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Volumn 6, Issue 12, 2009, Pages 1261-1282

Recent advances in intravenous delivery of poorly water-soluble compounds

Author keywords

Cochleate; Complexing agent; Cyclodextrin; Dendrimer; I.v. formulation; Liposome; Liquid crystalline nanoparticle; Nanoparticle; Polymeric micellar system; Prodrug

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALPHA CYCLODEXTRIN; AMIODARONE; AMPHOTERICIN B CHOLESTEROL SULFATE; AMPHOTERICIN B LIPID COMPLEX; APREPITANT; BETA CYCLODEXTRIN SULFOBUTYL ETHER; CALCITRIOL; CEREBRYX; CREMOPHOR; CYCLODEXTRIN DERIVATIVE; DENDRIMER; DISSOCUBES; DODECYL SULFATE SODIUM; DRF 4367; FENOFIBRATE; FOSPROPOFOL; HDDS; IRINOTECAN; ISOXAZOLE DERIVATIVE; ITRACONAZOLE; LINTEC; LUSEDRA; MEGLUMINE; MITOEXTRA; MITOMYCIN; MITOMYCIN C; NANOCRYSTAL; NANOEDGE; NANOMATERIAL; NANOMORPH; NANOPURE; NAPROXEN; NARINGENIN; NSC 639829; OTAXIO; PACLITAXEL; PLURONICS; POLYSORBATE; POLYSORBATE 20; POLYSORBATE 80; POVIDONE; PROPOFOL; PROSTAGLANDIN E1; PROSTAVASIN; RAPAMYCIN; RIGIDUR; SULFAFURAZOLE; TEBOROXIME TC 99M; TRIETHANOLAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERTEPORFIN; VINPOCETINE; VORICONAZOLE; XYTOTAX; ZIPRASIDONE;

EID: 71249130735     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425240903307423     Document Type: Review
Times cited : (76)

References (147)
  • 1
    • 55749089746 scopus 로고    scopus 로고
    • Strategies for formulating development of poorly water-soluble drug candidates - A recent perspective
    • Timpe C. Strategies for formulating development of poorly water-soluble drug candidates - a recent perspective. Am Pharm Rev 2007;0(3):104-109
    • (2007) Am Pharm Rev , vol.0 , Issue.3 , pp. 104-109
    • Timpe, C.1
  • 2
    • 0344540215 scopus 로고    scopus 로고
    • 2nd edition, Boca Raton, FL: CRC Press, Taylor & Francis Group A key reference for various water-insoluble drug formulation approaches
    • Liu R. Water insoluble drug formulation, 2nd edition, Boca Raton, FL: CRC Press, Taylor & Francis Group; 2008 . A key reference for various water-insoluble drug formulation approaches.
    • (2008) Water Insoluble Drug Formulation
    • Liu, R.1
  • 4
    • 71249109556 scopus 로고
    • Avis KE, Lieberman HA, Lachman L, editors 2nd edition New York NY: Marcel Dekker, Inc. . A key reference describing basic considerations in parenteral drug administration
    • In: Avis KE, Lieberman HA, Lachman L, editors, Pharmaceutical dosage forms: parenteral medications, 2nd edition New York NY: Marcel Dekker, Inc.; 1992. p. 17-58 . A key reference describing basic considerations in parenteral drug administration.
    • (1992) Pharmaceutical Dosage Forms: Parenteral Medications , pp. 17-58
  • 7
    • 0006573092 scopus 로고
    • Avis KE, Lieberman HA, Lachman L, editors 2nd edition. New York NY: Marcel Dekker, Inc. A key reference describing the development of small volume parenteral formulations
    • In: Avis KE, Lieberman HA, Lachman L, editors, Pharmaceutical dosage forms: parenteral medications. 2nd edition. New York NY: Marcel Dekker, Inc.; 1992. p. 173-248 . A key reference describing the development of small volume parenteral formulations.
    • (1992) Pharmaceutical Dosage Forms: Parenteral Medications , pp. 173-248
  • 8
    • 0003941956 scopus 로고    scopus 로고
    • Washington D.C.: American Chemical Society A key reference for estimation of solubility properties
    • Yalkowsky SH. Solubility and solubilization in aqueous media. Washington, D.C.: American Chemical Society; 1999 . A key reference for estimation of solubility properties.
    • (1999) Solubility and Solubilization in Aqueous Media
    • Yalkowsky, S.H.1
  • 9
    • 1242337285 scopus 로고    scopus 로고
    • Solubilizing excipients in oral and injectable formulations
    • Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm Res 2004;21:201-230
    • (2004) Pharm Res , vol.21 , pp. 201-230
    • Strickley, R.G.1
  • 10
    • 23644462081 scopus 로고    scopus 로고
    • Cyclodextrins in drug delivery
    • A key reference for formulation approaches using cyclodextrin complexation
    • Loftsson T, Jarho P, Masson M, Jarvinen T. Cyclodextrins in drug delivery. Expert Opin Drug Deliv 2005;2:335-351 . A key reference for formulation approaches using cyclodextrin complexation.
    • (2005) Expert Opin Drug Deliv , vol.2 , pp. 335-351
    • Loftsson, T.1    Jarho, P.2    Masson, M.3    Jarvinen, T.4
  • 11
    • 0035964466 scopus 로고    scopus 로고
    • Cyclodextrins in topical drug formulations: Theory and practice
    • Loftsson T, Masson M. Cyclodextrins in topical drug formulations: theory and practice. Int J Pharm 2001;225:15-30
    • (2001) Int J Pharm , vol.225 , pp. 15-30
    • Loftsson, T.1    Masson, M.2
  • 12
    • 24344508654 scopus 로고    scopus 로고
    • Evaluation of cyclodextrin solubilization of drugs
    • Loftsson T, Hreinsdottir D, Masson M. Evaluation of cyclodextrin solubilization of drugs. Int J Pharm 2005;302:18-28
    • (2005) Int J Pharm , vol.302 , pp. 18-28
    • Loftsson, T.1    Hreinsdottir, D.2    Masson, M.3
  • 13
    • 0037211341 scopus 로고    scopus 로고
    • Determination of second-order association constants by global analysis of 1H and 13C NMR chemical shifts Application to the complexation of sodium fusidate and potassium helvolate by beta- and gamma-cyclodextrin
    • Al-Soufi W, Cabrer PR, Jover A, et al. Determination of second-order association constants by global analysis of 1H and 13C NMR chemical shifts. Application to the complexation of sodium fusidate and potassium helvolate by beta- and gamma-cyclodextrin. Steroids 2003;68:43-53
    • (2003) Steroids , vol.68 , pp. 43-53
    • Al-Soufi, W.1    Cabrer, P.R.2    Jover, A.3
  • 14
    • 6344248531 scopus 로고    scopus 로고
    • Inclusion complexes of paclitaxel and oligo (ethylenediamino) bridged bis (beta-cyclodextrin)s: Solubilization and antitumor activity
    • Liu Y, Chen GS, Chen Y, et al. Inclusion complexes of paclitaxel and oligo (ethylenediamino) bridged bis (beta-cyclodextrin)s: solubilization and antitumor activity. Bioorg Med Chem 2004;12:5767-5775
    • (2004) Bioorg Med Chem , vol.12 , pp. 5767-5775
    • Liu, Y.1    Chen, G.S.2    Chen, Y.3
  • 15
    • 2942714975 scopus 로고    scopus 로고
    • Evidence for the 2:1 molecular recognition and inclusion behaviour between beta- and gamma-cyclodextrins and cinchonine
    • Wen X, Liu Z, Zhu T, et al. Evidence for the 2:1 molecular recognition and inclusion behaviour between beta- and gamma-cyclodextrins and cinchonine. Bioorg Chem 2004;32:223-233
    • (2004) Bioorg Chem , vol.32 , pp. 223-233
    • Wen, X.1    Liu, Z.2    Zhu, T.3
  • 16
    • 0037084343 scopus 로고    scopus 로고
