The genetics of pre-eclampsia: A feto-placental or maternal problem?

Clinical Genetics

Volumn 64, Issue 2, 2003, Pages 96-103

  Cross, J C ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Cardiovascular disease; Fetus; Gestation; Hypertension; Kidney

Indexed keywords

ANGIOTENSIN; PROTEIN P57; RENIN;

ADAPTATION; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; CARDIOVASCULAR FUNCTION; CIRCULATION; CLINICAL FEATURE; CONTROLLED STUDY; DELIVERY; DISEASE CLASSIFICATION; DISEASE EXACERBATION; DISEASE MODEL; DISEASE PREDISPOSITION; FEMALE; FETOPLACENTAL UNIT; GENETIC ANALYSIS; GENETIC RISK; GENETICS; GLOMERULOSCLEROSIS; HUMAN; HYPERTENSION; KIDNEY DISEASE; MATERNAL BLOOD; MATERNAL HYPERTENSION; MEDICAL RESEARCH; MOTHER; MOUSE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA FUNCTION; PREECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROTEINURIA; RENIN RELEASE; REPRODUCTION; REVIEW; RISK ASSESSMENT; RISK FACTOR; SYMPTOM; TRANSGENIC MOUSE; VASCULAR DISEASE; VASOCONSTRICTION;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPERTENSION; MICE; PLACENTATION; PRE-ECLAMPSIA; PREGNANCY;

ANIMALIA; MUS MUSCULUS;

EID: 0042131726     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0004.2003.00127.x     Document Type: Review

References (45)

