Toll-like receptor signaling in cell proliferation and survival

Cytokine

Volumn 49, Issue 1, 2010, Pages 1-9

  Li, Xinyan ^a   Jiang, Song ^a   Tapping, Richard I ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cancer; Proliferation; Signaling; Survival; Toll like receptor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR;

CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC INFLAMMATION; ENZYME ACTIVITY; GENE CONTROL; GROWTH REGULATION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR; TRANSCRIPTION INITIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVATION; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID DIFFERENTIATION FACTOR 88; NEOPLASMS; NF-KAPPA B; REGENERATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 71649086180     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2009.08.010     Document Type: Review

References (108)

1. Akira S., and Takeda K. Toll-like receptor signalling. Nat Rev Immunol 4 (2004) 499-511
2. Banerjee A., and Gerondakis S. Coordinating TLR-activated signaling pathways in cells of the immune system. Immunol Cell Biol 85 (2007) 420-424
3. Wagner H. Endogenous TLR ligands and autoimmunity. Adv Immunol 91 (2006) 159-173
4. Hasan U.A., Trinchieri G., and Vlach J. Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts. J Biol Chem 280 (2005) 20620-20627
5. Jego G., Bataille R., Geffroy-Luseau A., Descamps G., and Pellat-Deceunynck C. Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors. Leukemia 20 (2006) 1130-1137
6. Bohnhorst J., Rasmussen T., Moen S.H., Flottum M., Knudsen L., Borset M., et al. Toll-like receptors mediate proliferation and survival of multiple myeloma cells. Leukemia 20 (2006) 1138-1144
7. Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., and Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118 (2004) 229-241
8. Jiang D., Liang J., Fan J., Yu S., Chen S., Luo Y., et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11 (2005) 1173-1179
9. Huang B., Zhao J., Unkeless J.C., Feng Z.H., and Xiong H. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene 27 (2008) 218-224
10. Naugler W.E., Sakurai T., Kim S., Maeda S., Kim K., Elsharkawy A.M., et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317 (2007) 121-124
11. Rakoff-Nahoum S., and Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317 (2007) 124-127
12. Swann J.B., Vesely M.D., Silva A., Sharkey J., Akira S., Schreiber R.D., et al. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci USA 105 (2008) 652-656
13. O'Neill L.A., and Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7 (2007) 353-364
14. Medzhitov R., Preston-Hurlburt P., Kopp E., Stadlen A., Chen C., Ghosh S., et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 2 (1998) 253-258
15. Kawai T., Adachi O., Ogawa T., Takeda K., and Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11 (1999) 115-122
16. Takeuchi O., Takeda K., Hoshino K., Adachi O., Ogawa T., and Akira S. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol 12 (2000) 113-117
17. Fitzgerald K.A., Palsson-McDermott E.M., Bowie A.G., Jefferies C.A., Mansell A.S., Brady G., et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413 (2001) 78-83
18. Kagan J.C., and Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125 (2006) 943-955
19. Kawai T., and Akira S. TLR signaling. Cell Death Differ 13 (2006) 816-825
20. Cao Z., Henzel W.J., and Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 271 (1996) 1128-1131
21. Deng L., Wang C., Spencer E., Yang L., Braun A., You J., et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103 (2000) 351-361
22. Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., and Chen Z.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412 (2001) 346-351
23. Ninomiya-Tsuji J., Kishimoto K., Hiyama A., Inoue J., Cao Z., and Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398 (1999) 252-256
24. Shibuya H., Yamaguchi K., Shirakabe K., Tonegawa A., Gotoh Y., Ueno N., et al. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 272 (1996) 1179-1182
25. Ishitani T., Takaesu G., Ninomiya-Tsuji J., Shibuya H., Gaynor R.B., and Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J 22 (2003) 6277-6288
26. Prickett T.D., Ninomiya-Tsuji J., Broglie P., Muratore-Schroeder T.L., Shabanowitz J., Hunt D.F., et al. TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. J Biol Chem 283 (2008) 19245-19254
27. Sakurai H., Miyoshi H., Mizukami J., and Sugita T. Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. FEBS Lett 474 (2000) 141-145
28. Kanayama A., Seth R.B., Sun L., Ea C.K., Hong M., Shaito A., et al. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell 15 (2004) 535-548
