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Volumn 17, Issue 1, 2010, Pages 93-102

Mdm2-mediated ubiquitylation: P53 and beyond

Author keywords

cancer therapy; MDM2; p53; ubiquitylation

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

EID: 77449101168     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.68     Document Type: Review
Times cited : (270)

References (130)
  • 2
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 3
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • DOI 10.1038/387296a0
    • Haupt Y, Maya R, Kazaz A, Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299. (Pubitemid 27220766)
    • (1997) Nature , vol.387 , Issue.6630 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 4
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • DOI 10.1016/S0014-5793(97)01480-4, PII S0014579397014804
    • Honda R, Tanaka H, Yasuda H (1997) Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS 420: 25-27. (Pubitemid 28037193)
    • (1997) FEBS Letters , vol.420 , Issue.1 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 5
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • DOI 10.1038/387299a0
    • Kubbutat MH, Jones SN, Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387: 299-303. (Pubitemid 27220767)
    • (1997) Nature , vol.387 , Issue.6630 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 7
    • 0035811563 scopus 로고    scopus 로고
    • An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2
    • DOI 10.1038/sj.onc.1204533
    • Evans SC, Viswanathan M, Grier JD, Narayana M, El-Naggar AK, Lozano G (2001) An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2. Oncogene 20: 4041-4049. (Pubitemid 32681609)
    • (2001) Oncogene , vol.20 , Issue.30 , pp. 4041-4049
    • Evans, S.C.1    Viswanathan, M.2    Grier, J.D.3    Narayana, M.4    El-Naggar, A.K.5    Lozano, G.6
  • 8
    • 0345824731 scopus 로고    scopus 로고
    • P53-Independent Functions of MDM2
    • Ganguli G, Wasylyk B (2003) p53-independent functions of MDM2. Mol Cancer Res 1: 1027-1035. (Pubitemid 38044978)
    • (2003) Molecular Cancer Research , vol.1 , Issue.14 , pp. 1027-1035
    • Ganguli, G.1    Wasylyk, B.2
  • 10
    • 0037329056 scopus 로고    scopus 로고
    • The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
    • Michael D, Oren M (2003) The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Cancer Biol 13: 49-58.
    • (2003) Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 12
    • 79959378585 scopus 로고    scopus 로고
    • Dynamics of the p53-Mdm2 feedback loop in individual cells
    • Levav-Cohen Y, Haupt S, Haupt Y (2004) Dynamics of the p53-Mdm2 feedback loop in individual cells. Growth Factors 23: 183-192.
    • (2004) Growth Factors , vol.23 , pp. 183-192
    • Levav-Cohen, Y.1    Haupt, S.2    Haupt, Y.3
  • 13
    • 0027459198 scopus 로고
    • Mdm2 Expression is induced by wild type p53 activity
    • Barak Y, Juven T, Haffner R, Oren M (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461-468. (Pubitemid 23073692)
    • (1993) EMBO Journal , vol.12 , Issue.2 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 17
    • 55949099028 scopus 로고    scopus 로고
    • Oscillations by the p53-Mdm2 feedback loop
    • Lahav G (2008) Oscillations by the p53-Mdm2 feedback loop. Adv Exp Med Biol 641: 28-38.
    • (2008) Adv Exp Med Biol , vol.641 , pp. 28-38
    • Lahav, G.1
  • 18
    • 0027325132 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1993) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 362: 857-860.
    • (1993) Nature , vol.362 , pp. 857-860
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 19
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Thut CJ, Goodrich JA, Tjian R (1997) Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev 11: 1974-1986. (Pubitemid 27332984)
    • (1997) Genes and Development , vol.11 , Issue.15 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 21
    • 33645751553 scopus 로고    scopus 로고
    • Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription
    • White DE, Talbott KE, Arva NC, Bargonetti J (2006) Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription. Cancer Res 66: 3463-3470.
