Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals

EMBO Journal

Volumn 21, Issue 18, 2002, Pages 4831-4840

  Eliopoulos, Aristides G ^a,b   Dumitru, Calin D ^a   Wang, Chun Chi ^a   Cho, Jeonghee ^a   Tsichlis, Philip N ^a,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

Cot; COX 2; LPS; Signaling; Tpl2

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOKINE; GALACTOSAMINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ENZYME INDUCTION; ENZYME REGULATION; IMMUNE RESPONSE; MACROPHAGE ACTIVATION; MEDIATOR RELEASE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TARGET CELL;

ANIMALS; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INDUCTION; GENES, REPORTER; GLYCOGEN SYNTHASE KINASE 3; INFLAMMATION; ISOENZYMES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MAP KINASE KINASE KINASES; MICE; PEROXIDASES; PLANT PROTEINS; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTO-ONCOGENE PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; RNA STABILITY; SIGNAL TRANSDUCTION;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037119996     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf478     Document Type: Article

References (44)

1. Arthur, J.S. and Cohen, P. (2000) MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. FEBS Lett., 482, 44-48.
2. Astiz, M., Saha, D., Lustbader, D., Lin, R. and Rackow, E. (1996) Monocyte response to bacterial toxins, expression of cell surface receptors, and release of anti-inflammatory cytokines during sepsis. J. Lab. Clin. Med., 128, 594-600.
3. Barrios-Rodiles, M., Tiraloche, G. and Chadee, K. (1999) Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1β and TNF-α. J. Immunol., 163, 963-969.
4. Caivano, M. and Cohen, P. (2000) Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1β in RAW264 macrophages. J. Immunol., 164, 3018-3025.
5. Ceci, J.D., Patriotis, C.P., Tsatsanis, C., Makris, A.M., Kovatch, R., Swing, D.A., Jenkins, N.A., Tsichlis, P.N. and Copeland, N.G. (1997) Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev., 11, 688-700.
6. Chen, C.C., Sun, Y.T., Chen, J.J. and Chang, Y.J. (2001) Tumor necrosis factor-α-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IκB kinase 1/2 in human alveolar epithelial cells. Mol. Pharmacol., 59, 493-500.
7. de Gregorio, R., Iniguez, M.A., Fresno, M. and Alemany, S. (2001) Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells. J. Biol. Chem., 276, 27003-27009.
8. Deak, M., Clifton, A.D., Lucocq, L.M. and Alessi, D.R. (1998) Mitogen-and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J., 17, 4426-4441.
9. Dinchuk, J.E. (1995) Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature, 378, 406-409.
10. Dumitru, C.D. et al. (2000) TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell, 103, 1071-1083.
11. Elder, D.J. and Paraskeva, C. (1998) COX-2 inhibitors for colorectal cancer. Nat. Med., 4, 392-393.
12. Eliopoulos, A.G., Gallagher, N.J., Blake, S.M.S., Dawson, C.W. and Young, L.S. (1999) Activation of the p38 MAPK pathway by Epstein-Barr virus encoded latent membrane protein 1 (LMP1) coregulates interleukin-6 and interleukin-8 production. J. Biol. Chem., 274, 16085-16096.
13. Eliopoulos, A.G., Davies, C., Blake, S.M.S., Murray, P., Najafipour, S., Tsichlis, P.N. and Young, L.S. (2002) The oncogenic protein kinase Tpl-2/cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-κB signaling downstream of TRAF2. J. Virol., 76, 4567-4579.
14. Erny, K.M., Peli, J., Lambert, J.F., Muller, V. and Diggelmann, H. (1996) Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis. Oncogene, 13, 2015-2020.
15. Frodin, M. and Gammeltoft, S. (1999) Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol. Cell. Endocrinol., 151, 65-77.
16. Hargrove, J.L. (1993) Microcomputer-assisted kinetic modeling of mammalian gene expression. FASEB J., 7, 1163-1170.
17. Herschman, H.R. (1996) Prostaglandin synthase 2. Biochim. Biophys. Acta, 1299, 125-140.
18. Howe, L.R., Subbaramaiah, K., Chung, W.J., Dannenberg, A.J. and Brown, A.M. (1999) Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. Cancer Res., 59, 1572-1577.
