Bioavailability enhancement of poorly water soluble and weakly acidic new chemical entity with 2-hydroxy propyl-β-cyclodextrin: Selection of meglumine, a polyhydroxy base, as a novel ternary component

Pharmaceutical Development and Technology

Volumn 11, Issue 4, 2006, Pages 443-451

  Basavaraj, S ^a   Sihorkar, Vaibhav ^a   Shantha Kumar, T R ^a   Sundaramurthi, Prakash ^a   Srinivas, Nuggehally R ^a   Venkatesh, P ^a   Ramesh, Mullangi ^a   Kumar Singh, Sunil ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

2 hydroxypropyl cyclodextrin; DRF 4367; Meglumine; New chemical entity; Polyhydroxy base; Solubilization; Ternary component

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ANTIINFLAMMATORY AGENT; DRF 4367; MEGLUMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; ENERGY TRANSFER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUSPENSION; THERMODYNAMICS;

ACIDS; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; MEGLUMINE; PYRAZOLES; SOLUBILITY; SULFONAMIDES; THERMODYNAMICS; WATER;

EID: 33845217776     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450600770577     Document Type: Article

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