    • (2006) Cancer Res , vol.66 , pp. 3463-3470
    • White, D.E.1    Talbott, K.E.2    Arva, N.C.3    Bargonetti, J.4
  • 22
    • 43049163953 scopus 로고    scopus 로고
    • Acetylation Is Indispensable for p53 Activation
    • DOI 10.1016/j.cell.2008.03.025, PII S0092867408004418
    • Tang Y, Zhao W, Chen Y, Zhao Y, Gu W (2008) Acetylation is indispensable for p53 activation. Cell 133: 612-626. (Pubitemid 351636297)
    • (2008) Cell , vol.133 , Issue.4 , pp. 612-626
    • Tang, Y.1    Zhao, W.2    Chen, Y.3    Zhao, Y.4    Gu, W.5
  • 23
    • 3142570737 scopus 로고    scopus 로고
    • Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
    • DOI 10.1016/j.cell.2004.06.016, PII S0092867404005859
    • Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP (2004) Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118: 83-97. (Pubitemid 38902816)
    • (2004) Cell , vol.118 , Issue.1 , pp. 83-97
    • Xirodimas, D.P.1    Saville, M.K.2    Bourdon, J.-C.3    Hay, R.T.4    Lane, D.P.5
  • 24
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones SN, Roe AE, Donehower LA, Bradley A (1995) Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 25
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna R, Wagner DS, Lozano G (1995) Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Montes De Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 26
    • 0344654959 scopus 로고    scopus 로고
    • Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice
    • DOI 10.1002/(SICI)1096-9896(199907)188:3<322::AID-PATH372>3.0.CO;2- F
    • McDonnell TJ, Montes de Oca Luna R, Cho S, Amelse LL, Chavez-Reyes A, Lozano G (1999) Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J Pathol 188: 322-328. (Pubitemid 29317778)
    • (1999) Journal of Pathology , vol.188 , Issue.3 , pp. 322-328
    • McDonnell, T.J.1    Montes De Oca Luna, R.2    Cho, S.3    Amelse, L.L.4    Chavez-Reyes, A.5    Lozano, G.6
  • 33
    • 54049109574 scopus 로고    scopus 로고
    • The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival
    • Valentin-Vega YA, Okano H, Lozano G (2008) The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival. Cell Death Differ 15: 1772-1781.
    • (2008) Cell Death Differ , vol.15 , pp. 1772-1781
    • Valentin-Vega, Y.A.1    Okano, H.2    Lozano, G.3
  • 34
    • 33845185824 scopus 로고    scopus 로고
    • Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
    • DOI 10.1016/j.ccr.2006.10.010, PII S1535610806003163
    • Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI (2006) Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10: 501-514. (Pubitemid 44854749)
    • (2006) Cancer Cell , vol.10 , Issue.6 , pp. 501-514
    • Ringshausen, I.1    O'Shea, C.C.2    Finch, A.J.3    Swigart, L.B.4    Evan, G.I.5
  • 35
    • 31544457877 scopus 로고    scopus 로고
    • P53 ubiquitination: Mdm2 and beyond
    • DOI 10.1016/j.molcel.2006.01.020, PII S1097276506000402
    • Brooks CL, Gu W (2006) p53 ubiquitination: Mdm2 and beyond. Mol Cell 21: 307-315. (Pubitemid 43163526)
    • (2006) Molecular Cell , vol.21 , Issue.3 , pp. 307-315
    • Brooks, C.L.1    Gu, W.2
  • 39
    • 33645769536 scopus 로고    scopus 로고
    • A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
    • Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M et al. (2006) A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell 9: 273-285.
    • (2006) Cancer Cell , vol.9 , pp. 273-285
    • Toledo, F.1    Krummel, K.A.2    Lee, C.J.3    Liu, C.W.4    Rodewald, L.W.5    Tang, M.6
  • 40
    • 35148847384 scopus 로고    scopus 로고
    • Targeted Inactivation of Mdm2 RING Finger E3 Ubiquitin Ligase Activity in the Mouse Reveals Mechanistic Insights into p53 Regulation
    • DOI 10.1016/j.ccr.2007.09.007, PII S1535610807002668
    • Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Lindström MS et al. (2007) Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 12: 355-366. (Pubitemid 47539309)
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 355-366
    • Itahana, K.1    Mao, H.2    Jin, A.3    Itahana, Y.4    Clegg, H.V.5    Lindstrom, M.S.6    Bhat, KrishnaP.7    Godfrey, V.L.8    Evan, G.I.9    Zhang, Y.10
  • 41
    • 8844232663 scopus 로고    scopus 로고
    • The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
    • DOI 10.1016/j.molcel.2004.10.016, PII S1097276504006422
    • Minsky N, Oren M (2004) The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell 16: 631-639. (Pubitemid 39531885)
    • (2004) Molecular Cell , vol.16 , Issue.4 , pp. 631-639
    • Minsky, N.1    Oren, M.2
  • 44
    • 0345268720 scopus 로고    scopus 로고
    • Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
    • DOI 10.1093/emboj/cdg133
    • Alt JR, Greiner TC, Cleveland JL, Eischen CM (2003) Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J 22: 1442-1450. (Pubitemid 36362707)
    • (2003) EMBO Journal , vol.22 , Issue.6 , pp. 1442-1450
    • Alt, J.R.1    Greiner, T.C.2    Cleveland, J.L.3    Eischen, C.M.4
  • 50
    • 0033767235 scopus 로고    scopus 로고
    • Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome- mediated degradation
    • Rodriguez MS, Desterro JM, Lain S, Lane DP, Hay RT (2000) Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol 20: 8458-8467.