19. Jones, M.K., Wang, H., Peskar, B.M., Levin, E., Itani, R.M., Sarfeh, I.J. and Tarnawski, A.S. (1999) Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat. Med., 5, 1418-1423.
20. Kundu, N., Yang, Q., Dorsey, R. and Fulton, A.M. (2001) Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. Int. J. Cancer, 93, 681-686.
21. Lasa, M., Mahtani, K.R., Finch, A., Brewer, G., Saklatvala, J. and Clark, A.R. (2000) Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol. Cell. Biol., 20, 4265-4274.
22. -/- mice. Brain Res., 825, 86-94.
23. Mayr, B. and Montminy, M. (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol., 2, 599-609.
24. Meade, E.A., Smith, W.L. and DeWitt, D.L. (1993) Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem., 268, 6610-6614.
25. Merienne, K., Pannetier, S., Harel-Bellan, A. and Sassone-Corsi, P. (2001) Mitogen-regulated rsk2-cbp interaction controls their kinase and acetylase activities. Mol. Cell. Biol., 21, 7089-7096.
26. Nakajima, T., Kinoshita, S., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T. and Akira, S. (1993) Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl Acad. Sci. USA, 90, 2207-2211.
27. Min/+ mice. J. Infect. Dis., 184, 227-230.
28. Oshima, M., Dinchuk, J.E., Kargman, S.L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J.M., Evans, J.F. and Taketo, M.M. (1996) Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell, 87, 803-809.
29. Parillo, J.E. (1993) Pathogenic mechanisms of septic shock. N. Engl. J. Med., 328, 1471-1477.
30. Patriotis, C., Makris, A., Bear, S.E. and Tsichlis, P.N. (1993) Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc. Natl Acad. Sci. USA, 90, 2251-2255.
31. Reddy, S.T. and Herschman, H.R. (1994) Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. J. Biol. Chem., 269, 15473-15480.
32. Sassone-Corsi, P., Mizzen, C.A., Cheung, P., Crosio, C., Monaco, L., Jacquot, S., Hanauer, A. and Allis, C.D. (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science, 285, 886-891.
33. Sheng, H., Williams, C.S., Shao, J., Liang, P., DuBois, R.N. and Beauchamp, R.D. (1998) Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J. Biol. Chem., 273, 22120-22127.
34. Shimamura, A., Ballif, B.A., Richards, S.A. and Blenis, J. (2000) Rsk1 mediates a MEK-MAP kinase cell survival signal. Curr. Biol., 10, 127-135.
35. Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F., Narumiya, S., Oshima, M. and Taketo, M.M. (2001) Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Δ716) knockout mice. Nat. Med., 7, 1048-1051.
36. Srivastava, R.A.K. and Schonfeld, G. (1998) Measurement of rate of transcription in isolated nuclei by nuclear 'run-off' assay. In Rapley, R. and Manning, D.L. (eds), Methods in Molecular Biology: RNA Isolation and Characterization Protocols, Vol. 86. Humana Press, Totowa, NJ.
37. Studley, M. and Smale, S.T. (1999) C/EBPβ regulation and its role in IL-12 induction in activated macrophages. Cold Spring Harb. Symp. Quant. Biol., 64, 206.
38. Syrbu, S.I., WatermanW.H., Molski, T.F., Nagarkatti, D., Hajjar, J.J. and Sha'afi, R.I. (1999) Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils. J. Immunol., 162, 2334-2340.
39. Thomson, S., Clayton, A.L., Hazzalin, C.A., Rose, S., Barratt, M.J. and Mahadevan, L.C. (1999) The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J., 18, 4779-4793.
40. Tilley, S.L., Coffman, T.M. and Koller, B.H. (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J. Clin. Invest., 108, 15-23.
41. Tsatsanis, C., Patriotis, C., Bear, S.E. and Tsichlis, P.N. (1998a) The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cells. Proc. Natl Acad. Sci. USA, 95, 3827-3832.
42. Tsatsanis, C., Patriotis, C. and Tsichlis, P.N. (1998b) Tpl-2 induces IL-2 expression in T cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB. Oncogene, 17, 2609-2618.
43. Wadleigh, D.J., Reddy, S.T., Kopp, E., Ghosh, S. and Herschman, H.R. (2000) Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages. J. Biol. Chem., 275, 6259-6266.
44. Xing, J., Kornhauser, J.M., Xia, Z., Thiele, E.A. and Greenberg, M.E. (1998) Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol. Cell. Biol., 18, 1946-1955.