Nutrigenomics: Exploiting systems biology in the nutrition and health arena

Current Opinion in Biotechnology

Volumn 13, Issue 5, 2002, Pages 517-521

  Van Ommen, Ben ^a   Stierum, Rob ^a  

^a TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BUTYRIC ACID; CALCITRIOL; CURCUMIN; RETINOIC ACID; SELENIUM; SULINDAC; TRICHOSTATIN A;

BIOLOGY; FOOD BIOTECHNOLOGY; GENE FUNCTION; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOME; GENOMICS; GENOTYPE; HEALTH; HUMAN; METABOLISM; NONHUMAN; NUTRIENT; NUTRITION; NUTRITIONAL SCIENCE; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SCREENING;

ARENA;

EID: 0036812118     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(02)00349-X     Document Type: Review

References (28)

1. MacGregor J.T., Jurd L. Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium. Mutat Res. 54:1978;297-309.
2. Zock P.L., Katan M.B., Mensink R.P. Dietary trans fatty acids and lipoprotein cholesterol. Am J Clin Nutr. 61:1995;617.
3. Goldstein J.L., Brown M.S. The low-density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem. 46:1977;897-930.
4. Wierzbicki A.S., Mikhailidis D.P. Beyond LDL-C - the importance of raising HDL-C. Curr Med Res Opin. 18:2002;36-44.
5. Sacks F.M., Tonkin A.M., Craven T., Pfeffer M.A., Shepherd J., Keech A., Furberg C.D., Braunwald E. Coronary heart disease in patients with low LDL-cholesterol: benefit of pravastatin in diabetics and enhanced role for HDL-cholesterol and triglycerides as risk factors. Circulation. 105:2002;1424-1428.
6. Craig I.H., Phillips P.J., Lloyd J.V., Watts S., Bracken A., Read R. Effects of modified fat diets on LDL/HDL ratio. Lancet. 2:1980;799.
7. Weggemans R.M., Zock P.L., Ordovas J.M., Ramos-Galluzzi J., Katan M.B. Genetic polymorphisms and lipid response to dietary changes in humans. Eur J Clin Invest. 31:2001;950-957.
8. Horton J.D., Goldstein J.L., Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 109:2002;1125-1131. Excellent review of molecular regulatory mechanisms in nutritional sciences.
9. Chen C.C., Shieh B., Jin Y.T., Liau Y.E., Huang C.H., Liou J.T., Wu L.W., Huang W., Young K.C., Lai M.D., et al. Microarray profiling of gene expression patterns in bladder tumor cells treated with genistein. J Biomed Sci. 8:2001;214-222.
10. Staels B. Regulation of lipid and lipoprotein metabolism by retinoids. J Am Acad Dermatol. 45:2001;S158-S167.
11. Seedorf U., Assmann G. The role of PPAR ( in obesity. Nutr Metab Cardiovasc Dis. 11:2001;189-194.
12. Debril M.B., Renaud J.P., Fajas L., Auwerx J. The pleiotropic functions of peroxisome proliferator-activated receptor γ J Mol Med. 79:2001;30-47.
13. Soukas A., Cohen P., Socci N.D., Friedman J.M. Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev. 14:2000;963-980.
14. Tang Y., Lu A., Aronow B.J., Sharp F.R. Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease. Ann Neurol. 50:2001;699-707. This paper both illustrates the possibilities of the technologies and the limitations of the data interpretation that are challenging us.
15. Walker J., Flower D., Rigley K. Microarrays in hematology. Curr Opin Hematol. 9:2002;23-29.
16. Mariadason J.M., Corner G.A., Augenlicht L.H. Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. Cancer Res. 60:2000;4561-4572. A nice paper using transcriptomics to study, at the molecular level, genetic reprogramming induced by dietary compounds. Comparison of structurally related compounds (curcumin and sulindac) or compounds related in terms of biochemical mechanism (butyrate and trichostatin A, both inhibitors of histone deacetylase activity) yields information on clusters of genes from which the expression is either associated with the compound's structure or with a particular biochemical mechanism.
17. Tan S., Seow T.K., Liang R.C., Koh S., Lee C.P., Chung M.C., Hooi S.C. Proteome analysis of butyrate-treated human colon cancer cells (HT-29). Int J Cancer. 98:2002;523-531. The first reports describing a proteome study conducted to understand the effects of short chain fatty acid on colorectal cancer cells. To our knowledge, this is also the first published paper describing the effects of a dietary compound using proteomics. Importantly, proteome data were validated using western blotting.
18. Xiao J., Gregersen S., Kruhoffer M., Pedersen S.B., Orntoft T.F., Hermansen K. The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray. Endocrinology. 142:2001;4777-4784.
19. Lee C.-K., Klopp R.G., Weindruch R., Prolla T.A. Gene expression profile of aging and its retardation by caloric restriction. Science. 285:1999;1390-1393. Provides the first global assessment of a dietary intervention (caloric restriction) at the molecular level and its effects on physiology (ageing).
20. Sreekumar R., Unnikrishnan J., Fu A., Nygren J., Short K.R., Schimke J., Barazzoni R., Nair K.S. Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am J Physiol Endocrinol Metab. 283:2002;E38-E43.
21. Sreekumar R., Unnikrishnan J., Fu A., Nygren J., Short K.R., Schimke J., Barazzoni R., Nair K.S. Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle. Am J Physiol Endocrinol Metab. 282:2002;E1055-E1061.
22. Ueda K. Detection of the retinoic acid-regulated genes in a RTBM1 neuroblastoma cell line using cDNA microarray. Kurume Med J. 48:2001;159-164.
23. 2+ influx-activating analog in osteoblastic ROS 17/2.8 cells. Steroids. 67:2002;467-470.
24. Rao L., Puschner B., Prolla T.A. Gene expression profiling of low selenium status in the mouse intestine: transcriptional activation of genes linked to DNA damage, cell cycle control and oxidative stress. J Nutr. 131:2001;3175-3181. Most often, nutrients are studied at non-physiologically high doses. An alternative is to study the nutrient under conditions of deficiencies or suboptimal intake. This study is an example showing the strength of functional genomics in combination with dietary deficiency of selenium.
25. Petrault I., Zimowska W., Mathieu J., Bayle D., Rock E., Favier A., Rayssiguier Y., Mazur A. Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency. Biochim Biophys Acta. 1586:2002;92-98.
26. Blanchard R.K., Moore J.B., Green C.L., Cousins R.J. Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency. Proc Natl Acad Sci USA. 98:2001;13507-13513.
27. Li J.Y., Lescure P.A., Misek D.E., Lai Y.M., Chai B.X., Kuick R., Thompson R.C., Demo R.M., Kurnit D.M., Michailidis G., et al. Food deprivation-induced expression of minoxidil sulfotransferase in the hypothalamus uncovered by microarray analysis. J Biol Chem. 277:2002;9069-9076.
28. Stierum R., Burgemeister R., van Helvoort A., Peijnenburg A., Schutze K., Seidelin M., Vang O., van Ommen B. Functional food ingredients against colorectal cancer. An example project integrating functional genomics, nutrition and health. Nutr Metab Cardiovasc Dis. 11:2001;94-98.