    • (2000) Mol Cell Biol , vol.20 , pp. 8458-8467
    • Rodriguez, M.S.1    Desterro, J.M.2    Lain, S.3    Lane, D.P.4    Hay, R.T.5
  • 53
    • 0141752762 scopus 로고    scopus 로고
    • C-Fos proto-oncoprotein is degraded by the proteasome independently of its own ubiquitinylation in vivo
    • DOI 10.1128/MCB.23.20.7425-7436.2003
    • Bossis G, Ferrara P, Acquaviva C, Jariel-Encontre I, Piechaczyk M (2003) c-Fos protooncoprotein is degraded by the proteasome independently of its own ubiquitinylation in vivo. Mol Cell Biol 23: 7425-7436. (Pubitemid 37211020)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.20 , pp. 7425-7436
    • Bossis, G.1    Ferrara, P.2    Acquaviva, C.3    Jariel-Encontre, I.4    Piechaczyk, M.5
  • 55
    • 0035868386 scopus 로고    scopus 로고
    • The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
    • DOI 10.1038/sj.onc.1204241
    • Argentini M, Barboule N, Wasylyk B (2001) The contribution of the acidic domain of MDM2 to p53 and MDM2 stability. Oncogene 20: 1267-1275. (Pubitemid 32269932)
    • (2001) Oncogene , vol.20 , Issue.11 , pp. 1267-1275
    • Argentini, M.1    Barboule, N.2    Wasylyk, B.3
  • 56
    • 0038788827 scopus 로고    scopus 로고
    • Critical contribution of the MDM2 acidic domain to p53 ubiquitination
    • DOI 10.1128/MCB.23.14.4939-4947.2003
    • Kawai H, Wiederschain D, Yuan ZM (2003) Critical contribution of the MDM2 acidic domain to p53 ubiquitination. Mol Cell Biol 14: 4939-4947. (Pubitemid 36793339)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.14 , pp. 4939-4947
    • Kawai, H.1    Wiederschain, D.2    Yuan, Z.-M.3
  • 59
    • 33846193699 scopus 로고    scopus 로고
    • An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
    • DOI 10.1038/sj.emboj.7601469, PII 7601469
    • Uldrijan S, Pannekoek WJ, Vousden KH (2007) An essential function of the extreme Cterminus of MDM2 can be provided by MDMX. EMBO J 26: 102-112. (Pubitemid 46094703)
    • (2007) EMBO Journal , vol.26 , Issue.1 , pp. 102-112
    • Uldrijan, S.1    Pannekoek, W.-J.2    Vousden, K.H.3
  • 60
    • 33846239416 scopus 로고    scopus 로고
    • The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
    • DOI 10.1038/sj.emboj.7601465, PII 7601465
    • Poyurovsky MV, Priest C, Kentsis A, Borden KL, Pan ZQ, Pavletich N et al. (2007) The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J 26: 90-101. (Pubitemid 46094702)
    • (2007) EMBO Journal , vol.26 , Issue.1 , pp. 90-101
    • Poyurovsky, M.V.1    Priest, C.2    Kentsis, A.3    Borden, K.L.B.4    Pan, Z.-Q.5    Pavletich, N.6    Prives, C.7
  • 61
    • 33748920505 scopus 로고    scopus 로고
    • Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53
    • DOI 10.1016/j.jmb.2006.08.027, PII S0022283606010564
    • Kostic M, Matt T, Martinez-Yamout MA, Dyson HJ, Wright PE (2006) Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J Mol Biol 363: 433-450. (Pubitemid 44436256)
    • (2006) Journal of Molecular Biology , vol.363 , Issue.2 , pp. 433-450
    • Kostic, M.1    Matt, T.2    Martinez-Yamout, M.A.3    Dyson, H.J.4    Wright, P.E.5
  • 63
    • 0033523015 scopus 로고    scopus 로고
    • Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2
    • Maki CG (1999) Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2. J Biol Chem 274: 16531-16535.