    • Dendritic galactosides based on a beta-cyclodextrin core for the construction of site-specific molecular delivery systems: Synthesis and molecular recognition studies
    • Vargas-Berenguel A, Ortega-Caballero F, Santoyo-Gonzalez F, et al. Dendritic galactosides based on a beta-cyclodextrin core for the construction of site-specific molecular delivery systems: synthesis and molecular recognition studies. Chemistry 2002;8:812-827
    • (2002) Chemistry , vol.8 , pp. 812-827
    • Vargas-Berenguel, A.1    Ortega-Caballero, F.2    Santoyo-Gonzalez, F.3
  • 17
    • 0038023185 scopus 로고    scopus 로고
    • Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers
    • Kolhe P, Misra E, Kannan RM, et al. Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers. Int J Pharm 2003;259:143-160
    • (2003) Int J Pharm , vol.259 , pp. 143-160
    • Kolhe, P.1    Misra, E.2    Kannan, R.M.3
  • 18
    • 0036905907 scopus 로고    scopus 로고
    • New dendrimer peptide host guest complexes: Towards dendrimers as peptide carriers
    • Boas U, Sontjens SH, Jensen KJ, et al. New dendrimer peptide host guest complexes: towards dendrimers as peptide carriers. Chembiochem 2002;3:433-439
    • (2002) Chembiochem , vol.3 , pp. 433-439
    • Boas, U.1    Sontjens, S.H.2    Jensen, K.J.3
  • 19
    • 1842780869 scopus 로고    scopus 로고
    • Dynamics of cellular entry and drug delivery by dendritic polymers into human lung epithelial carcinoma cells
    • Kannan S, Kolhe P, Raykova V, et al. Dynamics of cellular entry and drug delivery by dendritic polymers into human lung epithelial carcinoma cells. J Biomater Sci Polym Ed 2004;15:311-330
    • (2004) J Biomater Sci Polym Ed , vol.15 , pp. 311-330
    • Kannan, S.1    Kolhe, P.2    Raykova, V.3
  • 20
    • 17444367675 scopus 로고    scopus 로고
    • Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications
    • Fuchs S, Otto H, Jehle S, et al. Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications. Chem Commun (Camb) 2005;1830-1832
    • (2005) Chem Commun (Camb) , pp. 1830-1832
    • Fuchs, S.1    Otto, H.2    Jehle, S.3
  • 21
    • 28744437107 scopus 로고    scopus 로고
    • Targeted drug delivery with dendrimers. comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex
    • Patri AK, Kukowska-Latallo JF, Baker JR Jr Targeted drug delivery with dendrimers. comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex. Adv Drug Deliv Rev 2005;57:2203-2214
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 2203-2214
    • Patri, A.K.1    Kukowska-Latallo, J.F.2    Baker Jr., J.R.3
  • 22
    • 31544443297 scopus 로고    scopus 로고
    • Synthesis and evaluation of novel dendrimers with a hydrophilic interior as nanocarriers for drug delivery
    • Dhanikula RS, Hildgen P. Synthesis and evaluation of novel dendrimers with a hydrophilic interior as nanocarriers for drug delivery. Bioconjug Chem 2006;17:29-41
    • (2006) Bioconjug Chem , vol.17 , pp. 29-41
    • Dhanikula, R.S.1    Hildgen, P.2
  • 23
    • 33846220323 scopus 로고    scopus 로고
    • Water-soluble carbosilane dendrimers: Synthesis biocompatibility and complexation with oligonucleotides; Evaluation for medical applications
    • Bermejo JF, Ortega P, Chonco L, et al. Water-soluble carbosilane dendrimers: synthesis biocompatibility and complexation with oligonucleotides; evaluation for medical applications. Chemistry 2007;13:483-495
    • (2007) Chemistry , vol.13 , pp. 483-495
    • Bermejo, J.F.1    Ortega, P.2    Chonco, L.3
  • 25
    • 71249161335 scopus 로고    scopus 로고
    • Molecules get suited up
    • Halford B. Molecules get suited up. Chem Eng News 2006;84(42):11
    • (2006) Chem Eng News , vol.84 , Issue.42 , pp. 11
    • Halford, B.1
  • 26
    • 33745819223 scopus 로고    scopus 로고
    • Fat-free albumin as a novel drug delivery system
    • Hussain R, Siligardi G. Fat-free albumin as a novel drug delivery system. Int J Peptide Res Ther 2006;2(3):311-315
    • (2006) Int J Peptide Res Ther , vol.2 , Issue.3 , pp. 311-315
    • Hussain, R.1    Siligardi, G.2
  • 27
    • 0242416983 scopus 로고    scopus 로고
    • Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis
    • Wunder A, Müller-Ladner U, Stelzer EH, et al. Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis. J Immunol 2003;170:4793-4801
    • (2003) J Immunol , vol.170 , pp. 4793-4801
    • Wunder, A.1    Müller-Ladner, U.2    Stelzer, E.H.3
  • 29
    • 0041703019 scopus 로고    scopus 로고
    • Pharmacological effects of formulation vehicles: Implications for cancer chemotheraphy
    • Ten Tije AJ, Verweij J, Loos WJ, Sparreboon A. Pharmacological effects of formulation vehicles: Implications for cancer chemotheraphy. Clin Pharmacokinet 2003;42(7):665-685
    • (2003) Clin Pharmacokinet , vol.42 , Issue.7 , pp. 665-685
    • Ten Tije, A.J.1    Verweij, J.2    Loos, W.J.3    Sparreboon, A.4
  • 30
    • 33750136313 scopus 로고    scopus 로고
    • Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery
    • Nishiyama N, Kataoka K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther 2006;112:630-648
    • (2006) Pharmacol Ther , vol.112 , pp. 630-648
    • Nishiyama, N.1    Kataoka, K.2
  • 31
  • 32
    • 13644262298 scopus 로고    scopus 로고
    • Block copolymer micelles as a solution for drug delivery problems
    • Torchilin VP. Block copolymer micelles as a solution for drug delivery problems. Expert Opin Ther Patents 2005;15(1):63-75
    • (2005) Expert Opin Ther Patents , vol.15 , Issue.1 , pp. 63-75
    • Torchilin, V.P.1
  • 33
    • 0037148656 scopus 로고    scopus 로고
    • Poly (ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery
    • Lavasanifar A, Samuel J, Kwon GS. Poly (ethylene oxide)-block-poly(L- amino acid) micelles for drug delivery. Adv Drug Deliv Rev 2002;54:169-190
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 169-190
    • Lavasanifar, A.1    Samuel, J.2    Kwon, G.S.3
  • 34
    • 0038759662 scopus 로고    scopus 로고
    • Amphiphilic block copolymers for drug delivery
    • Adams ML, Lavasanifar A, Kwon GS. Amphiphilic block copolymers for drug delivery. J Pharm Sci 2003;92:1343-1355
    • (2003) J Pharm Sci , vol.92 , pp. 1343-1355
    • Adams, M.L.1    Lavasanifar, A.2    Kwon, G.S.3
  • 35
    • 0037151313 scopus 로고    scopus 로고
    • Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery
    • Kabanov AV, Batrakova EV, Alakhov VY. Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. J Control Release 2002;82(2-3):189-212
    • (2002) J Control Release , vol.82 , Issue.2-3 , pp. 189-212
    • Kabanov, A.V.1    Batrakova, E.V.2    Alakhov, V.Y.3
  • 36
    • 4444231342 scopus 로고    scopus 로고
