Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis

Journal of Neurochemistry

Volumn 72, Issue 2, 1999, Pages 693-699

  Bruening, Wendy ^c,d   Josée, Roy ^c   Giasson, Benoit ^a,e   Figlewicz, Denise A ^b   Mushynski, Walter E ^a   Durham, Heather D ^c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF ROCHESTER   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d FOX CHASE CANCER CENTER   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Chaperones; Cu Zn superoxide dismutase; Familial amyotrophic lateral sclerosis; Heat shock proteins; Motor neurons; Neuroprotection; Preferential vulnerability; SOD 1; Stress proteins; Stress response

Indexed keywords

CATALASE; CHAPERONE; COPPER ZINC SUPEROXIDE DISMUTASE; HEAT SHOCK PROTEIN; MUTANT PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE TRANSFER; LUMBAR SPINAL CORD; MOTONEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN TARGETING; TRANSGENIC MOUSE;

3T3 CELLS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL SURVIVAL; CHAPERONINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE TRANSFER TECHNIQUES; HEAT-SHOCK RESPONSE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NEUROPROTECTIVE AGENTS; SPINAL CORD; SUPEROXIDE DISMUTASE; TRANSFECTION; UP-REGULATION;

EID: 0344507132     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0720693.x     Document Type: Article

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