    • (1999) J Biol Chem , vol.274 , pp. 16531-16535
    • Maki, C.G.1
  • 64
    • 42149105590 scopus 로고    scopus 로고
    • Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
    • DOI 10.1038/sj.cdd.4402309, PII 4402309
    • Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL (2008) Structure of the MDM2/ MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ 15: 841-848. (Pubitemid 351524426)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.5 , pp. 841-848
    • Linke, K.1    Mace, P.D.2    Smith, C.A.3    Vaux, D.L.4    Silke, J.5    Day, C.L.6
  • 66
    • 0141442586 scopus 로고    scopus 로고
    • Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins
    • DOI 10.1146/annurev.cellbio.19.110701.154617
    • Hicke L, Dunn R (2003) Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu Rev Cell Dev Biol 19: 141-172. Review. (Pubitemid 37487346)
    • (2003) Annual Review of Cell and Developmental Biology , vol.19 , pp. 141-172
    • Hicke, L.1    Dunn, R.2
  • 67
    • 0348134742 scopus 로고    scopus 로고
    • Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2
    • DOI 10.1126/science.1091362
    • Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, Gu W (2003) Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302: 1972-1975. (Pubitemid 37523506)
    • (2003) Science , vol.302 , Issue.5652 , pp. 1972-1975
    • Li, M.1    Brooks, C.L.2    Wu-Baer, F.3    Chen, D.4    Baer, R.5    Gu, W.6
  • 68
    • 0033559256 scopus 로고    scopus 로고
    • A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
    • Stommel JM, Marchenko ND, Jimenez GS, Moll UM, Hope TJ, Wahl GM (1999) A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J 18: 1660-1672. (Pubitemid 29127078)
    • (1999) EMBO Journal , vol.18 , Issue.6 , pp. 1660-1672
    • Stommel, J.M.1    Marchenko, N.D.2    Jimenez, G.S.3    Moll, U.M.4    Hope, T.J.5    Wahl, G.M.6
  • 69
    • 31544457877 scopus 로고    scopus 로고
    • P53 ubiquitination: Mdm2 and beyond
    • DOI 10.1016/j.molcel.2006.01.020, PII S1097276506000402
    • Brooks CL, Gu W. p53 ubiquitination: Mdm2 and beyond. Mol Cell 2006; 21: 307-315. Review. (Pubitemid 43163526)
    • (2006) Molecular Cell , vol.21 , Issue.3 , pp. 307-315
    • Brooks, C.L.1    Gu, W.2
  • 70
    • 34047103990 scopus 로고    scopus 로고
    • C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
    • DOI 10.1038/ncb1562, PII NCB1562
    • Carter S, Bischof O, Dejean A, Vousden KH (2007) C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol 9: 428-435. (Pubitemid 46511076)
    • (2007) Nature Cell Biology , vol.9 , Issue.4 , pp. 428-435
    • Carter, S.1    Bischof, O.2    Dejean, A.3    Vousden, K.H.4
  • 71
    • 34347205250 scopus 로고    scopus 로고
    • MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation
    • DOI 10.1074/jbc.M610514200
    • Sasaki M, Nie L, Maki CG (2007) MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation. J Biol Chem 282: 14626-14634. (Pubitemid 47100428)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.19 , pp. 14626-14634
    • Sasaki, M.1    Nie, L.2    Maki, C.G.3
  • 72
    • 34347263061 scopus 로고    scopus 로고
    • Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination
    • DOI 10.1074/jbc.M610515200
    • Nie L, Sasaki M, Maki CG. Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination. J Biol Chem 2007; 282: 14616-14625. (Pubitemid 47100427)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.19 , pp. 14616-14625
    • Nie, L.1    Sasaki, M.2    Maki, C.G.3
  • 74
    • 33747819484 scopus 로고    scopus 로고
    • Divorcing ARF and p53: An unsettled case
    • DOI 10.1038/nrc1954, PII NRC1954
    • Sherr CJ (2006) Divorcing ARF and p53: an unsettled case. Nat Rev Cancer 6: 663-673. (Pubitemid 44285999)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 663-673
    • Sherr, C.J.1
  • 76
    • 35148893194 scopus 로고    scopus 로고
    • The Wip1 Phosphatase Acts as a Gatekeeper in the p53-Mdm2 Autoregulatory Loop
    • DOI 10.1016/j.ccr.2007.08.033, PII S1535610807002656
    • Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA (2007) The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell 12: 342-354. (Pubitemid 47539308)
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 342-354
    • Lu, X.1    Ma, O.2    Nguyen, T.-A.3    Jones, S.N.4    Oren, M.5    Donehower, L.A.6
  • 78
    • 58749114576 scopus 로고    scopus 로고
    • Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites
    • Rossi M, Demidov ON, Anderson CW, Appella E, Mazur SJ (2008) Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites. Nucleic Acids Res 36: 7168-7180.
    • (2008) Nucleic Acids Res , vol.36 , pp. 7168-7180
    • Rossi, M.1    Demidov, O.N.2    Anderson, C.W.3    Appella, E.4    Mazur, S.J.5
  • 80
    • 33846520458 scopus 로고    scopus 로고
    • Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers
    • DOI 10.1007/s10549-006-9304-y
    • Yu E, Ahn YS, Jang SJ, Kim MJ, Yoon HS, Gong G et al. (2007) Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers. Breast Cancer Res Treat 101: 269-278. (Pubitemid 46169880)
    • (2007) Breast Cancer Research and Treatment , vol.101 , Issue.3 , pp. 269-278
    • Yu, E.1    Ahn, Y.S.2    Jang, S.J.3    Kim, M.-J.4    Yoon, H.S.5    Gong, G.6    Choi, J.7
  • 81
    • 42949171936 scopus 로고    scopus 로고
    • Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage
    • DOI 10.1016/j.molcel.2008.03.016, PII S1097276508002402
    • Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G (2008) Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell 30: 277-289. (Pubitemid 351615316)
    • (2008) Molecular Cell , vol.30 , Issue.3 , pp. 277-289
    • Batchelor, E.1    Mock, C.S.2    Bhan, I.3    Loewer, A.4    Lahav, G.5
  • 83
    • 0346455772 scopus 로고    scopus 로고
    • Posttranslational Modification of MDM2
    • Meek DW, Knippschild U (2003) Posttranslational modification of MDM2. Mol Cancer Res 1: 1017-1026. Review. (Pubitemid 38044977)
    • (2003) Molecular Cancer Research , vol.1 , Issue.14 , pp. 1017-1026
    • Meek, D.W.1    Knippschild, U.2
  • 84
    • 58149175974 scopus 로고    scopus 로고
    • SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
    • Chiu SY, Asai N, Costantini F, Hsu W (2008) SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol 6: e310.
