M. D. Mosher. Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB J. 7: 566-571, 1993.
13. Conrad, K. P., and M. D. Lindheimer. Renal and cardiovascular changes in normal pregnancy and preeclampsia. In: Chesley's Hypertensive Disorders in Pregnancy (2nd ed.), edited by M. D. Lindheimer, F. G. Cunningham, and J. M. Roberts. Stamford, CT: Appleton & Lange, 1999, p. 263-326.
14. Conrad, K. P., and K. A. Vernier. Plasma level, urinary excretion, and metabolic production of cGMP during gestation in rats. Am. J. Physiol. 257 (Regulatory Integrative Comp. Physiol. 26): R847-R853, 1989.
15. Conrad, K. P., M. Vill, P. G. McGuire, W. G. Dail, and A. K. Davis. Expression of nitric oxide synthase by syncytiotrophoblast in human placental villi. FASEB J. 7: 1269-1276, 1993.
16. Danielson, L. A., and K. P. Conrad. Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats. J. Clin. Invest. 96: 482-490, 1995.
17. Danielson, L. A., and K. P. Conrad. Prostaglandins maintain renal vasodilation and hyperfiltration during chronic nitric oxide synthase blockade in conscious pregnant rats. Circ. Res. 79: 1161-1166, 1996.
18. De Nucci, G., R. Thomas, P. D'Orleans-Juste, E. Antunes, C. Walder, T. D. Warner, and J. R. Vane. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc. Natl. Acad. Sci. USA 85: 9797-9800, 1988.
19. Dobrowolski, L., K. Endlich, J. Sadowski, and M. Steinhausen. Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin. Acta Physiol. Scand. 159: 7-13, 1997.
20. B receptors increases glomerular cGMP via an L-arginine-dependent pathway. Am. J. Physiol. 263 (Renal Fluid Electrolyte Physiol. 32): F1020-F1025, 1992.
21. Emori, T., Y. Hirata, and F. Marumo. Specific receptors for endothelin-3 in cultured bovine endothelial cells and its cellular mechanism of action. FEBS Lett. 263: 261-264, 1990.
22. Ercan, Z. S., R. K. Turker, C. Uluoglu, O. Yazar, and H. Zengil. The effects of endothelin peptides in the rabbit isolated perfused kidney. Gen. Pharmacol. 25: 1471-1476, 1994.
23. Gellai, M. Physiological role of endothelin in cardiovascular and renal hemodynamics: studies in animals. Curr. Opin. Nephrol. Hypertens. 6: 64-68, 1997.
24. Gellai, M., R. De Wolf, T. Fletcher, and P. Nambi. Contribution of endogenous endothelin-1 to the maintenance of vascular tone: role of nitric oxide. Pharmacology 55: 299-308, 1997.
25. Gellai, M., T. Fletcher, M. Pullen, and P. Nambi. Evidence for the existence of endothelin-B receptor subtypes and their physiological roles in the rat. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R254-R261, 1996.
26. Harrison, G. L., and L. G. Moore. Blunted vasoreactivity in pregnant guinea pigs is not restored by meclofenamate. Am. J. Obstet. Gynecol. 160: 258-264, 1989.
27. Hirata, Y., T. Emori, S. Eguchi, K. Kanno, T. Imai, K. Ohta, and F. Marumo. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J. Clin. Invest. 91: 1367-1373, 1993.
28. Hirata, Y., H. Hayakawa, E. Suzuki, K. Kimura, K. Kikuchi, T. Nagano, M. Hirobe, and M. Omata. Direct measurements of endothelium-derived nitric oxide release by stimulation of endothelin receptors in rat kidney and its alteration in salt-induced hypertension. Circulation 91: 1229-1235, 1995.
29. Kloog, Y., I. Ambar, M. Sokolovsky, E. Kochva, Z. Wollberg, and A. Bdolah. Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain. Science 242: 268-270, 1988.
30. Kourembanas, S., L. P. McQuillan, G. K. Leung, and D. V. Fallen Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J. Clin. Invest. 92: 99-104, 1993.
31. Kurihara, Y., H. Kurihara, H. Suzuki, T. Kodama, K. Maemura, R. Nagai, H. Oda, T. Kuwaki, W.-H. Cao, N. Kamada, K. Jishage, Y. Ouchi, S. Azuma, Y. Toyoda, T. Ishikawa, M. Kumada, and Y. Yazaki. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 368: 703-710, 1994.
32. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
33. Lüscher, T. F., and P. M. Vanhoutte. The Endothelium: Modulator of Cardiovascular Function. Boca Raton, FL: CRC Press, 1990.
34. Matsuo, G., Y. Matsumura, K. Tadano, T. Hashimoto, and S. Morimoto. Effects of sarafotoxin S6c on renal haemodynamics and urine formation in anaesthetized dogs. Clin. Exp. Pharmacol. Physiol. 24: 487-491, 1997.
35. B-receptor agonist, in anesthetized rats. Jpn. J. Pharmacol. 71: 213-222, 1996.
36. Morrison, A., L. Berwick, L. Ori, and A. Winegrad. Morphology and metabolism of an aortic intima-media preparation in which an intact endothelium is preserved. J. Clin. Invest. 57: 650-656, 1976.
37. Myatt, L., D. E. Brockman, G. Langdon, and J. S. Pollock. Constitutive calcium-dependent isoform of nitric oxide synthase in the human placental villous vascular tree. Placenta 14: 373-383, 1993.
38. Naden, R. P., C. A. Iliya, B. S. Arant, N. F. Gant, and C. R. Rosenfeld. Hemodynamic effects of indomethacin in chronically instrumented pregnant sheep. Am. J. Obstet. Gynecol. 151: 484-493, 1985.
39. Ohlstein, E. H., P. Nambi, S. A. Douglas, R. M. Edwards, M. Gellai, A. Lago, J. D. Leber, R. D. Cousins, A. Gao, J. S. Frazee, C. E. Peishoff, J. W. Bean, D. S. Eggleston, N. A. Elshourbagy, C. Kumar, J. A. Lee, T.-L. Yue, C. Louden, D. P. Brooks, J. Weinstock, G. Feuerstein, G. Poste, R. R. Ruffolo, J. G. Gleason, and J. D. Elliott. SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc. Natl. Acad. Sci. USA 91: 8052-8056, 1994.
40. Qiu, C., L. Samsell, and C. Baylis. Actions of endogenous endothelin on glomerular hemodynamics in the rat. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R469-R473, 1995.
41. Sorensen, T. K., T. R. Easterling, K. L. Carlson, D. A. Brateng, and T. J. Benedetti. The maternal hemodynamic effect of indomethacin in normal pregnancy. Obstet. Gynecol. 79: 661-663, 1992.
42. Tack, I., E. M. Castano, C. Pecher, F. Praddaude, J. L. Bascands, G. Bompart, J. L. Ader, and J. P. Girolami. Endothelin increases NO-dependent cGMP production in isolated glomeruli but not in mesangial cells. Am. J. Physiol. 272 (Renal Physiol. 41): F31-F39, 1997.
43. B receptor-selective antagonist. Biochem. Biophys. Res. Commun. 209: 712-716, 1995.
44. Tanaka, T., E. Tsukuda, M. Nozawa, H. Nonaka, T. Ohno, H. Kase, K. Yamada, and Y. Matsuda. RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin. Mol. Pharmacol. 45: 724-730, 1994.
45. B receptor in endothelial cells. J. Biol. Chem. 269: 21778-21785, 1994.
46. Vanhoutte, P. M. A matter of life and breath. Nature 368: 693-694, 1994.
47. Venuto, R. C., and A. J. M. Donker. Prostaglandin E2, plasma renin activity, and renal function throughout rabbit pregnancy. J. Lab. Clin. Med. 99: 239-246, 1982.
48. Webb, M. L., and T. D. Meek. Inhibitors of endothelin. Med. Res. Rev. 17: 17-67, 1997.
49. Whittemore, S. L., M. K. McLaughlin, S. T. Davidge, and K. P. Conrad. Effect of pregnancy on vascular cGMP production and vasorelaxation in the rat. Hypertension Pregnancy 13: 227-244, 1994.
50. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, and T. Masaki. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415, 1988.
51. Yokokawa, K., J. Johnson, M. Kohno, A. K. Mandal, M. Yanagisawa, T. Horio, K. Yasunari, and T. Takeda. Phosphoinositide turnover signaling stimulated by ET-3 in endothelial cells from spontaneously hypertensive rats. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R635-R644, 1994.
52. Zar, J. H. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice Hall, 1994.