Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1

Molecular Brain Research

Volumn 127, Issue 1-2, 2004, Pages 89-95

  Saito, Atsushi ^a   Hayashi, Takeshi ^a   Okuno, Shuzo ^a   Nishi, Tatsuro ^a   Chan, Pak H ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Apoptosis; Cerebral ischemia; Disorders of the nervous system; Ischemia; Omi HtrA2; Smac DIABLO; XIAP

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE INHIBITOR; COPPER ZINC SUPEROXIDE DISMUTASE; REGULATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; CYTOSOL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REACTOR CASCADE; REPERFUSION; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE; X CHROMOSOME LINKAGE;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; BLOTTING, WESTERN; BRAIN; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; CYTOSOL; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPRECIPITATION; ISCHEMIC ATTACK, TRANSIENT; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NUCLEAR PROTEINS; OXYGEN; PHENANTHRIDINES; PROTEINS; REPERFUSION; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TIME FACTORS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

MUS MUSCULUS;

EID: 4043170492     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.05.012     Document Type: Article

References (39)

1. Bindokas V.P., Jordán J., Lee C.C., Miller R.J. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J. Neurosci. 16:1996;1324-1336
2. Boveris A., Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem. J. 134:1973;707-716
3. Brustovetsky N., Dubinsky J.M., Antonsson B., Jemmerson R. Two pathways for tBID-induced cytochrome c release from rat brain mitochondria: BAK- versus BAX-dependence. J. Neurochem. 84:2003;196-207
4. Cao G., Minami M., Pei W., Yan C., Chen D., O'Horo C., Graham S.H., Chen J. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. J. Cereb. Blood Flow Metab. 21:2001;321-333
5. Chan P.H. Oxygen radicals in focal cerebral ischemia. Brain Pathol. 4:1994;59-65
6. Chan P.H. Role of oxidants in ischemic brain damage. Stroke. 27:1996;1124-1129
7. Deveraux Q.L., Reed J.C. IAP family proteins - suppressors of apoptosis. Genes Dev. 13:1999;239-252
8. Endres M., Namura S., Shimizu-Sasamata M., Waeber C., Zhang L., Gómez-Isla T., Hyman B.T., Moskowitz M.A. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J. Cereb. Blood Flow Metab. 18:1998;238-247
9. Eskes R., Desagher S., Antonsson B., Martinou J.C. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol. Cell. Biol. 20:2000;929-935
10. Fujimura M., Morita-Fujimura Y., Kawase M., Copin J.C., Calagui B., Epstein C.J., Chan P.H. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J. Neurosci. 19:1999;3414-3422
11. Fujimura M., Morita-Fujimura Y., Noshita N., Sugawara T., Kawase M., Chan P.H. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci. 20:2000;2817-2824
12. Gill R., Soriano M., Blomgren K., Hagberg H., Wybrecht R., Miss M.-T., Hoefer S., Adam G., Niederhauser O., Kemp J.A., Loetscher H. Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain. J. Cereb. Blood Flow Metab. 22:2002;420-430
13. Goyal L. Cell death inhibition: keeping caspases in check. Cell. 104:2001;805-808
14. Han D., Antunes F., Canali R., Rettori D., Cadenas E. Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J. Biol. Chem. 278:2003;5557-5563
15. Hegde R., Srinivasula S.M., Zhang Z., Wassell R., Mukattash R., Cilenti L., DuBois G., Lazebnik Y., Zervos A.S., Fernandes-Alnemri T., Alnemri E.S. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J. Biol. Chem. 277:2002;432-438
16. Kim G.W., Chan P.H. Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid. J. Cereb. Blood Flow Metab. 22:2002;798-809
17. Kinouchi H., Epstein C.J., Mizui T., Carlson E., Chen S.F., Chan P.H. Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc. Natl. Acad. Sci. U. S. A. 88:1991;11158-11162