    • (2008) PLoS Biol , vol.6
    • Chiu, S.Y.1    Asai, N.2    Costantini, F.3    Hsu, W.4
  • 85
    • 2942627487 scopus 로고    scopus 로고
    • Asymmetric cell division
    • DOI 10.1016/j.ceb.2004.02.010, PII S0955067404000195
    • Roegiers F, Jan YN (2004) Asymmetric cell division. Curr Opin Cell Biol 16: 195-205. Review. (Pubitemid 38757296)
    • (2004) Current Opinion in Cell Biology , vol.16 , Issue.2 , pp. 195-205
    • Roegiers, F.1    Jan, Y.N.2
  • 89
    • 0028961442 scopus 로고
    • Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics
    • Sherley JL, Stadler PB, Johnson DR (1995) Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics. Proc Natl Acad Sci USA 92: 136-140.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 136-140
    • Sherley, J.L.1    Stadler, P.B.2    Johnson, D.R.3
  • 93
    • 0034624678 scopus 로고    scopus 로고
    • Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
    • Honda R, Yasuda H (2000) Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 19: 1473-1476. (Pubitemid 30171179)
    • (2000) Oncogene , vol.19 , Issue.11 , pp. 1473-1476
    • Honda, R.1    Yasuda, H.2
  • 94
    • 2342567852 scopus 로고    scopus 로고
    • Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
    • DOI 10.1038/sj.emboj.7600145
    • Stommel JM, Wahl GM (2004) Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J 23: 1547-1556. (Pubitemid 38579515)
    • (2004) EMBO Journal , vol.23 , Issue.7 , pp. 1547-1556
    • Stommel, J.M.1    Wahl, G.M.2
  • 95
    • 40549099702 scopus 로고    scopus 로고
    • Unlocking the Mdm2-p53 loop: Ubiquitin is the key
    • Clegg HV, Itahana K, Zhang Y (2008) Unlocking the Mdm2-p53 loop: ubiquitin is the key. Cell Cycle 7: 287-292. (Pubitemid 351366489)
    • (2008) Cell Cycle , vol.7 , Issue.3 , pp. 287-292
    • Clegg, H.V.1    Itahana, K.2    Zhang, Y.3
  • 98
    • 2342491487 scopus 로고    scopus 로고
    • Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
    • DOI 10.1016/S1535-6108(04)00110-2, PII S1535610804001102
    • Kurki S, Peltonen K, Latonen L, Kiviharju TM, Ojala PM, Meek D et al. (2004) Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2- mediated degradation. Cancer Cell 5: 465-475. (Pubitemid 38610248)
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 465-475
    • Kurki, S.1    Peltonen, K.2    Latonen, L.3    Kiviharju, T.M.4    Ojala, P.M.5    Meek, D.6    Laiho, M.7
  • 101
    • 33847779971 scopus 로고    scopus 로고
    • Putting a finger on growth surveillance: Insight into MDM2 zinc finger-ribosomal protein interactions
    • Lindström MS, Deisenroth C, Zhang Y (2007) Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions. Cell Cycle 6: 434-437. Review. (Pubitemid 46393446)
    • (2007) Cell Cycle , vol.6 , Issue.4 , pp. 434-437
    • Lindstrom, M.S.1    Deisenroth, C.2    Zhang, Y.3
  • 102
    • 53249142431 scopus 로고    scopus 로고
    • Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
    • Horn HF, Vousden KH (2008) Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. Oncogene 27: 5774-5784.
    • (2008) Oncogene , vol.27 , pp. 5774-5784
    • Horn, H.F.1    Vousden, K.H.2
  • 103
    • 33646817102 scopus 로고    scopus 로고
    • Translational research? Ribosome integrity and a new p53 tumor suppressor checkpoint
    • Review
    • Opferman JT, Zambetti GP (2006) Translational research? Ribosome integrity and a new p53 tumor suppressor checkpoint. Cell Death Differ 3: 898-901. Review.
    • (2006) Cell Death Differ , vol.3 , pp. 898-901
    • Opferman, J.T.1    Zambetti, G.P.2
  • 105
    • 58749094954 scopus 로고    scopus 로고
    • Targeting Mdm2 and Mdmx in cancer therapy: Better living through medicinal chemistry?
    • Wade M, Wahl GM (2009) Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res 7: 1-11.
    • (2009) Mol Cancer Res , vol.7 , pp. 1-11
    • Wade, M.1    Wahl, G.M.2
  • 108
    • 33846030177 scopus 로고    scopus 로고
    • Mdm2 targets the p53 transcription cofactor JMY for degradation
    • DOI 10.1038/sj.embor.7400855, PII 7400855
    • Coutts AS, Boulahbel H, Graham A, La Thangue NB (2007) Mdm2 targets the p53 transcription cofactor JMY for degradation. EMBO Rep 8: 84-90. (Pubitemid 46043805)
    • (2007) EMBO Reports , vol.8 , Issue.1 , pp. 84-90
    • Coutts, A.S.1    Boulahbel, H.2    Graham, A.3    La Thangue, N.B.4
  • 109
    • 28944446040 scopus 로고    scopus 로고
    • HnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage
    • DOI 10.1016/j.cell.2005.09.032, PII S009286740501038X
    • Moumen A, Masterson P, O'Connor MJ, Jackson SP (2005) hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell 123: 1065-1078. (Pubitemid 41785421)
    • (2005) Cell , vol.123 , Issue.6 , pp. 1065-1078
    • Moumen, A.1    Masterson, P.2    O'Connor, M.J.3    Jackson, S.P.4
  • 111
    • 18244379872 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 phosphorylates p53 at ser 46 and mediates apoptosis
    • D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S et al. (2002) Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4: 11-19.