29. Yamamoto M., Sato S., Hemmi H., Uematsu S., Hoshino K., Kaisho T., et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 4 (2003) 1144-1150
30. Hirotani T., Yamamoto M., Kumagai Y., Uematsu S., Kawase I., Takeuchi O., et al. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. Biochem Biophys Res Commun 328 (2005) 383-392
31. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 (2003) 640-643
32. Clement J.F., Meloche S., and Servant M.J. The IKK-related kinases: from innate immunity to oncogenesis. Cell Res 18 (2008) 889-899
33. Chen W., Lam S.S., Srinath H., Jiang Z., Correia J.J., Schiffer C.A., et al. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol 15 (2008) 1213-1220
34. Sen R., and Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46 (1986) 705-716
35. Vallabhapurapu S., and Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27 (2009) 693-733
36. Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (2004) 461-466
37. Wolska A., Lech-Maranda E., and Robak T. Toll-like receptors and their role in hematologic malignancies. Curr Mol Med 9 (2009) 324-335
38. Arbibe L., Mira J.P., Teusch N., Kline L., Guha M., Mackman N., et al. Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol 1 (2000) 533-540
39. Saccani S., Pantano S., and Natoli G. p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol 3 (2002) 69-75
40. Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
41. Palmer A., Gavin A.C., and Nebreda A.R. A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. EMBO J 17 (1998) 5037-5047
42. Treinies I., Paterson H.F., Hooper S., Wilson R., and Marshall C.J. Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal to stimulate DNA synthesis. Mol Cell Biol 19 (1999) 321-329
43. Sancho R., Nateri A.S., de Vinuesa A.G., Aguilera C., Nye E., Spencer-Dene B., et al. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J 28 (2009) 1843-1854
44. Hui L., Bakiri L., Stepniak E., and Wagner E.F. P38alpha: a suppressor of cell proliferation and tumorigenesis. Cell Cycle 6 (2007) 2429-2433
45. Zhang W., and Liu H.T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12 (2002) 9-18
46. Dumitru C.D., Ceci J.D., Tsatsanis C., Kontoyiannis D., Stamatakis K., Lin J.H., et al. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103 (2000) 1071-1083
47. Lee F.S., Hagler J., Chen Z.J., and Maniatis T. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88 (1997) 213-222
48. Huang Q., Yang J., Lin Y., Walker C., Cheng J., Liu Z.G., et al. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat Immunol 5 (2004) 98-103
49. Zhang D., Facchinetti V., Wang X., Huang Q., Qin J., and Su B. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways. EMBO J 25 (2006) 97-107
50. Matsuzawa A., Saegusa K., Noguchi T., Sadamitsu C., Nishitoh H., Nagai S., et al. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6 (2005) 587-592
51. Eliopoulos A.G., Dumitru C.D., Wang C.C., Cho J., and Tsichlis P.N. Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J 21 (2002) 4831-4840
52. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev 18 (2004) 2195-2224
53. Mayr B., and Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2 (2001) 599-609
54. Shaulian E., and Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 4 (2002) E131-E136
55. Ananieva O., Darragh J., Johansen C., Carr J.M., McIlrath J., Park J.M., et al. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol 9 (2008) 1028-1036
56. Zaru R., Ronkina N., Gaestel M., Arthur J.S., and Watts C. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol 8 (2007) 1227-1235
57. Bonni A., Brunet A., West A.E., Datta S.R., Takasu M.A., and Greenberg M.E. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286 (1999) 1358-1362
58. Rowlett R.M., Chrestensen C.A., Nyce M., Harp M.G., Pelo J.W., Cominelli F., et al. MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. Am J Physiol Gastrointest Liver Physiol 294 (2008) G452-G459
59. Andersson K., and Sundler R. Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages. Cytokine 33 (2006) 52-57
60. Okkenhaug K., and Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 3 (2003) 317-330
61. Koyasu S. The role of PI3K in immune cells. Nat Immunol 4 (2003) 313-319
62. Ojaniemi M., Glumoff V., Harju K., Liljeroos M., Vuori K., and Hallman M. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol 33 (2003) 597-605
63. Laird M.H., Rhee S.H., Perkins D.J., Medvedev A.E., Piao W., Fenton M.J., et al. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 85 (2009) 966-977
