An Intersubunit Disulfide Bond Prevents in Vitro Aggregation of a Superoxide Dismutase-1 Mutant Linked to Familial Amytrophic Lateral Sclerosis

Biochemistry

Volumn 43, Issue 17, 2004, Pages 4899-4905

  Ray, Soumya S ^a,b   Nowak, Richard J ^a,b   Strokovich, Konstantin ^a   Brown Jr , Robert H ^a,c   Walz, Thomas ^a   Lansbury Jr , Peter T ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; CHEMICAL BONDS; DISSOCIATION; MUTAGENESIS; NEUROLOGY; PROTEINS;

MOTOR NEURONS; NEURONAL LOSS;

BIOCHEMISTRY;

COPPER ZINC SUPEROXIDE DISMUTASE; MUTANT PROTEIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CONCENTRATION RESPONSE; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME STABILITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN AGGREGATION;

AMYOTROPHIC LATERAL SCLEROSIS; CELL AGGREGATION; CHROMATOGRAPHY, GEL; DIMERIZATION; DISULFIDES; ENZYME STABILITY; HUMANS; MODELS, MOLECULAR; MUTATION; POINT MUTATION; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 2142761528     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030246r     Document Type: Article

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