    • (2002) Nat Cell Biol , vol.4 , pp. 11-19
    • D'Orazi, G.1    Cecchinelli, B.2    Bruno, T.3    Manni, I.4    Higashimoto, Y.5    Saito, S.6
  • 112
    • 33847365838 scopus 로고    scopus 로고
    • MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
    • DOI 10.1016/j.molcel.2007.02.008, PII S1097276507000883
    • Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F et al. (2007) MDM2- regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damageinduced apoptosis. Mol Cell 25: 739-750. (Pubitemid 46341925)
    • (2007) Molecular Cell , vol.25 , Issue.5 , pp. 739-750
    • Rinaldo, C.1    Prodosmo, A.2    Mancini, F.3    Iacovelli, S.4    Sacchi, A.5    Moretti, F.6    Soddu, S.7
  • 115
    • 57049114832 scopus 로고    scopus 로고
    • The genetics of the p53 pathway, apoptosis and cancer therapy
    • Review
    • Vazquez A, Bond EE, Levine AJ, Bond GL (2008) The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov 7: 979-987. Review.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 979-987
    • Vazquez, A.1    Bond, E.E.2    Levine, A.J.3    Bond, G.L.4
  • 116
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358: 80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 117
    • 34548692296 scopus 로고    scopus 로고
    • High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas
    • DOI 10.1016/j.humpath.2007.03.005, PII S0046817707001517
    • Valentin-Vega YA, Barboza JA, Chau GP, El-Naggar AK, Lozano G (2007) High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas. Hum Pathol 38: 1553-1562. (Pubitemid 47418967)
    • (2007) Human Pathology , vol.38 , Issue.10 , pp. 1553-1562
    • Valentin-Vega, Y.A.1    Barboza, J.A.2    Chau, G.P.3    El-Naggar, A.K.4    Lozano, G.5
  • 119
    • 0028081261 scopus 로고
    • The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of Bcell origin
    • Watanabe T, Hotta T, Ichikawa A, Kinoshita T, Nagai H, Uchida T et al. (1994) The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of Bcell origin. Blood 84: 3158-3165.
    • (1994) Blood , vol.84 , pp. 3158-3165
    • Watanabe, T.1    Hotta, T.2    Ichikawa, A.3    Kinoshita, T.4    Nagai, H.5    Uchida, T.6
  • 122
    • 47949105325 scopus 로고    scopus 로고
    • Mdm2 promotes genetic instability and transformation independent of p53
    • Bouska A, Lushnikova T, Plaza S, Eischen CM (2008) Mdm2 promotes genetic instability and transformation independent of p53. Mol Cell Biol 28: 4862-4874.
    • (2008) Mol Cell Biol , vol.28 , pp. 4862-4874
    • Bouska, A.1    Lushnikova, T.2    Plaza, S.3    Eischen, C.M.4
  • 123
    • 53649093334 scopus 로고    scopus 로고
    • Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival
    • Froment P, Dupont J, Christophe-Marine J (2008) Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival. Cell Cycle 7: 3098-3103.
    • (2008) Cell Cycle , vol.7 , pp. 3098-3103
    • Froment, P.1    Dupont, J.2    Christophe-Marine, J.3
  • 125
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
    • DOI 10.1016/j.cell.2006.12.007, PII S0092867406015972
    • Martins CP, Brown-Swigart L, Evan GI (2006) Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127: 1323-1334. (Pubitemid 44960417)
    • (2006) Cell , vol.127 , Issue.7 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 127
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • DOI 10.1038/nature05529, PII NATURE05529
    • Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V et al. (2007) Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445: 656-660. (Pubitemid 46232886)
    • (2007) Nature , vol.445 , Issue.7128 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6    Cordon-Cardo, C.7    Lowe, S.W.8


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