64. Ruse M., and Knaus U.G. New players in TLR-mediated innate immunity: PI3K and small Rho GTPases. Immunol Res 34 (2006) 33-48
65. Gunzl P., and Schabbauer G. Recent advances in the genetic analysis of PTEN and PI3K innate immune properties. Immunobiology 213 (2008) 759-765
66. Fukao T., Tanabe M., Terauchi Y., Ota T., Matsuda S., Asano T., et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 3 (2002) 875-881
67. Yu Y., Nagai S., Wu H., Neish A.S., Koyasu S., and Gewirtz A.T. TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. J Immunol 176 (2006) 6194-6201
68. Tsukamoto K., Hazeki K., Hoshi M., Nigorikawa K., Inoue N., Sasaki T., et al. Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. J Immunol 180 (2008) 2054-2061
69. Doble B.W., and Woodgett J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116 (2003) 1175-1186
70. Martin M., Rehani K., Jope R.S., and Michalek S.M. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6 (2005) 777-784
71. Hu X., Paik P.K., Chen J., Yarilina A., Kockeritz L., Lu T.T., et al. IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity 24 (2006) 563-574
72. Guiducci C., Ghirelli C., Marloie-Provost M.A., Matray T., Coffman R.L., Liu Y.J., et al. PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med 205 (2008) 315-322
73. Cao W., Manicassamy S., Tang H., Kasturi S.P., Pirani A., Murthy N., et al. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol 9 (2008) 1157-1164
74. Jefferies C.A., Doyle S., Brunner C., Dunne A., Brint E., Wietek C., et al. Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem 278 (2003) 26258-26264
75. Lee K.G., Xu S., Wong E.T., Tergaonkar V., and Lam K.P. Bruton's tyrosine kinase separately regulates NFkappaB p65RelA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B cells. J Biol Chem 283 (2008) 11189-11198
76. Sochorova K., Horvath R., Rozkova D., Litzman J., Bartunkova J., Sediva A., et al. Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. Blood 109 (2007) 2553-2556
77. Liljeroos M., Vuolteenaho R., Morath S., Hartung T., Hallman M., and Ojaniemi M. Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages. Cell Signal 19 (2007) 625-633
78. Mansell A., Smith R., Doyle S.L., Gray P., Fenner J.E., Crack P.J., et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol 7 (2006) 148-155
79. Gray P., Dunne A., Brikos C., Jefferies C.A., Doyle S.L., and O'Neill L.A. MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem 281 (2006) 10489-10495
80. Chen L.Y., Zuraw B.L., Liu F.T., Huang S., and Pan Z.K. IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription. J Immunol 169 (2002) 3934-3939
81. Manukyan M., Nalbant P., Luxen S., Hahn K.M., and Knaus U.G. RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. J Immunol 182 (2009) 3522-3529
82. Hippenstiel S., Soeth S., Kellas B., Fuhrmann O., Seybold J., Krull M., et al. Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells. Blood 95 (2000) 3044-3051
83. Schmeck B., Brunsch M., Seybold J., Krull M., Eichel-Streiber C., Suttorp N., et al. Rho protein inhibition blocks cyclooxygenase-2 expression by proinflammatory mediators in endothelial cells. Inflammation 27 (2003) 89-95
84. Monick M.M., Powers L.S., Butler N.S., and Hunninghake G.W. Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. J Immunol 171 (2003) 2625-2630
85. Harokopakis E., Albzreh M.H., Martin M.H., and Hajishengallis G. TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae. J Immunol 176 (2006) 7645-7656
86. Chen B.C., Kang J.C., Lu Y.T., Hsu M.J., Liao C.C., Chiu W.T., et al. Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway. Mol Immunol 46 (2009) 1179-1188
87. Burdelya L.G., Krivokrysenko V.I., Tallant T.C., Strom E., Gleiberman A.S., Gupta D., et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320 (2008) 226-230
88. Cheng I., Plummer S.J., Casey G., and Witte J.S. Toll-like receptor 4 genetic variation and advanced prostate cancer risk. Cancer Epidemiol Biomarkers Prev 16 (2007) 352-355
89. Song J., Kim D.Y., Kim C.S., Kim H.J., Lee D.H., Lee H.M., et al. The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men. Cancer Genet Cytogenet 190 (2009) 88-92
90. Chen Y.C., Giovannucci E., Kraft P., Lazarus R., and Hunter D.J. Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer. Cancer Epidemiol Biomarkers Prev 16 (2007) 1982-1989
91. Stevens V.L., Hsing A.W., Talbot J.T., Zheng S.L., Sun J., Chen J., et al. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. Int J Cancer 123 (2008) 2644-2650
92. Pandey S, Mittal RD, Srivastava M, Srivastava K, Singh S, Srivastava S, et al. Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women. Gynecol Oncol 2009;114:501-5.
