A common property of amyotrophic lateral sclerosis-associated variants. Destabilization of the copper/zinc superoxide dismutase electrostatic loop

Journal of Biological Chemistry

Volumn 284, Issue 45, 2009, Pages 30965-30973

  Molnar, Kathleen S ^a   Karabacak, N Murat ^b   Johnson, Joshua L ^b   Wang, Qi ^b   Tiwari, Ashutoshi ^c   Hayward, Lawrence J ^c   Coales, Stephen J ^a   Hamuro, Yoshitomo ^a   Agar, Jeffrey N ^b  

^a ExSAR Corporation   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; BINDING LOOP; CELLULAR CONSTITUENTS; COMMON PROPERTY; COPPER/ZINC SUPEROXIDE DISMUTASE; DYNAMIC CHANGES; DYNAMIC PROPERTY; GAIN-OF FUNCTION; HYDROGEN-DEUTERIUM EXCHANGE; METAL BINDING AFFINITY;

BINDING ENERGY; DEUTERIUM; ELECTROSTATICS; OXYGEN; ZINC;

GENE ENCODING;

COPPER ZINC SUPEROXIDE DISMUTASE; ZINC;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING AFFINITY; DEUTERIUM HYDROGEN EXCHANGE; ELECTRICITY; ENZYME STRUCTURE; GENE MUTATION; GENETIC VARIABILITY; HUMAN; METAL BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

AMYOTROPHIC LATERAL SCLEROSIS; BINDING SITES; GENETIC VARIATION; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; STATIC ELECTRICITY; SUPEROXIDE DISMUTASE;

EID: 71449104857     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.023945     Document Type: Article

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