Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability

Journal of Biological Chemistry

Volumn 282, Issue 1, 2007, Pages 345-352

  Wang, Jiou ^a   Caruano Yzermans, Amy ^b   Rodriguez, Angela ^c   Scheurmann, Jonathan P ^c   Slunt, Hilda H ^a,d   Cao, Xiaohang ^c   Gitlin, Jonathan ^b   Hart, P John ^c   Borchelt, David R ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER LIGAND HISTIDINE RESIDUES; MOTOR NEURON INJURY; MUTATIONS;

BINDING ENERGY; COPPER; DISEASES; ELECTROPHORESIS; LIGANDS; X RAY DIFFRACTION ANALYSIS;

AMINO ACIDS;

COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; HISTIDINE; LIGAND; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DATA ANALYSIS; FEMALE; GENE MUTATION; GENETIC TRANSFECTION; LIGAND BINDING; MOTOR NEURON DISEASE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; TRANSGENIC MOUSE; TWO HYBRID SYSTEM; X RAY DIFFRACTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; HUMAN; METABOLISM; MOUSE; MUTATION; NERVE CELL; PROTEIN BINDING;

MUS MUSCULUS;

ANIMALS; COPPER; DIMERIZATION; HISTIDINE; HUMANS; LIGANDS; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; MUTATION; NEURONS; PROTEIN BINDING; SUPEROXIDE DISMUTASE; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33847003354     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604503200     Document Type: Article

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