    • Poly (N-vinylpyrrolidone)-block-poly(D, L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: In vitro and in vivo evaluation
    • Le GD, Gori S, Luo L, et al. Poly (N-vinylpyrrolidone)-block-poly(D, L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation. J Control Release 2004;99:83-101
    • (2004) J Control Release , vol.99 , pp. 83-101
    • Le Gd Gori, S.1    Luo, L.2
  • 37
    • 0034950084 scopus 로고    scopus 로고
    • Novel polymeric micelles based on the amphiphilic diblock copolymer poly (N-vinyl-2-pyrrolidone)-block-poly(D, L-lactide)
    • Benahmed A, Ranger M, Leroux JC. Novel polymeric micelles based on the amphiphilic diblock copolymer poly (N-vinyl-2-pyrrolidone)-block-poly(D, L-lactide). Pharm Res 2001;18:323-328
    • (2001) Pharm Res , vol.18 , pp. 323-328
    • Benahmed, A.1    Ranger, M.2    Leroux, J.C.3
  • 38
    • 28544450961 scopus 로고    scopus 로고
    • Block copolymer micelles: Preparation, characterization and application in drug delivery
    • Gaucher G, Dufresne MH, Sant VP, et al. Block copolymer micelles: preparation, characterization and application in drug delivery. J Control Release 2005;109:169-188
    • (2005) J Control Release , vol.109 , pp. 169-188
    • Gaucher, G.1    Dufresne, M.H.2    Sant, V.P.3
  • 39
    • 0036181889 scopus 로고    scopus 로고
    • Practical aspects of lyophilization using non-aqueous co-solvent systems
    • Teagarden DL, Baker DS. Practical aspects of lyophilization using non-aqueous co-solvent systems. Eur J Pharm Sci 2002;15:115-133
    • (2002) Eur J Pharm Sci , vol.15 , pp. 115-133
    • Teagarden, D.L.1    Baker, D.S.2
  • 40
    • 0036000109 scopus 로고    scopus 로고
    • Pluronic block copolymers in drug delivery: From micellar nanocontainers to biological response modifiers
    • Kabanov AV, Alakhov VY. Pluronic block copolymers in drug delivery: from micellar nanocontainers to biological response modifiers. Crit Rev Ther Drug Carrier Syst 2002;19:1-72
    • (2002) Crit Rev Ther Drug Carrier Syst , vol.19 , pp. 1-72
    • Kabanov, A.V.1    Alakhov, V.Y.2
  • 41
    • 0033743807 scopus 로고    scopus 로고
    • Relationship between Pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes
    • Kozlov MY, Milik-Nubarov NS, Batrakova EV, Kabanov AV. Relationship between Pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes. Macromolecules 2000;33:3305-3313
    • (2000) Macromolecules , vol.33 , pp. 3305-3313
    • Kozlov, M.Y.1    Milik-Nubarov, N.S.2    Batrakova, E.V.3    Kabanov, A.V.4
  • 43
    • 1942470679 scopus 로고    scopus 로고
    • Phase i dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer
    • Danson S, Ferry D, Alakhov V, et al. Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer. Br J Cancer 2004;90:2085-2091
    • (2004) Br J Cancer , vol.90 , pp. 2085-2091
    • Danson, S.1    Ferry, D.2    Alakhov, V.3
  • 44
    • 0033991545 scopus 로고    scopus 로고
    • Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone
    • Allen C, Han J, Yu Y, et al. Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone. J Control Release 2000;63:275-286
    • (2000) J Control Release , vol.63 , pp. 275-286
    • Allen, C.1    Han, J.2    Yu, Y.3
  • 45
    • 0034234649 scopus 로고    scopus 로고
    • Polymeric micellar paclitaxel phosphorylates Bcl 2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors
    • Leung SY, Jackson J, Miyake H, et al. Polymeric micellar paclitaxel phosphorylates Bcl 2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors. Prostate 2000;44:156-163
    • (2000) Prostate , vol.44 , pp. 156-163
    • Leung, S.Y.1    Jackson, J.2    Miyake, H.3
  • 46
    • 2542559832 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies
    • Kim TY, Kim DW, Chung JY, et al. Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies. Clin Cancer Res 2004;10:3708-3716
    • (2004) Clin Cancer Res , vol.10 , pp. 3708-3716
    • Kim, T.Y.1    Kim, D.W.2    Chung, J.Y.3
  • 47
    • 16544373481 scopus 로고    scopus 로고
    • A multi-center, late phase II clinical trial of Genexol (paclitaxel) and cisplatin for patients with advanced gastric cancer
    • Park SR, Oh DY, Kim DW, et al. A multi-center, late phase II clinical trial of Genexol (paclitaxel) and cisplatin for patients with advanced gastric cancer. Oncol Rep 2004;12:1059-1064
    • (2004) Oncol Rep , vol.12 , pp. 1059-1064
    • Park, S.R.1    Oh, D.Y.2    Kim, D.W.3
  • 48
    • 10844293438 scopus 로고    scopus 로고
    • Phase i clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin
    • Matsumura Y, Hamaguchi T, Ura T, et al. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin. Br J Cancer 2004;91:1775-1781
    • (2004) Br J Cancer , vol.91 , pp. 1775-1781
    • Matsumura, Y.1    Hamaguchi, T.2    Ura, T.3
  • 49
    • 20944450473 scopus 로고    scopus 로고
    • NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel
    • Hamaguchi T, Matsumura Y, Suzuki M, et al. NK105, a paclitaxel- incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br J Cancer 2005;92:1240-1246
    • (2005) Br J Cancer , vol.92 , pp. 1240-1246
    • Hamaguchi, T.1    Matsumura, Y.2    Suzuki, M.3
  • 50
    • 0035816145 scopus 로고    scopus 로고
    • Development of the polymer micelle carrier system for doxorubicin
    • Nakanishi T, Fukushima S, Okamoto K, et al. Development of the polymer micelle carrier system for doxorubicin. J Control Release 2001;74:295-302
    • (2001) J Control Release , vol.74 , pp. 295-302
    • Nakanishi, T.1    Fukushima, S.2    Okamoto, K.3
  • 51
    • 0036803285 scopus 로고    scopus 로고
    • Polyethylene glycol-diacyllipid micelles demonstrate increased accumulation in subcutaneous tumors in mice
    • Lukyanov AN, Gao Z, Mazzola L, Torchilin VP. Polyethylene glycol-diacyllipid micelles demonstrate increased accumulation in subcutaneous tumors in mice. Pharm Res 2002;9:1424-1429
    • (2002) Pharm Res , vol.9 , pp. 1424-1429
    • Lukyanov, A.N.1    Gao, Z.2    Mazzola, L.3    Torchilin, V.P.4
  • 52
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • Maeda H, Wu J, Sawa T, et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 2000;65:271-284
    • (2000) J Control Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3
  • 53
    • 33845791448 scopus 로고    scopus 로고
    • Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs
    • Liu SQ, Wiradharma N, Gao SJ, et al. Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs. Biomaterials 2007;28:1423-1433
    • (2007) Biomaterials , vol.28 , pp. 1423-1433
    • Liu, S.Q.1    Wiradharma, N.2    Gao, S.J.3
  • 54
    • 14844286179 scopus 로고    scopus 로고
    • Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery
    • Soga O, Van Nostrum CF, Fens M, et al. Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. J Control Release 2005;103:341-353