93. Fukata M., Chen A., Vamadevan A.S., Cohen J., Breglio K., Krishnareddy S., et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133 (2007) 1869-1881
94. Fukata M., Chen A., Klepper A., Krishnareddy S., Vamadevan A.S., Thomas L.S., et al. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: role in proliferation and apoptosis in the intestine. Gastroenterology 131 (2006) 862-877
95. Kim S., Takahashi H., Lin W.W., Descargues P., Grivennikov S., Kim Y., et al. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457 (2009) 102-106
96. Huang B., Zhao J., Li H., He K.L., Chen Y., Chen S.H., et al. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 65 (2005) 5009-5014
97. Huang B., Zhao J., Shen S., Li H., He K.L., Shen G.X., et al. Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res 67 (2007) 4346-4352
98. Sasu S., LaVerda D., Qureshi N., Golenbock D.T., and Beasley D. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ Res 89 (2001) 244-250
99. Wang Z.J., Zhang F.M., Wang L.S., Yao Y.W., Zhao Q., and Gao X. Lipopolysaccharides can protect mesenchymal stem cells (MSCs) from oxidative stress-induced apoptosis and enhance proliferation of MSCs via Toll-like receptor (TLR)-4 and PI3K/Akt. Cell Biol Int 33 (2009) 665-674
100. Chow E.K., O'connell R.M., Schilling S., Wang X.F., Fu X.Y., and Cheng G. TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. EMBO J 24 (2005) 4071-4081
101. Hasan U.A., Caux C., Perrot I., Doffin A.C., Menetrier-Caux C., Trinchieri G., et al. Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs. Proc Natl Acad Sci USA 104 (2007) 8047-8052
102. Salaun B., Lebecque S., Matikainen S., Rimoldi D., and Romero P. Toll-like receptor 3 expressed by melanoma cells as a target for therapy?. Clin Cancer Res 13 (2007) 4565-4574
103. Paone A., Starace D., Galli R., Padula F., De Cesaris P., Filippini A., et al. Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism. Carcinogenesis 29 (2008) 1334-1342
104. Aliprantis A.O., Yang R.B., Mark M.R., Suggett S., Devaux B., Radolf J.D., et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285 (1999) 736-739
105. Aliprantis A.O., Yang R.B., Weiss D.S., Godowski P., and Zychlinsky A. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J 19 (2000) 3325-3336
106. Lehner M., Bailo M., Stachel D., Roesler W., Parolini O., and Holter W. Caspase-8 dependent apoptosis induction in malignant myeloid cells by TLR stimulation in the presence of IFN-alpha. Leuk Res 31 (2007) 1729-1735
107. Zhang J., Cado D., Chen A., Kabra N.H., and Winoto A. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392 (1998) 296-300
108. Imtiyaz H.Z., Rosenberg S., Zhang Y., Rahman Z.S., Hou Y.J., Manser T., et al. The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells. J Immunol 176 (2006) 6852-6861