Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 10, 2008, Pages 1686-1696

  Nito, Chikako ^a,b   Kamada, Hiroshi ^a   Endo, Hidenori ^a   Niizuma, Kuniyasu ^a   Myer, D Jeannie ^a   Chan, Pak H ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Blood brain barrier; Cytosolic phospholipase A2; Focal cerebral ischemia; Mitogen activated protein kinase; Oxidative stress; Superoxide dismutase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOSOLIC PHOSPHOLIPASE A2; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE A2; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN EDEMA; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRAVASATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN ISCHEMIA; CEREBRAL INFARCTION; CYCLOOXYGENASE 2; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MALE; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASES A2, CYTOSOLIC; PHOSPHORYLATION; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 52549132911     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2008.60     Document Type: Article

References (40)

1. 2 stimulation and hydroxyl radical generation in transient cerebral ischemia. J Neurosci Res 73:308-15
2. 2 mediates ischemic injury in the hippocampus: a regional difference of neuronal vulnerability. Eur J Neurosci 13:2319-23
3. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-6
4. 2. [Letter]. Nature 390:622-5
5. 2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets. Eur J Biochem 245:751-9
6. 2 knockout mouse. J Neurochem 87:1471-7
7. Chan PH, Fishman RA (1978) Brain edema: induction in cortical slices by polyunsaturated fatty acids. Science 201:358-60
8. Chan PH, Kawase M, Murakami K, Chen SF, Li Y, Calagui B, Reola L, Carlson E, Epstein CJ (1998) Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J Neurosci 18:8292-9
9. 2 after transient global forebrain ischemia in the rat. Stroke 27:527-35
10. 2 cascade in hydroperoxide-stressed platelets. Free Radic Biol Med 35:616-25
11. Duane PG, Rice KL, Charboneau DE, King MB, Gilboe DP, Niewoehner DE (1991) Relationship of oxidant-mediated cytotoxicity to phospholipid metabolism in endothelial cells. Am J Respir Cell Mol Biol 4:408-16
12. 2 synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-κB. J Neurochem 75:2020-8
13. Gasche Y, Copin J-C, Sugawara T, Fujimura M, Chan PH (2001) Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J Cereb Blood Flow Metab 21:1393-400
14. 2 by MNK1-related protein kinases. J Biol Chem 275:37542-51
15. 2. J Biol Chem 274:5163-9
16. Irving EA, Bamford M (2002) Role of mitogen- and stress-activated kinases in ischemic injury. J Cereb Blood Flow Metab 22:631-47
17. Kim GW, Gasche Y, Grzeschik S, Copin J-C, Maier CM, Chan PH (2003) Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption? J Neurosci 23:8733-42
18. Kinouchi H, Epstein CJ, Mizui T, Carlson E, Chen SF, Chan PH (1991) Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc Natl Acad Sci USA 88:11158-62
19. Kondo T, Reaume AG, Huang T-T, Carlson E, Murakami K, Chen SF, Hoffman EK, Scott RW, Epstein CJ, Chan PH (1997) Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci 17:4180-9
20. 2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-β peptide. FASEB J 19:85-7
21. Krupinski J, Slevin M, Marti E, Catena E, Rubio F, Gaffney J (2003) Time-course phosphorylation of the mitogen activated protein (MAP) kinase group of signalling proteins and related molecules following middle cerebral artery occlusion (MCAO) in rats. Neuropathol Appl Neurobiol 29:144-58
22. Larsen JK, Yamboliev IA, Weber LA, Gerthoffer WT (1997) Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle. Am J Physiol Lung Cell Mol Physiol 273:L930-40
23. 2. J Biol Chem 272:16709-12
24. 2 is phosphorylated and activated by MAP kinase. Cell 72:269-78
25. Maier CM, Ahern Kv, Cheng ML, Lee JE, Yenari MA, Steinberg GK (1998) Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia. Effects on neurologic outcome, infarct size, apoptosis, and inflammation. Stroke 29:2171-80
26. Okuno S, Saito A, Hayashi T, Chan PH (2004) The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J Neurosci 24:7879-87
27. Papadopoulos SM, Black KL, Hoff JT (1989) Cerebral edema induced by arachidonic acid: role of leukocytes and 5-lipoxygenase products. Neurosurgery 25:369-72
28. Piao CS, Che Y, Han P-L, Lee J-K (2002) Delayed and differential induction of p38 MAPK isoforms in microglia and astrocytes in the brain after transient global ischemia. Mol Brain Res 107:137-44
29. 4: role in transient cerebral ischemia of gerbils. Neurochem Res 24:1225-32
30. 2 in the release of free fatty acids during ischemia-reperfusion in the rat cerebral cortex. Neurosci Lett 233:97-100
31. Smith WL, Garavito RM, DeWitt DL (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271:33157-60
32. 2 is induced in reactive glia following different forms of neurodegeneration. Glia 27:110-28
33. Sugino T, Nozaki K, Takagi Y, Hattori I, Hashimoto N, Moriguchi T, Nishida E (2000) Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus. J Neurosci 20:4506-14
34. Suzuki YJ, Forman HJ, Sevanian A (1997) Oxidants as stimulators of signal transduction. Free Radic Biol Med 22:269-85
35. 2 are less susceptible to cerebral ischemia/reperfusion injury. Acta Neurochir Suppl 86:169-72
36. Unterberg A, Wahl M, Hammersen F, Baethmann A (1987) Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid. Acta Neuropathol (Berl) 73:209-19
37. Watanabe T, Egawa M (1994) Effects of an antistroke agent MCI-186 on cerebral arachidonate cascade. J Pharmacol Exp Ther 271:1624-9
38. 2 are abrogated by an inhibitor of the p38 mitogenactivated protein kinase cascade in human neutrophils. Biochem J 319:17-20
39. 2 phosphorylation and arachadonic acid release in primary murine astrocytes. J Neurochem 83:259-70
40. 2 in response to PMA. Biochem J 388:527-35