ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization

Journal of Molecular Biology

Volumn 332, Issue 3, 2003, Pages 601-615

  DiDonato, Michael ^a,b   Craig, Lisa ^a   Huff, Mary E ^a   Thayer, Maria M ^a   Cardoso, Rosa M F ^a   Kassmann, Carey J ^a   Lo, Terence P ^a,c   Bruns, Cami K ^a,d   Powers, Evan T ^a   Kelly, Jeffery W ^a   Getzoff, Elizabeth D ^a   Tainer, John A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GNF   (United States)

^c Department of Life Sciences   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

Aggregation; ALS; Lou Gehrig's disease; Neurodegenerative; Superoxide dismutase

Indexed keywords

AMYLOID; CONGO RED; CYSTEINE; MUTANT PROTEIN; SUPEROXIDE DISMUTASE; THIOFLAVINE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; BETA SHEET; ENERGY; HUMAN; MOLECULAR DYNAMICS; NERVE CELL; NONHUMAN; PATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFECT; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE;

EID: 0042736853     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00889-1     Document Type: Article

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