    • (2005) J Control Release , vol.103 , pp. 341-353
    • Soga, O.1    Van Nostrum, C.F.2    Fens, M.3
  • 55
    • 0038106270 scopus 로고    scopus 로고
    • Poly (L-histidine)-PEG block copolymer micelles and pH-induced destabilization
    • Lee ES, Shin HJ, Na K, Bae YH. Poly (L-histidine)-PEG block copolymer micelles and pH-induced destabilization. J Control Release 2003;90:363-374
    • (2003) J Control Release , vol.90 , pp. 363-374
    • Lee, E.S.1    Shin, H.J.2    Na, K.3    Bae, Y.H.4
  • 56
    • 33847671358 scopus 로고    scopus 로고
    • TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors
    • Sethuraman VA, Bae YH. TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors. J Control Release 2007;118:216-224
    • (2007) J Control Release , vol.118 , pp. 216-224
    • Sethuraman, V.A.1    Bae, Y.H.2
  • 57
    • 33644818008 scopus 로고    scopus 로고
    • Solubilization of poorly soluble PDT agent, meso-tetraphenylporphin, in plain or immunotargeted PEG-PE micelles results in dramatically improved cancer cell killing in vitro
    • Roby A, Erdogan S, Torchilin VP. Solubilization of poorly soluble PDT agent, meso-tetraphenylporphin, in plain or immunotargeted PEG-PE micelles results in dramatically improved cancer cell killing in vitro. Eur J Pharm Biopharm 2006;62:235-240
    • (2006) Eur J Pharm Biopharm , vol.62 , pp. 235-240
    • Roby, A.1    Erdogan, S.2    Torchilin, V.P.3
  • 58
    • 0141921484 scopus 로고    scopus 로고
    • Micelles from polyethylene glycol/ phosphatidylethanolamine conjugates for tumor drug delivery
    • Lukyanov AN, Gao Z, Torchilin VP. Micelles from polyethylene glycol/ phosphatidylethanolamine conjugates for tumor drug delivery. J Control Release 2003;91:97-102
    • (2003) J Control Release , vol.91 , pp. 97-102
    • Lukyanov, A.N.1    Gao, Z.2    Torchilin, V.P.3
  • 59
    • 28444473061 scopus 로고    scopus 로고
    • Folate-conjugated methoxy poly(ethylene glycol)/poly(epsilon- caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery
    • Park EK, Kim SY, Lee SB, Lee YM. Folate-conjugated methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery. J Control Release 2005;109:158-168
    • (2005) J Control Release , vol.109 , pp. 158-168
    • Park, E.K.1    Kim, S.Y.2    Lee, S.B.3    Lee, Y.M.4
  • 60
    • 1842638560 scopus 로고    scopus 로고
    • Folate receptor targeted biodegradable polymeric doxorubicin micelles
    • Yoo HS, Park TG. Folate receptor targeted biodegradable polymeric doxorubicin micelles. J Control Release 2004;96:273-283
    • (2004) J Control Release , vol.96 , pp. 273-283
    • Yoo, H.S.1    Park, T.G.2
  • 61
    • 4544383493 scopus 로고    scopus 로고
    • Nanosuspensions in drug delivery
    • Rabinow BE. Nanosuspensions in drug delivery. Nat Rev Drug Discov 2004;3:785-796
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 785-796
    • Rabinow, B.E.1
  • 62
    • 33845238460 scopus 로고    scopus 로고
    • Pharmacokinetics of itraconazole and hydroxyitraconazole in healthy subjects after single and multiple doses of a novel formulation
    • Mouton JW, Van Peer A, De Beule K, et al. Pharmacokinetics of itraconazole and hydroxyitraconazole in healthy subjects after single and multiple doses of a novel formulation. Antimicrob Agents Chemother 2006;50:4096-4102
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 4096-4102
    • Mouton, J.W.1    Van Peer, A.2    De Beule, K.3
  • 63
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: Theory to practice
    • Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001;53:283-318
    • (2001) Pharmacol Rev , vol.53 , pp. 283-318
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 64
    • 5344234787 scopus 로고    scopus 로고
    • The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs
    • Kipp, JE. The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Int J Pharm 2004;284:109-122
    • (2004) Int J Pharm , vol.284 , pp. 109-122
    • Kipp, J.E.1
  • 65
    • 0037312695 scopus 로고    scopus 로고
    • Nanosizing: A formulation approach for poorly-water-soluble compounds
    • Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur J Pharm Sci 2003;18:113-120
    • (2003) Eur J Pharm Sci , vol.18 , pp. 113-120
    • Merisko-Liversidge, E.1    Liversidge, G.G.2    Cooper, E.R.3
  • 66
    • 4644309307 scopus 로고    scopus 로고
    • Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology
    • Moschwitzer J, Achleitner G, Pomper H, Müller RH. Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology. Eur J Pharm Biopharm 2004;58:615-619
    • (2004) Eur J Pharm Biopharm , vol.58 , pp. 615-619
    • Moschwitzer, J.1    Achleitner, G.2    Pomper, H.3    Müller, R.H.4
  • 67
    • 42649115104 scopus 로고    scopus 로고
    • Suspensions for intravenous (IV) injection: A review of development, preclinical and clinical aspects
    • Wong J, Brugger A, Khare A, et al. Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects. Adv Drug Deliv Rev 2008;60:939-954
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 939-954
    • Wong, J.1    Brugger, A.2    Khare, A.3
  • 68
    • 41949100244 scopus 로고    scopus 로고
    • Drug nanoparticles: Formulating poorly water-soluble compounds
    • Merisko-Liversidge EM, Liversidge GG. Drug nanoparticles: formulating poorly water-soluble compounds. Toxicol Pathol 2008;36:43-48
    • (2008) Toxicol Pathol , vol.36 , pp. 43-48
    • Merisko-Liversidge, E.M.1    Liversidge, G.G.2
  • 69
    • 28444461830 scopus 로고    scopus 로고
    • Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation
    • Keck CM, Müller RH. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. Eur J Pharm Biopharm 2006;62:3-16
    • (2006) Eur J Pharm Biopharm , vol.62 , pp. 3-16
    • Keck, C.M.1    Müller, R.H.2
  • 70
    • 0035937599 scopus 로고    scopus 로고
    • Nanosuspensions as particulate drug formulations in therapy Rationale for development and what we can expect for the future
    • Müller RH, Jacobs C, Kayser O. Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. Adv Drug Deliv Rev 2001;47:3-19
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 3-19
    • Müller, R.H.1    Jacobs, C.2    Kayser, O.3
  • 72
    • 71249096264 scopus 로고    scopus 로고
    • DissoCubes. SkyePharma PLC, London UK Available from Last accessed 9 March 2009
    • DissoCubes. SkyePharma PLC, London, UK, 2008. Available from: www. skyepharma.com/technology/oral technology/particle engineering technologies/dissocubes.html [Last accessed 9 March 2009]
    • (2008)
  • 73
    • 71249091483 scopus 로고    scopus 로고
    • Baxter International Microprecipitation method for preparing submicron suspensions. US6607784 2003