1. Roberts JM, Lain KY. Recent insights into the pathogenesis of pre-eclampsia. Placenta 2002: 23: 359-372.
2. Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet 2001: 357: 53-56.
3. Cross JC. Trophoblast function in normal and preeclamptic pregnancy. Fet Mat Med Rev 1996: 8: 57-66.
4. Lachmeijer AM, Dekker GA, Pals G, Aarnoudse JG, ten Kate LP, Arngrimsson R. Searching for preeclampsia genes: The current position. Eur J Obstet Gynecol Reprod Biol 2002: 105: 94-113.
5. Kanayama N, Takahashi K, Matsuura T et al. Deficiency in p57kip2 expression induces preeclampsia-like symptoms in mice. Mol Hum Reprod 2002: 8: 1129-1135.
6. Davisson RL, Hoffmann DS, Butz GM et al. Discovery of a spontaneous genetic mouse model of preeclampsia. Hypertension 2002: 39: 337-342.
7. Maynard SE, Min JY, Merchan J et al. Excess placental soluble fms-like tyrosine kinase 1 (sflt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003: 111: 649-658.
8. Faas MM, Schuiling GA, Baller JF, Bakker WW. Glomerular inflammation in pregnant rats after infusion of low dose endotoxin. An immunohistological study in experimental pre-eclampsia. Am J Pathol 1995: 147: 1510-1518.
9. Sakawi Y, Tarpey M, Chen YF, Calhoun DA, Connor MG, Chestnut DH, et al. Evaluation of low-dose endotoxin administration during pregnancy as a model of preeclampsia. Anesthesiology 2000: 93: 1446-1455.
10. Wardle EN. The functional role of intravascular coagulation renal disease. Scott Med 1976: 21: 83-91.
11. Teasdale F. Histomorphometry of the human placenta in maternal preeclampsia. Am J Obstet Gynecol 1985: 152: 25-31.
12. Fox H. The villous cytotrophoblast as an index of placental ischaemia. J Obstet Gynaecol Br Commonwealth 1964: 71: 885-893.
13. Arnholdt H, Meisel F, Fandrey K, Lohrs U. Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies. Virchows Arch B Cell Pathol Incl Mol Pathol 1991: 60: 365-372.
14. Redline RW, Patterson P. Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol 1995: 26: 594-600.
15. Jones CJP, Fox H. An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia. Placenta 1980: 1: 67-76.
16. Gerretsen G, Huisjes HJ, Elema JD. Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardation. Br J Obstet Gynaecol 1981: 88: 876-881.
17. Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentafion in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 1986: 93: 1049-1059.
18. Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Ann 1972: 1: 177-191.
19. Lin S, Shimizu I, Suehara N, Nakayama M, Aono T. Uterine artery Doppler velocimetry in relation to trophoblast migration into the myometrium of the placental bed. Obstet Gynecol 1995: 85: 760-765.
20. Iwata M, Matsuzaki N, Shimizu I, Mitsuda N, Nakayama M, Suehara N. Prenatal detection of ischemic changes in the placenta of the growth-retarded fetus by Doppler flow velocimetry of the maternal uterine artery. Obstet Gynecol 1993: 82: 494-499.
21. Jackson MR, Walsh AJ, Morrow RJ, Mullen JB, Lye SJ, Ritchie JW. Reduced placental villous tree elaboration in small-for-gestational-age pregnancies: Relationship with umbilical artery Doppler waveforms. Am J Obstet Gynecol 1995: 172: 518-525.
22. Arngrimsson R, Bjornsson H, Geirsson RT. Analysis of different inheritance patterns in preeclampsia/eclampsia syndrome. Hypertens Pregnancy 1995: 14: 27-38.
23. Treloar SA, Cooper DW, Brennecke SP, Grehan MM, Martin NG. An Australian twin study of the genetic basis of preeclampsia and eclampsia. Am J Obstet Gynecol 2001: 184: 374-381.
24. Lachmeijer AM, Arngrimsson R, Bastiaans EJ et al. A genome-wide scan for preeclampsia in the Netherlands. Eur J Hum Genet 2001: 9: 758-764.
25. Ward K, Hata A, Jeunemaitre X et al. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 1993: 4: 59-61.
26. Arngrimsson R, Hayward C, Nadaud S et al. Evidence for a familial pregnancy-induced hypertension locus in the enos-gene region. Am J Hum Genet 1997: 61: 354-362.
27. Eskenazi B, Fenster L, Sidney S. A multivariate analysis of risk factors for preeclampsia. JAMA 1991: 266: 237-241.
28. Sibai BM, Gordon T, Thom E et al. Risk factors for pre-eclampsia in healthy nulliparous women: a prospective multi-center study. The national institute of child health and human development network of maternal-fetal medicine units. Am J Obstet Gynecol 1995: 172: 642-648.
29. Redman CW. Current topic: pre-eclampsia and the placenta. Placenta 1991: 12: 301-308.
30. Cross JC, Baczyk D, Dobric N et al. Genes, development and evolution of the placenta. Placenta 2003: 24: 123-130.
31. Rossant J, Cross JC. Placental development: lessons from mouse mutants. Nat Rev Genet 2001: 2: 538-548.
32. Wong AY, Kulandavelu S, Whiteley KJ, Qu D, Langille BL, Adamson SL. Maternal cardiovascular changes during pregnancy and postpartum in mice. Am J Physiol Heart Circ Physiol 2002: 282: H918-925.
33. Cross JC. Genetic insights into trophoblast differentiation and placental morphogenesis. Sem Cell Dev Biol 2000: 11: 105-113.
34. Hemberger M, Cross JC. Genes governing placental development. Trends Endocrin Metab 2001: 12: 162-168.
35. Li Y, Behringer RR. Esx1 is an x-chromosome-imprinted regulator of placental development and fetal growth. Nat Genet 1998: 20: 309-311.
36. Constancia M, Hemberger M, Hughes J et al. Placental-specific igf-ii is a major modulator of placental and fetal growth. Nature 2002: 417: 945 948.
37. Crossey PA, Pillai CC, Miell JP. Altered placental development and intrauterine growth restriction in igf binding protein-1 transgenic mice. J Clin Invest 2002: 110: 411-418.
38. Croy BA, Di Santo JP, Greenwood JD, Chantakru S, Ashkar AA. Transplantation into genetically alymphoid mice as an approach to dissect the roles of uterine natural killer cells during pregnancy - a review. Placenta 2000: 21 (Suppl. A): S77-S80.
39. Cross JC, Hemberger M, Lu Y et al. Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta. Mol Cell Endocrinol 2002: 187: 207-212.
40. Xia Y, Wen H, Prashner HR et al. Pregnancy-induced changes in renin gene expression in mice. Biol Reprod 2002: 66: 135-143.
41. Cooper AC, Robinson G, Vinson GP, Cheung WT, Broughton Pipkin F. The localization and expression of the renin-angiotensin system in the human placenta throughout pregnancy. Placenta 1999: 20: 467-474.
42. Takimoto E, Ishida J, Sugiyama F, Horiguchi H, Murakami K, Fukamizu A. Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen. Science 1996: 274: 995-998.
43. Caron KM, James LR, Kim HS et al. A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci USA 2002: 99: 8248-8252.
44. Takahashi K, Kobayashi T, Kanayama N. P57(kip2) regulates the proper development of labyrinthine and spongiotrophoblasts. Mol Hum Reprod 2000: 6: 1019-1025.
45. Croy BA, Ashkar AA, Minhas K, Greenwood JD. Can murine uterine natural killer cells give insights into the pathogenesis of preeclampsia? J Soc Gynecol Invest 2000: 7: 12-20.