Strategies for formulation development of poorly water-soluble drug candidates - A recent perspective

American Pharmaceutical Review

Volumn 10, Issue 2, 2007, Pages

  Timpe, Carsten ^a  

^a Lilly Forschung

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; CLOFAZIMINE; CREMOPHOR; CYCLODEXTRIN; EXCIPIENT; KETOCONAZOLE; LABRASOL; LIPID; WATER;

DISSOLUTION; DOSE CALCULATION; DRUG ABSORPTION; DRUG DESIGN; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RESEARCH; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; EXPERIMENTAL ANIMAL; EXPERIMENTAL MODEL; EXPERIMENTATION; HUMAN; IN VIVO STUDY; LIPOPHILICITY; MATHEMATICAL COMPUTING; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; RAMAN SPECTROMETRY; REVIEW; STOMACH PH; THERMODYNAMICS;

EID: 55749089746     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (16)

1. Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy and Paul J. Feeney, Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Advanced Drug Delivery Reviews, Vol. 23, Issues 1-3, 1997, p. 3-25
2. G.L. Amidon, H. Lennernäs, V.P. Shah, J.R. Crison (1995), A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of In Vitro Drug Product Dissolution and In Vivo Bioavailability, Pharmaceutical Research 12:413-420.
3. Noyes, A., Whitney, W., The rate of solution of solid substances in their own solution, J. Am. Chem. Soc., 19 (1897) 930-934
4. Robert G. Strickley, Solubilizing Excipients in Oral and Injectable Formulations, Pharmaceutical Research, Vol. 21, No. 2, February 2004, p. 201-230
5. Kevin C. Johnson and Archie C. Swindell, Guidance in the Setting of Drug Particle Size Specification to Minimize Variability in Absorption", Pharmaceutical Research, Vol. 13, No. 12, 1996, p. 1795-1798.
6. NC.W. Pouton, Formulation of Poorly Water-Soluble Drugs For Oral Administration, Bulletin Technique Gattefossé, 2005
7. K. Miyazaki, The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlled release formulations, European Journal of Pharmaceutical Sciences 26 (2005) 1-8
8. Martin Wunderlich, Robert Becker, Thomas Bock, Rolf-Stefan Brickl, Willy Roth, Jennifer B. Dressman, Predicting drug formulation effects on the precipitation of a poorly soluble basic drug in the small intestine, J. Pharm. Pharmacol., 2004, vol. 56, no1, pp. 43-51
9. D. Hörter, J.B. Dressmann ,Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract, Advanced Drug Delivery Reviews 25 ( 1997) 3-14
10. Cadé, D., Cole, E.T., Mayer, J.-Ph., Wittwer, F. (1987), Liquid-filled and sealed hard gelatin capsules, Acta Pharm. Technol., 33, p. 97-100
11. Jörg Breitenbach, Melt Extrusion Can Bring Benefits to HIV Therapy: The Example of Kaletra Tablets, American Journal of Drug Delivery; 4(2): 61-64
12. J. Breitenbach et al., Confocal Raman-Spectroscopy: Analytical Approach to Solid Dispersions and Mapping of Drugs, Pharm. Res. 16: 1109-1113 (1999)
13. L. Yu, Amorphous pharmaceutical solids: preparation, characterization and stabilization, Advanced Drug Delivery Reviews, Volume 48, Issue 1, 16 May 2001, Pages 27-42
14. C. Leuner, J. Dressman, Improving drug solubility for oral delivery using solid dispersions, European Journal of Pharmaceutics and Biopharmaceutics 50 (2000), p. 47-60
15. A.K.Bansal et al., Stability and Solubility of Celecoxib-PVP Amorphous Dispersions: A Molecular Perspective, Pharm. Res. 21: 1762-1769 (2004)
16. M. Akimoto et al., Europ.J. Pharmaceut. Biopharmaceut. 49, 99-102 (2000)]