    • Baxter International Microprecipitation method for preparing submicron suspensions. US6607784; 2003
  • 75
    • 33947250628 scopus 로고    scopus 로고
    • Stable carbamazepine colloidal systems using the cosolvent technique
    • Douroumis D, Fahr A. Stable carbamazepine colloidal systems using the cosolvent technique. Eur J Pharm Sci 2007;30:367-374
    • (2007) Eur J Pharm Sci , vol.30 , pp. 367-374
    • Douroumis, D.1    Fahr, A.2
  • 76
    • 71249140865 scopus 로고    scopus 로고
    • Abbott Gmbh & Co., KG, Ludwigshafen, GermanyAvailable from Last accessed 9 March 2009
    • Nanomorph-: Introduction. SOLIQS, Abbott Gmbh & Co., KG, Ludwigshafen, GermanyAvailable from: www.soliqs.com/ NanoMorph R.20.0.html [Last accessed 9 March 2009]
    • Nanomorph: Introduction
  • 77
    • 34848863383 scopus 로고    scopus 로고
    • Amorphous drug nanosuspensions. 3. Particle dissolution and crystal growth
    • Lindfors L, Skantze P, Skantze U, et al. Amorphous drug nanosuspensions. 3. Particle dissolution and crystal growth. Langmuir 2007;23:9866-9874
    • (2007) Langmuir , Issue.23 , pp. 9866-9874
    • Lindfors, L.1    Skantze, P.2    Skantze, U.3
  • 78
    • 71249122064 scopus 로고    scopus 로고
    • paclitaxel albumin-bound particles) for Injectable Suspension prescription information. Abraxis BioScience, LLC, Los Angeles, CA, 2008 Available from [Last accessed 9 March 2009]
    • ABRAXANE- (paclitaxel albumin-bound particles) for Injectable Suspension prescription information. Abraxis BioScience, LLC, Los Angeles, CA, 2008 Available from: www.abraxane.com [Last accessed 9 March 2009]
  • 81
    • 32244448722 scopus 로고    scopus 로고
    • Nanoparticles of poorly water-soluble drugs prepared by supercritical fluid extraction of emulsions
    • Shekunov BY, Chattopadhyay P, Seitzinger J, Huff R. Nanoparticles of poorly water-soluble drugs prepared by supercritical fluid extraction of emulsions. Pharm Res 2006;23:196-204
    • (2006) Pharm Res , vol.23 , pp. 196-204
    • Shekunov, B.Y.1    Chattopadhyay, P.2    Seitzinger, J.3    Huff, R.4
  • 82
    • 31444432429 scopus 로고    scopus 로고
    • Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics
    • Pasquali I, Bettini R, Giordano F. Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics. Eur J Pharm Sci 2006;27:299-310
    • (2006) Eur J Pharm Sci , vol.27 , pp. 299-310
    • Pasquali, I.1    Bettini, R.2    Giordano, F.3
  • 83
    • 33645030096 scopus 로고    scopus 로고
    • Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs
    • Kocbek P, Baumgartner S, Kristl J. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int J Pharm 2006;312:179-186
    • (2006) Int J Pharm , vol.312 , pp. 179-186
    • Kocbek, P.1    Baumgartner, S.2    Kristl, J.3
  • 84
    • 0028200490 scopus 로고
    • Hydrosols: Alternatives for the parenteral application of poorly water soluble drugs
    • Gassmann P, List M, Schweitzer A, Sucker H. Hydrosols: alternatives for the parenteral application of poorly water soluble drugs. Eur J Pharm Biopharm 1994;40(22):64-72
    • (1994) Eur J Pharm Biopharm , vol.40 , Issue.22 , pp. 64-72
    • Gassmann, P.1    List, M.2    Schweitzer, A.3    Sucker, H.4
  • 85
    • 33947250628 scopus 로고    scopus 로고
    • Stable carbamazepine colloidal systems using the cosolvent technique
    • Douroumis D, Fahr A. Stable carbamazepine colloidal systems using the cosolvent technique. Eur J Pharm Sci 2007;0(5):367-374
    • (2007) Eur J Pharm Sci , vol.0 , Issue.5 , pp. 367-374
    • Douroumis, D.1    Fahr, A.2
  • 86
    • 0345593759 scopus 로고    scopus 로고
    • An investigation into the distribution of lecithins in nanosuspension systems using low frequency dielectric spectroscopy
    • Peters K, Müller RH, Craig DQ. An investigation into the distribution of lecithins in nanosuspension systems using low frequency dielectric spectroscopy. Int J Pharm 1999;184:53-61
    • (1999) Int J Pharm , vol.184 , pp. 53-61
    • Peters, K.1    Müller, R.H.2    Craig, D.Q.3
  • 87
    • 0001732841 scopus 로고
    • Studies on the formation and inversion of solids First paper: Supersaturation and supercooling
    • Ostwald W. Studies on the formation and inversion of solids. First paper: supersaturation and supercooling. Z Physik Chemie 1897;22:289-330
    • (1897) Z Physik Chemie , vol.22 , pp. 289-330
    • Ostwald, W.1
  • 88
    • 33244462200 scopus 로고    scopus 로고
    • Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening
    • Lindfors L, Skantze P, Skantze U, et al. Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening. Langmuir 2006;22:906-910
    • (2006) Langmuir , vol.22 , pp. 906-910
    • Lindfors, L.1    Skantze, P.2    Skantze, U.3
  • 89
    • 33344464389 scopus 로고    scopus 로고
    • Critical freezing rate in freeze drying nanocrystal dispersions
    • Lee J, Cheng Y. Critical freezing rate in freeze drying nanocrystal dispersions. J Control Release 2006;111:185-192
    • (2006) J Control Release , vol.111 , pp. 185-192
    • Lee, J.1    Cheng, Y.2
  • 90
    • 41949100244 scopus 로고    scopus 로고
    • Drug nanoparticles: Formulating poorly water-soluble compounds
    • Merisko-Liversidge EM, Liversidge GG. Drug nanoparticles: formulating poorly water-soluble compounds. Toxicol Path 2008;36:43-48
    • (2008) Toxicol Path , vol.36 , pp. 43-48
    • Merisko-Liversidge, E.M.1    Liversidge, G.G.2
  • 91
    • 34250879747 scopus 로고    scopus 로고
    • Itraconazole IV nanosuspension enhances efficacy through altered pharmacokinetics in the rat
    • Rabinow B, Kipp J, Papadopoulos P, et al. Itraconazole IV nanosuspension enhances efficacy through altered pharmacokinetics in the rat. Int J Pharm 2007;339(1-2):251-260
    • (2007) Int J Pharm , vol.339 , Issue.1-2 , pp. 251-260
    • Rabinow, B.1    Kipp, J.2    Papadopoulos, P.3
  • 92
  • 94
    • 71249131031 scopus 로고    scopus 로고
    • ABELCET Bridgewater NJ. Available from Last accessed 9 March 2009
    • ABELCET. Enzon Pharmaceuticals, Inc., Bridgewater, NJ, 2008. Available from: www.enzon.com/index.php?id=35 [Last accessed 9 March 2009]
    • (2008)
  • 95
    • 24644453083 scopus 로고    scopus 로고
    • Transfer of lipophilic drugs between liposomal membranes and biological interfaces: Consequences for drug delivery
    • Fahr A, Van HP, May S, et al. Transfer of lipophilic drugs between liposomal membranes and biological interfaces: consequences for drug delivery. Eur J Pharm Sci 2005;26:251-265
    • (2005) Eur J Pharm Sci , vol.26 , pp. 251-265
    • Fahr, A.1    Van Hp May, S.2
  • 97
    • 71249091482 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corp., East Hanover N. Available from [Last accessed 9 March 2009]