18. Kira Y., Sato E.F., Inoue M. Association of Cu,Zn-type superoxide dismutase with mitochondria and peroxisomes. Arch. Biochem. Biophys. 399:2002;96-102
19. Madesh M., Hajnóczky G. VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J. Cell Biol. 155:2001;1003-1015
20. Martins L.M., Iaccarino I., Tenev T., Gschmeissner S., Totty N.F., Lemoine N.R., Savopoulos J., Gray C.W., Creasy C.L., Dingwall C., Downward J. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J. Biol. Chem. 277:2002;439-444
21. Murakami K., Kondo T., Kawase M., Li Y., Sato S., Chen S.F., Chan P.H. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J. Neurosci. 18:1998;205-213
22. Okado-Matsumoto A., Fridovich I. Subcellular distribution of superoxide dismutases (SOD) in rat liver Cu,Zn-SOD in mitochondria. J. Biol. Chem. 276:2001;38388-38393
23. Piantadosi C.A., Zhang J. Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke. 27:1996;327-332
24. Plesnila N., Zinkel S., Le D.A., Amin-Hanjani S., Wu Y., Qiu J., Chiarugi A., Thomas S.S., Kohane D.S., Korsmeyer S.J., Moskowitz M.A. BID mediates neuronal cell death after oxygen/glucose deprivation and focal cerebral ischemia. Proc. Natl. Acad. Sci. U. S. A. 98:2001;15318-15323
25. Reed J.C. Apoptosis-regulating proteins as targets for drug discovery,. Trends Mol. Med. 7:2001;314-319
26. Saito A., Hayashi T., Okuno S., Ferrand-Drake M., Chan P.H. Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 23:2003;1010-1019
27. Saito A., Hayashi T., Okuno S., Ferrand-Drake M., Chan P.H. Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. J. Neurosci. 23:2003;1710-1718
28. Shimizu S., Narita M., Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature. 399:1999;483-487
29. Sugawara T., Noshita N., Lewén A., Gasche Y., Ferrand-Drake M., Fujimura M., Morita-Fujimura Y., Chan P.H. Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J. Neurosci. 22:2002;209-217
30. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., Jacotot E., Costantini P., Loeffler M., Larochette N., Goodlett D.R., Aebersold R., Siderovski D.P., Penninger J.M., Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor [letter]. Nature. 397:1999;441-446
31. Suzuki Y., Imai Y., Nakayama H., Takahashi K., Takio K., Takahashi R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell. 8:2001;613-621
32. Takahashi R., Deveraux Q., Tamm I., Welsh K., Assa-Munt N., Salvesen G.S., Reed J.C. A single BIR domain of XIAP sufficient for inhibiting caspases. J. Biol. Chem. 273:1998;7787-7790
33. van Loo G., van Gurp M., Depuydt B., Srinivasula S.M., Rodriguez I., Alnemri E.S., Gevaert K., Vandekerckhove J., Declercq W., Vandenabeele P. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ. 9:2002;20-26
34. L prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell. 3:1999;159-167
35. Verhagen A.M., Ekert P.G., Pakusch M., Sike J., Connolly L.M., Reid G.E., Moritz R.L., Simpson R.J., Vaux D.L. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 102:2000;43-53
36. Verhagen A.M., Silke J., Ekert P.G., Pakusch M., Kaufmann H., Connolly L.M., Day C.L., Tikoo A., Burke R., Wrobel C., Moritz R.L., Simpson R.J., Vaux D.L. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277:2002;445-454
37. Wei M.C., Lindsten T., Mootha V.K., Weiler S., Gross A., Ashiya M., Thompson C.B., Korsmeyer S.J. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14:2000;2060-2071
38. Yang G., Chan P.H., Chen J., Carlson E., Chen S.F., Weinstein P., Epstein C.J., Kamii H. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke. 25:1994;165-170
39. Zamzami N., Marchetti P., Castedo M., Decaudin D., Macho A., Hirsch T., Susin S.A., Petit P.X., Mignotte B., Kroemer G. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 182:1995;367-377