    • Visudyne. Novartis Pharmaceuticals Corp., East Hanover, N, 2008. Available from: www.visudyne.com/info/visudyne/ visudyne.jsp [Last accessed 9 March 2009]
    • (2008)
  • 98
    • 71249162179 scopus 로고    scopus 로고
    • Phase III study of paclitaxel (Pac) versus pegylated liposomal doxorubicin (PLD) for the treatment of advanced human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS): An Eastern Cooperative Oncology Group (ECOG) and AIDS Malignancy Consortium. 2007 ASCO Annual Meeting Proceedings
    • Von Roenn JH, Lee S, Cianfrocca M, et al. Phase III study of paclitaxel (Pac) versus pegylated liposomal doxorubicin (PLD) for the treatment of advanced human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS): an Eastern Cooperative Oncology Group (ECOG) and AIDS Malignancy Consortium. 2007 ASCO Annual Meeting Proceedings. J Clin Oncol 2007;25(18S):, 20503aa
    • (2007) J Clin Oncol , vol.25 , Issue.18 S
    • Von Roenn, J.H.1    Lee, S.2    Cianfrocca, M.3
  • 100
    • 0036308763 scopus 로고    scopus 로고
    • Phase II study of liposomal annamycin in the treatment of doxorubicin-resistant breast cancer
    • Booser DJ, Esteva FJ, Rivera E, et al. Phase II study of liposomal annamycin in the treatment of doxorubicin-resistant breast cancer. Cancer Chemother Pharmacol 2002;50(1):6-8
    • (2002) Cancer Chemother Pharmacol , vol.50 , Issue.1 , pp. 6-8
    • Booser, D.J.1    Esteva, F.J.2    Rivera, E.3
  • 101
    • 0016820946 scopus 로고
    • Cochleate lipid cylinders: Formation by fusion of unilamellar lipid vesicles
    • Papahadjopoulos D, Vail WJ, Jacobson K, Poste G. Cochleate lipid cylinders: formation by fusion of unilamellar lipid vesicles. Biochim Biophys Acta 1975;394:483-491
    • (1975) Biochim Biophys Acta , vol.394 , pp. 483-491
    • Papahadjopoulos, D.1    Vail, W.J.2    Jacobson, K.3    Poste, G.4
  • 102
    • 0035991636 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution after intravenous administration of a single dose of amphotericin B cochleates, a new lipid-based delivery system
    • Segarra I, Movshin Da L, Zarif L. Pharmacokinetics and tissue distribution after intravenous administration of a single dose of amphotericin B cochleates, a new lipid-based delivery system. J Pharm Sci 2002;91(8):1827-1837
    • (2002) J Pharm Sci , vol.91 , Issue.8 , pp. 1827-1837
    • Segarra, I.1    Movshin Da, L.2    Zarif, L.3
  • 103
    • 71249145421 scopus 로고    scopus 로고
    • CAMURUS AB, Lund, Sweden, Available from: [Last accessed 9 March 2009]
    • FluidCrystal- NP Injection nanoparticles. CAMURUS AB, Lund, Sweden, 2009 Available from: camurus.verkstad.org/ index.asp?DocumentID=3& DocumentIDSub=8&Lang=&ShowSub= (2)&Show=(3) &main=Technologies [Last accessed 9 March 2009]
    • (2009) FluidCrystal NP Injection Nanoparticles
  • 104
    • 33750058273 scopus 로고    scopus 로고
    • Physicochemical and drug delivery aspects of lipid-based liquid crystalline nanoparticles: A case study of intravenously administered propofol
    • Johnsson M, Barauskas J, Norlin A, Tiberg F. Physicochemical and drug delivery aspects of lipid-based liquid crystalline nanoparticles: a case study of intravenously administered propofol. J Nanosci Nanotechnol 2006;6:3017-3024
    • (2006) J Nanosci Nanotechnol , vol.6 , pp. 3017-3024
    • Johnsson, M.1    Barauskas, J.2    Norlin, A.3    Tiberg, F.4
  • 105
    • 34548023228 scopus 로고    scopus 로고
    • Prodrugs and parenteral drug delivery (2.2.2)
    • Stella, et al., editors Part I New York, NY: AAPS Press, Springer Science + Business Media, LLC; A key reference for prodrugs prepared for parenteral administration
    • Hemenway J, Stella VJ. Prodrugs and parenteral drug delivery (2.2.2). In: Stella, et al., editors, Prodrugs: challenges and rewards, Part I New York, NY: AAPS Press, Springer Science + Business Media, LLC; 2007. p. 218-81 . A key reference for prodrugs prepared for parenteral administration.
    • (2007) Prodrugs: Challenges and Rewards , pp. 218-81
    • Hemenway, J.1    Stella, V.J.2
  • 106
    • 13644254552 scopus 로고    scopus 로고
    • Cubic phases and cubic phase dispersions in a phospholipid-based system
    • Johnsson M, Barauskas J, Tiberg F. Cubic phases and cubic phase dispersions in a phospholipid-based system. J Am Chem Soc 2005;127:1076-1077
    • (2005) J Am Chem Soc , vol.127 , pp. 1076-1077
    • Johnsson, M.1    Barauskas, J.2    Tiberg, F.3
  • 107
    • 15844373752 scopus 로고    scopus 로고
    • Cubic phase nanoparticles (Cubosome): Principles for controlling size, structure, and stability
    • Barauskas J, Johnsson M, Joabsson F, Tiberg F. Cubic phase nanoparticles (Cubosome): principles for controlling size, structure, and stability. Langmuir 2005;21:2569-2577
    • (2005) Langmuir , vol.21 , pp. 2569-2577
    • Barauskas, J.1    Johnsson, M.2    Joabsson, F.3    Tiberg, F.4
  • 108
    • 12444281009 scopus 로고    scopus 로고
    • TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and pharmacological properties
    • Ishikawa T, Matsunaga N, Tawada H, et al. TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties. Bioorg Med Chem 2003;11:2427-2437
    • (2003) Bioorg Med Chem , vol.11 , pp. 2427-2437
    • Ishikawa, T.1    Matsunaga, N.2    Tawada, H.3
  • 109
    • 0034082277 scopus 로고    scopus 로고
    • Fosphenytoin and phenytoin in patients with status epilepticus: Improved tolerability versus increased costs
    • Detoledo JC, Ramsay RE. Fosphenytoin and phenytoin in patients with status epilepticus: improved tolerability versus increased costs. Drug Saf 2000;22(6):459-466
    • (2000) Drug Saf , vol.22 , Issue.6 , pp. 459-466
    • Detoledo, J.C.1    Ramsay, R.E.2
  • 110
    • 0037229835 scopus 로고    scopus 로고
    • Fosphenytoin: Clinical pharmacokinetics and comparative advantages in the acute treatment of seizures
    • Fischer JH, Patel TV, Fischer PA. Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures. Clin Pharmacokinet 2003;42:33-58
    • (2003) Clin Pharmacokinet , vol.42 , pp. 33-58
    • Fischer, J.H.1    Patel, T.V.2    Fischer, P.A.3
  • 112
    • 12444258723 scopus 로고    scopus 로고
    • Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: Synthesis and biological properties
    • Ueda Y, Matiskella JD, Golik J, et al. Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties. Bioorg Med Chem Lett 2003;13:3669-3672
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 3669-3672
    • Ueda, Y.1    Matiskella, J.D.2    Golik, J.3
  • 114
    • 0038198601 scopus 로고    scopus 로고
    • A mechanistic and kinetic study of the E-ring hydrolysis and lactonization of a novel phosphoryloxymethyl prodrug of camptothecin
    • Hanson BA, Schowen RL, Stella VJ. A mechanistic and kinetic study of the E-ring hydrolysis and lactonization of a novel phosphoryloxymethyl prodrug of camptothecin. Pharm Res 2003;20:1031-1038
    • (2003) Pharm Res , vol.20 , pp. 1031-1038
    • Hanson, B.A.1    Schowen, R.L.2    Stella, V.J.3
  • 115
    • 0037014697 scopus 로고    scopus 로고
    • A versatile prodrug approach for liposomal core-loading of water-insoluble camptothecin anticancer drugs
    • Liu X, Lynn BC, Zhang J, et al. A versatile prodrug approach for liposomal core-loading of water-insoluble camptothecin anticancer drugs. J Am Chem Soc 2002;124(26):7650-7651
    • (2002) J Am Chem Soc , vol.124 , Issue.26 , pp. 7650-7651
    • Liu, X.1    Lynn, B.C.2    Zhang, J.3
  • 117
    • 0036906513 scopus 로고    scopus 로고
    • Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC
    • Takata J, Hidaka R, Yamasaki A, et al. Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC. J Lipid Res 2002;43:2196-2204
    • (2002) J Lipid Res , vol.43 , pp. 2196-2204
    • Takata, J.1    Hidaka, R.2    Yamasaki, A.3
  • 118
    • 0034993240 scopus 로고    scopus 로고
    • The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting
    • Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 2001;41:189-207
    • (2001) Adv Enzyme Regul , vol.41 , pp. 189-207
    • Maeda, H.1
  • 119
    • 34347207622 scopus 로고    scopus 로고
    • Polymer drug conjugates as modulators of cellular apoptosis
    • Vicent MJ. Polymer drug conjugates as modulators of cellular apoptosis. AAPS J 2007;9(2):E200-7
    • (2007) AAPS J , vol.9 , Issue.2
    • Vicent, M.J.1
  • 120
    • 0032959549 scopus 로고    scopus 로고
    • Phase i clinical and pharmacokinetics study of PK1 [N-(2-hydroxypropyl) methacrylamide copolymer doxorubicin] first member of a new class of chemotherapeutic agents drug polymer conjugates
    • Vasey PA, Kaye SB, Morrison R, et al. Phase I clinical and pharmacokinetics study of PK1 [N-(2-hydroxypropyl) methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents drug polymer conjugates. Clin Cancer Res 1999;5:83-94
    • (1999) Clin Cancer Res , vol.5 , pp. 83-94
    • Vasey, P.A.1    Kaye, S.B.2    Morrison, R.3
  • 121
    • 84969784315 scopus 로고    scopus 로고
    • N-(2-hydroxypropyl) methacrylamide copolymer conjugates
    • Kwon editor New York NY: Marcel Dekker
    • Duncan R. N-(2-hydroxypropyl) methacrylamide copolymer conjugates. In: Kwon, editor, Polymeric drug delivery systems, New York, NY: Marcel Dekker; 2005. p. 1-92
    • (2005) Polymeric Drug Delivery Systems , pp. 1-92
    • Duncan, R.1
  • 122
    • 33748344520 scopus 로고    scopus 로고
    • Nanotechnology in caner therapeutics: Bioconjugated nanoparticles for drug delivery
    • Sinha R, Kim GJ, Nie S, Shin DM. Nanotechnology in caner therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 2006;5:1909-1917
    • (2006) Mol Cancer Ther , vol.5 , pp. 1909-1917
    • Sinha, R.1    Kim, G.J.2    Nie, S.3    Shin, D.M.4
  • 123
    • 33747840618 scopus 로고    scopus 로고
    • Polymer conjugates as anticancer nanomedicines
    • A current review on the use of polymer prodrugs for cancer treatments
    • Ducan R. Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer 2006;6:688-701 . A current review on the use of polymer prodrugs for cancer treatments.
    • (2006) Nat Rev Cancer , vol.6 , pp. 688-701
    • Ducan, R.1
  • 124
    • 18744372716 scopus 로고    scopus 로고
    • A phase i and pharmacokinetic study of camptothecin as a 1-hour infusion every 3 weeks in patients with advanced solid malignancies
    • Rowinsky EK, Rizzo J, Ocho L, et al. A phase I and pharmacokinetic study of camptothecin as a 1-hour infusion every 3 weeks in patients with advanced solid malignancies. J Clin Oncol 2003;21:148-157
    • (2003) J Clin Oncol , vol.21 , pp. 148-157
    • Rowinsky, E.K.1    Rizzo, J.2    Ocho, L.3
  • 125
    • 32944471178 scopus 로고    scopus 로고
    • Pegamotecan (EZ-246) a novel PEGylated camptothecin conjugate, for treatment of adenocarcinomas of the stomach and gastroesophageal (GE) junction: Preliminary results of a sing-agent phase-2 study
    • Scott L, Evans T, Uao J, et al. Pegamotecan (EZ-246) a novel PEGylated camptothecin conjugate, for treatment of adenocarcinomas of the stomach and gastroesophageal (GE) junction: Preliminary results of a sing-agent phase-2 study. J Clin Oncol 2004;22(14S):4030
    • (2004) J Clin Oncol , vol.22 , Issue.14 S , pp. 4030
    • Scott, L.1    Evans, T.2    Uao, J.3
  • 126
    • 0037413560 scopus 로고    scopus 로고
    • Synthesis and in vivo antitumor activity of poly(L-glutamic acid) conjugates of 20(S)-camptothecin
    • Bhatt R, De Vries P, Tulinsky J, et al. Synthesis and in vivo antitumor activity of poly(L-glutamic acid) conjugates of 20(S)-camptothecin. J Med Chem 2003;46:190-193
    • (2003) J Med Chem , vol.46 , pp. 190-193
    • Bhatt, R.1    De Vries, P.2    Tulinsky, J.3
  • 127
    • 0035816202 scopus 로고    scopus 로고
    • Water-soluble poly-(L-glutamic acid)-Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo
    • Singer JW, Bhatt R, Tulinsky J, et al. Water-soluble poly-(L-glutamic acid)-Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo. J Control Release 2001;74:243-247
    • (2001) J Control Release , vol.74 , pp. 243-247
    • Singer, J.W.1    Bhatt, R.2    Tulinsky, J.3
  • 128
    • 0034509559 scopus 로고    scopus 로고
    • Conjugation of camptothecin to poly-(L-glutamic acid)
    • Singer JW, De Vries P, Bhatt R, et al. Conjugation of camptothecin to poly-(L-glutamic acid). Ann NY Acad Sci 2000;922:136-150
    • (2000) Ann NY Acad Sci , vol.922 , pp. 136-150
    • Singer, J.W.1    De Vries, P.2    Bhatt, R.3
  • 129
    • 0037619168 scopus 로고    scopus 로고
    • Poly-(L)-Glutamic acid-paclitaxel (CT-2103) [XYOTAX-], a biodegradable polymeric drug conjugate. Characterization, preclinical pharmacology, and preliminary clinical data
    • Maeda, et al. editors New York NY: Kluwer Academic/Plenum Publishers
    • Singer J, Baker B, De Vries P, et al. Poly-(L)-Glutamic acid-paclitaxel (CT-2103) [XYOTAX-], a biodegradable polymeric drug conjugate. Characterization, preclinical pharmacology, and preliminary clinical data. In: Maeda, et al. editors, Polymer drugs in the clinical stage advantages and prospects, New York NY: Kluwer Academic/Plenum Publishers; 2003. p. 81-99
    • (2003) Polymer Drugs in the Clinical Stage Advantages and Prospects , pp. 81-99
    • Singer, J.1    Baker, B.2    De Vries, P.3
  • 130
    • 0036187909 scopus 로고    scopus 로고
    • Superior therapeutic profile of poly-L-glutamic acid-paclitaxel copolymer compared with taxol in xenogeneic compartmental models of human ovarian caricinoma
    • Auzenne E, Donato NJ, Li C, et al. Superior therapeutic profile of poly-L-glutamic acid-paclitaxel copolymer compared with taxol in xenogeneic compartmental models of human ovarian caricinoma. Clin Cancer Res 2002;8:573-581
    • (2002) Clin Cancer Res , vol.8 , pp. 573-581
    • Auzenne, E.1    Donato, N.J.2    Li, C.3
  • 131
    • 36248957157 scopus 로고    scopus 로고
    • Application of the O-N intramolecular acyl migration reaction in medicinal chemistry
    • Skwarczynski M, Kiso Y. Application of the O-N intramolecular acyl migration reaction in medicinal chemistry. Curr Med Chem 2007;14:2813-2823
    • (2007) Curr Med Chem , vol.14 , pp. 2813-2823
    • Skwarczynski, M.1    Kiso, Y.2
  • 132
    • 0041919716 scopus 로고    scopus 로고
    • A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: Design and synthesis of isotaxel
    • Hayashi Y, Skwarczynski M, Hamada Y, et al. A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: design and synthesis of isotaxel. J Med Chem 2003;46:3782-3784
    • (2003) J Med Chem , vol.46 , pp. 3782-3784
    • Hayashi, Y.1    Skwarczynski, M.2    Hamada, Y.3
  • 133
    • 71249163976 scopus 로고    scopus 로고
    • Thinking inside the box: The application of isolation technology for aseptic processing
    • Agalloco JP. Thinking inside the box: the application of isolation technology for aseptic processing. Pharm Technol 2006;30:8-11
    • (2006) Pharm Technol , vol.30 , pp. 8-11
    • Agalloco, J.P.1
  • 134
    • 0347418153 scopus 로고    scopus 로고
    • Combined effect of SLS and (SBE) (7M)-beta-CD on the solubilization of NSC-639829
    • Yang G, Jain N, Yalkowsky SH. Combined effect of SLS and (SBE) (7M)-beta-CD on the solubilization of NSC-639829. Int J Pharm 2004;269:141-148
    • (2004) Int J Pharm , vol.269 , pp. 141-148
    • Yang, G.1    Jain, N.2    Yalkowsky, S.H.3
  • 135
    • 5644285730 scopus 로고    scopus 로고
    • Combined effect of pH and polysorbates with cyclodextrins on solubilization of naringenin
    • Tommasini S, Calabro ML, Raneri D, et al. Combined effect of pH and polysorbates with cyclodextrins on solubilization of naringenin. J Pharm Biomed Anal 2004;36:327-333
    • (2004) J Pharm Biomed Anal , vol.36 , pp. 327-333
    • Tommasini, S.1    Calabro, M.L.2    Raneri, D.3
  • 136
    • 0242270818 scopus 로고    scopus 로고
    • The effect of pH and triethanolamine on sulfisoxazole complexation with hydroxypropyl-beta-cyclodextrin
    • Gladys G, Claudia G, Marcela L. The effect of pH and triethanolamine on sulfisoxazole complexation with hydroxypropyl-beta-cyclodextrin. Eur J Pharm Sci 2003;20:285-293
    • (2003) Eur J Pharm Sci , vol.20 , pp. 285-293
    • Gladys, G.1    Claudia, G.2    Marcela, L.3
  • 137
    • 33845217776 scopus 로고    scopus 로고
    • Bioavailability enhancement of poorly water soluble and weakly acidic new chemical entity with 2-hydroxypropyl-beta-cyclodextrin: Selection of meglumine, a polyhydroxy base, as a novel ternary component
    • Basavaraj S, Sihorkar V, Shantha Kumar TR, et al. Bioavailability enhancement of poorly water soluble and weakly acidic new chemical entity with 2-hydroxypropyl-beta-cyclodextrin: selection of meglumine, a polyhydroxy base, as a novel ternary component. Pharm Dev Technol 2006;11:443-451
    • (2006) Pharm Dev Technol , vol.11 , pp. 443-451
    • Basavaraj, S.1    Sihorkar, V.2    Shantha Kumar, T.R.3
  • 138
    • 0037422375 scopus 로고    scopus 로고
    • Effect of PVP K-25 on the formation of the naproxen: Beta-ciclodextrin complex
    • Valero M, Perez-Revuelta BI, Rodriguez LJ. Effect of PVP K-25 on the formation of the naproxen: beta-ciclodextrin complex. Int J Pharm 2003;253:97-110
    • (2003) Int J Pharm , vol.253 , pp. 97-110
    • Valero, M.1    Perez-Revuelta, B.I.2    Rodriguez, L.J.3
  • 139
    • 33748766100 scopus 로고    scopus 로고
    • Simultaneous effect of cyclodextrin complexation, pH, and hydrophilic polymers on naproxen solubilization
    • Cirri M, Maestrelli F, Corti G, et al. Simultaneous effect of cyclodextrin complexation, pH, and hydrophilic polymers on naproxen solubilization. J Pharm Biomed Anal 2006;42:126-131
    • (2006) J Pharm Biomed Anal , vol.42 , pp. 126-131
    • Cirri, M.1    Maestrelli, F.2    Corti, G.3
  • 140
    • 0036274480 scopus 로고    scopus 로고
    • Solubilization of a naphthoquinone derivative by hydroxypropyl-beta- cyclodextrin (HP-beta-CD) and polyvinylpyrrolidone (PVP-K30) the influence of PVP-K30 and pH on solubilizing effect of HP-beta-CD
    • Granero G, De Bertorello MM, Longhi M. Solubilization of a naphthoquinone derivative by hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and polyvinylpyrrolidone (PVP-K30). The influence of PVP-K30 and pH on solubilizing effect of HP-beta-CD. Boll Chim Farm 2002;141:63-66
    • (2002) Boll Chim Farm , vol.141 , pp. 63-66
    • Granero, G.1    De Bertorello, M.M.2    Longhi, M.3
  • 141
    • 11144224538 scopus 로고    scopus 로고
    • Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studies
    • Ribeiro L, Carvalho RA, Ferreira DC, Veiga FJ. Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studies. Eur J Pharm Sci 2005;24:1-13
    • (2005) Eur J Pharm Sci , vol.24 , pp. 1-13
    • Ribeiro, L.1    Carvalho, R.A.2    Ferreira, D.C.3    Veiga, F.J.4
  • 142
    • 71249100048 scopus 로고    scopus 로고
    • AI 850- Our reformulation of paclitaxel and potential bioequivalent of Abraxane-. Acusphere, Inc., Watertown, MA, Available from Last accessed 9 March 2009
    • AI 850- Our reformulation of paclitaxel and potential bioequivalent of Abraxane-. Acusphere, Inc., Watertown, MA, 2008 Available from: www.acusphere.com/ product/prod-ai850.html [Last accessed 9 March 2009]
    • (2008)
  • 143
    • 17644364059 scopus 로고    scopus 로고
    • Intravenous hydrophobic drug delivery: A porous particle formulation of paclitaxel (AI-850)
    • Straub JA, Chickering DE, Lovely JC, et al. Intravenous hydrophobic drug delivery: a porous particle formulation of paclitaxel (AI-850). Pharm Res 2005;22:347-355
    • (2005) Pharm Res , vol.22 , pp. 347-355
    • Straub, J.A.1    Chickering, D.E.2    Lovely, J.C.3
  • 146
    • 71249110831 scopus 로고    scopus 로고
    • North Ryde NSW Last accessed 9 March 2009 Australia, 2008Available from
    • Telesso Technologies Limited, North Ryde NSW, Australia, 2008Available from: http://telesso.com/ [Last accessed 9 March 2009]
  • 147
    • 71249161734 scopus 로고    scopus 로고
    • Available from Raleigh NC Last accessed 9 March 2009
    • Bioral Technology. BioDelivery Sciences International, Raleigh, NC, 2009. Available from: www.biodeliverysciences. com/Bioral.php [Last accessed 9 March 2009]
    • (2009) Bioral Technology


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